scholarly journals Synthesis and Antibacterial Property of An Encapsulated Sulfonamide Nanoparticle in a Multidisciplinary Approach

2021 ◽  
Vol 9 (9) ◽  
pp. 151-157
Author(s):  
Ashli Brown ◽  
Mercedes Fernandez ◽  
Shaquan Parker ◽  
ZeAndra D. Whitfield ◽  
Xiaomei Zheng ◽  
...  
Keyword(s):  
Undergraduate Students ◽  
Multidisciplinary Approach ◽  
Antibacterial Property ◽  
Ethanol Solution ◽  
Water Soluble ◽  
Spectroscopic Methods ◽  
Gram Negative Bacteria ◽  
Sulfa Drug ◽  
Gram Negative ◽  
Drug Complex

Multigram quantity of a novel Sulfa Drug complex -poly(amido)amine-sulfonamide or PAMAM-Sulfa- was synthesized, from commercially available materials. It was characterized with spectroscopic methods such as nuclear magnetic resonance (NMR). The Kirby-Bauer test was used to test it against gram positive and/or gram negative bacteria using different concentrations of an ethanol solution of the PAMAM-Sulfa complex. The goal of this experiment was to synthesize and study the effect of water soluble encapsulated sulfonamides on common bacteria by undergraduate students engaging in research involving more than one STEM discipline. Students synthesized a dendrimer-sulfonamide complex before evaluating its antibiotic properties. In doing so, students employed research methods that are common to chemistry, biology and nanoscience while also learning about mechanism of infectious diseases, drugs and drug resistance. This project allowed students to combine aspects of scientific research that are usually done separately, and an opportunity to observe the seamlessness of multidisciplinary science.

scholarly journals Synthesis and Anti-Proliferative Effect of Linalool propionate Loaded Carbon Nanoparticles

2019 ◽  
Author(s):  
Gayathri P Kothandaraman ◽  
K Sathish Kumar ◽  
Nikhishaa Sree R. ◽  
J Rithika ◽  
S Dhanasree
Keyword(s):  
Proliferative Activity ◽  
Carbon Nanoparticles ◽  
Antibacterial Property ◽  
Water Soluble ◽  
Gram Negative Bacteria ◽  
Carbon Nanoparticle ◽  
Gram Negative ◽  
Proliferative Effect ◽  
Transmission Electron ◽  
Medicinal Properties

The essential oils (EOs) extracted from plants hold many medicinal properties. But the delivery of the EOs and maintenance of its stability is a challenge. In this study, a linalool associated compound isolated from Coriander sativum was conjugated with carbon nanoparticle (CNP). The conjugate was characterized by Fourier transform Infrared spectroscopy (FTIR), transmission electron microscope (TEM), and particle size (PS) analysis. The nano-sized conjugate showed similar antioxidant and anti-proliferative activity when compared to the pure extract. In the case of antibacterial property, conjugate showed good inhibition against both gram-positive and gram-negative bacteria whereas the extract showed inhibition only against gram-negative bacteria. In short, the activity of the compound was not altered by its conjugation with CNP. This conjugated compound was completely water soluble which shall make it a likely formulation for hydrophilic based drug delivery applications.

scholarly journals In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A

2018 ◽  
Vol 10 (464) ◽  
pp. eaal0033 ◽  
Author(s):  
Ahsan R. Akram ◽  
Sunay V. Chankeshwara ◽  
Emma Scholefield ◽  
Tashfeen Aslam ◽  
Neil McDonald ◽  
...  
Keyword(s):  
Lipid A ◽  
Respiratory Infections ◽  
Bacterial Species ◽  
Water Soluble ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Human Lungs ◽  
Fluorescent Peptide ◽  
Bacterial Lipid

Respiratory infections in mechanically ventilated patients caused by Gram-negative bacteria are a major cause of morbidity. Rapid and unequivocal determination of the presence, localization, and abundance of bacteria is critical for positive resolution of the infections and could be used for patient stratification and for monitoring treatment efficacy. Here, we developed an in situ approach to visualize Gram-negative bacterial species and cellular infiltrates in distal human lungs in real time. We used optical endomicroscopy to visualize a water-soluble optical imaging probe based on the antimicrobial peptide polymyxin conjugated to an environmentally sensitive fluorophore. The probe was chemically stable and nontoxic and, after in-human intrapulmonary microdosing, enabled the specific detection of Gram-negative bacteria in distal human airways and alveoli within minutes. The results suggest that pulmonary molecular imaging using a topically administered fluorescent probe targeting bacterial lipid A is safe and practical, enabling rapid in situ identification of Gram-negative bacteria in humans.

Glycosides from Cephalaria Species

2010 ◽  
Vol 65 (11) ◽  
pp. 1384-1392 ◽  
Author(s):  
Erkan Halay ◽  
Süheyla Kırmızıgül
Keyword(s):  
Mass Spectrometry ◽  
Oleanolic Acid ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Nmr Techniques ◽  
Basic Hydrolysis ◽  
Hydrolysis Of ◽  
Chemical Evidence

Three novel triterpene glycosides (1 - 3), namely lycicoside I, II and cilicicoside I, were isolated from two different Cephalaria (Dipsacaceae) species along with one known oleanane- and one iridoit- type of glycoside. The structures of these compounds were established as 3-O-[β -D-glucopyranosyl( 1→3)-α-L-rhamnopyranosyl(1→4)-β -D-xylopyranosyl(1→4)-β -D-xylopyranosyl]-28-O-[β -Dglucopyranosyl( 1→6)-β -D-glucopyranosyl]-oleanolic acid (1), 3-O-[β -D-xylopyranosyl(1→3)-α- L-rhamnopyranosyl(1→4)-β -D-xylopyranosyl]-28-O-[β -D-glucopyranosyl]-oleanolic acid (2) from Cephalaria lycica Matthew and 3-O-{β -D-glucopyranosyl(1→4)-β -D-xylopyranosyl(1→3)-α-Lrhamnopyranosyl( 1→2)-[β -D-glucopyranosyl(1→3)]-α -L-rhamnopyranosyl}-28-O-[β -D-glucopyranosyl( 1→6)-β -D-glucopyranosyl]-hederagenin (3) from Cephalaria cilicica Boiss. & Kotschy, on the basis of spectroscopic methods (1D and 2D NMR techniques, mass spectrometry) and chemical evidence. In addition, three new prosapogenins, 1B - 3B, were obtained from the basic hydrolysis of 1 - 3. The antimicrobial activity of 1 - 3 was tested against some Gram-positive and Gram-negative bacteria strains.

Nitric Oxide Inhibitory Activity of Xanthones from the Green Fruits of Cratoxylum formosum ssp. pruniflorum

2010 ◽  
Vol 63 (11) ◽  
pp. 1550 ◽  
Author(s):  
Nawong Boonnak ◽  
Achjana Khamthip ◽  
Chatchanok Karalai ◽  
Suchada Chantrapromma ◽  
Chanita Ponglimanont ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antibacterial Activity ◽  
Inhibitory Activity ◽  
Spectroscopic Methods ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
X Ray ◽  
X Ray Crystallography ◽  
Ic50 Values ◽  
Mic Value

Three new xanthones, pruniflorone M-O (1–3), and a new xanthonolignoid, 3-methoxy-5′-demethoxycadensin G (4), were isolated from the green fruits of Cratoxylum formosum ssp. pruniflorum along with three known xanthones (5–7) and a known flavonoid (8). Their structures were elucidated by spectroscopic methods and the structure of 1 was also determined by X-ray crystallography. Compounds 2 and 7 showed potent nitric oxide inhibitory activity with IC50 values of 4.4 and 4.3 μM, respectively. Moreover, 7 also showed strong antibacterial activity against both Gram-positive and Gram-negative bacteria with an MIC value of 4.67 μg mL–1.

scholarly journals Asymmetric one-pot synthesis of cyclopropanes

2016 ◽  
Vol 35 (1) ◽  
pp. 45
Author(s):  
Naoufel Ben Hamadi ◽  
Ahlem Guesmi ◽  
Wided Nouira
Keyword(s):  
Escherichia Coli ◽  
Water Soluble ◽  
Gram Negative Bacteria ◽  
Protecting Group ◽  
Gram Positive ◽  
One Pot ◽  
Gram Negative ◽  
Activity Screening ◽  
High Yields

Cycloaddition of the diazoalkanes to electron-deficient olefins (in situ) affords polysubstituted cyclopropanes in high yields (up to 85%). Deprotection of the ketal protecting group provided water-soluble cyclopropane-bearing carbohydrate in good yields. Antimicrobial activity screening of the synthesized compounds 8 and 9, utilizing a variety of Gram-positive (Staphylococcus aureus and Enterococcus fecalis), Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae) and yeast (Candida albicans), exhibited that all the prepared analogues acquire promising activities against both Gram-positive and Gram-negative bacteria especially compounds 9b and 9c (antimicrobial active agents against Gram-negative bacteria).

scholarly journals Antibacterial Screening of some Heterocyclic Compounds Containing Quinoline Nucleus

2017 ◽  
Vol 76 ◽  
pp. 27-40
Author(s):  
Shipra Baluja ◽  
Nilesh Godvani ◽  
Sumitra Chanda
Keyword(s):  
Heterocyclic Compounds ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Spectroscopic Methods ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
H Nmr ◽  
Antibacterial Screening ◽  
Derivatives Of ◽  
Agar Well Diffusion Method

In this work, some novel derivatives of Cyanopyridines and Isoxazoles were synthesized using Vilsmeier-Haack reagent and their structures were confirmed by FTIR, 1H NMR and mass spectroscopic methods. The antibacterial activities of these synthesized compounds were studied in DMSO and DMF by agar well diffusion method against some Gram positive and Gram negative bacteria. It is observed that activity depends upon three S: solvent, strain and structure.

Photodynamic inactivation of Escherichia coli with cationic ammonium Zn(ii) phthalocyanines

2015 ◽  
Vol 14 (10) ◽  
pp. 1872-1879 ◽  
Author(s):  
Deisy M. G. C. Rocha ◽  
N. Venkatramaiah ◽  
Maria C. Gomes ◽  
Adelaide Almeida ◽  
Maria A. F. Faustino ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Water Soluble ◽  
Gram Negative Bacteria ◽  
Photodynamic Inactivation ◽  
Gram Negative ◽  
Soluble Zinc

The aim of this work was the development of a family of novel water soluble zinc(ii) phthalocyanines (Pc) for the photodynamic inactivation of Gram-negative bacteria.

scholarly journals Preparation of New Biologically Active and Water Soluble Dyes: Characterization, Aggregation and Extraction of Metal Ions from Solutions

2019 ◽  
Vol 31 (6) ◽  
pp. 1398-1404
Author(s):  
NEDRA TOUJ ◽  
ABDULLAH SULAIMAN AL-AYED ◽  
NACEUR HAMDI
Keyword(s):  
Azo Dye ◽  
Water Soluble ◽  
Biologically Active ◽  
Gram Negative Bacteria ◽  
Dpph Radical ◽  
Gram Negative ◽  
Ic50 Values ◽  
Ft Ir ◽  
Uv Visible

The synthesis of metallo-phthalocyanines complexes (M = Co, Ni, Cu, Zn) containing azo dye were described in this study. The metallophthalocyanines have been supported by elemental analysis, UV-visible, FT-IR and NMR. The aggregation of phthalocyanine compounds was investigated in different solvents and concentrations. The newly synthesized metallophthalocyanines possess modest antibacterial activity against various Gram-positive and Gram-negative bacteria. Moreover, these complexes have been tested as antioxidant and presented remarkable activities by two different in vitro chemical assays. They were able to reduce DPPH % radical with IC50 values ranging from 3.8 to 7.5 μmol L-1 and some of them also reduced ABTS % radical cation.

scholarly journals Synthesis of the new sodium pectinate metal complexes with cobalt and nickel ions and their antimicrobial activity

2019 ◽  
Vol 487 (5) ◽  
pp. 511-514
Author(s):  
S. T. Minzanova ◽  
D. M. Arkhipova ◽  
A. V. Khabibullina ◽  
L. G. Mironova ◽  
A. D. Voloshina ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Physicochemical Properties ◽  
Cobalt Complexes ◽  
Water Soluble ◽  
Gram Negative Bacteria ◽  
Salt Formation ◽  
Gram Negative ◽  
Nickel Ions ◽  
Bacteria And Fungi ◽  
Cobalt And Nickel

New water-soluble nickel and cobalt complexes-sodium cobalt pectinate (PNaCo) and sodium nickel pectinate (PNaNi)-have been obtained from sodium pectinate with a salt formation extent of 35%, and their physicochemical properties have been studied. Antimicrobial activity of PNaCo and PNaNi against gram-positive and gram-negative bacteria and fungi has been shown.

scholarly journals Antibacterial and Cytotoxic Limonoids from the Seeds of Swietenia mahagony

1970 ◽  
Vol 8 (2) ◽  
pp. 141-145
Author(s):  
Md Abdul Kader ◽  
Md Ekramul Haque ◽  
Proma Khondkar ◽  
Md Monirul Islam ◽  
M Mukhlesur Rahman
Keyword(s):  
Antibacterial Activity ◽  
Brine Shrimp ◽  
Soluble Fraction ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Chloroform Extract ◽  
Spectroscopic Methods ◽  
Gram Negative Bacteria ◽  
2D Nmr Spectroscopy ◽  
Gram Negative

Two limonoids, swietenine (1) and 3-O-tigloylswietenolide (2), were isolated from the chloroform soluble fraction of an ethanolic extract of Swietenia mahagony seed. The structures of these compounds were confirmed by spectroscopic methods, including both 1D and 2D NMR spectroscopy. The chloroform extract and the limonoids (1 and 2) exhibited moderate antibacterial activity against a series of Gram positive and Gram negative bacteria. The minimum inhibitory concentrations (MICs) of 1 and 2 were found to be in the range of 32-64 μg/ml against Bacillus megatorium and Escherichia coli. Compounds 1 and 2 were also assessed for preliminary cytotoxicity against brine shrimp and the LC50 values were found to be 14.6 and 12.5 μg/ml, respectively. Key words: Swietenia mahagony; Meliaceae; Limonoids; Swietenine; 3-tigloylswietenolide; Antibacterial activity; Cytotoxicity. DOI: 10.3329/dujps.v8i2.6028 Dhaka Univ. J. Pharm. Sci. 8(2): 141-145, 2009 (December)

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