The Impact of Coenzyme Q10 on Neurodegeneration: a Comprehensive Review

2022 ◽  
Author(s):  
Monika Kadian ◽  
Garima Sharma ◽  
Shivani Pandita ◽  
Kritika Sharma ◽  
Kanishka Shrivasatava ◽  
...  
Keyword(s):  
Coenzyme Q10 ◽  
Comprehensive Review ◽  
The Impact

The Impact of L-Carnitine and Coenzyme Q10 as Protection Against Busulfan-Oxidative Stress in the Liver of Adult Rats

2020 ◽  
Vol 10 (5) ◽  
pp. 578-586
Author(s):  
Areeg M. Abdelrazek ◽  
Shimaa A. Haredy
Keyword(s):  
Oxidative Stress ◽  
Coenzyme Q10 ◽  
Protective Role ◽  
Albino Rats ◽  
Distilled Water ◽  
Negative Effects ◽  
Adult Rats ◽  
Stress Damage ◽  
The Impact ◽  
Liver Tissues

Background: Busulfan (Bu) is an anticancer drug with a variety of adverse effects for cancer patients. Oxidative stress has been considered as a common pathological mechanism and it has a key role in the initiation and progression of liver injury by Bu. Aim: The study aimed to evaluate the antioxidant impact of L-Carnitine and Coenzyme Q10 and their protective role against oxidative stress damage in liver tissues. Methods and Material: Thirty-six albino rats were divided equally into six groups. G1 (con), received I.P. injection of DMSO plus 1 ml of distilled water daily by oral gavages; G2 (Bu), received I.P. injection of Bu plus 1 ml of the distilled water daily; G3 (L-Car), received 1 ml of L-Car orally; G4 (Bu + L-Car) received I.P. injection of Bu plus 1 ml of L-Car, G5 (CoQ10) 1 ml of CoQ10 daily; and G6 (Bu + CoQ10) received I.P. injection of Bu plus 1 ml of CoQ10 daily. Results: The recent data showed that Bu induced significant (P<0.05) elevation in serum ALT, AST, liver GSSG, NO, MDA and 8-OHDG, while showing significant (P<0.05) decrease in liver GSH and ATP. On the other hand, L-Carnitine and Coenzyme Q10 ameliorated the negative effects prompted by Bu. Immunohistochemical expression of caspase-3 in liver tissues reported pathological alterations in Bu group while also showed significant recovery in L-Car more than CoQ10. Conclusion: L-Car, as well as CoQ10, can enhance the hepatotoxic effects of Bu by promoting energy production in oxidative phosphorylation process and by scavenging the free radicals.

scholarly journals Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine—a meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e039358
Author(s):  
Suhairul Sazali ◽  
Salziyan Badrin ◽  
Mohd Noor Norhayati ◽  
Nur Suhaila Idris
Keyword(s):  
Random Effects ◽  
Coenzyme Q10 ◽  
Migraine Headache ◽  
Meta Analysis ◽  
Adult Patients ◽  
Control Group ◽  
Cochrane Central Register ◽  
Statistical Heterogeneity ◽  
Coq10 Supplementation ◽  
The Impact

ObjectiveTo determine the effects of coenzyme Q10 (CoQ10) for reduction in the severity, frequency of migraine attacks and duration of headache in adult patients with migraine.DesignSystematic review and meta-analysis.Data sourcesCochrane Central Register of Controlled Trials, CENTRAL, MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Psychological Information Database (PsycINFO) from inception till December 2019.Study selectionAll randomised control trials comparing CoQ10 with placebo or used as an adjunct treatment included in this meta-analysis. Cross-over designs and controlled clinical trials were excluded.Data synthesisHeterogeneity at face value by comparing populations, settings, interventions and outcomes were measured and statistical heterogeneity was assessed by means of the I2 statistic. The treatment effect for dichotomous outcomes were using risk ratios and risk difference, and for continuous outcomes, mean differences (MDs) or standardised mean difference; both with 95% CIs were used. Subgroup analyses were carried out for dosage of CoQ10 and if CoQ10 combined with another supplementation. Sensitivity analysis was used to investigate the impact risk of bias for sequence generation and allocation concealment of included studies.ResultsSix studies with a total of 371 participants were included in the meta-analysis. There is no statistically significant reduction in severity of migraine headache with CoQ10 supplementation. CoQ10 supplementation reduced the duration of headache attacks compared with the control group (MD: −0.19; 95% CI: −0.27 to −0.11; random effects; I2 statistic=0%; p<0.00001). CoQ10 usage reduced the frequency of migraine headache compared with the control group (MD: −1.52; 95% CI: −2.40 to −0.65; random effects; I2 statistic=0%; p<0.001).ConclusionCoQ10 appears to have beneficial effects in reducing duration and frequency of migraine attack.PROSPERO registration numberCRD42019126127.

The impact of air pollution on skin and related disorders: A comprehensive review

2021 ◽  
Author(s):  
Ruhollah Abolhasani ◽  
Farnaz Araghi ◽  
Mohammadreza Tabary ◽  
Armin Aryannejad ◽  
Baharnaz Mashinchi ◽  
...  
Keyword(s):  
Air Pollution ◽  
Comprehensive Review ◽  
The Impact

scholarly journals A Global Perspective on Firefly Extinction Threats

BioScience ◽  
2020 ◽  
Vol 70 (2) ◽  
pp. 157-167 ◽  
Author(s):  
Sara M Lewis ◽  
Choong Hay Wong ◽  
Avalon C S Owens ◽  
Candace Fallon ◽  
Sarina Jepsen ◽  
...  
Keyword(s):  
Conservation Status ◽  
Economic Value ◽  
Global Perspective ◽  
Current Evidence ◽  
Cultural Significance ◽  
Comprehensive Review ◽  
Survey Results ◽  
The Impact ◽  
Recent Attention

Abstract Insect declines and their drivers have attracted considerable recent attention. Fireflies and glowworms are iconic insects whose conspicuous bioluminescent courtship displays carry unique cultural significance, giving them economic value as ecotourist attractions. Despite evidence of declines, a comprehensive review of the conservation status and threats facing the approximately 2000 firefly species worldwide is lacking. We conducted a survey of experts from diverse geographic regions to identify the most prominent perceived threats to firefly population and species persistence. Habitat loss, light pollution, and pesticide use were regarded as the most serious threats, although rankings differed substantially across regions. Our survey results accompany a comprehensive review of current evidence concerning the impact of these stressors on firefly populations. We also discuss risk factors likely to increase the vulnerability of certain species to particular threats. Finally, we highlight the need to establish monitoring programs to track long-term population trends for at-risk firefly taxa.

The impact of α-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice

2004 ◽  
Vol 36 (8) ◽  
pp. 1043-1057 ◽  
Author(s):  
Cheol-Koo Lee ◽  
Thomas D Pugh ◽  
Roger G Klopp ◽  
Jode Edwards ◽  
David B Allison ◽  
...  
Keyword(s):  
Gene Expression ◽  
Life Span ◽  
Caloric Restriction ◽  
Lipoic Acid ◽  
Coenzyme Q10 ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
The Impact

scholarly journals Nonalcoholic fatty liver disease and bariatric surgery: a comprehensive review

2017 ◽  
Vol 135 (3) ◽  
pp. 277-295 ◽  
Author(s):  
Everton Cazzo ◽  
José Carlos Pareja ◽  
Elinton Adami Chaim
Keyword(s):  
Bariatric Surgery ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Health Concern ◽  
Comprehensive Review ◽  
Nonalcoholic Fatty Liver ◽  
Mesh Terms ◽  
The Impact

ABSTRACT CONTEXT AND OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) has been increasingly diagnosed worldwide and is now recognized as a source of public health concern. It comprises a wide spectrum of histological features that range from simple steatosis to severe forms of fibrosis, steatohepatitis and even cirrhosis. The impact of bariatric surgery on the course of NAFLD in individuals with obesity has been extensively studied. DESIGN AND SETTING: Narrative review; public university hospital. METHODS: A comprehensive review was conducted based on an online search on the electronic databases MEDLINE and LILACS using the MeSH terms “fatty liver” and “bariatric surgery”. RESULTS: The exact mechanisms that lead to improvement in NAFLD following bariatric surgery are not completely understood. Since Roux-en-Y gastric bypass (RYGB) is the bariatric surgical procedure most performed worldwide, it is also the one from which the effects on NAFLD have been most studied, although there is also consistent evidence regarding the effects from gastric banding, sleeve gastrectomy and biliopancreatic diversions. CONCLUSION: According to the currently available evidence, bariatric surgery leads to significant improvement in NAFLD. Further research, especially by means of randomized controlled trials enrolling larger cohorts of individuals, is needed to determine the optimal procedure for this group of subjects.

scholarly journals THE IMPACT OF CARDIOVASCULAR AND BRONCHOPULMONARY DISEASES ON COENZYME Q10 PLASMA CONCENTRATION

2019 ◽  
Vol 10 (1) ◽  
pp. 16-21
Author(s):  
V. I. Zozina ◽  
E. S. Melnikov ◽  
L. M. Krasnykh ◽  
O. A. Goroshko ◽  
V. G. Kukes
Keyword(s):  
Coenzyme Q10 ◽  
High Performance ◽  
Sharp Decrease ◽  
Atp Synthesis ◽  
Mitochondrial Respiratory Chain ◽  
Pulmonary Diseases ◽  
Main Function ◽  
Bronchopulmonary Diseases ◽  
The Impact ◽  
The Relationship

Introduction. Coenzyme Q10 plays an important role in the human body. Its main function is not only the transfer of electrons in the mitochondrial respiratory chain for the ATP synthesis, but it is also one of the most powerful antioxidants in the body.The aim of research is to monitor the relationship between cardiovascular and pulmonary diseases, and the concentration of coenzyme Q10 in the blood plasma.Materials and methods. Coenzyme Q10 was determined using high performance liquid chromatography with mass spectrometric detection.Results and discussion. During the study, it was found that the concentration of coenzyme Q10 in plasma is affected not only by the main diseases, but also by comorbidities, as well as by the therapy. A sharp decrease in plasma coenzyme Q10 concentration was noted in patients with cardiovascular pathologies, especially in those with concomitant endocrine diseases. Also, it was recorded a decrease in the concentration of coenzyme Q10 in the plasma of patients with pneumonia. Conclusion. During the experiment, the coenzyme Q10 concentration was found to be dependent on cardiovascular and pulmonary diseases.

scholarly journals The Impact of N-Acetyl Cysteine and Coenzyme Q10 Supplementation on Skeletal Muscle Antioxidants and Proteome in Fit Thoroughbred Horses

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1739
Author(s):  
Marisa L. Henry ◽  
Deborah Velez-Irizarry ◽  
Joe D. Pagan ◽  
Lorraine Sordillo ◽  
Jeff Gandy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Coenzyme Q10 ◽  
Maximal Exercise ◽  
Citrate Synthase ◽  
Tca Cycle ◽  
Redox Status ◽  
Thoroughbred Horses ◽  
Redox Capacity ◽  
Acetyl Cysteine ◽  
The Impact

Horses have one of the highest skeletal muscle oxidative capacities amongst mammals, which, combined with a high glycolytic capacity, could perturb redox status during maximal exercise. We determined the effect of 30 d of oral coenzyme Q10 and N-acetyl-cysteine supplementation (NACQ) on muscle glutathione (GSH), cysteine, ROS, and coenzyme Q10 concentrations, and the muscle proteome, in seven maximally exercising Thoroughbred horses using a placebo and randomized cross-over design. Gluteal muscle biopsies were obtained the day before and 1 h after maximal exercise. Concentrations of GSH, cysteine, coenzyme Q10, and ROS were measured, and citrate synthase, glutathione peroxidase, and superoxide dismutase activities analyzed. GSH increased significantly 1 h post-exercise in the NACQ group (p = 0.022), whereas other antioxidant concentrations/activities were unchanged. TMT proteomic analysis revealed 40 differentially expressed proteins with NACQ out of 387 identified, including upregulation of 13 mitochondrial proteins (TCA cycle and NADPH production), 4 Z-disc proteins, and down regulation of 9 glycolytic proteins. NACQ supplementation significantly impacted muscle redox capacity after intense exercise by enhancing muscle glutathione concentrations and increasing expression of proteins involved in the uptake of glutathione into mitochondria and the NAPDH-associated reduction of oxidized glutathione, without any evident detrimental effects on performance.

scholarly journals Information and Communication in a Networked Infosphere - a Review of Concepts and Application in Social Branding

2015 ◽  
Vol 13 (1) ◽  
pp. 9-29
Author(s):  
Fernando Manuel Santos Ramos ◽  
Óscar Emanuel Chaves Mealha ◽  
Catarina Franco Lélis
Keyword(s):  
Information And Communication Technologies ◽  
Human Life ◽  
Communication Technologies ◽  
Research Project ◽  
Comprehensive Review ◽  
Working Models ◽  
New Information ◽  
Nuevas Tecnologías ◽  
Information And Communication ◽  
The Impact

Abstract:This paper aims at providing a contribution to the comprehensive review of the impact of information and communication, and their supporting technologies, in the current transformation of human life in the infosphere. The paper also offers an example of the power of new social approaches to the use of information and communication technologies to foster new working models in organizations by presenting the main outcomes of a research project on social branding. A discussion about some trends of the future impact of new information and communication technologies in the infosphere is also included.Resumen:Este artículo tiene como objetivo proporcionar una contribución a la revisión global del impacto de la información y la comunicación, y sus tecnologías de apoyo, en la actual transformación de la vida humana en la infosfera. El artículo también ofrece un ejemplo del poder de los nuevos enfoques sociales sobre el uso de las tecnologías de información y comunicación para fomentar nuevos modelos de trabajo en las organizaciones mediante la presentación de los principales resultados de un proyecto de investigación sobre desarrollo social de marca. Una discusión sobre algunas de las tendencias del futuro impacto de las nuevas tecnologías de la información y la comunicación en la infosfera también se incluye. 

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