Alternative Strategies to Regulate Quorum Sensing and Biofilm Formation of Pathogenic Pseudomonas by Quorum Sensing Inhibitors of Diverse Origins

2018 ◽  
pp. 33-61
Author(s):  
P. Sankar Ganesh ◽  
V. Ravishankar Rai
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Alternative Strategies ◽  
Quorum Sensing Inhibitors

Quorum Sensing – A Stratagem for Conquering Multi-Drug Resistant Pathogens

2020 ◽  
Vol 26 ◽  
Author(s):  
Madison Tonkin ◽  
Shama Khan ◽  
Mohmmad Younus Wani ◽  
Aijaz Ahmad
Keyword(s):  
Drug Resistance ◽  
Quorum Sensing ◽  
Virulence Factors ◽  
Biofilm Formation ◽  
Cell Communication ◽  
Natural Compounds ◽  
Quorum Sensing Inhibitors ◽  
Communication Technique ◽  
Multicellular Organisms ◽  
Chemical Strategies

: Quorum sensing is defined as cell to cell communication between microorganisms, which enables microorganisms to behave as multicellular organisms. Quorum sensing enables many collaborative benefits such as synchronisation of virulence factors and biofilm formation. Both quorum sensing as well as biofilm formation encourage the development of drug resistance in microorganisms. Biofilm formation and quorum sensing are causally linked to each other and play role in the pathogenesis of microorganisms. With the increasing drug resistance against the available antibiotics and antifungal medications, scientists are combining different options to develop new strategies. Such strategies rely on the inhibition of the communication and virulence factors rather than on killing or inhibiting the growth of the microorganisms. This review encompasses the communication technique used by microorganisms, how microorganism resistance is linked to quorum sensing and various chemical strategies to combat quorum sensing and thereby drug resistance. Several compounds have been identified as quorum sensing inhibitors and are known to be effective in reducing resistance as they do not kill the pathogens but rather disrupt their communication. Natural compounds have been identified as anti-quorum sensing agents. However, natural compounds present several related disadvantages. Therefore, the need for the development of synthetic or semi-synthetic compounds has arisen. This review argues that anti-quorum sensing compounds are effective in disrupting quorum sensing and could therefore be effective in reducing microorganism drug resistance.

Calcium-Binding Polymer-Coated Poly(lactide-co-glycolide) Microparticles for Sustained Release of Quorum Sensing Inhibitors to Prevent Biofilm Formation on Hydroxyapatite Surfaces

2019 ◽  
Vol 11 (8) ◽  
pp. 7686-7694 ◽  
Author(s):  
Minji Kang ◽  
Sungwhan Kim ◽  
Heejin Kim ◽  
Youngjun Song ◽  
Dongwook Jung ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Sustained Release ◽  
Calcium Binding ◽  
Biofilm Formation ◽  
Quorum Sensing Inhibitors

New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation

2017 ◽  
Vol 137 ◽  
pp. 76-87 ◽  
Author(s):  
Ji Su Park ◽  
Eun-Ju Ryu ◽  
Linzi Li ◽  
Bong-Kyu Choi ◽  
B. Moon Kim
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Bacterial Biofilm ◽  
Autoinducer 2 ◽  
Quorum Sensing Inhibitors ◽  
Brominated Furanones

Staphylococcus aureus: biofilm formation and strategies against it

2021 ◽  
Vol 22 ◽  
Author(s):  
Ahmad Nasser ◽  
Mohammad Mehdi Soltan Dallal ◽  
Shiva Jahanbakhshi ◽  
Taher Azimi ◽  
Leila Nikouei
Keyword(s):  
Staphylococcus Aureus ◽  
Drug Resistance ◽  
Quorum Sensing ◽  
Antimicrobial Therapy ◽  
Biofilm Formation ◽  
Bacterial Species ◽  
Influential Factors ◽  
Quorum Sensing Inhibitors ◽  
Biofilm Production ◽  
Biofilm Inhibitor

: The formation of Staphylococcus aureus biofilm causes significant infections in the human body. Biofilm forms through the aggregation of bacterial species and brings about many complications. It mediates drug resistance and persistence and facilitates the recurrence of infection at the end of antimicrobial therapy. Biofilm formation goes through a series of steps to complete, and any interference in these steps can disrupt its formation. Such interference may occur at any stage of biofilm production, including attachment, monolayer formation, and accumulation. Interfering agents can act as quorum sensing inhibitors and interfere in the functionality of quorum sensing receptors, attachment inhibitors and affect the cell hydrophobicity. Among these inhibiting strategies, attachment inhibitors could serve as the best agents against biofilm formation. If pathogens abort the attachment, the following stages of biofilm formation, e.g., accumulation and dispersion, will fail to materialize. Inhibition at this stage leads to suppression of virulence factors and invasion. One of the best-known inhibitors is a chelator that collects metal, Fe+, Zn+, and magnesium critical for biofilm formation. These influential factors in the binding and formation of biofilm are investigated, and the coping strategy is discussed. This review examines the stages of biofilm formation and determines what factors interfere in the continuity of these steps. Finally, the inhibition strategies are investigated, reviewed, and discussed. Keywords: Biofilm, Staphylococcus, Biofilm inhibitor, Dispersion, Antibiofilm agent, EPS, PIA.

Environmental fate and effects of novel quorum sensing inhibitors that can control biofilm formation

Chemosphere ◽  
2016 ◽  
Vol 164 ◽  
pp. 52-58 ◽  
Author(s):  
Adam Lillicrap ◽  
Ailbhe Macken ◽  
Aina Charlotte Wennberg ◽  
Merete Grung ◽  
Jan Thomas Rundberget ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Environmental Fate ◽  
Quorum Sensing Inhibitors

scholarly journals NATURAL ANTIMICROBIALS IN THE PIPELINE AND POSSIBLE SYNERGISM WITH ANTIBIOTICS TO OVERCOME MICROBIAL RESISTANCE

2019 ◽  
pp. 15-21
Author(s):  
EMTENAN M HANAFI ◽  
ENAS N DANIAL
Keyword(s):  
Quorum Sensing ◽  
Bioactive Compounds ◽  
Biofilm Formation ◽  
Bacterial Resistance ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Quorum Sensing Inhibitors ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

The unresponsive use of antibiotics led to the appearance of multiple drug-resistant bacteria strains. Studying the mechanism by which bacteria can resist antibiotics, the so called quorum sensing and biofilm formation, enabled the researchers to find bioactive compounds, derived from eukaryotes and prokaryotes. The disrupt of this mechanism is called quorum sensing inhibitors or quorum quenchers. This article provides an overview on the current research done on such bioactive compounds, the possible use of them as antibiotic alternatives, what are the advantage and disadvantages, the source from which it has been extracted, and how it may succeed to overcome bacterial resistance. The recommendation of researchers is to use some of these natural antimicrobial compounds combined to lower doses of antibiotics for treatment, the fastest way to limit the adverse effects of the exploitation of antibiotics and to avoid bacterial resistance.

scholarly journals Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance ofP. aeruginosaClinical Strains

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Daria Bortolotti ◽  
Claudio Trapella ◽  
Alessandra Bragonzi ◽  
Paolo Marchetti ◽  
Vinicio Zanirato ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Homoserine Lactone ◽  
Drug Dosage ◽  
Clinical Strains ◽  
Quorum Sensing Inhibitors ◽  
Antibiotic Drug ◽  
Bacterial Structure ◽  
First Time ◽  
Improve Patient

Pseudomonas aeruginosais a Gram-negative bacterium that commonly infects subjects with weakened immune system causing deadly infections above all at pulmonary level. During infection,P. aeruginosaproduces a well-organized bacterial structure, called biofilm, activating the quorum-sensing (QS) signaling, a mechanism of gene regulation. In this work, we synthesized already known QS inhibitors (QSi) designed on the scaffold of the N-(3-oxododecanoyl) homoserine lactone (3O-C12-HSL) QS molecule and conjugated them with ciprofloxacin to inhibitP. aeruginosabiofilm formation and increase the antibiotic susceptibility of clinical strains. We identified, for the first time, a QSi conjugated with ciprofloxacin (ET37), that is able to reduce the formation of biofilm and the onset of tolerant clones inP. aeruginosaclinical strains. This compound could have a wide application in clinical setting. The possibility to affect biofilm formation in chronically infected patients, such as patients affected by cystic fibrosis, and to reduce the onset of ciprofloxacin resistance would improve patient healing and allow to decrease antibiotic drug dosage.

Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors

2017 ◽  
Vol 111 ◽  
pp. 99-107 ◽  
Author(s):  
Ellappan Kalaiarasan ◽  
Kottha Thirumalaswamy ◽  
Belgode Narasimha Harish ◽  
Vasuki Gnanasambandam ◽  
Veeresh Kumar Sali ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Biofilm Formation ◽  
Quorum Sensing Inhibitors

scholarly journals Quorum Sensing Inhibition or Quenching in Acinetobacter baumannii: The Novel Therapeutic Strategies for New Drug Development

2021 ◽  
Vol 12 ◽  
Author(s):  
Shan Zhong ◽  
Songzhe He
Keyword(s):  
Quorum Sensing ◽  
Acinetobacter Baumannii ◽  
Biofilm Formation ◽  
Quorum Quenching ◽  
The Novel ◽  
Antimicrobial Drugs ◽  
Quorum Sensing Inhibitors ◽  
Bacterial Drug Resistance ◽  
A Cell ◽  
Novel Therapeutic Strategies

Acinetobacter baumannii is a Gram-negative opportunistic nosocomial pathogen, which can cause ventilator-related and blood infection in critically ill patients. The resistance of A. baumannii clinical isolates to common antimicrobials and their tolerance to desiccation have emerged as a serious problem to public health. In the process of pathogenesis, bacteria release signals, which regulate virulence and pathogenicity-related genes. Such bacteria coordinate their virulent behavior in a cell density-dependent phenomenon called quorum sensing (QS). In contrast, the two main approaches of QS interference, quorum sensing inhibitors (QSIs) and quorum quenching (QQ) enzymes, have been developed to reduce the virulence of bacteria, thus reducing the pressure to produce bacterial drug resistance. Therefore, QSIs or QQ enzymes, which interfere with these processes, might potentially inhibit bacterial QS and ultimately biofilm formation. In this review, we aim to describe the state-of-art in the QS process in A. baumannii and elaborate on the use of QSIs or QQ enzymes as antimicrobial drugs in various potential sites of the QS pathway.

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