Aircraft are used in a number of resource management operations, including fire suppression, seeding and fertilizing operations, and the application of pesticides to agricultural, forest, and rangelands. The objectives of any aerial application are to apply the material, either liquid or solid, to the target area safely, efficaciously, and economically and to avoid drift, that is, off-target displacement of the agents. Barry (1993) is a general reference for aerial spraying of forests. Picot and Kristmanson (1997) provide an overview of all aspects of this topic. Bache and Johnstone (1993) give a detailed description of spray meteorology. The emphasis in this chapter is on the role of meteorology in the aerial application of liquid pest control agents to manage plant, fungal, and animal pests in mountainous forested areas. The effectiveness of a spray operation depends on the timing of the operation relative to phenological conditions, the characteristics of the forest canopy or rangeland being targeted, the spray formulation, pilot skills and attitude, the aircraft type and spray equipment used, and weather conditions. Pest control agents are regulated by federal, state, and local agencies. Restrictions on the use of agents are specified on the product label and may include weather conditions. Drift reduces the efficacy of a spray operation and can have unintended and undesirable impacts on nontarget species, residences, and public areas near the target area. Although there is a driftable component in every spray operation, the drift potential is generally greater for liquids than for solids because the size of liquid droplets becomes smaller after release into the atmosphere, depending on the volatility of the substance itself, the aircraft and spray equipment used, and the meteorological conditions at the time of spraying. The smaller the droplets, the greater the potential for drift. Weather conditions have a significant impact on drift because wind speed and direction, temperature, humidity, and atmospheric stability affect the transport, diffusion, evaporation, settling, and deposition of both solid particles and liquid droplets. The collection of meteorological data and the use of professional weather forecasts are thus an integral part of a spraying operation.