Operation reliability of NPP I&C and its components is considered in this chapter. Besides quantitative measures, qualitative features that provide required functional reliability such as protection against Common Cause Failures (CCF), single-failure criterion, redundancy, diversity, prevention of personnel errors, and technical diagnostics, are discussed. A group of features of NPP I&C and its components, united by “performance resistance,” is also considered. In particular, they are resistance to environment influences, mechanical influences (including earthquake impacts), insensitivity changes of power supply, and electromagnetic disturbances. Operation quality issues are considered. By quality (in a broad sense), the authors mean the accuracy, response rate characteristics, and features of human-machine interfaces. Features that provide NPP I&C independence from malfunction or removal from operation of system components (including redundant ones) or from adjacent NPP I&C, and the decrease of possible impact of components on other adjacent systems (electromagnetic emission, fire safety) are described as well.