Overexpression of melanoma-associated antigen A2 has a clinical significance in embryonal carcinoma and is associated with tumor progression

2021 ◽  
Author(s):  
Leili Saeednejad Zanjani ◽  
Mahdieh Razmi ◽  
Fahimeh Fattahi ◽  
Elham Kalantari ◽  
Maryam Abolhasani ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Clinical Significance ◽  
Embryonal Carcinoma

scholarly journals Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer

2013 ◽  
Vol 30 (6) ◽  
pp. 2838-2844 ◽  
Author(s):  
TAKAAKI ARIGAMI ◽  
YOSHIKAZU UENOSONO ◽  
SUMIYA ISHIGAMI ◽  
SHIGEHIRO YANAGITA ◽  
TAKAHIKO HAGIHARA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Progression ◽  
Clinical Significance ◽  
Stanniocalcin 2

scholarly journals MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Zhi-qiang Ye ◽  
Chang-lin Zou ◽  
Han-bin Chen ◽  
Ming-jie Jiang ◽  
Zhu Mei ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Progression ◽  
Clinical Significance ◽  
Cancer Progression ◽  
Cox Proportional Hazards Model ◽  
The Cancer Genome Atlas ◽  
Cancer Tissue ◽  
Advanced Tumor ◽  
Potential Biomarker ◽  
Tumor Stages

MicroRNAs play critical roles in tumor progression. Our recent study has indicated that microRNA-7 (miR-7) impairs autophagy-derived pools of glucose to suppress the glycolysis in pancreatic cancer progression. However, the roles of miR-7 in clinical significance and chemoresistance of pancreatic cancer remain unexplored. The aim of this study was to assess the expression of miR-7 in patients with pancreatic cancer and to evaluate the possibility of its usage as a prognostic molecular biomarker. MicroRNA array-based quantification analysis of 372 miRNAs was compared in serum between pancreatic cancer and healthy individuals, gemcitabine-sensitive and gemcitabine-resistance patients. We identified miR-7 showed the potential predictive power for gemcitabine-sensitive patients with pancreatic cancer. Then, the results were validated in pancreatic tissue microarray and The Cancer Genome Atlas (TCGA) dataset, demonstrating that lower miR-7 expression was correlated with more advanced tumor stages and worse prognosis in pancreatic cancer. The Cox proportional-hazards model analysis identified miR-7 to be an independent variable for prediction of the survival. Furthermore, the mechanistic exploration suggested the clinical significance of miR-7 involved its interference effect on autophagy and glycolysis in pancreatic cancer using pancreatic cancer tissue microarrays and TCGA data. Therefore, the results of the present study provide evidences that low microRNA-7 expression may contribute to tumor progression and poor prognosis in pancreatic cancer.

Clinical significance of HuR expression, an mRNA-binding protein in non-small cell lung cancer (NSCLC)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10098-10098
Author(s):  
F. Tanaka ◽  
E. Ogawa ◽  
H. Wada ◽  
M. Shanker ◽  
A. E. Garcia-Soto ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Tumor Progression ◽  
Clinical Significance ◽  
Survival Rates ◽  
Protein Translation ◽  
Independent Prognostic Factor ◽  
Significant Prognostic Factor ◽  
Cell Cycle Regulators ◽  
Mrna Stabilization ◽  
Cox 2

10098 Background: HuR is a nucleo-cytoplasmic shuttling protein that specifically binds to mRNA that has AU rich (ARE) sites at the 3’end and transports the RNA to the cytoplasm for protein translation. In addition to mRNA transportation, HuR plays a role in mRNA stabilization and protein translation. Preclinical studies have shown mRNA’s of several growth factors, cell-cycle regulators, and transcription-regulating proteins have ARE’s at the 3’end and bound by HuR. However, there has been reported no clinical data on HuR expression in NSCLC. Thus, in the present study, we assessed clinical significance of HuR expression in NSCLC. Patients and Methods: A total of 236 patients with completely resected p-stage I-IIIA, NSCLC, were reviewed, and HuR expression was evaluated immunohistochemically. Results (Table): HuR expression was seen in the nucleus and cytoplasm of tumor cells. Cytoplasmic HuR expression was positively correlated with tumor progression (p-stage, P<0.01), especially nodal metastasis, microvessel density (MVD), and COX-2 expression. Enhanced nuclear HuR expression was also correlated with tumor progression and COX-2 expression, but not with MVD. Positive cytoplasmic HuR expression was a significant factor to predict a poor prognosis in all patients (5-year survival rates: 85% for HuR-negative and 43% for HuR-positive patients; P<0.01) and in any p-stage/histology subset patients. Nuclear HuR expression status was also a significant prognostic factor in all patients, but not in all subsets. A multivariate analysis confirmed that cytoplasmic HuR status was an independent prognostic factor (hazard ratio [95% CI], 4.261 [2.109–8.609]; P<0.001). Conclusions: Cytoplasmic HuR expression was correlated with tumor progression, and was a significant and independent prognostic factor in correlation with enhanced COX-2 expression and increased tumor angiogenesis. [Table: see text] No significant financial relationships to disclose.

scholarly journals MicroRNA-935 mediates the regulatory effect of lncRNA KCNQ1OT1 on tumor progression of breast cancer

2020 ◽  
Author(s):  
Chunjie Zhang ◽  
Cuixue Gong ◽  
Jianzhao Li ◽  
Jiaying Tang
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Tumor Progression ◽  
Clinical Significance ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Regulatory Effect ◽  
Promoting Effect ◽  
Aberrant Expression

Abstract Background The biological function of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have received increasing attention in the pathogenesis of various malignancies. This study aimed to evaluate the functional role and clinical significance of the KCNQ1OT1/miR-935 axis in breast cancer (BCa) progression. Methods Expression of KCNQ1OT1 and miR-935 was estimated using quantitative real-time PCR (qRT-PCR). The interaction between KCNQ1OT1 and miR-935 was confirmed by luciferase reporter assay. BCa cell proliferation, migration and invasion were evaluated using CCK-8 and Transwell assays. The clinical significance of the KCNQ1OT1/miR-935 axis in BCa diagnosis was examined by ROC analysis. Results The expression of KCNQ1OT1 was significantly elevated, but the miR-935 expression was decreased in BCa cells (all P < 0.01). KCNQ1OT1 could directly bind to miR-935, leading to the decreased miR-935 expression in BCa cells (P < 0.001). The overexpression of miR-935 could inhibit BCa cell proliferation, migration and invasion, and remarkably reversed the regulatory effect of KCNQ1OT1 on BCa cell biological processes (all P < 0.05). Serum KCNQ1OT1 levels were negatively correlated with miR-935 levels in BCa patients. The aberrant expression of KCNQ1OT1 and miR-935 had relatively high diagnostic accuracy for the screening of BCa patients. Conclusion In conclusion, miR-935 expression is downregulated in BCa cells, which can be inhibited by KCNQ1OT1 and mediates the promoting effect of KCNQ1OT1 on BCa tumor progression in vivo. Serum reduced expression of miR-935 may serve as a diagnostic biomarker of BCa, and the KCNQ1OT1/miR-935 axis provides potential therapeutic targets for BCa treatment.

scholarly journals CLINICAL SIGNIFICANCE OF MICRORNA-21 ExPRESSION IN MONITORINGOF TUMOR PROGRESSION WITH CEREBRAL GLIOMAS

2015 ◽  
Vol 7 (4) ◽  
pp. 47-51
Author(s):  
R Yu Seliverstov ◽  
M I Zarayskiy ◽  
A A Sazanov ◽  
E E Zueva ◽  
S V Lobzyn ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Clinical Significance ◽  
Metabolic Changes ◽  
Cerebral Glioma ◽  
Actual Problem ◽  
Screening Technique ◽  
Neoplastic Lesions ◽  
Cerebral Gliomas ◽  
Highly Correlated ◽  
Evolutional Process

The early verifying of cerebral ’s gliomas progression is an actual problem. It was found that the level of mircroRNA-21 expression is a highly specific in a tumor’s evolutional process. That the aim of the study was the assessment with level of mircroRNA-21 expression in blood and saliva of patients with cerebral glioma progression and patients without it which were verified by PET using [ 11C] methionine. It was found that in majority of cases, the negative dynamics of cerebral neoplastic lesions coincided with an increase in metabolic changes in the residual glioma and highly correlated with the level of mircroRNA-21 expression. This allows us to consider a highly significant the level of mircroRNA-21 expression as a screening technique in monitoring the evolution of the tumor process and the effectiveness of the treatment.

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