Microbes, combined with insects, convert organic waste into products of value. Resulting insects can be harvested and used as a high-quality protein resource, while the residues can be used as fertiliser. Microbes play an important role in the conversion process. This review’s aim was focused on how microbes promote insects such as black soldier fly (Hermetia illucens L.), house fly (Musca domestica L.), waxworm (Plodia interpunctella) and yellow meal worm (Tenebrio molitor L.), to convert organic waste, while also harmlessly reducing organic waste pollution. The novelty is reflected in some core gut microbiota and their secreted enzymes degrade macromolecules such as protein, fat, polysaccharide, cellulose, polystyrene and polyethylene. Gut microbiota also could help insects degrade hazardous substances such as antibiotics, mycotoxin, odorous substances, and inhibit pathogens in organic wastes to make substrates more fit for insects.