Modified Appleby Operation for Advanced Malignant Tumors of the Body and Tail of the Pancreas

2019 ◽  
pp. 63-69
Author(s):  
Qi-Fan Zhang
Keyword(s):  
Malignant Tumors ◽  
The Body ◽  
Modified Appleby Operation

scholarly journals A Role of Tumor-Released Exosomes in Paracrine Dissemination and Metastasis

2018 ◽  
Vol 19 (12) ◽  
pp. 3968 ◽  
Author(s):  
Enrico Spugnini ◽  
Mariantonia Logozzi ◽  
Rossella Di Raimo ◽  
Davide Mizzoni ◽  
Stefano Fais
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Malignant Tumors ◽  
The Body ◽  
Mesenchymal Transition ◽  
Metastatic Cascade ◽  
Target Organs

Metastatic diffusion is thought to be a multi-step phenomenon involving the release of cells from the primary tumor and their diffusion through the body. Currently, several hypotheses have been put forward in order to explain the origin of cancer metastasis, including epithelial–mesenchymal transition, mutagenesis of stem cells, and a facilitating role of macrophages, involving, for example, transformation or fusion hybridization with neoplastic cells. In this paradigm, tumor-secreted extracellular vesicles (EVs), such as exosomes, play a pivotal role in cell communications, delivering a plethora of biomolecules including proteins, lipids, and nucleic acids. For their natural role in shuttling molecules, EVs have been newly considered a part of the metastatic cascade. They have a prominent role in preparing the so-called “tumor niches” in target organs. However, recent evidence has pointed out an even more interesting role of tumor EVs, consisting in their ability to induce malignant transformation in resident mesenchymal stem cells. All in all, in this review, we discuss the multiple involvements of EVs in the metastatic cascade, and how we can exploit and manipulate EVs in order to reduce the metastatic spread of malignant tumors.

scholarly journals Clinicopathological study of soft tissue sarcoma-retrospective study of tertiary cancer institute in eastern India

2020 ◽  
Vol 8 (11) ◽  
pp. 4075
Author(s):  
Kunhi Mohammed K. P. ◽  
Snehasis Pradhan ◽  
Supratim Bhattacharyya ◽  
Prafulla Kumar Das ◽  
Muhammed Navas N. K.
Keyword(s):  
Retrospective Study ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Malignant Tumors ◽  
Soft Tissue Sarcomas ◽  
The Body ◽  
Female Ratio ◽  
Pleomorphic Sarcoma ◽  
Frequent Variety ◽  
Male To Female

Background: Soft tissue sarcomas are a rare and heterogeneous group of malignant tumors of mesenchymal origin that comprise less than 1 percent of all adult malignancies. Although they occur anywhere in the body, they involve most commonly in extremities, trunk, retroperitoneum and head and neck. The aim of the study was to analyze clinical and histopathological features of various soft tissue sarcomas.Methods: This was a retrospective study, conducted in tertiary cancer centre in Odisha during the period 2015 to 2018. We collected clinical parameters like age, sex, site of swelling, any associated pain and biopsy reports and these variables were correlated with final histopathology reports.Results: A total of 107 patients were included in the study, with male to female ratio of 2:1(71 and 36) and average age of 43.45 years. All of them presented with a swelling. The lower extremities were the most common sites i.e. 44.62%. Pleomorphic sarcoma was the most frequent histologic variety comprising 43% and less frequent variety were angiosarcoma, and myxoid sarcoma.Conclusions: Soft tissue sarcoma are predominant in males and middle aged population are frequently affected. Most common affected site is lower extremity and pleomorphic sarcoma is the prominent histologic type.

scholarly journals СT and MRI in the assessment of resectable and borderline resectable pancreatic tumors

2021 ◽  
Vol 26 (1) ◽  
pp. 34-47
Author(s):  
A. V. Kudryavtseva ◽  
S. S. Bagnenko ◽  
I. I. Dzidzawa ◽  
I. S. Zheleznyak ◽  
G. E. Trufanov ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
The Body ◽  
Ductal Adenocarcinoma ◽  
Pancreatic Tumors ◽  
Borderline Resectable ◽  
Dynamic Contrast Enhancement ◽  
Pancreas Head ◽  
Diffusion Weighted Images ◽  
Depth Analysis ◽  
Ct And Mri

Aim. To evaluate the capabilities of CT and MRI in the assessment of resectable and potentially resectable pancreatic tumors.Materials and methods. From 2015 to 2020 CT and MRI examination of the abdomen was performed in 220 patients with pancreatic ductal adenocarcinoma. The average age of the patients was 54.6 ± 9.9 years. 198 (90%) patients had a tumor of the pancreas head, 22 (10%) patients had a tumor of the body or tail of the organ. 110 (50%) people were recognized as inoperable. The results of examination of 88 (40%) patients were subjected to in-depth analysis.Results. Eighty eight patients were assessed for tumor resectability. In 36 (40.9%) cases, the neoplasm was recognized as resectable, and the standard resection was performed. In 52 (59.1%) cases, the tumor was determined as borderline resectable; extended gastropancreatoduodenal resection was performed.The usefulness of CT was shown in assessing the features of the variable vascular anatomy of the hepatopancreatobiliary area, determining the nature of the involvement of key vessels in the pathological process and lesions of the pancreas as a whole. The importance of using multiphase CT scanning is demonstrated and emphasized. The advantages of the MRI are indicated, including examples of the effective use of diffusion-weighted images.Conclusion. Multiphase MDCT and MRI with dynamic contrast enhancement are the leading methods of radiological diagnosis of malignant tumors of the pancreas and effectively complement each other.

scholarly journals Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Nafise Shamloo ◽  
Alireza Ghanadan ◽  
Fahimeh Sadat Hashemian ◽  
Maedeh Ghorbanpour
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Tumors ◽  
The Body ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Cross Sectional ◽  
Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

scholarly journals Histopathological study of soft tissue tumours in a tertiary health centre in southern part of Assam

2021 ◽  
Vol 9 (11) ◽  
pp. 3391
Author(s):  
Khadija S. Tapadar ◽  
Manoj K. Deka ◽  
R. N. Chaubey ◽  
Shah A. Sheikh ◽  
Gargi R. Choudhury ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Soft Tissue Tumors ◽  
The Body ◽  
World Health ◽  
Vascular Tumors ◽  
Benign Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Pleomorphic Sarcoma ◽  
Younger Age

Background: Soft tissue tumors are defined as mesenchymal proliferations which occur in the extraskeletal non-epithelial tissues of the body, excluding the viscera, coverings of brain and   lymphoreticular system. The objective of this study was to study the histopathological features of soft tissue tumors and to study the occurrence of soft tissue tumors in relation to age, sex and anatomical site.Methods: This study comprised of 89 cases studied over a period of two years. All soft tissue tumors, their gross features, microscopic findings were analysed in detail. Soft tissue tumors were divided into benign and malignant categories and further sub typing were done according to World Health Organization (WHO) classification. The distribution of soft tissue tumors according to the age, sex and site of occurrence was studied.Results: Out of 89 cases of soft tissue tumors, 76 cases were benign, 4 cases belonged to intermediate category and 9 cases were malignant. Adipocytic tumors formed the largest group constituting 39 cases. Vascular tumors were the second commonest (26 cases) followed by peripheral nerve sheath tumors (11 cases). The benign tumors were seen in younger age as compared to malignant tumors. Malignant soft tissue tumors was seen to be more common in male than female and pleomorphic sarcoma and liposarcoma was commonest (3 cases each).Conclusions: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma and schwannoma. The most common malignant tumor was pleomorphic sarcoma. The benign tumors were seen in younger age as compared to malignant tumors.

Qualitative Diagnosis of Solid Breast Mass by Blood Flow in Solid Breast Mass

2021 ◽  
Vol 11 (7) ◽  
pp. 1887-1894
Author(s):  
Chen Cheng ◽  
Chunhong Hu ◽  
Shengli Zhou ◽  
Hongyan Zhao ◽  
Ming Yu
Keyword(s):  
Breast Cancer ◽  
Blood Flow ◽  
High Speed ◽  
Malignant Tumors ◽  
Resistance Index ◽  
The Body ◽  
Breast Mass ◽  
Physical And Mental Health ◽  
Clinical Value ◽  
Hemodynamic Information

Breast cancer is one of the most common malignant tumors that seriously endangers women’s physical and mental health and even life-threatening. With the increasing incidence of breast malignant tumors year by year, people are increasingly concerned about the health of female breasts. However, due to the lack of primary prevention methods for breast cancer, the key to improving the cure rate of breast cancer and reducing mortality is early detection, early diagnosis, and early treatment. Hemodynamics embodies the characteristics and laws of the movement of blood and its components in the body. Clinically, monitoring of hemodynamic indicators is usually used to reveal the physiological or pathological changes of the body and understand the development process of the disease. The blood flow in the tumor tissue is high-speed and high-impedance. CDFI can show the distribution of blood flow in the mass. The highest peak velocity (PSV), resistance index (RI) and pulsatility index (PI) of systolic phase can be measured by sampling. This study use contrast-enhanced ultrasound (CEUS) combined with color energy Doppler flow imaging (CDFI) to explore the hemodynamic information of the main blood supply arteries and masses of the breast, analyze the abnormal hemodynamic information of tumors and surrounding tissues, and explore the blood in the breast, the clinical value of hydrodynamics in the qualitative diagnosis of breast masses.

Retropancreatic Retroperitoneal Tumors: A 30-year Experience with 38 Cases

2013 ◽  
Vol 79 (5) ◽  
pp. 470-475
Author(s):  
Tao-Tao Zhang ◽  
Ke-Jian Guo ◽  
Gang Ma ◽  
Shao-Wei Song
Keyword(s):  
Magnetic Resonance ◽  
Surgical Management ◽  
Malignant Tumors ◽  
Pancreatic Head ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Uncinate Process ◽  
The Body ◽  
Number Of Patients ◽  
Retroperitoneal Tumors

Retropancreatic retroperitoneal tumors (RRTs) are seldom encountered in clinical practice. The lack of characteristics on clinical presentation and imaging make preoperative diagnosis difficult and surgical management remains a challenge. This retrospective report surveys the presenting diagnosis and surgical management of 38 patients with RRTs presenting at our center between August 1981 and May 2012. Six patients were misdiagnosed on the basis of computerized tomography and one each by magnetic resonance imaging and magnetic resonance cholangiopancreatography. Tumors were localized posterior to the pancreatic head and uncinate process (n = 18); posterior to the neck and body of the pancreas (n = 9); or posterior to the body and tail of the pancreas (n = 11). Thirty-three patients underwent surgical resections. Operative approaches were chosen on the basis of tumor size and localization. The tumors were mostly commonly originating from neurogenic tissue (n = 16). There were 25 benign neoplasms (65.8%), 10 malignant tumors (26.3%), and three undefined tumors. The morbidity of postsurgical complications was 21 per cent (eight of 38). The number of patients who underwent follow-up was 21, and the mean follow-up time was 35 months (range, 2 to 90 months). Three patients died during follow-up. The morbility of local recurrence was 10.5 per cent (four of 38). Definitive diagnosis of RRTs is made at laparotomy. Complete resection remains the fundamental objective of disease management. Different operative approaches should be used according to tumor localization and size.

Thermal Environmental Effect on Breast Tumor Growth

2009 ◽  
Author(s):  
Na Ma ◽  
Ping Liu ◽  
Chao Chen ◽  
Aili Zhang ◽  
Lisa X. Xu
Keyword(s):  
Oxidative Phosphorylation ◽  
Atp Hydrolysis ◽  
Malignant Tumors ◽  
Performance Status ◽  
Symptomatic Improvement ◽  
The Body ◽  
Hyperthermia Treatment ◽  
Short Period ◽  
The Relationship

Tissue hypoxia is a common and important feature of rapidly growing malignant tumors and their metastases. Tumor cells mainly depend on energy production thru anaerobic glycolysis rather than aerobic oxidative phosphorylation in mitochondria [1]. Intervening the tumor metabolic process via thermal energy infusion is worthy attempting. And hyperthermia, mildly elevated local temperature above the body temperature, is one of such kind. Previously, after being heated for a short period of time, tumor glucose and lactate level increased and ATP level decreased, which suggested energy metabolism was modified following hyperthermia through increased ATP hydrolysis, intensified glycolysis and impaired oxidative phosphorylation [2]. Many researchers designed experiments to determine thermal dose in hyperthermia [3], but few focused on the relationship between tumor and energy, especially for a long-term local hyperthermia treatment. One clinical trial indicated the effective long-term hyperthermo-therapy for maintaining performance status, symptomatic improvement, and prolongation of survival time in patients with peritoneal dissemination [4].

scholarly journals PEComa: A Perivascular Epithelioid Cell Tumor in the Liver—A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Faseeh Khaja ◽  
Allison Carilli ◽  
Said Baidas ◽  
Aravindhan Sriharan ◽  
Shanedelle Norford
Keyword(s):  
Malignant Tumors ◽  
Mtor Inhibitors ◽  
Epithelioid Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
The Body ◽  
Benign Tumors ◽  
Review Of The Literature ◽  
Perivascular Epithelioid Cell ◽  
Perivascular Epithelioid Cell Tumors

Perivascular epithelioid cell tumors are soft tissue tumors that can occur in various locations in the body whose incidence is rising. Hepatic PEComas are quite rare and diagnosis involves positivity of Melan-A and HMB45 on immunohistochemistry. Usual treatment is surgery for benign tumors and chemotherapy including mTOR inhibitors for malignant tumors. Here we discuss the radiological and pathological diagnosis, evaluation, and management of a hepatic PEComa. We describe a 51-year-old patient who was diagnosed incidentally after unusual physical exam findings.

Risk Factors of Malignant Neoplasms of Female Genital Organs (Review of Literature)

10.12737/3326 ◽  
2014 ◽  
Vol 21 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Сулейманова ◽  
N. Suleymanova
Keyword(s):  
Malignant Tumors ◽  
Pathological Process ◽  
The Body ◽  
Morbidity Rate ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Scientific Review ◽  
Papillomavirus Infection ◽  
Hormone Homeostasis ◽  
Female Genital

The scientific review discusses the correlation between the MN morbidity rate of the female genitalia and the factors of the external and internal environment of the body: genetic (hereditary) and environmental (exogenous and endogenous). The author notes that the significance of the factors in the development of oncological process is different depending on the form and localizations of malignant tumors. Identified genes are responsible for the appearance of hereditary ovarian cancer (however, the genes of predisposition to cancer of body and cervix of the uterus don’t identified so far). The role of human papillomavirus infection (in the genesis of pre-cancerous lesions and cervical cancer) in hormone homeostasis due to functional and anatomical changes in the hypothalamic-pituitary-ovarian system (in formation of cancer of the womb and ovaries) is proved, including the background processes and pre-cancerous changes in the occurrence of all forms of genital cancer. A number of researchers consider benign tumors as an intermediate in the pathological process changes that lead with time under the influence of certain factors to be precancerous and malignant transformation. Significant fluctuations in the frequency of malignant tumors of female genital organs in different ethnic groups of the population are scientifically confirmed. Correlation frequency of cancer of the genitalia in women with age, and state of the immune system are noted.

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