Prognostic impact of splenic vessel involvement and tumor size in distal pancreatectomy for adenocarcinoma: a retrospective multicentric cohort study

Abstract Background Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase in mortality. However, this has not been investigated in a larger cohort. We aimed to determine whether the association between lactate levels around ICU admission and mortality is different in metformin users compared to metformin nonusers. Methods This cohort study included patients admitted to ICUs in northern Denmark between January 2010 and August 2017 with any circulating lactate measured around ICU admission, which was defined as 12 h before until 6 h after admission. The association between the mean of the lactate levels measured during this period and 30-day mortality was determined for metformin users and nonusers by modelling restricted cubic splines obtained from a Cox regression model. Results Of 37,293 included patients, 3183 (9%) used metformin. The median (interquartile range) lactate level was 1.8 (1.2–3.2) in metformin users and 1.6 (1.0–2.7) mmol/L in metformin nonusers. Lactate levels were strongly associated with mortality for both metformin users and nonusers. However, the association of lactate with mortality was different for metformin users, with a lower mortality rate in metformin users than in nonusers when admitted with similar lactate levels. This was observed over the whole range of lactate levels, and consequently, the relation of lactate with mortality was shifted rightwards for metformin users. Conclusion In this large observational cohort of critically ill patients, early lactate levels were strongly associated with mortality. Irrespective of the degree of hyperlactataemia, similar lactate levels were associated with a lower mortality rate in metformin users compared with metformin nonusers. Therefore, lactate levels around ICU admission should be interpreted according to metformin use.

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Radical antegrade modular pancreatosplenectomy vs standard distal pancreatectomy for pancreatic adenocarcinoma of the body and tail - a cohort study from a single center

HPB ◽

10.1016/j.hpb.2020.11.746 ◽

2021 ◽

Vol 23 ◽

pp. S295-S296

Author(s):

Y. Jie ◽

L. Zipeng ◽

W. Pengfei ◽

Z. Kai ◽

D. Cuncai ◽

...

Keyword(s):

Cohort Study ◽

Distal Pancreatectomy ◽

Pancreatic Adenocarcinoma ◽

The Body ◽

Single Center ◽

Radical Antegrade Modular Pancreatosplenectomy

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Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer

Current Oncology ◽

10.3390/curroncol28030155 ◽

2021 ◽

Vol 28 (3) ◽

pp. 1663-1672

Author(s):

Satomi Hattori ◽

Nobuhisa Yoshikawa ◽

Kazumasa Mogi ◽

Kosuke Yoshida ◽

Masato Yoshihara ◽

...

Keyword(s):

Cervical Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Tumor Size ◽

Concurrent Chemoradiotherapy ◽

Primary Treatment ◽

Prognostic Impact ◽

Primary Tumor Size ◽

Node Metastasis ◽

Aortic Lymph Node

(1) This study investigated the prognostic impact of tumor size in patients with metastatic cervical cancer. (2) Methods: Seventy-three cervical cancer patients in our institute were stratified into two groups based on distant metastasis: para-aortic lymph node metastasis alone (IIIC2) or spread to distant visceral organs with or without para-aortic lymph node metastasis (IVB) to identify primary tumor size and concurrent chemoradiotherapy. (3) Results: The overall survival (OS) for patients with a tumor >6.9 cm in size was significantly poorer than that for patients with a tumor ≤6.9 cm in the IVB group (p = 0.0028); the corresponding five-year OS rates in patients with a tumor ≤6.9 and >6.9 cm were 53.3% and 13.4%, respectively. In the multivariate analysis, tumor size and primary treatment were significantly associated with survival in metastatic cervical cancer. (4) Conclusions: Tumor size ≤6.9 cm and concurrent chemoradiotherapy as the primary treatment were favorable prognostic factors for patients with metastatic cervical cancer.

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Tumor size may influence the prognosis of solitary hepatocellular carcinoma patients with cirrhosis and without macrovascular invasion after hepatectomy

Scientific Reports ◽

10.1038/s41598-021-95835-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Bin-yong Liang ◽

Jin Gu ◽

Min Xiong ◽

Er-lei Zhang ◽

Zun-yi Zhang ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Size ◽

Staging System ◽

Prognostic Impact ◽

Term Survival ◽

Long Term Survival ◽

Before And After ◽

Cirrhotic Patients ◽

Curative Hepatectomy

AbstractHepatocellular carcinoma (HCC) is usually associated with varying degrees of cirrhosis. Among cirrhotic patients with solitary HCC in the absence of macro-vascular invasion, whether tumor size drives prognosis or not after hepatectomy remains unknown. This study aimed to investigate the prognostic impact of tumor size on long-term outcomes after hepatectomy for solitary HCC patients with cirrhosis and without macrovascular invasion. A total of 813 cirrhotic patients who underwent curative hepatectomy for solitary HCC and without macrovascular invasion between 2001 and 2014 were retrospectively studied. We set 5 cm as the tumor cut-off value. Propensity score matching (PSM) was performed to minimize the influence of potential confounders including cirrhotic severity that was histologically assessed according to the Laennec staging system. Recurrence-free survival (RFS) and overall survival (OS) were compared between the two groups before and after PSM. Overall, 464 patients had tumor size ≤ 5 cm, and 349 had tumor size > 5 cm. The 5-year RFS and OS rates were 38.3% and 61.5% in the ≤ 5 cm group, compared with 25.1% and 59.9% in the > 5 cm group. Long-term survival outcomes were significantly worse as tumor size increased. Multivariate analysis indicated that tumor size > 5 cm was an independent risk factor for tumor recurrence and long-term survival. These results were further confirmed in the PSM cohort of 235 pairs of patients. In cirrhotic patients with solitary HCC and without macrovascular invasion, tumor size may significantly affect the prognosis after curative hepatectomy.

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Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy — Prospective multicenter cohort study

International Journal of Cardiology ◽

10.1016/j.ijcard.2012.12.058 ◽

2013 ◽

Vol 168 (3) ◽

pp. 1900-1904 ◽

Cited By ~ 34

Author(s):

Koichi Kimura ◽

Katsu Takenaka ◽

Aya Ebihara ◽

Kansei Uno ◽

Hiroyuki Morita ◽

...

Keyword(s):

Cohort Study ◽

Muscular Dystrophy ◽

Becker Muscular Dystrophy ◽

Left Ventricular ◽

Prognostic Impact ◽

Left Ventricular Noncompaction ◽

Multicenter Cohort Study ◽

Ventricular Noncompaction ◽

Multicenter Cohort

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Prognostic Impact of Additional Pancreatic Resection for Cancer Positive Cut Margins During Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma

Gastroenterology ◽

10.1016/s0016-5085(17)34307-x ◽

2017 ◽

Vol 152 (5) ◽

pp. S1290-S1291

Author(s):

Satoshi Nara ◽

Minoru Esaki ◽

Yoji Kishi ◽

Toshimitsu Iwasaki ◽

Kazuaki Shimada

Keyword(s):

Pancreatic Ductal Adenocarcinoma ◽

Distal Pancreatectomy ◽

Pancreatic Resection ◽

Ductal Adenocarcinoma ◽

Prognostic Impact

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Laparoscopic spleen-preserving distal pancreatectomy with and without splenic vessel preservation – a comparative study

HPB ◽

10.1016/j.hpb.2016.03.158 ◽

2016 ◽

Vol 18 ◽

pp. e441 ◽

Cited By ~ 1

Author(s):

S. Raveendran Nair ◽

B. Senadhipan

Keyword(s):

Comparative Study ◽

Distal Pancreatectomy ◽

Splenic Vessel ◽

Spleen Preserving ◽

Vessel Preservation ◽

Splenic Vessel Preservation

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Prognostic Impact of Branch Vessel Involvement on Computed Tomography versus Clinical Presentation of Malperfusion in Patients With Type a Acute Aortic Dissection

The American Journal of Cardiology ◽

10.1016/j.amjcard.2021.05.005 ◽

2021 ◽

Author(s):

Osamu Hashimoto ◽

Yuichi Saito ◽

Takashi Nakayama ◽

Shinichi Okino ◽

Yoshiaki Sakai ◽

...

Keyword(s):

Computed Tomography ◽

Aortic Dissection ◽

Acute Aortic Dissection ◽

Clinical Presentation ◽

Type A ◽

Prognostic Impact ◽

Branch Vessel ◽

Vessel Involvement

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FOLLOW-UP OF PATIENTS AND PROGNOSTIC IMPACT OF TUMOUR MARKER CA 15-3 ON PATIENTS OF BREAST CANCER: A RETROSPECTIVE COHORT STUDY

International Journal of Advanced Research ◽

10.21474/ijar01/12052 ◽

2020 ◽

Vol 8 (11) ◽

pp. 656-660

Author(s):

Anjali Vinocha ◽

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Cancer Patients ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Relative Survival ◽

Rank Test ◽

Prognostic Impact ◽

Breast Cancer Patients

Introduction:Breast cancer is the most common cancer in women, with 5- and 10-year relative survival rates are 91% and 84%, respectively for women with invasive breast cancer. This study aimed to detect the role of serum breast cancer marker CA 15-3 for early detection of metastasis, relapse or recurrence for management of breast cancer patients. Methods: It was a retrospective cohort study with a total of 132 breast cancer patients from the year 2010 to march 2020 were taken and followed up. For these patients demographic, biochemical parameters, radiological and clico-pathological data were collected and analysed. Result: The mean age at the time of presentation and mean duration of follow-up was 47 years and 31 months respectively. There was elevation in the serum level of CA 15-3 at the time of diagnosis of metastasis, recurrence or residual disease in 41 patients. This shows that sensitivity of elevated CA 15-3 (> 30 IU/ml) level in Ca Breast patients was 84%, 75 % and 75 % with respect to metastasis, recurrence and relapse. Log Rank test Chi- square value was 7.39 which was statistically significant (p=0.007). Cox proportional hazard model was created for effect of age at presentation, CA 15-3 at the time of diagnosis and MRM on distant metastasis and was statistically significant (p=0.037). Conclusion: We recommend that for the management of breast cancer patients, Cancer antigen (CA 15-3) levels can be used as prognostic marker for early diagnosis of metastasis, recurrence or relapse.

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