INTEGRATION OF NEW DATA TYPES WITH HISTORICAL ARCHIVES TO PROVIDE INSIGHT INTO COASTAL ECOSYSTEM CHA

2006 ◽  
pp. 183-197
Author(s):  
JENNIFER GEBELEIN
Keyword(s):  
Coastal Ecosystem ◽  
Data Types ◽  
Historical Archives ◽  
Insight Into

scholarly journals Brain Tumor Discovery Using Image Preprocessing

2020 ◽  
Vol 11 (4) ◽  
pp. 6870-6875
Author(s):  
Prem Jacob T ◽  
Polakam Sukanya ◽  
Thatiparthi Madhavi
Keyword(s):  
Big Data Analytics ◽  
Malignant Growth ◽  
Data Types ◽  
Mri Scan ◽  
Tree Disease ◽  
Cancer Prediction ◽  
Wired Communication ◽  
The Brain ◽  
Highlight Extraction ◽  
Insight Into

The segmentation of attractive reverberation images assumes a critical job in therapeutic fields since it removes the required territory from the picture. Generally, there is no unique methodology for the segmentation of the picture. Tumour division from MRI information is a critical tedious manual undertaking performed by therapeutic specialists. In this paper, the Brain Cancer prediction System has been detailed. The framework utilizes PC based methods to recognize tumor squares and classify the tumour utilizing Artificial Neural Network. The picture preparing strategies, for example, histogram evening out, picture division, picture improvement, and highlight extraction, have been produced for the location of the cerebrum tumor in the MRI pictures of the malignant growth Detected patients. This paper focuses around another and exceptionally acclaimed algorithm for mind tumor division of MRI scan image by ANN and SVM algorithms to analyze precisely the locale of malignant growth as a result of its straightforwardness and computational proficiency. The MATLAB output will be shown in pc and furthermore observe the yield to insert framework utilizing wired communication. To the best of our insight into the zone of therapeutic big data analytics, none of the current work concentrated on the two data types. Contrasted with a few runs of the typical algorithms, the computation precision of our proposed algorithm achieves 94.8% with an assembly speed, which is quicker than that of the Decision tree disease hazard prediction.

scholarly journals The European Nucleotide Archive in 2019

2019 ◽  
Author(s):  
Clara Amid ◽  
Blaise T F Alako ◽  
Vishnukumar Balavenkataraman Kadhirvelu ◽  
Tony Burdett ◽  
Josephine Burgin ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Molecular Biology ◽  
Scientific Community ◽  
Sequence Data ◽  
European Bioinformatics Institute ◽  
Data Types ◽  
Nucleotide Sequence Data ◽  
European Nucleotide Archive ◽  
Access Services ◽  
Insight Into

Abstract The European Nucleotide Archive (ENA, https://www.ebi.ac.uk/ena) at the European Molecular Biology Laboratory’s European Bioinformatics Institute provides open and freely available data deposition and access services across the spectrum of nucleotide sequence data types. Making the world’s public sequencing datasets available to the scientific community, the ENA represents a globally comprehensive nucleotide sequence resource. Here, we outline ENA services and content in 2019 and provide an insight into selected key areas of development in this period.

scholarly journals Comparative Study of Computational Methods for Reconstructing Genetic Networks of Cancer-Related Pathways

2014 ◽  
Vol 13s2 ◽  
pp. CIN.S13781
Author(s):  
Nafiseh Sedaghat ◽  
Takumi Saegusa ◽  
Timothy Randolph ◽  
Ali Shojaie
Keyword(s):  
Biological Networks ◽  
Genetic Interaction ◽  
Empirical Evaluation ◽  
Network Reconstruction ◽  
Data Types ◽  
Reconstruction Methods ◽  
Cancer Initiation ◽  
Diverse Data ◽  
Substantial Heterogeneity ◽  
Insight Into

Network reconstruction is an important yet challenging task in systems biology. While many methods have been recently proposed for reconstructing biological networks from diverse data types, properties of estimated networks and differences between reconstruction methods are not well understood. In this paper, we conduct a comprehensive empirical evaluation of seven existing network reconstruction methods, by comparing the estimated networks with different sparsity levels for both normal and tumor samples. The results suggest substantial heterogeneity in networks reconstructed using different reconstruction methods. Our findings also provide evidence for significant differences between networks of normal and tumor samples, even after accounting for the considerable variability in structures of networks estimated using different reconstruction methods. These differences can offer new insight into changes in mechanisms of genetic interaction associated with cancer initiation and progression.

scholarly journals From the Legacy of the Landfras Printing Works in the Jindřichův Hradec Archives – a Mirror of Time in Family Correspondence

2019 ◽  
Vol 63 (3-4) ◽  
pp. 177-181
Author(s):  
Helena Hálová
Keyword(s):  
The State ◽  
Private Lives ◽  
Historical Archives ◽  
The Family ◽  
Leading Position ◽  
Inner World ◽  
The University ◽  
The Town ◽  
Insight Into ◽  
Synoptic Table

The article studies the set of 27 original letters deposited in the Documentation Collection – Cultural-Historical Archives of the State District Archives of Jindřichův Hradec. This collection contains documents of non-official provenance concerning, among other topics, also remarkable figures of the town. A leading position among them is assumed by the Landfras family, whose members were not only owners of a prosperous printing works, but also patriots, leaders of the town, and supporters of education, societies and culture. The letters provide an insight into the private lives of the members of the Landfras family, in particular its most significant member, Alois Landfras, and people connected with the family. The article deals with an overall comparison of the letters. It studies references to them and to events in their family, and connections with their life in Jindřichův Hradec. It adds some less known information on the studies of Alois Landfras at the university in Prague, providing an insight into his inner world. The article is complemented by a synoptic table of all letters, including the quoted persons and places.

Robert Hart and Gustav Detring during the Boxer Rebellion

2006 ◽  
Vol 40 (3) ◽  
pp. 631-662 ◽  
Author(s):  
HANS VAN DE VEN
Keyword(s):  
Critical Role ◽  
Historical Archives ◽  
Foreign Countries ◽  
Boxer Rebellion ◽  
Queen's University ◽  
Insight Into ◽  
The Way

This article focuses on Robert Hart during the Boxer Rebellion. My reconstruction of his activities is based on a recently discovered file in the archives of the Chinese Maritime Customs Service held at the Second Historical Archives in Nanjing. While it has long been known that Hart corresponded with Qing officials during the Siege itself and while a few letters have been published, the file contains more than one hundred exchanges between Hart and Qing officials written after the end of the Siege of the Legations. I have further relied on a box of documents dealing with the Boxer Rebellion in the Hart Manuscript Collection at the Queen's University of Belfast, including Hart's notes on his meetings with Qing officials. These materials provide insight into the way Hart was able to persuade the Qing and foreign countries to begin negotiations and illustrate the critical role he played in fashioning the Boxer Protocol signed on 7 September 1901.

Disruption of protocadherin function as an indicator of cancer progression.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e21159-e21159
Author(s):  
James Shima ◽  
Joseph Delaney ◽  
Anita Umesh ◽  
Jenny Park ◽  
Gregory Wall ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Lymph Node Metastases ◽  
Wilms Tumor ◽  
Breast Cancer Patients ◽  
Data Types ◽  
Node Metastases ◽  
Gamma Locus ◽  
Insight Into

e21159 Background: Protocadherins (PCDH) are a large family of calcium-dependent cell–cell adhesion molecules that are involved in tissue morphogenesis, in particular the development of the central nervous system. Recently, alteration of PCDH alpha/beta/gamma locus genes have been implicated in a number of oncogenic processes: hypermethylation of the PCDH locus in Wilms’ tumor progression and metastasis, differential expression of some PCDH genes between bone and brain metastases in breast cancer patients, and epigenetic silencing of PCDH gamma A11 in astrocytoma invasion of the adjacent parenchyma. Assessment of PCDH function could help guide treatment decisions by aiding in the identification of cancer patients who are more likely to develop metastases. Methods: Identification of altered PCDH locus genes in cancer patient samples was performed using the NextBio platform which incorporates curated public genomic data from numerous sources, including TCGA, GEO, COSMIC, and others. Correlation of numerous data types was used to identify deleterious mutations, altered RNA expression, and copy number changes that were indicative of metastasis or a more advanced disease state. Results: A nearly 3-fold increase in the frequency of potentially detrimental somatic mutations in the PCDH gamma locus was observed in breast and ovarian cancer patients with extensive lymph node metastases (N3) compared to patients with a lower degree of lymph node metastasis (N0-N2). Similarly, expression of PCDH locus genes was down-regulated in cases of lymphoma, in metastatic samples across a number of diseases, and in diseases that commonly result in lymph node metastases including breast and lung cancer. Conclusions: Stratification of patient subgroups based on molecular signatures has become increasingly important for both assigning patients to appropriate clinical trials as well as providing insight into effective treatment options. Examination of PCDH perturbations may provide insight into a patient’s risk of developing a metastatic disease, in particular metastases to lymph nodes, and help identify patients who may benefit from a more aggressive treatment regimen.

Calibration problems in hydrogen luminosities

1966 ◽  
Vol 24 ◽  
pp. 322-330
Author(s):  
A. Beer
Keyword(s):  
Galactic Structure ◽  
B Stars ◽  
Insight Into

The investigations which I should like to summarize in this paper concern recent photo-electric luminosity determinations of O and B stars. Their final aim has been the derivation of new stellar distances, and some insight into certain patterns of galactic structure.

Stochasting modeling of planetary ring systems

1984 ◽  
Vol 75 ◽  
pp. 461-469 ◽  
Author(s):  
Robert W. Hart
Keyword(s):  
Maximum Entropy ◽  
Ring System ◽  
The Sun ◽  
Ultimate State ◽  
Interparticle Interactions ◽  
Ring Systems ◽  
First Order ◽  
Planetary Ring ◽  
Insight Into

ABSTRACTThis paper models maximum entropy configurations of idealized gravitational ring systems. Such configurations are of interest because systems generally evolve toward an ultimate state of maximum randomness. For simplicity, attention is confined to ultimate states for which interparticle interactions are no longer of first order importance. The planets, in their orbits about the sun, are one example of such a ring system. The extent to which the present approximation yields insight into ring systems such as Saturn's is explored briefly.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

Structure and function of neural networks in the retina

1988 ◽  
Vol 46 ◽  
pp. 26-27
Author(s):  
Peter Sterling
Keyword(s):  
Ganglion Cells ◽  
Three Dimensional ◽  
Structure And Function ◽  
Synaptic Connections ◽  
Visual Axis ◽  
One Dimensional ◽  
Cat Retina ◽  
Ultrathin Sections ◽  
And Function ◽  
Insight Into

The synaptic connections in cat retina that link photoreceptors to ganglion cells have been analyzed quantitatively. Our approach has been to prepare serial, ultrathin sections and photograph en montage at low magnification (˜2000X) in the electron microscope. Six series, 100-300 sections long, have been prepared over the last decade. They derive from different cats but always from the same region of retina, about one degree from the center of the visual axis. The material has been analyzed by reconstructing adjacent neurons in each array and then identifying systematically the synaptic connections between arrays. Most reconstructions were done manually by tracing the outlines of processes in successive sections onto acetate sheets aligned on a cartoonist's jig. The tracings were then digitized, stacked by computer, and printed with the hidden lines removed. The results have provided rather than the usual one-dimensional account of pathways, a three-dimensional account of circuits. From this has emerged insight into the functional architecture.

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