The inhibitory effect of neem (Azadirachta indica) leaf extracts on aflatoxin synthesis inAspergillus parasiticus

1988 ◽  
Vol 65 (7) ◽  
pp. 1166-1168 ◽  
Author(s):  
Deepar Bhatnagar ◽  
Susan P. McCormick
Keyword(s):  
Azadirachta Indica ◽  
Inhibitory Effect ◽  
Leaf Extracts

scholarly journals ALLELOPATHIC POTENTIAL OF EXTRACTS AND LEACHATES OF AZADIRACHTA INDICA A. JUSS LEAVES ON GERMINATION AND GROWTH OF ELEUSINE CORACANA (L.) GAERTNER

2015 ◽  
Vol 2 (2) ◽  
pp. 129-132
Author(s):  
Elavazhagan P
Keyword(s):  
Azadirachta Indica ◽  
Shoot Growth ◽  
Dry Weight ◽  
Inhibitory Effect ◽  
Germination Percentage ◽  
Eleusine Coracana ◽  
Leaf Extracts ◽  
Allelopathic Potential ◽  
Root And Shoot Growth ◽  
Germination And Growth

Various concentrations (5%, 10%, 15% and 20%) of leaf leachates and leaf extracts prepared from fully senesced fallen and matured leaves of Azadirachta indica A. Juss. and used for the present experiments to determine their allelopathic potential on growth and developmental changes on Eleusine coracana (L.) Gaertner. Leaf leachates and leaf extracts sowed an inhibitory effect on germination percentage, root and shoot growth, and fresh and dry weight of E. coracana seedlings. The leaf extracts had more inhibitory effect at 20%concentration,than that of leaf leachates on morphological parameters of E. coracana

scholarly journals Inhibition of Snake Venom Enzymes and Antivenom Adjuvant Effects of Azadirachta indica A. Juss. (Meliaceae) Leaf Extracts

2020 ◽  
pp. 114-128
Author(s):  
Ibrahim Sani ◽  
Rabi’u Aliyu Umar ◽  
Sanusi Wara Hassan ◽  
Umar Zaki Faruq ◽  
Fatima Bello ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Snake Venom ◽  
Azadirachta Indica ◽  
Inhibitory Effect ◽  
Albino Rats ◽  
Adjuvant Effect ◽  
Leaf Extracts ◽  
Degree Of Protection ◽  
Adjuvant Effects

Snake venom enzymes are the key substances involved in snake venom toxicity. Thus, inactivating these enzymes is generally considered to be the fundamental step in the management of snakebite. Conventionally, snakebite envenomation is treated parenterally with serum-based antivenins, and adjuvants to these antivenins are required for maximum protection of victims. Hence, this research was aimed at evaluating the inhibitory effect of Azadirachta indica leaf extracts on Naja nigricollis Reinhardt venom enzymes and screens for their antivenom adjuvant effects. A. indica leaf was collected, authenticated and extracted using 95% methanol followed by fractionation using hexane and ethyl acetate. The venom enzymes inhibition assays was evaluated using in vitro methods, while, adjuvant effect was screened using Albino rats. The results revealed that both the hexane and the ethyl acetate fractions showed capability of inhibiting the venom enzymes significantly (P<0.05) when compared with the venom controls in varying degrees of efficacies. For the adjuvant effect, no significant effect (P>0.05) of the venom at the administered dose was observed on bleeding time, clotting time, defibrinogenating and haemorrhagic effects compared to the normal control. However, the size of necrotic lesion and the percentage haemolysis were significantly (P<0.05) higher in the venom control rats. Both the hexane and the ethyl acetate fractions significantly mitigated these effects in the treated animals. The degree of protection was about 3 folds more than when the antivenin was used alone. Finally, these findings would be of importance in the area of drug development with a view to actualizing the substitution or enhancing the effect of conventional snakebite therapeutic options.

scholarly journals Inhibitory effect of neem (Azadirachta indica) and moringa (Moringa oleifera) leaf extracts on egg hatch of root knot nematode Meloidogyne incognita

2019 ◽  
Vol 1 (2) ◽  
pp. 028-033
Author(s):  
Yunusa Ladi Bello ◽  
Kabir Muhammad Ayuba ◽  
Joy Bitsu ◽  
Marufat Alake Nafiu ◽  
Jumoke Sarah Odewale
Keyword(s):  
Azadirachta Indica ◽  
Meloidogyne Incognita ◽  
Moringa Oleifera ◽  
Inhibitory Effect ◽  
Root Knot Nematode ◽  
Leaf Extracts ◽  
Egg Hatch

scholarly journals EVALUATION OF NEEM (AZADIRACHTA INDICA) SEED AND CASSIA ALATA LEAF EXTRACTS AS SURFACE PROTECTANTS AGAINST SEED BORNE FUNGI OF MAIZE (ZEA MAYS L.)

2017 ◽  
Vol 29 (1) ◽  
pp. 01
Author(s):  
Elias N.K. Sowley ◽  
Ruth A. Ofori ◽  
Frederick Kankam
Keyword(s):  
Zea Mays ◽  
Aqueous Extract ◽  
Azadirachta Indica ◽  
Inhibitory Effect ◽  
Seed Extract ◽  
Neem Seed ◽  
Leaf Extracts ◽  
Cassia Alata ◽  
Ethanol Extracts ◽  
Neem Seed Extract

Seed borne fungi constitute a major constraint to maize production and this is aggravated by the use of farmer-saved seeds which may be unhealthy. The study was aimed at testing the efficacy of Cassia alata leaf and neem (Azadirachta indica) seed extracts against seed borne fungi. Maize (Zea mays) seeds were obtained from three farmers in each of ten communities randomly selected from the Tolon-Kumbungu district. Seed borne fungi were isolated from seed samples by plating on PDA. Four fungi belonging to three genera namely Aspergillus niger, A. flavus, Botryodiplodia theobromae and Penicillium digitatum were isolated from the seed samples. These fungi were grown on PDA plates amended with aqueous and ethanol extracts of Cassia alata leaf and neem seed, carbendazim and sodium hypochlorite and their radial growth measured. Ethanol extracts of C. alata leaf and neem seed were similar but had a higher inhibition than their aqueous extracts. Aqueous extract of C. alata leaf inhibited growth to a significantly higher (P<0.05) extent than aqueous neem seed extract. Although ethanol extracts of C. alata leaf and neem seed had a significantly higher (P<0.05) inhibitory effect, aqueous extract of the former was better than the neem seed extract and may therefore be used by farmers in treating their seeds since ethanol is relatively expensive.

scholarly journals The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3040
Author(s):  
Alexandra Ciorîță ◽  
Cezara Zăgrean-Tuza ◽  
Augustin C. Moț ◽  
Rahela Carpa ◽  
Marcel Pârvu
Keyword(s):  
Bacterial Infections ◽  
Inhibitory Effect ◽  
Total Phenolic ◽  
Phytochemical Analysis ◽  
Leaf Extracts ◽  
Antitumor Effects ◽  
Cytotoxic Effects ◽  
E Coli ◽  
Lactate Dehydrogenase Release ◽  
Nitric Oxide Concentration

The phytochemical analysis of Vinca minor, V. herbacea, V. major, and V. major var. variegata leaf extracts showed species-dependent antioxidant, antibacterial, and cytotoxic effects correlated with the identified phytoconstituents. Vincamine was present in V. minor, V. major, and V. major var. variegata, while V. minor had the richest alkaloid content, followed by V. herbacea. V. major var. variegata was richest in flavonoids and the highest total phenolic content was found in V. herbacea which also had elevated levels of rutin. Consequently, V. herbacea had the highest antioxidant activity followed by V. major var. variegata. Whereas, the lowest one was of V. major. The V. minor extract showed the most efficient inhibitory effect against both Staphylococcus aureus and E. coli. On the other hand, V. herbacea had a good anti-bacterial potential only against S. aureus, which was most affected at morphological levels, as indicated by scanning electron microscopy. The Vinca extracts acted in a dose-depended manner against HaCaT keratinocytes and A375 melanoma cells and moreover, with effects on the ultrastructure, nitric oxide concentration, and lactate dehydrogenase release. Therefore, the Vinca species could be exploited further for the development of alternative treatments in bacterial infections or as anticancer adjuvants.

scholarly journals The Effects of Extracts of Lantana camara (L.) and Azadirachta indica (A. Juss) on the Population Dynamics of Plutella xylostella, Brevicoryne brassicae and Hellula undalis on Cabbage

2012 ◽  
Vol 1 (2) ◽  
pp. 229 ◽  
Author(s):  
P. K. Baidoo ◽  
J. I. Adam
Keyword(s):  
Population Dynamics ◽  
Plant Extracts ◽  
Azadirachta Indica ◽  
Plutella Xylostella ◽  
Block Design ◽  
Petroleum Ether Extract ◽  
Brevicoryne Brassicae ◽  
Lantana Camara ◽  
Leaf Extracts ◽  
Hellula Undalis

<p>The effects of ethanolic extract of neem, <em>Azadirachta indica</em> (Meliaceae), seeds and petroleum ether extract of <em>Lantana camara</em> leaves (Verbenaceae) on the populations of three cabbage pests, <em>Plutella xylostella</em>, <em>Brevicoryne brassicae</em> and <em>Hellula undalis</em> were studied. The study was conducted between January and April 2008. Extracts of the two plants were sprayed on cabbage plants to control these pests. A standard synthetic chemical insecticide (Mektin) was used as reference product. The experiment was conducted in a randomized complete block design and each treatment was replicated four times. The effects of plant extracts on the population dynamics of the pests’ species, the level of infestation and yield were assessed. Significantly more of the pests infested the control plants than the treated plants (<em>P</em>&lt; 0.01). The mean weight of cabbage heads on the sprayed plots was significantly heavier than that of the control unsprayed plots. The use of <em>A. indica</em> seeds and <em>L. camara</em> leaf extracts increased yield by 37.05% and 25.80%, respectively. Spraying the cabbage plants with the plant extracts significantly reduced the numbers of pests compared with the control plants. The use of these plant extracts can be incorporated into an overall control programme of these pests.</p>

scholarly journals LARVICIDAL ACTIVITY OF LANTANA INDICA AND VITEX NEGUNDO ON CULEX QUINQUEFASCIATUS

2018 ◽  
Vol 11 (5) ◽  
pp. 414
Author(s):  
Rathnasagar K ◽  
Thiyagaraj Anand
Keyword(s):  
Larvicidal Activity ◽  
Culex Quinquefasciatus ◽  
Binding Protein ◽  
Inhibitory Effect ◽  
Negative Control ◽  
Vitex Negundo ◽  
Leaf Extracts ◽  
Active Compounds ◽  
Sterol Binding

Objectives: The activity of two different leaf extracts of Lantana indica and Vitex negundo is tested against the 3rd and 4th instar Culex quinquefasciatus larvae to evaluate the potency of the extracts as a larvicide and to find an ecologically sustainable alternative to chemical insecticides. A bioinformatics screening approach was performed to evaluate the in vivo results.Methods: The obtained larvae’s from nearby water sources were tested with N, N-diethyl-meta-toluamide (DEET) as the positive control which is the commercial chemical mosquito repellent and the solvents used for the respective plant extracts act as the negative control. Petroleum ether (PE), ethyl acetate (EA) and an aqueous (AQ) extract were prepared for both L. indica and V. negundo extracts, and its larvicidal activity was tested. A docking based approach was used to study the inhibitory effect of known active compounds from L. indica and V. negundo against acetylcholine esterase (AChE) and sterol binding protein as targets.Results: On comparing the results between three plants extract for its larvicidal activity, the EA extract of V. negundo and L. indica is found to be potent with a low LC50 value. Further, the docking studies between active compounds of L. indica and V. negundo with AChE and Sterol binding protein as targets showed that the compound tangeritin-1 had a good docking score compared to DEET and could be a natural alternative for larvicidal activity in the mosquito.Conclusion: Individual activity of tangeritin-1 could be further studied with mosquito mortality studies and molecular simulations and develop tangeritin-1 as a potential larvicidal compound for commercial use.

scholarly journals Effects of botanicals against anthracnose and blight diseases of Houttuynia cordata Thunb

2016 ◽  
Vol 42 (1) ◽  
pp. 41-48
Author(s):  
Trisha Saha ◽  
Shamim Shamsi
Keyword(s):  
Azadirachta Indica ◽  
Pathogenic Fungi ◽  
Tagetes Erecta ◽  
Citrus Limon ◽  
Leaf Extracts ◽  
Houttuynia Cordata ◽  
Datura Metel ◽  
Houttuynia Cordata Thunb

Anthracnose and blight were recorded on Houttuynia cordata Thunb. during April 2013 to December 2013. The isolated fungi from the symptomatic plants were identified as Alterneria alternata (Fr.) Keissler and Colletotrichum gloeosporoides (Penz.) Sacc. Ethanol leaf extracts of five plants viz.,Azadirachta indica L., Citrus limon L., Datura metel L., Sennaalata L. and Tagetes erecta L.were evaluated against the pathogenic fungi A. alternata and C. gloeosporoides at 5%, 10% and 20% concentrations in vitro. A. indica recorded as good inhibitor against the test fungi followed by C. limon, S. alata, D. metel and T.erecta. In vivo treatment also showed that A.indica is the most effective in controlling diseases at 10% concentration. The plants treated with A. indica were fresh and healthy up to one month of observation.J. Asiat. Soc. Bangladesh, Sci. 42(1): 41-48, June 2016

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