The structural transformation of modern societies (e.g. aging of population, mobility) as well as continuously increasing market dynamics (e.g. mergers, technological advancement) induce health care organizations, more than ever, to reduce their costs while enhancing service delivery at the same time. In other industrial sectors this was achieved by optimizing cooperation, coordination, and communication particularly with regard to the supplier base. However, as the pressure to innovate will increase extensively in the next years, similar developments are becoming relevant for the health care supply chain, too. In this chapter we therefore adapt the current findings on supplier relationship management (SRM) to the health care context. We analyze theoretical foundations of SRM and explore one particular area of application in health care, namely the ordering of pharmaceuticals by hospitals. On the basis of a case study we develop a future scenario for drugs supply management and discuss potential performance and quality improvements.