Predictive value of inflammatory markers for postoperative recovery following colorectal surgery

Abstract This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with COVID-19. Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for ICU admission, need for mechanical ventilation and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.

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Comparison of Short-Term Outcomes Between Robotic-Assisted and Laparoscopic Surgery in Colorectal Cancer

Surgical Innovation ◽

10.1177/1553350618797822 ◽

2018 ◽

Vol 26 (1) ◽

pp. 57-65 ◽

Cited By ~ 1

Author(s):

Xiao-Long Zhu ◽

Pei-Jing Yan ◽

Liang Yao ◽

Rong Liu ◽

De-Wang Wu ◽

...

Keyword(s):

Colorectal Cancer ◽

Laparoscopic Surgery ◽

Colorectal Surgery ◽

Hospital Stay ◽

Bowel Function ◽

Postoperative Recovery ◽

Postoperative Hospital Stay ◽

Robot Assisted ◽

Short Term ◽

Robotic Colorectal Surgery

Aim. The robotic technique has been established as an alternative approach to laparoscopy in colorectal surgery. The aim of this study was to compare short-term outcomes of robot-assisted and laparoscopic surgery in colorectal cancer. Methods. The cases of robot-assisted or laparoscopic colorectal resection were collected retrospectively between July 2015 and October 2017. We evaluated patient demographics, perioperative characteristics, and pathologic examination. A multivariable linear regression model was used to assess short-term outcomes between robot-assisted and laparoscopic surgery. Short-term outcomes included time to passage of flatus and postoperative hospital stay. Results. A total of 284 patients were included in the study. There were 104 patients in the robotic colorectal surgery (RCS) group and 180 in the laparoscopic colorectal surgery (LCS) group. The mean age was 60.5 ± 10.8 years, and 62.0% of the patients were male. We controlled for confounding factors, and then the multiple linear model regression indicated that the time to passage of flatus in the RCS group was 3.45 days shorter than the LCS group (coefficient = −3.45, 95% confidence interval [CI] = −5.19 to −1.71; P < .001). Additionally, the drainage of tube duration (coefficient = 0.59, 95% CI = 0.3 to 0.87; P < .001) and transfers to the intensive care unit (coefficient = 7.34, 95% CI = 3.17 to 11.5; P = .001) influenced the postoperative hospital stay. The total costs increased by 15501.48 CNY in the RCS group compared with the LCS group ( P = .008). Conclusions. The present study suggests that colorectal cancer robotic surgery was more beneficial to patients because of shorter postoperative recovery time of bowel function and shorter hospital stays.

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Assessment of postoperative gastrointestinal motility in colorectal surgery: a study with the Motilis 3D-transit system

BMJ Innovations ◽

10.1136/bmjinnov-2019-000396 ◽

2020 ◽

Vol 7 (1) ◽

pp. 53-60

Author(s):

Jesper Nors ◽

Mette Winther Klinge ◽

Thorbjørn Sommer ◽

Søren Laurberg ◽

Klaus Krogh ◽

...

Keyword(s):

Colorectal Surgery ◽

Transit Time ◽

Primary Anastomosis ◽

Postoperative Recovery ◽

University Hospital ◽

Double Blind ◽

Transit System ◽

Study Region ◽

Gi Transit ◽

Gi Motility

PurposePostoperative recovery following colorectal surgery remains impaired by severe complications including postoperative ileus (POI). Human studies of POI have been limited by a lack of safe and easy-to-use objective methods. Motilis 3D-transit is a completely ambulatory, minimally invasive system whereby electromagnetic capsules are followed by external sensors during their passage of the gastrointestinal (GI) tract. The aim of this study was to evaluate the applicability of the 3D-transit system in a surgical setting.MethodWe included 12 patients as a substudy of the randomised double blind controlled Stimulation of the Autonomic Nervous System In Colorectal Surgery by perioperative nutrition (SANICS)-II trial undergoing elective segmental colonic resection with primary anastomosis at Aarhus University Hospital and Randers Regional Hospital, Denmark. To study region-specific motility, three electromagnetic capsules were administered. One was taken 3 hours before surgery, the next was taken 1 hour before surgery, while the third was placed distal to the anastomosis during surgery. Total and regional GI transit times as well as time until first propulsive colonic contraction were determined.ResultsAll patients tolerated the setup well with no adverse events related to the 3D-transit system. Large variations were found in total GI transit time (26.7–127.6 hours), gastric emptying (0.07–>106.9 hours), small intestinal (1.2–58.4 hours) and colorectal transit time (14.3–>118.1 hours). Time from end of surgery to first propulsive movement in the colon varied from 3.9 to 85 hours. No correlation was found between parameters of GI motility and tolerance of an oral diet or recovery of bowel function.ConclusionThe 3D-transit system allows safe assessment of GI motility in patients operated with segmental colonic resections and primary anastomosis for colorectal cancer. Postsurgical motility varies significantly between patients.

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Predictive value of a series of inflammatory markers in COPD for lung cancer diagnosis: a case-control study

Respiratory Research ◽

10.1186/s12931-019-1155-2 ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 4

Author(s):

Cecilia Mouronte-Roibás ◽

Virginia Leiro-Fernández ◽

Alberto Ruano-Raviña ◽

Cristina Ramos-Hernández ◽

Pedro Casado-Rey ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Predictive Value ◽

Inflammatory Markers ◽

Case Control Study ◽

Case Control ◽

Lung Cancer Diagnosis ◽

Control Study

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Is colorectal surgery beyond the age of 80 still feasible with acceptable mortality? An analysis of the predictive value of CR-POSSUM and life expectancy after hospital discharge

Colorectal Disease ◽

10.1111/codi.13539 ◽

2017 ◽

Vol 19 (1) ◽

pp. 58-64 ◽

Cited By ~ 7

Author(s):

A. de Buck van Overstraeten ◽

J. Stijns ◽

A. Laenen ◽

S. Fieuws ◽

A. M. Wolthuis ◽

...

Keyword(s):

Colorectal Surgery ◽

Life Expectancy ◽

Hospital Discharge ◽

Predictive Value

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Evaluating the Use of Serum Inflammatory Markers for Preoperative Diagnosis of Infection in Patients with Nonunions

BioMed Research International ◽

10.1155/2017/9146317 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Song Wang ◽

Peng Yin ◽

Chenliang Quan ◽

Kamran Khan ◽

Guoqi Wang ◽

...

Keyword(s):

Predictive Value ◽

Inflammatory Markers ◽

Positive Culture ◽

Serum Levels ◽

Infected Nonunion ◽

Reactive Protein ◽

Number Of Patients ◽

Sensitivity Specificity ◽

Diagnosis Of Infection ◽

Serum Inflammatory Markers

Purpose. The aim of this study is to evaluate the effectiveness of laboratory serum tests in the diagnosis of infected nonunion.Methods. Forty-two patients suspected of having infected nonunion were investigated in the study. The serum levels of white blood-cell count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and interleukin-6 (IL-6) were measured. A positive diagnosis of infection was made on the basis of the positive culture results. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of each test were calculated.Results. The sensitivity and specificity of CRP both were higher than IL-6: 60.0% versus 57.1% and 85.7% versus 57.1%, respectively. With one, two, three, and four positive tests, the predicted probabilities of infection were 66.7%, 90.9%, 100%, and 100%, respectively, but the number of patients who had three or four positive tests was small.Conclusions. The diagnostic utility of IL-6 is inferior to CRP and the finding conflicts with previous conclusions drawn from periprosthetic infections. Laboratory analysis of serum inflammatory markers alone is not an effective screening tool for patients suspected of having an infected nonunion.

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Evaluation of inflammatory markers as predictors of hospital stay and unplanned readmission after colorectal surgery

Polish Journal of Surgery ◽

10.2478/pjs-2013-0030 ◽

2013 ◽

Vol 85 (4) ◽

Cited By ~ 6

Author(s):

David M. Krpata ◽

Deborah S. Keller ◽

Hoda Samia ◽

Justin Lawrence ◽

Izi Obokhare ◽

...

Keyword(s):

Colorectal Surgery ◽

Hospital Stay ◽

Inflammatory Markers ◽

Unplanned Readmission

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Preoperative Nutritional Evaluation of Elderly Patients with Prostate Cancer Undergoing Laparoscopic Radical Prostatectomy

10.21203/rs.3.rs-332306/v1 ◽

2021 ◽

Author(s):

Shu Wang ◽

Jie Fan ◽

Chunyan Hu ◽

Tao Wu ◽

Yuan Liu ◽

...

Keyword(s):

Prostate Cancer ◽

Postoperative Complications ◽

Radical Prostatectomy ◽

Elderly Patients ◽

Predictive Value ◽

Postoperative Recovery ◽

Laparoscopic Radical Prostatectomy ◽

Drainage Tube ◽

Postanesthesia Care Unit ◽

Nutritional Risk Index

Abstract Objective The purpose of this study is to evaluate the association and predictive value of geriatric nutritional risk index (GNRI) in elderly patients with prostate cancer(PCa) undergoing laparoscopic radical prostatectomy (LRP). Methods the clinical data of 72 elderly patients (aged ≥ 65 y) with PCa undergoing LRP in the Department of Urology, Affiliated Hospital of North Sichuan Medical College from January 2018 to December 2020 were retrospectively analyzed. The basic information, laboratory examination indexes, operation conditions, postoperative complications and postoperative recovery indexes of patients were included. Clavien-Dindo Classification System (CDCS) was used to assess the postoperative complications. T-test was used to analyze the grouping variables. ROC curve was drawn to study the predictive value of GNRI for postoperative complications. Results The body weight, BMI, preoperative HGB, ALB values of malnutrition group (MNg) and normal nutrition group (NNg) were significantly positively correlated (P༜0.01); the incidence and severity of postoperative complications of MNg were significantly higher than those of NNg (P༜0.05). The average hospitalization costs of MNg was higher, the duration of postanesthesia care unit (PACU), duration of antibiotic use was longer and the duration of indwelling drainage tube were longer than NNg (P༜0.05). The volume of indwelling drainage tube were more than NNg (P༜0.05). Conclusion GNRI is an effective and reliable tool to evaluate preoperative nutritional status of prostate cancer, which is closely related to postoperative recovery and complications,and has predictive value.

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Preoperative C-reactive protein and other inflammatory markers as predictors of postoperative complications in patients with colorectal neoplasia

10.21203/rs.3.rs-96106/v2 ◽

2021 ◽

Author(s):

Sufana Alsaif ◽

Ailín C Rogers ◽

Priscilla Pua ◽

Paul T Casey ◽

Geoff G Aherne ◽

...

Keyword(s):

Postoperative Complications ◽

Colorectal Surgery ◽

Inflammatory Markers ◽

Postoperative Morbidity ◽

Colorectal Neoplasia ◽

Full Blood Count ◽

C Reactive Protein ◽

Elective Colorectal Surgery ◽

Reactive Protein ◽

Grade 3

Abstract Background: Inflammatory markers are measured following colorectal surgery to detect postoperative complications. However, the association of these markers preoperatively with subsequent postoperative course has not yet been usefully studied. Aim: The aim of this study is to assess the ability of preoperative C-reactive protein (CRP) and other inflammatory marker measurements in the prediction of postoperative morbidity after elective colorectal surgery. Methods: This retrospective study catalogues 218 patients undergoing elective, potentially-curative surgery for colorectal neoplasia. Preoperative laboratory results of the full blood count (FBC), C-reactive protein (CRP) and carcinoembryonic antigen (CEA) were recorded. Multivariable analysis was performed to examine preoperative variables against 30-day postoperative complications by type and grade (Clavien-Dindo (CD)), adjusting for age, sex, BMI, smoking status, medical history, open versus laparoscopic operation, and tumor characteristics. Results: Elevated preoperative CRP (≥ 5 mg/L) was significantly predictive of all-cause mortality, with an OR of 17.0 (p < 0.001) and was the strongest factor to predict a CD morbidity grade ≥ 3 (OR 41.9, p < 0.001). Other factors predictive of CD morbidity grade ≥ 3 included smoking, elevated preoperative platelet count and elevated preoperative neutrophil-lymphocyte ratio (OR 15.6, 8.6 and 6.3 respectively, all p < 0.05). CRP values above 5.5 mg/L were indicative of all-cause morbidity (AUC=0.871), and values above 17.5 mg/L predicted severe complications (AUC=0.934). Conclusions: Elevated preoperative CRP predicts increased postoperative morbidity in this patient cohort. The results herein aid risk and resource stratification and encourage preoperative assessment of inflammatory propensity besides simple sepsis exclusion.

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