Long-Term Microvascular Complications: New Ideas for Research

2016 ◽  
pp. 65-76
Author(s):  
Gianpaolo Zerbini ◽  
Silvia Maestroni
Keyword(s):  
Microvascular Complications ◽  
New Ideas

The Effects of P75NTR on Learning Memory Mediated by Hippocampal Apoptosis and Synaptic Plasticity

2020 ◽  
Vol 26 ◽  
Author(s):  
Jun-Jie Tang ◽  
Shuang Feng ◽  
Xing-Dong Chen ◽  
Hua Huang ◽  
Min Mao ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Learning And Memory ◽  
Neurological Diseases ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Negative Effects ◽  
Apoptotic Effect ◽  
New Ideas ◽  
The Relationship

: Neurological diseases bring great mental and physical torture to the patients, and have long-term and sustained negative effects on families and society. The attention to neurological diseases is increasing, and the improvement of the material level is accompanied by an increase in the demand for mental level. The p75 neurotrophin receptor (p75NTR) is a low-affinity neurotrophin receptor and involved in diverse and pleiotropic effects in the developmental and adult central nervous system (CNS). Since neurological diseases are usually accompanied by the regression of memory, the pathogenesis of p75NTR also activates and inhibits other signaling pathways, which has a serious impact on the learning and memory of patients. The results of studies shown that p75NTR is associated with LTP/LTD-induced synaptic enhancement and inhibition, suggest that p75NTR may be involved in the progression of synaptic plasticity. And its pro-apoptotic effect is associated with activation of proBDNF and inhibition of proNGF, and TrkA/p75NTR imbalance leads to pro-survival or pro-apoptotic phenomena. It can be inferred that p75NTR mediates apoptosis in the hippocampus and amygdale, which may affect learning and memory behavior. This article mainly discusses the relationship between p75NTR and learning memory and associated mechanisms, which may provide some new ideas for the treatment of neurological diseases.

scholarly journals Retinal vascular fractals predict long-term microvascular complications in type 1 diabetes mellitus: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

Diabetologia ◽  
2014 ◽  
Vol 57 (10) ◽  
pp. 2215-2221 ◽  
Author(s):  
Rebecca Broe ◽  
Malin L. Rasmussen ◽  
Ulrik Frydkjaer-Olsen ◽  
Birthe S. Olsen ◽  
Henrik B. Mortensen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Pediatric Diabetes ◽  
Danish Cohort

ADA Standards of Medical Care in Diabetes: implications for Older Adults

2020 ◽  
Vol 35 (6) ◽  
pp. 258-265
Author(s):  
Catherine E. Travis ◽  
Caren McHenry Martin
Keyword(s):  
Older Adults ◽  
Older People ◽  
Medical Care ◽  
Microvascular Complications ◽  
Cost Of Care ◽  
Individualized Treatment ◽  
Treatment Goals ◽  
Long Term Outcomes ◽  
New Literature

Each year, new literature and recommendations are incorporated into updates in the American Diabetes Association's Standards of Medical Care in Diabetes. The 2020 update increased the focus on the rising cost of care for diabetes, long-term outcomes of newer antihyperglycemics in reducing macrovascular and microvascular complications of diabetes, and the importance of individualized treatment goals. These principles are of particular significance when managing older people with diabetes. This article focuses on updates pertinent to care of the older people.

scholarly journals Diabetes Complications and their Relation to Glycemic Control among Patients Attending Diabetic Clinic at King Khalid National Guard Hospital in Jeddah, Saudi Arabia

2011 ◽  
Vol 1 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Abdullah M. Krawagh ◽  
Abdullah M. Alzahrani ◽  
Tariq A. Naser
Keyword(s):  
Diabetes Mellitus ◽  
Saudi Arabia ◽  
Heart Disease ◽  
Glycemic Control ◽  
Ischemic Heart Disease ◽  
National Guard ◽  
Microvascular Complications ◽  
Ischemic Heart ◽  
Diabetic Clinic

This study addresses the prevalence of ischemic heart disease, hypertension and long-term complications of diabetes mellitus among patients attending the diabetic clinic and their relation to glycemic control. Methods: A study was conducted on a cross-section on all consecutive patients attending the diabetic clinic at King Khalid National Guard Hospital in Jeddah, Saudi Arabia, from January 2007 to January 2008. The degree of glycemic control was gauged using blood level of glycosylated hemoglobin (HbA1C) and classified into good (less 7%), fair (7.1-8%), poor (8.1-9%) and very poor (greater than 9%). All patients were screened for hypertension, ischemic heart disease and microvascular complications. Results: Two hundred and ten patients were recruited in the study. Glycemic control was good in 17 (8.1%), fair in 49 (23.2%), poor in 56 (26.6%) and very poor in 88 (41.9%). There was high prevalence of retinopathy (76; 36%), microalbuminuria (80; 37.9%), neuropathy (108; 51.2%) and ischemic heart disease (51; 24.2%), especially among patients with poor and very poor control. Although the presence of hypertension, frank nephropathy and peripheral vascular disease was also disturbingly high among diabetic patients, their frequency was the same among good, fair, poor and very poor glycemic control groups. Conclusion: The prevalence of long-term complications of diabetes mellitus was alarmingly high among Saudi nationals. Microvascular complications and ischemic heart disease were also noticed to be more common in diabetics with poor and very poor glycemic control. This emphasizes the need of national awareness program about the gravity of the problem.

scholarly journals Recovery-informed Theory: Situating the Subjective in the Science of Substance Use Disorder Recovery

2019 ◽  
Vol 1 (3) ◽  
pp. 1-15 ◽  
Author(s):  
Austin M Brown ◽  
Robert D Ashford
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Substance Use Disorder ◽  
Systems Of Care ◽  
Grand Theory ◽  
Recovery Strategies ◽  
Recovery Capital ◽  
New Ideas

As recovery from substance use disorder becomes more than a mere quantifiable outcome, there exists a need to discuss and propose the underlying theoretical constructs that ultimately describe and identify the science of recovery. In this abstract undertaking, we propose an initial formulation of a grand theory of recovery science, built upon the seminal theories of recovery capital, recovery-oriented systems of care, and socioecological theory. This grand theory - labeled recovery-informed theory (RIT) - states that successful long-term recovery is self-evident and is a fundamentally emancipatory set of processes. This paper will discuss, analyze, and explore this theory as it is situated within the larger substance use, misuse, and disorder contexts. The uses, implications, and benefits of RIT as an organizing point of inquiry for recovery science are also discussed. By promoting the role of subjective recovery experience in the formulation of the study of recovery, it may be possible to summon new ideas, metrics, and strategies that can directly address substance use disorders in society. Adopting a recovery-informed understanding as follows from this grand theory may allow individual recovery and wellness trajectories to be explored, adapted, and modified to exemplify person-centered and individualized recovery strategies.

Ideas and Aspirations

2021 ◽  
pp. 221-239
Author(s):  
Oscar Calvo-Gonzalez
Keyword(s):  
United States ◽  
Technological Progress ◽  
Wide Spectrum ◽  
The United States ◽  
Policy Innovation ◽  
The State ◽  
Policy Entrepreneurs ◽  
New Ideas ◽  
Practical Agenda

This chapter explores how, behind the change in economic policymaking, lies a change in the ideas of the elite. And behind the change in ideas was a relentless scanning of experience outside Spain, especially in Europe. The chapter documents how the technocrats that held increasing power in 1960s Spain consistently sought out new ideas about policymaking from Europe and the United States. They were deliberate policy entrepreneurs. Like their Western European peers, the technocrats considered a responsibility of the state to seek to advance progress for a wide spectrum of society. To pursue this objective, they considered it critical to increase efficiency and put great faith in technological progress. The chapter concludes that what truly stands out of the technocrats is that they were able to implement their practical agenda over a sustained period. There had been previous technocratic efforts to emulate European practices, sometimes from reformers that reached even higher levels of government. A long-term horizon allowed policies to evolve without unnecessary volatility, striking a balance between policy innovation and policy continuity.

scholarly journals Chronic Microvascular Complications in Prediabetic States—An Overview

2020 ◽  
Vol 9 (10) ◽  
pp. 3289
Author(s):  
Angelika Baranowska-Jurkun ◽  
Wojciech Matuszewski ◽  
Elżbieta Bandurska-Stankiewicz
Keyword(s):  
Risk Factor ◽  
Glucose Metabolism ◽  
Microvascular Complications ◽  
Current Data ◽  
Chronic Complications ◽  
Prediabetic State ◽  
Complications Of Diabetes ◽  
Glucose Levels ◽  
Abnormal Glucose Metabolism

A prediabetic state is a major risk factor for the development of diabetes, and, because of an identical pathophysiological background of both conditions, their prevalence increases parallelly and equally fast. Long-term hyperglycemia is the main cause inducing chronic complications of diabetes, yet the range of glucose levels at which they start has not been yet unequivocally determined. The current data show that chronic microvascular complications of diabetes can be observed in patients with abnormal glucose metabolism in whom glycaemia is higher than optimal but below diagnostic criteria for diabetes. Prediabetes is a heterogenous nosological unit in which particular types are differently characterized and show different correlations with particular kinds of complications. Analysis of the latest research results shows the need to continue studies in a larger population and can imply the need to verify the currently employed criteria of diagnosing diabetes and chronic complications of diabetes in people with prediabetes.

A Review of Pramlintide in the Management of Diabetes

2009 ◽  
Vol 1 ◽  
pp. CMT.S2369
Author(s):  
Caroline Messer ◽  
Dina Green
Keyword(s):  
Microvascular Complications ◽  
Effective Means ◽  
Postprandial Glucose ◽  
Tight Glycemic Control ◽  
Minimal Risk ◽  
Patients With Diabetes ◽  
Insulin Dependent

Tight glycemic control in type 1 and type 2 diabetes reduces the risk for microvascular complications, including retinopathy, nephropathy, and neuropathy. Yet, despite intensive insulin regimens, many insulin-dependent patients are unable to achieve euglycemic states. This review will focus on pramlintide, an equipotent amylin analog, and its role in the management of diabetes. Pramlintide lowers glucose through the same mechanisms as amylin: it slows gastric emptying, suppresses the postprandial rise of glucagon in patients with diabetes, and promotes satiety. Long-term clinical trials have shown that the use of pramlintide as an adjunct to insulin minimizes postprandial glucose excursions and reduces both HbA1C and body weight when compared to placebo. Although its effects on HbA1C are modest, pramlintide has gained popularity as a result of its relatively few contraindications, limited side effects, minimal risk for hypoglycemia, and potential for weight loss. The combination of insulin and pramlintide may provide an effective means for patients with diabetes to meet their HbA1C goals.

scholarly journals Advances in research on the effects of natural drugs with immune-promoting effects on immune function

2020 ◽  
Vol 18 ◽  
pp. 205873922092687
Author(s):  
Lu Wang ◽  
Sha Li ◽  
Haibo Liu ◽  
Lidao Bao
Keyword(s):  
Pharmacological Effects ◽  
Specific Immunity ◽  
Natural Medicine ◽  
Wide Range ◽  
Great Progress ◽  
New Ideas ◽  
Natural Drugs ◽  
Natural Medicines ◽  
Made In

Immune-enhanced natural medicines have gradually formed unique functions and usages through long-term medical practice, which contained rich immunological ideas and contents. The immune-enhancing natural medicine has a wide range of pharmacological effects in anti-inflammatory, anti-tumor, anti-viral, and immunity enhancement. In recent years, great progress has been made in the study of immune-enhanced natural drugs. In this article, the main active ingredients of some natural drugs with immune-enhancing function are reviewed, which can enhance immunity by regulating the level of some cytokines and affecting the function of non-specific immunity and specific immunity. The experimental research provides the basis and prospects for the research and development of immune-enhanced natural drugs in the future, providing new ideas for immunotherapy.

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