scholarly journals Fetal Wound Healing

2020 ◽  
pp. 3-9
Author(s):  
Magda M. W. Ulrich
Keyword(s):  
Wound Healing ◽  
Animal Studies ◽  
Healing Process ◽  
Intrinsic Property ◽  
Wound Healing Process ◽  
Skin Wounds ◽  
Fetal Skin ◽  
Uterine Environment ◽  
Fetal Wound ◽  
Scarless Healing

AbstractFirst- and second-trimester fetal skin wounds are known to heal without scarring.Research has excluded factors like the sterile uterine environment as the cause of scarless repair, and it is believed that scarless healing is an intrinsic property of early fetal skin. However, increasing wound size and induction of the inflammatory reaction can evoke a scar response in the fetus.For decades, research is performed to elucidate the mechanisms responsible for scarless healing in fetuses. Much research has been performed in animal studies, and several mechanisms have been proposed to be involved such as the microenvironment and the extracellular matrix, a reduced inflammatory response, differences in growth factor profile, and differences in fibroblast phenotype.It is clear that the wound healing process leading to scarless healing cannot be attributed to just one factor or mechanism but will be the result of a complex of interconnected processes.This chapter describes some of the possible mechanisms which may play a role in scarless healing.

Skin wounds’ healing basic problems and the use of skin substitutes

2015 ◽  
Vol 6 (2) ◽  
pp. 85-95 ◽  
Author(s):  
Mariya Valer’yevna Konstantinova ◽  
Nikolay Valentinovich Khaytsev ◽  
Aleftina Alekseevna Kravtsova ◽  
Lev Dmitrievich Balashov
Keyword(s):  
Wound Healing ◽  
Mast Cells ◽  
Adult Stem Cells ◽  
Healing Process ◽  
Wound Healing Process ◽  
Skin Wounds ◽  
Skin Substitutes ◽  
Standard Methods ◽  
Heterogenous Group ◽  
Methods Of Treatment

Kin substitutes present a heterogenous group of substances that aid in temporary or permanent covering of wounds of various types. Although they can not replace surgical debridement or standard methods of treatment they proffer an alternative to standard methods of treatment whenever the latter are ineffective. Skin substitutes require less wound vascularization, they increase the wound’s cutaneous component, decrease or eliminate inhibitory factors, decrease inflammatory process and grant quick and safe wound closing. Mast cells besides regulating vascular reactions in trauma zone also boost immune, defensive and reparative processes in the wound. Stimulatory influence of mast cells upon fibrosis depend on activation of fibroblasts rather than direct collagen production by mast cells. Attention is focused at studies of autologous adult stem-cells’ stimulation in various organs and tissues as well as at intercellular matrix (ICM). ICM besides being cells’ fastening substrate also controls proliferation, differentiation, migration, apoptosis cells’ functions. Collagen, fibronectin, laminin, proteoglycanes, cytokines and chemokynes are important ICM components. Microcirculation plays a substantial role in wound healing process. Cultivated fibroblasts due to their ability for long-term synthesis of ICM components can effectively correct wound healing process. Allogenic fibroblasts can be successfully used as skin substitutes’ components in the treatment of skin wounds and burns. Unlike autologous fibroblasts the allogenic cells may be obtained in advance and freeze-stored in large quantities.

Advances in Gelatin-based Hydrogels for Wound Management

2021 ◽  
Author(s):  
Jeon Il Kang ◽  
Kyung Min Park
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Wound Management ◽  
Wound Healing Process ◽  
Skin Wounds ◽  
Normal Wound Healing

Skin wounds can be classified into two categories, namely acute and chronic. While acute wounds are healed by the normal wound healing process, chronic wounds are not normally healed, causing...

The Importance of Cutaneous Innervation in Wound Healing: From Animal Studies to Clinical Applications

2021 ◽  
pp. 153473462110450
Author(s):  
Shealinna Ge ◽  
Amor Khachemoune
Keyword(s):  
Wound Healing ◽  
Nervous System ◽  
Animal Studies ◽  
Wound Repair ◽  
Healing Process ◽  
Animal Experiments ◽  
Science Research ◽  
Human Studies ◽  
Wound Healing Process ◽  
Cutaneous Innervation

The skin is a neuroimmunoendocrine organ that regularly undergoes injury and repair. The complex process of wound healing relies heavily on the cutaneous nervous system. Despite the observation that wound healing deficiencies cause significant morbidity and mortality for patients with nervous dysfunction across many disciplinaries, the role of cutaneous innervation in wound repair has not been well elucidated. In a previous article, we learned the basics of cutaneous neuroanatomy and the important neuropeptides involved in the wound healing process. Currently, we aim to synthesize the basics with observations from animal models and human studies for a more comprehensive understanding of nervous system involvement in cutaneous wound healing. We have demonstrated in this review, the importance of the cutaneous nervous system in each phase of wound healing through basic science research, animal experiments, and human studies.

scholarly journals THE DYNAMICS OF WOUND HEALING IN THE TREATMENT WITH THE OINTMENT WITH A DRY EXTRACT OF POTENTILLA

2018 ◽  
Vol 25 (6) ◽  
pp. 105-109
Author(s):  
L. P. Lezhnevа ◽  
A. M. Temirbulatova ◽  
E. F. Stepanova ◽  
D. V. Veselova
Keyword(s):  
Wound Healing ◽  
Dosage Form ◽  
Healing Process ◽  
Control Group ◽  
Wound Healing Process ◽  
Skin Wounds ◽  
Full Thickness ◽  
Dry Extract ◽  
Full Thickness Skin ◽  
Thickness Skin

Aim. The study was designed for the evaluation of the effect of ointments with dry extracts of potentilla on the dynamics of the healing process of full-thickness skin wounds.Materials and methods. The wound healing activity estimation of the proposed dosage form was conducted on white Wistar rats. The results of macroscopic studies (the area of the wound defect, the state of the scab, the presence of hemorrhage beneath it, the degree of inflammatory processes in the underlying tissues, including deeply located tissue structures, up to the muscle elements) and the results of histological examination were the criterion for evaluating the effectiveness of the wound healing agent. In the course of the experiment, the animals were divided into 4 groups: the main group (treatment with the ointment with a dry extract of potentilla), control group No. 1 (treatment with the ointment base), control group No. 2 (without treatment), and control group No. 3 (treatment with the «Chlorophyllipt» drug.Results. The results of the macroscopic and histological studies made it possible to conclude that the wound healing process in the treatment with the ointment with a dry extract of potentilla had a number of features. The proposed dosage form enhanced the regeneration of the multilayered squamous epithelium, accelerated the maturation of the granulation tissue, and eliminated the inflammation and infiltration in the first days of treatment, which led to a significant reduction in the healing time when it was applied (15-18 days). In the animals of the control groups No. 1 and No. 2, the described processes occurred much more slowly, and inflammatory infiltration persisted almost throughout the entire experiment. The wound surface was healed on the 27-30th day. A lot of common features were noted in the mechanism and timing of wound healing in the treatment with the ointment with a dry extract of potentilla and a reference preparation – «Сhlorophyllipt». Conclusion. The ointment with a dry extract of potentilla significantly speeds up the healing process of full-thickness skin wounds.

Adult-Fetal Fibroblast Interactions: Effects on Cell Migration and Implications for Cell Transplantation

2005 ◽  
Vol 14 (5) ◽  
pp. 331-337 ◽  
Author(s):  
Vlad C. Sandulache ◽  
Joseph E. Dohar ◽  
Patricia A. Hebda
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Intrinsic Property ◽  
Cell Types ◽  
Wound Healing Process ◽  
Complex Process ◽  
Culture Model ◽  
Multiple Cell ◽  
Close Cooperation

Wound healing is a complex process involving close cooperation between multiple cell types. During wound healing, fibroblasts are primarily responsible for synthesis of the replacement extracellular matrix. Fibroblast therapy is under investigation in this and other laboratories for its potential use to modulate the final outcome of the wound-healing process. This study addresses the potential interactions between transplanted and host fibroblasts, using a two-dimensional mixed culture model. Our results show that fibroblasts of two different phenotypes, fetal and adult, exhibit different speeds of in vitro migration. These migration speeds are conserved in mixed cocultures, suggesting that the migratory response is an intrinsic property of the fibroblast rather than a response to juxtacrine or paracrine signals. These results have relevance for cell-based therapies in that they demonstrate that donor fibroblasts of a different phenotype may at least partially retain that phenotype in the host environment and in the presence of endogenous fibroblasts.

scholarly journals Development and evaluation of drug delivery patch for topical wound healing application

2021 ◽  
Vol 3 (10) ◽  
Author(s):  
Sadia Hassan ◽  
Murtaza Najabat Ali ◽  
Mariam Mir ◽  
Ammad Ahmed ◽  
Munam Arshad
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Animal Studies ◽  
Healing Process ◽  
Delivery Systems ◽  
In Vivo Studies ◽  
Wound Healing Process

AbstractWound treatment remains a challenge to many clinicians because of the complexities of the wound healing process. With the astonishing progress of biomedical engineering during the past few decades, conventional drug delivery systems have been evolved into smart drug delivery systems with stimuli-responsive characteristics. The objective of this study was to develop and evaluate an electromechanically actuated drug dispensation device which can release active pharmaceutical compound in a controlled fashion. Additive manufacturing was employed to design and fabricate the device. Haptic technology was used to provide stimulation for drug release, and Cicatrin was used to evaluate the drug release patterns of device. Drug release study was comprised of in vitro drug release, static study, and the purpose of this study was to develop a compliance chart for different wound conditions. The effectiveness of shortlisted drug regimen from compliance chart was validated through microbial study and animal studies. The results of animal studies were compared with commercially available drug release systems. The results of drug release studies gave different dose regimens for different wound conditions. The effective dose regimen was able to create 1-cm-wide microbial zone of inhibitions. The wound healing rate of mice for commercially available release system for five consecutive days was 10%, 10%, 20%, 40% and 50% and for test device was 10%, 30%, 60%, 90% and 100%. Hence, the device proved its effectiveness and efficacy of dosage regimen for wound healing applications through in vitro, microbial and in vivo studies. In conclusion, this device proved to be an accurate and specific drug delivery system with improved medication and therapeutic outcomes for personalized medication.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

2017 ◽  
Vol 2 (1) ◽  
pp. 20-28
Author(s):  
Fitriani ◽  
Tenriwati
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Healing Process ◽  
Data Retrieval ◽  
Observational Research ◽  
Wound Healing Process ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

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