scholarly journals Cancer research in need of a scientific revolution: Using ‘paradigm shift’ as a method of investigation

2015 ◽  
Vol 40 (3) ◽  
pp. 657-666 ◽  
Author(s):  
Didier Wion ◽  
Florence Appaix ◽  
Meriwether Burruss ◽  
François Berger ◽  
Boudewijn van der Sanden
2018 ◽  
Vol 71 (5) ◽  
pp. 2584-2588 ◽  
Author(s):  
Cláudio José de Souza ◽  
Zenith Rosa Silvino

ABSTRACT Objective: To reflect on the key concepts of the book The Structure of Scientific Revolutions and its applicability in professional master's in nursing. Method: This is a theoretical-reflective study that uses the philosophical and epistemological conceptions of the philosopher Thomas Samuel Kuhn to consider its applicability on the paradigm shift of stricto sensu graduate courses in nursing. The main concepts of Kuhn were used as support: paradigm, anomaly, scientific community and scientific revolution. Results: The propositions of this philosopher are applied to and support the theoretical reflection on professional master's programs, contributing to clarify what would be a paradigmatic visionary perspective in stricto sensu master's models in nursing. Conclusion: From Kuhn's propositions it was possible to conclude that professional master's programs in nursing can break away from the dominant paradigm, strengthening a scientific revolution within the academia.


2021 ◽  
Vol 32 (2) ◽  
pp. 91-97
Author(s):  
John M. Coffin

The simultaneous discovery in 1970 of reverse transcriptase in virions of retroviruses by Howard Temin and David Baltimore was perhaps the most dramatic scientific moment of the second half of the 20th century. Ten years previously, Temin’s observation of cells transformed by Rous Sarcoma virus led him to the conclusion that retroviruses replicate through a DNA intermediate he called the provirus. This heretical hypothesis was greeted with derision by fellow scientists; Temin and Baltimore performed a simple experiment, rapidly reproduced, and convincing to all. Its result was a major paradigm shift—reversal of the central dogma of molecular biology. It immediately grabbed the attention of both the scientific and lay press. It also came at a key time for cancer research, at the start of the “War on Cancer.” As a theoretical base and fundamental molecular tool, it enabled a decade of (largely fruitless) search for human oncogenic retroviruses but laid the foundation for the discovery of HIV 13 years later, leading to the development of effective therapy. I had the good fortune, as a student in Temin’s lab, to witness these events. I am honored to be able to share my recollection on the occasion of their 50th anniversary.


Author(s):  
Dag von Lubitz

Information Technology (IT), and the subsequent broad acceptance of Information and Knowledge Management (IM/KM) methods revolutionized the way business is thought of and practiced. With e-business facilitating the ability to do more, more, faster, at a wider range, and to influence ever larger and more diverse consumer groups, the impact of technology on commerce, finance, and global economy has been frequently compared to the “paradigm shift” that Kuhn (1970) proposed as the essence of scientific revolution. Yet, despite the transformational influence of modernity on the ancient art, the fundamental principles of business have not changed: overreliance on the facilitation of business operations as the substitution for the adherence to the soundness of their conduct fuelled rampant growth of corporate laisse faire, and already twice brought the world to the brink of economic disaster (Stiglitz, 2003; Steingart, 2008).


2008 ◽  
Vol 38 (1) ◽  
pp. 45-75 ◽  
Author(s):  
Evelyn Fox Keller

Over the last quarter century, the term "self-organization" has acquired a currency that, notwithstanding its long history, has been taken to signal a paradigm shift, and perhaps even a scientific revolution, introducing a new Weltanschauungin fields as diverse as mathematics, physics, biology, ecology, cybernetics, economics, sociology, and engineering. But there is a prehistory to this revolution, as to the term itself, with at least two earlier episodes in which the same term was used to signal two other, quite different revolutions. In this paper, I review the pre-history of "self-organization," starting with Immanuel Kant, who first introduced the term, and then turn to the dramatic reframing of the concept by mid-twentieth century engineers. In a subsequent paper, I will review the more recent history of this concept when the term was once again reframed, this time by physicists. My aim will be to situate this latest incarnation of "self-organization" against the backdrop of earlier discussions.


Author(s):  
Agus Arwani

The paper aims to explore the ideological interpretation of Islamic accounting. It is hoped that the results of various interpretations of Islamic accounting are obtained comprehensively. The research method used is qualitative research. Qualitative research is called Participant-Observation because the researcher himself must be the main instrument in collecting data by directly observing the object being examined While the research approach uses a literature study. The results of this study found that there are several views on the interpretation of Islamic accounting ideology. The fragile philosophical foundation of context knowledge is enough to create counter paradigm rivals as a consequence of the scientific revolution (science revolutions) in the form of an alternative paradigm shift due to the failure of the old paradigm to answer a set of problems. The content of the Islamic substance is liberation, making accounting perceived as a treatise.


Çédille ◽  
2020 ◽  
pp. 79-111
Author(s):  
Lourdes Pérez González ◽  

Between 17th and 18th centuries we witnessed a scientific revolution in all the branches of knowledge, whose most remarkable names history keeps record of. But be-hind, on the sidelines, in the distance, many other names – of women too – participated in this process of carrying out different tasks, including translation (especially to / from French, language of greater projection then). We will examine the paradigm shift in physics and chemistry, focusing on this dark zone of the hinge which is needed to explain how this long transformation took place, putting the focus on some female translators, self-taught scientists, whose indispensable role for transmission, dissemination and consolida-tion of knowledge was veiled or blurred.


2020 ◽  
Vol 2 (1) ◽  
pp. 53-63
Author(s):  
Athoillah Islamy

The phenomenon of liberalism on Islamic marriage law in Indonesia often creates social problems. Therefore, it is important to understand understanding and wise attitudes towards the phenomenon within the framework of the scientific paradigm. This research aims to understand various forms of liberalism on Islamic marriage law in Indonesia in the perspective of the philosophy of Science. This research is a qualitative research in the form of literature review. The type of legal research in this study is philosophical normative legal research. The research data used is various research on liberalism on the law of Islamic marriage in the Compilation of Islamic Law (KHI). Meanwhile, the theory used as a knife of analysis is the theory of the scientific revolution of Thomas Samuel Kuhn. This study concludes that liberalism on Islamic marriage law in Indonesia is a form of paradigm shift over the construction of legal thinking in various KHI articles that are considered to have experienced anomalies, which are not relevant to social development and do not answer the challenges of modernity, such as issues of gender equality, democracy, human rights Humans, and pluralism. Such conditions have encouraged contemporary Islamic law reviewers in Indonesia to voice a paradigm shift and even a scientific revolution by giving birth to the construction of new Islamic marriage law.


2004 ◽  
Vol 26 (2) ◽  
pp. 221-239 ◽  
Author(s):  
Cristel de Rouvray

This paper investigates the actions of a small, yet influential group of American economists who sought to claim economic history for themselves and use it as a springboard to launch a wider transformation of economics. Their actions constitute an episode of dissent in the history of twentieth century economics, albeit an unusual one. These dissenters were not a socially or intellectually marginalized group, but rather a set of privileged scholars who were able to leverage their contacts within the profession and amongst its patrons to further their vision. Their actions could almost be described in Kuhnian terms: they consciously sought to trigger a “paradigm shift” to bring about a social science better suited, in their views, to a world in political and economic turmoil (Kuhn 1962). In spite of the Kuhnian allusion to “scientific revolution,” this paper is not about the 1960s “cliometric revolution,” but about the 1940s and '50s and the little known events that led to the creation of the Economic History Association, the Journal of Economic History, and Explorations in Entrepreneurial History (subsequently Explorations in Economic History).


2014 ◽  
Vol 60 (3) ◽  
pp. 199-199
Author(s):  
KAZUHISA TAKAHASHI

2017 ◽  
Vol 6 (1) ◽  
pp. 008
Author(s):  
Mario César Sánchez Villa

The triumph of the reason as the only way of natural knowledge was the most remarkable result of the paradigm shift occurred during the so-called Scientific Revolution, which reaches from the Renaissance to the Enlightenment, and in which dogmatic reasoning lost progressively its role as the principal form of knowledge. Nevertheless, during the following centuries, a large part of the men of science were willing to favour the conversion of dogma into an agent of rational thought. This paper, tries to offer a point of reflection on the influence that the biblical account maintained in the construction of the modern scientific theories that, somehow, tried to explain relevant issues such as the origin of physical and moral differences between humans. The broader objective is to demonstrate that, as a form of cultural expression, the dogmatic-religious thought continued to play a transcendental role in the legitimation of a part of the modern rational scientific discourse, committed to defending the civilizing role and the physical and moral superiority of Western states, far beyond what the simple use of reason permitted.


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