Mass media and society, a popular concept in media studies, has constituted much discourse due to roles media play in society and perceived effects that can result thereof. This chapter is inspired by the term ‘medicalization of the society' whereby ailments are regarded as medical issues and subjected to medical diagnosis and treatment, regardless of their true causes. Similarly, the violence, moral decadence and ethno-religious crises witnessed in the society are largely ascribed to the media. This chapter examined the said effects of mass media with society's social systems, cultures and values, with a view to finding a relationship. It argues that these societal makeups especially ones as formidable as Africa's also affect largely members' conducts and reactions to media contents. However, it advocates children's news segment, adherence to media ethics, and use of media programmes to enhance learning, proper socialization, abolishment of negative cultures, media literacy among others.