Intention to revisit tourist destinations in Indonesia

This study aims to examine the effect of tourism image, experiential value, and satisfaction on the intention of revisiting the tourist area. The present study used associative analysis to ascertain the link between two or more variables. The study is being conducted in North Sumatera province, Indonesia, specifically in the tourist area of Lake Toba. The research population is comprised of an undetermined number of tourists that visited the tourist area around Lake Toba. The sample size of 324 was determined, which was obtained by multiplying the least number of samples by four or five questionnaire item categories. An accidental sampling approach was employed in this study, and data processing was performed using descriptive and inferential statistics and Smart-PLS software. The empirical findings indicate that although the tourism image has a significant and positive impact on experiential satisfaction, the direct effect of experiential value has a negative value on experiential satisfaction. Moreover, through tourism experiential satisfaction, experiential value has a negative value on intentions to revisit the destination. On the other hand, the indirect relationship between the tourism image and the intention to revisit through tourism experiential satisfaction has a positive value. AcknowledgmentWe would like to express our gratitude to the Ministry of Education and Culture’s Directorate of Research and Community Service for funding this study via the “Higher Education Excellent Basic Research Grant Fund” program.

Ways to Improve the Regulation of Projects of the “Megascience” Class

The creation of unique scientific facilities of the “Megascience” class is a very complex and lengthy organizational and technical process, for the implementation of which the resources of several states are usually involved. In connection with the participation in the creation and implementation of a scientific project of the “Megascience” class of several states, it becomes necessary to distribute the rights, duties, costs and powers of project management among the participants. Currently, the Russian Federation lacks a sufficient level of legal regulation of projects of the “Megascience” class. Based on the analysis of Russian and foreign experience in the implementation of scientific projects of the “Megascience” class, the article presents proposals for improving the legal regulation of these projects being implemented on the territory of the Russian Federation. The article also discusses the specific problems that one has to face when implementing projects of the “Megascience” class in Russia, and the ways to solve them. In addition, the authors’ definitions of such key terms as “Megascience” class project, “unique scientific facility of the “Megascience class” and “scientific collaboration,” which are absent in the current legislation, are proposed. This research was supported by the Russian Foundation for Basic Research (grant 18-29-15036mk “Models for legal regulation of unique scientific facilities of ‘Megascience’ class at the national and international levels in the context of technological development of the Russian Federation”).

AB0001 INTERFERON SIGNATURE IN CHILDREN WITH CHRONIC NON-BACTERIAL OSTEOMYELITIS AND IT’S DYNAMIC AFTER BISPHOSPHONATES TREATMENT

Background:Chronic non-bacterial osteomyelitis (CNO) is an immune-mediated chronic inflammatory bone disease which predominantly affects children and adolescents. The pathogenesis of CNO related to imbalance between pro-inflammatory and anti-inflammatory cytokines. Interferon-I mediated pathway is associated with pathogenesis of different pediatric rheumatic diseases, such as juvenile systemic lupus erythematosus (jSLE), juvenile dermatomyositis (JDM), systemic onset of juvenile idiopathic arthritis (soJIA), and, most of all, with macrophage activation syndrome. The data on interferon-I- regulated pathway in CNO is absent. NSAIDs, non-biologic and biologic anti-inflammatory drugs and bisphosphonates (BF) are treatment options for patients with CNO. The main adverse event of BF is a flu-like syndrome probably caused by the excessive cytokine release stimulated by BF.Objectives:The aim of our study was to evaluate activity of Interferon-I mediated pathway in CNO patients and it’s dynamics after BF treatment.Methods:This prospective study included children with CNO requiring BF treatment (n=9), patients with soJIA (n=8), JDM (n=11) and jSLE (n=40) and healthy controls (HC, n=21). The activity of Interferon-I mediated pathway was assessed using interferon I score (IFN1 score). The score represented the median expression of 5 IFN1-regulated genes (IFI44L, IFI44, IFIT3, LY6E, MX1) measured by quantitative real-time PCR. Patients with CNO were treated with standard 3-day regimen (1 mg/kg/day). We measured interferon score before pamidronate (Day 0, n=9) and after (Day 3, n=7).Results:Median interferon score was 1.09 (0.96; 1.67) in CNO patients, 1.95 (1.3; 5.75) in soJIA, 7.6 (1.78; 29.0) in JDM and 16.9 (2.55; 40.3) in jSLE and 0.95 (0.82; 1.17) in HC (p=0.00001). Where were no difference in the IFN1 score between CNO and HC (p=0.222). In 6/7 CNO patients interferon score increased after pamidronate (p=0.015). The median interferon score after pamidronate increased and became 3.06 (0.87; 4,9, p=0.043); this may possibly explain the development of BF-related flu-like symptoms (cytokine release syndrome).Conclusion:While interferon I-regulated pathway is not directly associated with CNO pathogenesis, BF likely activates interferon-I-regulated pathway and thus could be a possible cause of flu-like syndrome.This work supported by the Russian Foundation for Basic Research (grant № 18-515-57001).Disclosure of Interests:None declared

Comparison of Plasma and Magnetic Overshoots of Interplanetary Shocks

<p>The structure of quasiperpendicular interplanetary (IP) shock fronts was studied based on the data from the BMSW plasma spectrometer, installed onboard the SPEKTR-R spacecraft, supplemented by magnetic field measurements on the WIND. Special attention was paid to periodic growths (overshoots) in the value of the ion flux relative to their mean values outside the ramp. A comparison of plasma overshoot was performed with the overshoot in the magnetic field, with the Mach number, and with the β parameter. Based on the analysis of 26 crossings of IP shocks, in which the overshoots in the ion flux and magnetic field value were observed, it was shown that the value of the magnetic field overshoot is, on the average, less than a similar value in the solar wind’s ion flux, which is associated with different time resolution of measurements.</p><p>The ion flux overshoot value is found to grow with the growth of the Mach number. It is shown that overshoots are formed not only in the supercritical shocks, but also in those with Mach numbers that are less than the value of the first critical Mach number. It is also found that the estimates of the coherent downstream oscillations of the ion flux and magnetic field good correlate with the convected ion gyroradius.</p><p>This work was supported by the Russian Foundation for Basic Research, grant no. 19-02-00177.</p>

Mineral assemblage within secondary crystallized melt inclusions in olivine of mantle xenoliths from the Bultfontein kimberlite pipe (Kaapvaal craton, South Africa)

<p>For the first time, snapshots of crystallized melts in olivine of sheared garnet peridotite xenoliths from the Bultfontein kimberlite pipe have been studied. This type of xenoliths represents the deepest mantle rocks derived from the base of lithosphere (at depths from 110 to 230 km for various ancient cratons). According to different models, such type of inclusions (secondary) in mantle minerals can be interpreted as relics of the most primitive (i.e., close-to-primary) kimberlite melt that infiltrated into sheared garnet peridotites. In general, these secondary inclusions are directly related to kimberlite magmatism that finally formed the Bultfontein diamond deposits. The primary/primitive composition of kimberlite melt is poorly constrained because kimberlites are ubiquitously contaminated by xenogenic material and altered by syn/post-emplacement hydrothermal processes. Thus, the study of these inclusions helps to significantly advance in solving numerous problems related to the kimberlite petrogenesis.</p><p>The unexposed melt inclusions were studied by using a confocal Raman spectroscopy. In total, fifteen daughter minerals within the inclusions were identified by this method. Several more phases give distinct Raman spectra, but their determination is difficult due to the lack of similar spectra in the databases. Various carbonates and carbonates with additional anions, alkali sulphates, phosphates and silicates were determined among daughter minerals in the melt inclusions: calcite CaCO<sub>3</sub>, magnesite MgCO<sub>3</sub>, dolomite CaMg(CO<sub>3</sub>)<sub>2</sub>, eitelite Na<sub>2</sub>Mg(CO<sub>3</sub>)<sub>2</sub>, nyerereite (Na,K)<sub>2</sub>Ca(CO<sub>3</sub>)<sub>2</sub>, gregoryite (Na,K,Ca)<sub>2</sub>CO<sub>3</sub>, K-Na-Ca-carbonate (K,Na)<sub>2</sub>Ca(CO<sub>3</sub>)<sub>2</sub>, northupite Na<sub>3</sub>Mg(CO<sub>3</sub>)<sub>2</sub>Cl, bradleyite Na<sub>3</sub>Mg(PO<sub>4</sub>)(CO<sub>3</sub>), burkeite Na<sub>6</sub>(CO<sub>3</sub>)(SO<sub>4</sub>)<sub>2</sub>, glauberite Na<sub>2</sub>Ca(SO<sub>4</sub>)<sub>2</sub>, thenardite Na<sub>2</sub>SO<sub>4</sub>, aphthitalite K<sub>3</sub>Na(SO<sub>4</sub>)<sub>2</sub>, apatite Ca<sub>5</sub>(PO<sub>4</sub>)<sub>3</sub>(OH,Cl,F) and tetraferriphlogopite KMg<sub>3</sub>FeSi<sub>3</sub>O<sub>10</sub>(F,Cl,OH). Note that carbonates are predominant among the daughter minerals in the melt inclusions. Moreover, there are quite a lot of alkali-rich daughter minerals within the inclusions as well. During the last decade, some research groups using different approaches proposed a model of carbonate/alkali‑carbonate composition of kimberlite melts in their source regions. This model contradicts to the generally accepted ultramafic silicate nature of parental kimberlite liquids. This study is a direct support of a new model of carbonatitic composition of kimberlite melts and also shows that alkali contents in kimberlite petrogenesis are usually underestimated.</p><p>This work was supported by the Russian Foundation for Basic Research (grant No. 20-35-70058).</p>

Model of Daytime Oxygen Emissions in the Mesopause Region and Above: New Results

<p>Atmospheric emissions of atomic and molecular oxygen have been observed since the middle of the 19th century. In the last decades, it has been shown that emissions of excited oxygen atom O(<sup>1</sup>D) and molecular oxygen in electronically-vibrationally excited states O<sub>2</sub>(b<sup>1</sup>Σ<sup>+</sup><sub>g</sub>, v) and O<sub>2</sub>(a<sup>1</sup>Δ<sub>g</sub>, v) are related by a unified photochemical mechanism in the mesosphere and lower thermosphere (MLT). The current study is performed in the framework of the state-of-the-art model of ozone and molecular oxygen photodissociation in the daytime MLT. In particular, the study includes a detailed description of the formation mechanism for excited oxygen components in the daytime MLT and presents the comparison of widely used photochemical models. The study also demonstrates new results such as i) new suggestions about possible products of collisional reactions of electronically-vibrationally excited oxygen molecules with atomic oxygen and ii) new estimates of O<sub>2</sub>(b<sup>1</sup>Σ<sup>+</sup><sub>g</sub>, v = 0 – 10) radiative lifetimes which are necessary for solving inverse problems in the lower thermosphere. Moreover, special attention is given to the Barth’s mechanism in order to demonstrate that its contribution to O<sub>2</sub>(b<sup>1</sup>Σ<sup>+</sup><sub>g</sub>, v) and O<sub>2</sub>(a<sup>1</sup>Δ<sub>g</sub>, v) populations is neglectable in daytime conditions regardless of fitting coefficients. In addition, possible applications of the daytime oxygen emissions are presented, e.g., the altitude profiles O(<sup>3</sup>P), O<sub>3</sub> and CO<sub>2</sub> can be retrieved by solving inverse photochemical problems where emissions from electronically vibrationally excited states of O<sub>2</sub> are used as proxies. The funding of V.Y., R.M. and I.M. was partly provided by the Russian Fund for Basic Research (grant RFBR No. 20-05-00450).</p>

Secular geomagnetic field variations in Bulgarian lands during Classical Age and Late Antiquity – new archaeomagnetic data

<p>Numerous historical sources and archaeological monuments attest the age of Antiquity in Bulgaria – from both the early Roman period (I – III c.) and Late Antiquity (IV – VI c.). Owing to systematic archaeological excavations, lasting more than 100 years, plenty of information has been accumulated concerning not only all aspects and manifestations of its material culture, but also their evolution and chronology.  This in turn allows for interdisciplinary fields such as archaeomagnetism to progress.</p><p>There are many archaeomagnetically studied archaeological structures from the Antiquity. The results included in the Bulgarian database form 74 reference points. However, only 20 of them are full-vector determinations because 70 % of the investigated materials are bricks. Hence, the secular variation of declination is poorly constrained within the considered period. Moreover, the reuse of bricks in the constructions occurred quite often (especially in the Late Antiquity) providing for possible errors in archaeological dating. In addition, stronger effects of magnetic anisotropy and cooling rate are usually expected for bricks than for hearths, domestic ovens, production kilns or burnt dwelling remains (there are no results from pottery in the Bulgarian dataset) and both factors are not evaluated for most of the older results. All this can explain the contradictions observed between some of the experimental results juxtaposed over the absolute time scale. In an attempt to clarify these contradictions 13 baked clay structures from eight archaeological sites were archaeomagnetically studied producing seven new directional and eight new intensity data. The samples collected possess variable magnetic properties suggesting differences in clay sources and/or firing conditions. Magnetically soft minerals prevail in seven structures but in the remaining six, abundant HCSLT phase is detected. The success rate of archaeointensity determination experiments vary from 49 to 100 %. It appears that samples containing HCSLT phase always produces good araeointensity results unlike those with the dominant presence of soft carriers.</p><p>The new reference points are compared with the present compilation of Bulgarian archaeomagnetic dataset and with the data from the neighboring countries.</p><p> </p><p>This study is supported by the grant KP-06-Russia-10 from the Bulgarian National Science Fund and Russian Foundation of the Basic Research grant 19-55-18006.</p>

High-temperature three-axis IRM Lowrie test

<p>The three-axis isothermal remanent magnetization (IRM) test (the Lowrie test; Lowrie, 1990, Geophys. Res. Lett., 17, 159-162) is a useful tool to identify ferromagnetic minerals by their coercivity and unblocking temperature spectra. In this study, we explore a variant of the Lowrie test in which measurements are conducted directly at elevated temperatures, and compare its performance with the results of the conventional stepwise procedure. IRM acquisition fields applied along three orthogonal axes were 1 T, 200 mT and 40 mT, respectively. The field value for the soft component was chosen so as to include ca. 90% of its coercivity spectrum. For the hard component the maximum available field was used. The test is applied to characterize the magnetic mineralogy of archaeological baked clays and bricks from Bulgaria and Russia. Bulgarian samples are baked clays from various Neolithic (5700-5300 BCE) archaeological sites and several bricks of the Roman epoch (III-IV c. AD). Samples from Russia are bricks originating from several regions with ages from XIII to early XIX c. AD.</p><p>The low- and intermediate-coercivity components of IRM in the studied samples are typically demagnetized by 520-550°C, compatible with substituted or cation-deficient magnetite or, possibly, maghemite. This is supported by the absence of the Verwey transition in studied samples (Kosterov et al., 2021, Geophys. J. Int., 224(2), 1256-1271). The high-coercivity component appears to be carried by two mineral phases with very distinct unblocking temperatures, 120-200°C and 500 to 640°C. The first phase is similar to the high coercivity, low unblocking temperature (HCSLT) phase described by McIntosh et al., 2007 (Geophys. Res. Lett., 34, L21302, doi: 10.1029/22007GL031168), and the second one appears to be hematite with variable degree of substitution.</p><p>Performance of the high-temperature variant of the Lowrie test compares favorably with the classical procedure, while the former is also significantly faster and yields a superior temperature resolution.</p><p>This study is supported by Russian Foundation of the Basic Research, grant 19-55-18006, and by Bulgarian National Science Fund, grant KP-06-Russia-10.</p>

Development of a domestic methodology for assessing the risks of acid effluent formation during storage and use of wastes from coal mining and processing

It is shown that the main ecologically significant characteristics of wastes from mining and processing of coal, which are considered when assessing their impact on the environment, are the indicators reflecting the risks of acidic water formation and leaching of macro- and microelements from rocks. A review of the methods used abroad to determine the risks of formation of acidic effluents during storage or use of wastes is carried out. It is shown that at present in the Russian Federation there is no regulatory support for assessing this indicator in wastes from mining, processing and combustion of coals. It is noted that for a preliminary assessment of the risks of acidic wastewater drainage, the most common method for determining the neutralization potential of waste is the so-called A. Sobek static test (ABA). The main stages of the development of the domestic method for determining the potential of neutralization in waste are presented and its approbation is carried out on existing research objects. The developed methodology takes into account the main provisions of the classical method for determining the neutralization potential of A. Sobek and makes additions to the procedure for testing of the samples, which makes it possible to increase the accuracy of the obtained results and extend the domestic methodology not only to wastes from mining and benefication of coals, but also to wastes from combustion and processing of coal, such as fly ash, slag and ash and slag wastes. The study was supported by the Russian Foundation for Basic Research, Grant No. 19-35-90117.

Study of model problem of structural bioinformatics

The paper is devoted to the study of methods for solving problems of structural bioinformatics on the example of solving a model problem of graphs layout on a plane. The paper considers an "energy" approach to solving this type of problems, based on the use of continuous optimization methods, the purpose of which is to find a configuration with a minimum energy. The paper formulates a model problem of graph layout, describes the structure of graphs to be processed, and defines an objective function that simulates the internal energy of graph layout. Several popular optimization methods are described, including a genetic algorithm and a differential evolution algorithm. Parallel variations of these two algorithms are considered. Implementation of a software system for automatic testing of a user-defined algorithm for solving model folding problems with support for parallel computing, web interface and visualization of computations is described. The work was carried out with the financial support of the Russian Foundation for Basic Research (Grant No. 20-07-01053 A).