Cross-Talk Between Phytohormone Signaling Pathways Under Both Optimal and Stressful Environmental Conditions

2012 ◽  
pp. 49-76 ◽  
Author(s):  
Marcia A. Harrison
Keyword(s):  
Signaling Pathways ◽  
Cross Talk ◽  
Environmental Conditions ◽  
Phytohormone Signaling

scholarly journals Molecular mechanisms of BMP-induced bone formation: Cross-talk between BMP and NF-κB signaling pathways in osteoblastogenesis

2010 ◽  
Vol 46 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Eijiro Jimi ◽  
Shizu Hirata ◽  
Masashi Shin ◽  
Masato Yamazaki ◽  
Hidefumi Fukushima
Keyword(s):  
Bone Formation ◽  
Signaling Pathways ◽  
Cross Talk ◽  
Molecular Mechanisms

3,5-Diiodothyronine-mediated transrepression of the thyroid hormone receptor beta gene in tilapia. Insights on cross-talk between the thyroid hormone and cortisol signaling pathways

2016 ◽  
Vol 425 ◽  
pp. 103-110 ◽  
Author(s):  
Gabriela Hernández-Puga ◽  
Pamela Navarrete-Ramírez ◽  
Arturo Mendoza ◽  
Aurora Olvera ◽  
Patricia Villalobos ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathways ◽  
Cross Talk ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Beta Gene ◽  
Receptor Beta

scholarly journals Targeting ERK-Hippo Interplay in Cancer Therapy

2020 ◽  
Vol 21 (9) ◽  
pp. 3236 ◽  
Author(s):  
Karel Vališ ◽  
Petr Novák
Keyword(s):  
Cancer Therapy ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Cross Talk ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Cancer Therapies ◽  
Anti Cancer ◽  
Targeted Inhibition

Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. Deregulation of the MAPK signaling occurs under many pathological conditions including neurodegenerative disorders, metabolic syndromes and cancers. Targeted inhibition of individual kinases of the MAPK signaling pathway using synthetic compounds represents a promising way to effective anti-cancer therapy. Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes of targeted therapies and plays important role during development of drug resistance in cancers. We discuss cross-talk of the MAPK/ERK signaling pathway with other signaling pathways, in particular interplay with the Hippo/MST pathway. We demonstrate the mechanism of cell death induction shared between MAPK/ERK and Hippo/MST signaling pathways and discuss the potential of combination targeting of these pathways in the development of more effective anti-cancer therapies.

scholarly journals Impaired apoptosis in lymphoblasts from Alzheimer’s disease patients: Cross-talk of Ca2+/calmodulin and ERK1/2 signaling pathways

2007 ◽  
Vol 64 (11) ◽  
pp. 1437-1448 ◽  
Author(s):  
F. Bartolomé ◽  
N. de las Cuevas ◽  
Ú. Muñoz ◽  
F. Bermejo ◽  
Á. Martín-Requero
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Signaling Pathways ◽  
Cross Talk

91 Invivo- and invitro-produced bovine embryos have different microRNA profiles after invitro individual culture

2020 ◽  
Vol 32 (2) ◽  
pp. 171
Author(s):  
A. Bridi ◽  
I. Motta ◽  
G. Andrade ◽  
M. Del Collado ◽  
A. Ávila ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Development ◽  
Signaling Pathways ◽  
Cross Talk ◽  
Geometric Mean ◽  
Fixed Time ◽  
Bioactive Molecules ◽  
Gnrh Analogue ◽  
Bovine Embryo ◽  
Bovine Embryos

Invivo- and invitro-produced bovine embryos have different metabolic characteristics, embryonic development, and gene transcription. Additionally, pregnancy rates at 30 days (on average 51% and 34% when using fixed-time AI and invitro production, respectively) are different in beef cattle. Between Days 8 and 17 of the oestrous cycle, concurrent with embryo-maternal recognition, is when 40% of embryonic losses occur. These losses may occur due to altered embryo-maternal cross-talk. MicroRNA (miRNA) can be involved in this communication; however, its potentially regulated pathways in invivo and invitro embryos on Day 9 are unknown. Our hypothesis is that bovine embryos produced invivo and invitro contain different miRNA profiles, even after invivo bovine embryo were invitro cultured. Cows had the follicular wave synchronized and were superovulated to produce invivo or invitro bovine embryos. For the invitro group, on Day −8 of the protocol, the dominant follicles were recovered by ovum pickup, and invitro embryo production was performed to obtain embryos. For the invivo group, on Day −8, the cows were inseminated 12 and 24h after GnRH analogue application and on Day 7 after expected oestrus, uterine flushing was performed to obtain the embryos. Embryos from both groups were individually cultured for 48h. Three pools (of 5 embryos each) per group were used for reverse transcription of miRNAs from total RNA using miScript II RT Kit (Qiagen). Relative levels of 383 bovine miRNAs were determined using the geometric mean of miR-99b, RNU43 snoRNA, and Hm/Ms/Rt U1 snRNA by RT-qPCR. Differences in relative levels of miRNAs were determined by Student's t-test. A total of 210 miRNAs were detected in invivo and invitro embryos, and 13 out of 210 were differently identified between the groups. In invivo embryos, 6 miRNAs were up-regulated, whereas 7 miRNAs were up-regulated in invitro embryos. TARGETSCAN software was used to identify genes predicted as modulated by each miRNA. The top 100 genes predicted were used to identify enriched pathways according to DAVID Bioinformatics Resources. The miRNAs (miR-129, miR-132, miR-155, miR-192, miR-215, and miR-377) up-regulated in invivo embryos modulated pathways that include signaling pathways regulating pluripotency of stem cells (16 genes), TGF-β (11), hippo (10), oestrogen (8), and cell cycle (7). Moreover, miR-23a, miR-338, miR-34a, miR-491, miR-92b, miR-940, and miR-1271, which were increased in invitro embryos, regulate PI3K-Akt (17 genes), signaling pathways regulating pluripotency of stem cells (10), oestrogen (9), toll-like receptor (9), Wnt (9), and HIF-1 (7). The results demonstrate that even after 48h of invitro culture, bovine embryos produced invivo and invitro have different miRNA profiles that modulate pathways associated with embryonic development on Day 9. Furthermore, these results suggest that bioactive molecules, such as miRNAs, can modify embryo-maternal cross-talk, depending on the environment where the embryos are produced. Funding was provided by FAPESP 2017/19681-9, 2014/22887-0, and 2018/13155-6.

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