Analysis of Protein Intramolecular and Solvent Bonding on Example of Major Sonovital Fluid Component

2021 ◽  
pp. 93-105
Author(s):  
Piotr Bełdowski ◽  
Krzysztof Domino ◽  
Damian Bełdowski ◽  
Robert Dobosz
Keyword(s):  
Fluid Component ◽  
Solvent Bonding

scholarly journals Analysis of Protein Intramolecular and Solvent Bonding on Example of Major Synovial Fluid Component

2019 ◽  
Author(s):  
Krzysztof Domino ◽  
Damian Bełdowski ◽  
Adam Mazurkiewicz ◽  
Janusz Musiał ◽  
Małgorzata Słomion ◽  
...  
Keyword(s):  
Amino Acids ◽  
Synovial Fluid ◽  
Hydrogen Bonds ◽  
Power Spectra ◽  
Point Of View ◽  
Experimental Setting ◽  
Scaling Exponents ◽  
Fluid Component ◽  
Solvent Bonding ◽  
Pi Interactions

In this paper we review dynamics and roughness of bonds in proteins on example of albumin, that is important from the physiological point of view. We have performed computer simulations of albumin chain. Statistics were collected by performing many simulations realizations for each experimental setting. We concentrate on hydrogen bonds, cation-π and π- π interactions and NP contacts. Histograms of hydrogen bonds length are positively skewed in contrary to histograms of interactions and HP contacts that are negatively skewed. Scaling exponents of power spectra of energies of bonds / interactions /contacts are in range -0.2 to -0.5 and significantly differ between various hydrogen bonds or interactions. Varying scaling of such spectra can be used to classify between distinct bonds or contacts. Concerning particular amino-acids, largest amount of HBO H20 bonds are between Glutamate (GLU) amino-acids and water particle, while large amount of HBO bonds are formed with Lysine (LYS). For HP contacts the mayor role plays Phenylalanine (PHE) and Leucine (LEU) amino-acids. From decay curves HBO H2O bonds decays in fastest rate, while HBO bonds and HP contacts at slowest rate. We present as well decay curves of bonds formed by particular amino-acids, that gives interesting results.

Transport: blood and circulation

2017 ◽  
Author(s):  
Derek Burton ◽  
Margaret Burton
Keyword(s):  
Carbon Dioxide ◽  
Blood Cells ◽  
Venous Return ◽  
White Blood Cells ◽  
Nutrient Transport ◽  
Blood System ◽  
Fluid Component ◽  
Nucleated Red Blood Cells ◽  
Ventral Aorta ◽  
Osmotic Effects

The blood system transports nutrients, oxygen, carbon dioxide and nitrogenous wastes; other functions include defence. Fish have a closed, single circulation in which blood is pumped by a contractile heart via a ventral aorta to the gills, then via the dorsal aorta to vessels supplying the tissues and organs, with a venous return to the heart. Large venous sinuses occur in elasmobranchs. Air-breathing fish have modifications of the circulation. Complex networks of narrow blood vessels can occur as red patches, retia, maximizing transfer of nutrients, oxygen or heat. Most fish have nucleated red blood cells (erythrocytes) with haemoglobin. The types of white blood cells (leucocytes) are similar to those of other vertebrates but there are thrombocytes rather than platelets. Nutrient transport is in the plasma, the fluid component of the blood, which may also carry antifreeze agents and molecules (e.g. urea in elasmobranchs) which counteract deleterious osmotic effects

3D Micromixer

2012 ◽  
Author(s):  
Bahador Farshchian ◽  
Junseo Choi ◽  
Sunggook Park
Keyword(s):  
Cover Plate ◽  
Bottom Surface ◽  
Mixing Efficiency ◽  
Molding Process ◽  
Specific Flow ◽  
Pdms Stamp ◽  
Fluorescein Dye ◽  
Solvent Bonding ◽  
Peeling Off

This paper presents the fabrication of a 3D microchannel whose sidewalls and bottom surface are patterned with ratchets using a modified 3D molding process. In the modified 3D molding process the surface of poly(methyl methacrylate) (PMMA) is first patterned using a brass mold having ratchet structures. Then PDMS prepolymer was spin coated over the surface of micropatterned PMMA and cured followed by the primary molding using a brass mold having a T-conjunction protrusion. After primary molding demolding was done by first demolding the brass mold and then peeling off PDMS stamp from PMMA substrate. By setting a 45° angle between direction of ratchets patterned on the surface of PMMA and the brass mold protrusion prior to primary molding 45° slanted ratchets were formed on the sidewall and bottom surface of microchannel using the modified 3D molding. The scanning electron microscope (SEM) micrographs show a successful integration of micropatterns inside the microchannel. Holes were drilled in the inlet and outlet area of the 3D channel before bonding. A solvent bonding technique was used for bonding of 3D channel to a plain cover plate. After bonding capillary tubes were inserted into the holes and glued to the chip using an epoxy glue. For characterization of mixing fluorescence intensity was quantified in the 3D microchannel as deionized water and fluorescein dye injected from different inlets of 3D micromixer were mixed along the 3D microchannel and mixing efficiency was calculated. The results were compared with the data obtained for similar microdevice whose surfaces were not patterned. The results demonstrate at a specific flow rate a faster mixing occurs in a microdevice whose sidewall and bottom surface are patterned with slanted 45° ratchets.

SPIN DIFFUSION COEFFICIENT OF A1-PHASE OF SUPERFLUID 3He AT LOW TEMPERATURES

2009 ◽  
Vol 23 (12) ◽  
pp. 1603-1610 ◽  
Author(s):  
R. AFZALI ◽  
F. PASHAEE
Keyword(s):  
Diffusion Coefficient ◽  
Boltzmann Equation ◽  
Low Temperatures ◽  
Spin Diffusion ◽  
Superfluid 3He ◽  
Total Spin ◽  
Equation Approach ◽  
Fluid Component ◽  
Melting Pressure ◽  
Superfluid Component

The spin diffusion coefficient tensor of the A1-phase of superfluid 3 He at low temperatures and melting pressure is calculated using the Boltzmann equation approach and Pfitzner procedure. Then considering Bogoliubov-normal interaction, we show that the total spin diffusion is proportional to 1/T2, the spin diffusion coefficient of superfluid component [Formula: see text] is proportional to T-2, and the spin diffusion coefficient of super-fluid component [Formula: see text] is independent of temperature. Furthermore, it is seen that superfluid components play an important role in spin diffusion of the A1-phase.

Microwave-induced, thermally assisted solvent bonding for low-cost PMMA microfluidic devices

2009 ◽  
Vol 20 (1) ◽  
pp. 015026 ◽  
Author(s):  
Mona Rahbar ◽  
Sumanpreet Chhina ◽  
Dan Sameoto ◽  
M Parameswaran
Keyword(s):  
Low Cost ◽  
Microfluidic Devices ◽  
Solvent Bonding

Production of Fluoropolymer Microchips for Droplet Microfluidics and DNA Amplification

2010 ◽  
Author(s):  
Stefano Begolo ◽  
Guillaume Colas ◽  
Laurent Malaquin ◽  
Jean-Louis Viovy
Keyword(s):  
Low Temperatures ◽  
Dna Amplification ◽  
Droplet Microfluidics ◽  
Cross Contamination ◽  
Uniform Pressure ◽  
Microfluidic Chips ◽  
Fabrication Technique ◽  
Flexible Membrane ◽  
Low Surface Energy ◽  
Solvent Bonding

In this paper we present a novel fabrication technique for production of monolithic microfluidic chips made from a fluoropolymer (Dyneon THV). This material retains numerous properties of commonly used fluoropolymers (low surface energy and compatibility with chemicals such as organic solvents or fluorinated oil), and is easily processable at relatively low temperatures (lower than 180°C). We used hot embossing to mold microstructures on flat sheets of this polymer. The microchips are sealed through a combination of thermal and solvent bonding by applying uniform pressure with a flexible membrane. These closed channels can be used for the production and circulation of aqueous droplets in fluorinated oil. This droplet microfluidic configuration is suitable for DNA amplification since it avoids cross contamination between adjacent droplets.

Comparative studies of energy saving polymers and fabrication of high performance transparent polymer by solvent bonding

2018 ◽  
Vol 39 (1) ◽  
pp. 68-75
Author(s):  
S.P. Aadhy ◽  
T. Hema Sinega ◽  
C. Karthikeyan ◽  
S. Akshay ◽  
Mohan Kumar Pitchan ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Energy Saving ◽  
High Performance ◽  
Solvent Mixture ◽  
Heat Transfer Analysis ◽  
Compression Moulding ◽  
Lap Shear ◽  
Visible Wavelengths ◽  
Pass Through ◽  
Solvent Bonding

Abstract This work investigates the possibility of using polyetherimide (PEI) as an energy saving alternative to glass, polymethylmethacrylate (PMMA) and polycarbonate (PC) by carrying out heat transfer analysis and suggests vaporized solvent bonding as a viable bonding technique for the fabrication of PEI. By heat transfer analysis using building energy simulation, it is observed that less energy is expended for space-conditioning of a building with windows made of PEI when compared to glass, PMMA and PC. The compression moulding technique is used to mould PEI and fabrication is done using a solvent mixture of dimethyl sulfoxide and tetrahydrofuran in 1:1 ratio. The optical properties of the bonded specimen are studied using UV-visible spectrophotometry and it is found that PEI does not allow UV wavelength radiation to pass through while transmitting visible wavelengths. The mechanical strength of the bond is tested using lap shear tensile strength test and the type of failure is observed to be cohesive from the structure. This is indicative of the fact that using this particular solvent to bond PEI results in the maximum possible strength.

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