Glucocorticoid receptors in alveolar macrophages: Methodological aspects of the determination of the number of glucocorticoid receptors per cell

1989 ◽  
Vol 26 (1-2) ◽  
pp. 128-131 ◽  
Author(s):  
P. Th. W. Hal ◽  
E. Mulder ◽  
H. C. Hoogsteden ◽  
C. Hilvering ◽  
R. Benner
Author(s):  
Т. В. Калінеску

The modern stage the development of Ukraine economy is require the reasonable methodological aspects to determination of effectiveness and authenticity the existence of clusters, its the applied value and virtual for the purpose of further aspects of development the theoretical principles of management enterprises in the conditions the modern progress of national economy trends. A research purpose is mark research of practice the using of clusters in modern Ukrainian reality, exposure of its virtual constituents, evaluation the role of clustering for development of theory practices the management of enterprises and its influence an economy on the competitiveness of national economy and maintenance of motion to the European and world society. As an object of research economic activity of enterprises the different industries comes forward economies of Ukraine, which are in the search of new directions of innovative development on the basis of creation of different types of clusters. Methods and principles of scientific cognition of general and special methods and receptions became methodological basis of research that the effective used in the process of ground and the applied value of the use of clustering. Including the methods of systematization and generalization? what are used for the analysis of the existent  aspects of creation the clusters in different industries of activity of enterprises; inductions and deductions, what are use for the ground of the applied value of clustering; between disciplinary analogy, what are use for the evaluation the virtual of application and adaptation of clusters to the operating of modern enterprises conditions. Supposition became the basic hypothesis of research, that modern cluster educations in different industries of Ukraine national economy have more virtual than practical application, and - basic its further development its legislatively-normative determination and use must become in the direction of creation the competitive products. The statement of basic materials. It is well-proven that the applied methods of clustering have likeness with the reliable methods of realization of prognosis, when the variety of the possible states of the economic systems is planned. Common reliable idea about development does not give reliable information a cluster about development of single enterprises in it, that is why conduct each in such cluster associations more casual character, than reliable activity to the cluster, has yet a subject. There is authenticity of that not every subject will be consistently and to move on a scenario which is offered in a cluster association, but will incarnate that which answers its idea about prosperity and necessities. In-process of expose was wrote the mechanisms of presentation the participants of cluster about a utility, satisfaction system of values, which is carried in itself by creation of different clusters. Offered approach consideration about cluster society have originality and practical meaningfulness and allow to send processes creation of clusters on determination of compatible values and necessities for its participants and receipt of public economic effects from it. The conducted research allowed to formulate a conclusion, that clustering have the hidden potentials, that not allow effective develop the economy of enterprises, but take in attention the virtual features of perception the clustering, it follows to pay attention to necessity: creation of legislatively-normative base in relation to functioning of clusters, presence of instruments the state support of activity of clusters on regional and national levels for creation of competitive products; creation of compatible values and requirements in mutual relations in a middle clusters and receipt of the objective applied effects in relation to functioning of clustering.


Food systems ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 144-153
Author(s):  
Ju. V. Nikitina ◽  
E. V. Topnikova ◽  
O. V. Lepilkina ◽  
O. G. Kashnikova

The features of technologies for low- and lactose-free dairy products, which provide for special operations to hydrolyze lactose or remove it using ultra- or nanofiltration followed by hydrolysis of the residual amount, are considered. Dairy products manufactured using these technologies in different countries as well as enterprises leading in this field of production are presented. The analysis of the methods used to determine the quantitative content of residual lactose in low- and lactose-free dairy products is carried out: enzymatic, HPLC, HPAEC-PAD, amperometric biosensors, Raman spectroscopy. Due to the dairy industry’s need for analytical methods for the determination of lactose in milk and dairy products with low- or lactose-free content, the AOAC Stakeholder Group on Strategic Food Analysis Methods approved Standard Performance Requirements for Biosensor Methods (SMPR®) 2018.009. These requirements were introduced for the quantitative determination of lactose in milk as well as in dairy and milk-containing products with a low or no lactose content. The biosensor method is recommended for use as the official first step of AOAC method. Additionally, it is advisable to use high performance liquid chromatography (HPLC) with mass spectrometric detection, as well as high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) as an international standard method of analysis for the determination of lactose in milk with low- or lactose-free content.


2009 ◽  
Vol 5 (4) ◽  
pp. 293-302 ◽  
Author(s):  
Jose Alvarez-Suarez ◽  
Sara Tulipani ◽  
Stefania Romandini ◽  
Alexis Vidal ◽  
Maurizio Battino

Author(s):  
Ye.V. Markelova ◽  
◽  
N.K. Zulina ◽  
O.I. Tomina ◽  
◽  
...  

The article gives definitions to the concepts of "rehabilitation", "habilitation", "individual rehabilitation program", "technical means of rehabilitation". The statistical data on primary disability of children with cerebral palsy in the city of Khabarovsk for the period 2016–2020 are presented. The characteristics of a wheelchair with additional fixation for patients with cerebral palsy are given. The requirements for the provision of disabled people with technical means of rehabilitation (wheelchairs) are noted, the principles of selection and the tasks that must be solved when using them are indicated. The method of correct determination of the parameters of the wheelchair is presented to help doctors of medical organizations in the preparation of referral documents for medical and social examination


Blood ◽  
1980 ◽  
Vol 56 (6) ◽  
pp. 1036-1040 ◽  
Author(s):  
R Mastrangelo ◽  
R Malandrino ◽  
R Riccardi ◽  
P Longo ◽  
FO Ranelletti ◽  
...  

Abstract We have performed in parallel, in 19 children with acute lymphoblastic leukemia, a quantitative determination of glucocorticoid levels, in vitro steroid induced inhibition of nucleic acid precursors, and a short-term clinical trial of corticosteroids alone, before the treatment was given, which included corticosteroids and other drugs. From our results it appears that high glucocorticoid receptor levels in acute lymphoblastic leukemia of children do not guarantee a clinical response to corticosteroids. On the other hand, glucocorticoid receptors may turn out to be of value in predicting a poor response to corticosteroids only if their levels are considerably low.


2019 ◽  
Vol 20 (6) ◽  
pp. 1401 ◽  
Author(s):  
Marius Schmidt

The focus of structural biology is shifting from the determination of static structures to the investigation of dynamical aspects of macromolecular function. With time-resolved macromolecular crystallography (TRX), intermediates that form and decay during the macromolecular reaction can be investigated, as well as their reaction dynamics. Time-resolved crystallographic methods were initially developed at synchrotrons. However, about a decade ago, extremely brilliant, femtosecond-pulsed X-ray sources, the free electron lasers for hard X-rays, became available to a wider community. TRX is now possible with femtosecond temporal resolution. This review provides an overview of methodological aspects of TRX, and at the same time, aims to outline the frontiers of this method at modern pulsed X-ray sources.


2019 ◽  
Vol 265 ◽  
pp. 07028 ◽  
Author(s):  
Maria Bovsunovskaya ◽  
Ivan Saltykov

Economic dimension of engineering and construction in Russian orthodox temple architecture (reliable determination of church construction estimate cost and it’s optimization) is in the best interest of engineering companies, the Russian Orthodox Church, state authorities and potential investors as basis for assessment of investment, cost control, cost saving in temple complex construction. The article gives methodological aspects of cost estimate determination in temple architecture, synthesizes cost expenditures for temple construction, proposes and analyses cost-saving solutions.


Author(s):  
Кондратов ◽  
S. Kondratov ◽  
Новиков ◽  
A. Novikov

The article deals with the methodological aspects of risk analysis for the carriage of dangerous goods by road, in the system «man - machine - environment - the goods». A functional model of risk in the transport of dangerous goods. Analyzed the main methods of risk assessment in the system «M-M-E-G». The possibility of experimental determination of dominant parameters.


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