scholarly journals Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle

2021 ◽  
Author(s):  
A. Langlois ◽  
A. Forterre ◽  
M. Pinget ◽  
K. Bouzakri
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Glycaemic Control ◽  
Metabolic Disorders ◽  
Acid Oxidation ◽  
Moderate Physical Activity ◽  
Moderate Activity ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
The Impact

AbstractFatty acids (FA) play a crucial role in glycaemia regulation in healthy and metabolic disorders conditions through various mechanisms. FA oxidation is one of the processes involved in lipid metabolism and can be modulated by exercise. Nowadays, physical activity is known to be an effective strategy for the prevention and treatment of Type 2 Diabetes. Moreover, its intensity, its duration, the sex-gender, the prandial state, exerkines… are as many parameters that can influence glycaemic control. However, the widely debated question is to determine the best type of exercise for patients with metabolic disorders. In this review, we will discuss the impact of exercise intensity, especially moderate activity, on glycaemic control by focussing on FA oxidation in pancreatic β-cells and skeletal muscle. Finally, thanks to all the recent data, we will determine whether moderate physical activity is a good therapeutic strategy and if FA oxidation represents a target of interest to treat diabetic, obese and insulin-resistant patients.

Pedometer Steps-Per-Minute, Moderate Intensity, and Individual Differences in 12- to 14-Year-Old Youth

2011 ◽  
Vol 8 (2) ◽  
pp. 272-278 ◽  
Author(s):  
Susan Vincent Graser ◽  
Alan Groves ◽  
Keven A. Prusak ◽  
Todd R. Pennington
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Individual Differences ◽  
Moderate Intensity ◽  
Moderate Physical Activity ◽  
Moderate Activity ◽  
Heart Rate Monitor ◽  
Activity Intensity ◽  
Intensity Threshold ◽  
The Impact

Background:Researchers have noted both the utility and limitations of using pedometers to measure physical activity (PA). While these unobtrusive devices are widely accepted for their ability to measure accumulated PA, they have been criticized for their inability to measure exercise intensity. However, recent steps-per-minute (SPM) research provides reasonably accurate measures of intensity allowing users to assess time spent at recommended PA levels. Therefore, the purpose of this study was to determine the SPM taken that are associated with moderate physical activity in 12- to 14-year-old youth.Methods:Ninety-three participants (49 boys and 44 girls; ages 12 to 14) walked on a treadmill for 3 minutes at each of 4 different speeds while wearing a pedometer and a heart rate monitor.Results:On average boys and girls reached their moderate activity intensity threshold at 122 SPM and 102 SPM, respectively. However, individual differences must be taken into account when determining appropriate SPM intensities for youth.Conclusions:The impact of individual differences underscores the need to address SPM for moderate intensity individually rather than with a single guideline for everyone at this age.

scholarly journals The prevalence of physical inactivity in Iranian adolescents and the impact of economic and social inequalities on it: results of a National Study in 2018

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ghobad Moradi ◽  
Farideh Mostafavi ◽  
Bakhtiar Piroozi ◽  
Bushra Zareie ◽  
Marzieh Mahboobi ◽  
...  
Keyword(s):  
Physical Activity ◽  
High School ◽  
Physical Inactivity ◽  
Social Inequalities ◽  
National Study ◽  
Moderate Physical Activity ◽  
Moderate Activity ◽  
Study Population ◽  
The Impact ◽  
Socioeconomic Levels

Abstract Background This study aims to determine the prevalence of physical inactivity in Iranian adolescents aged 10–12 years and the impact of socioeconomic inequality on it. Methods In this descriptive study, the study population consisted of 10–12 years old adolescents from an Iranian population from Kurdistan, Fars and Markazi provinces in 2018. The sample size was 1590 individuals. The sampling method was cluster sampling. Data was collected using demographic questionnaire, modifiable activity questionnaire (MAQ) and socioeconomic questionnaire. Cut points on the MAQ for light activity, moderate activity and heavy activity were MET< 3, MET = 3–6 and MET> 6, respectively. Linear and logistic regression were used to estimate the final model and the Oaxaca analysis method was applied. All analyses were performed in Stata/SE 14.0. Results Of the 1590 participants, 52.82% were male. The results showed that 25.79% of the subjects were physically inactive and 7.30% engaged in moderate physical activity during the week. The average physical activity during 1 week was more in boys than in girls (P-value< 0.05). Adolescents of mothers with secondary and high school education were more likely to have physical inactivity than mothers with a high school diploma or higher (AOR: 1.35, 95% CI: 1.02–1.77). The concentration index was −.11, indicating a greater concentration of physical inactivity in adolescents with low socioeconomic levels. Conclusion One-fourth of the study population had physical inactivity in this age group. Socioeconomic levels, parental literacy, and sex of adolescents were associated with the level of physical activity.

The Effect of Changes to Question Order on the Prevalence of ‘Sufficient’ Physical Activity in an Australian Population Survey

2013 ◽  
Vol 10 (3) ◽  
pp. 390-396
Author(s):  
Christine Hanley ◽  
Mitch J. Duncan ◽  
W. Kerry Mummery
Keyword(s):  
Physical Activity ◽  
Binary Logistic Regression ◽  
Total Activity ◽  
Order Effects ◽  
Computer Assisted ◽  
Moderate Activity ◽  
Question Order ◽  
Recreational Walking ◽  
Cati Survey ◽  
The Impact

Background:Population surveys are frequently used to assess prevalence, correlates and health benefits of physical activity. However, nonsampling errors, such as question order effects, in surveys may lead to imprecision in self reported physical activity. This study examined the impact of modified question order in a commonly used physical activity questionnaire on the prevalence of sufficient physical activity.Methods:Data were obtained from a telephone survey of adults living in Queensland, Australia. A total of 1243 adults participated in the computer-assisted telephone interview (CATI) survey conducted in July 2008 which included the Active Australia Questionnaire (AAQ) presented in traditional or modified order. Binary logistic regression analyses was used to examine relationships between question order and physical activity outcomes.Results:Significant relationships were found between question order and sufficient activity, recreational walking, moderate activity, vigorous activity, and total activity. Respondents who received the AAQ in modified order were more likely to be categorized as sufficiently active (OR = 1.28, 95% CI 1.01−1.60).Conclusions:This study highlights the importance of question order on estimates of self reported physical activity. This study has shown that changes in question order can lead to an increase in the proportion of participants classified as sufficiently active.

scholarly journals TWIST1 and TWIST2 regulate glycogen storage and inflammatory genes in skeletal muscle

2015 ◽  
Vol 224 (3) ◽  
pp. 303-313 ◽  
Author(s):  
Jonathan M Mudry ◽  
Julie Massart ◽  
Ferenc L M Szekeres ◽  
Anna Krook
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Diseases ◽  
Glycogen Synthesis ◽  
C2c12 Cells ◽  
Acid Oxidation ◽  
Diabetic Patients ◽  
Mrna Levels ◽  
Intact Mouse ◽  
Mouse Muscle ◽  
The Impact

TWIST proteins are important for development of embryonic skeletal muscle and play a role in the metabolism of tumor and white adipose tissue. The impact of TWIST on metabolism in skeletal muscle is incompletely studied. Our aim was to assess the impact of TWIST1 and TWIST2 overexpression on glucose and lipid metabolism. In intact mouse muscle, overexpression of Twist reduced total glycogen content without altering glucose uptake. Expression of TWIST1 or TWIST2 reducedPdk4mRNA, while increasing mRNA levels ofIl6,Tnfα, andIl1β. Phosphorylation of AKT was increased and protein abundance of acetyl CoA carboxylase (ACC) was decreased in skeletal muscle overexpressing TWIST1 or TWIST2. Glycogen synthesis and fatty acid oxidation remained stable in C2C12 cells overexpressing TWIST1 or TWIST2. Finally, skeletal muscle mRNA levels remain unaltered inob/obmice, type 2 diabetic patients, or in healthy subjects before and after 3 months of exercise training. Collectively, our results indicate that TWIST1 and TWIST2 are expressed in skeletal muscle. Overexpression of these proteins impacts proteins in metabolic pathways and mRNA level of cytokines. However, skeletal muscle levels of TWIST transcripts are unaltered in metabolic diseases.

scholarly journals Accelerometer-Measured Physical Activity and Its Impact on Sleep Quality in Persons Suffering From Restless Legs Syndrome

2020 ◽  
Author(s):  
Anne Reimers ◽  
Verena Heidenreich ◽  
Hans-Joachim Bittermann ◽  
Guido Knapp ◽  
Carl-Detlev Reimers
Keyword(s):  
Physical Activity ◽  
Sleep Quality ◽  
Negative Correlation ◽  
Restless Legs Syndrome ◽  
Quality Parameters ◽  
Moderate Physical Activity ◽  
Activity Levels ◽  
Restless Legs ◽  
Physical Activity Levels ◽  
The Impact

Abstract Background: Main symptoms of the restless legs syndrome (RLS) are sleep onset insomnia and difficulty to maintain sleep. Previous studies showed that regular physical activity can reduce the risk of developing RLS. However, the relationships of physical activity on sleep quality parameters in subjects suffering from RLS have not been investigated by applying accelerometry. Thus, the present study investigates the impact of physical activity during the day (7-12 h, 12-18 h, 18-23 h) on sleep quality in subject suffering from idiopathic RLS as well as their intensity and extent of physical activity by applying a real-time approach.Methods: In a sample of 47 participants suffering from idiopathic RLS, physical activity and sleep quality were captured over one week by using accelerometers. For data analysis physical activity levels and step counts during three periods of a day (morning, afternoon, evening) were correlated with sleep quality parameters of the following night.Results: In this observational study, significant correlations of physical activity with the sleep parameters were rarely confirmed (exception: negative correlation of steps in the morning with periodic leg movements in sleep and negative correlation of physical activity in the evening and total sleep period). However, the physical activity levels of the participants were unexpectedly high compared to population-level data and variance in physical activity was low. The average activity was 13,817 (SD=4,086) steps and 347 (SD=117) minutes of moderate physical activity per day in females and 10,636 (SD=3,748) steps and 269 (SD=69) minutes of moderate physical activity in males, respectively. However, the participants conducted no vigorous physical activity.Conclusions: To investigate the effects of daily physical activity and RLS symptoms interventional studies with different intensities of physical activities at different points of time during the day are needed.

scholarly journals Impact of Physical Activity and Lifestyle in Pre-infection on the Susceptibility and Prognosis of Infects With COVID-19

2020 ◽  
Author(s):  
Baozhen Huang ◽  
Shixi Zhang ◽  
Jiuyu Gong ◽  
Yanlin Niu ◽  
Fengjuan Zhang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Hospital Stay ◽  
Regression Models ◽  
Moderate Physical Activity ◽  
Intensity Level ◽  
Moderate Activity ◽  
Special Effect ◽  
Lifestyle Habits ◽  
Logistic Regression Models ◽  
Lack Of Sleep

Abstract Background There are very few studies focusing on the relationship between COVID-19 and pre-infection lifestyle. In the absence of effective vaccines and special-effect medicines, it is very meaningful to actively respond to the disease pandemic by improving lifestyle habits. Methods This is a multicenter, retrospective cohort study enrolled 431 adult people including 228 normal people and 203 confirmed infects in Wubei, Henan and Shandong Provinces. Questionnaires were used to collect information on physical activity and lifestyle by competent doctors. The univariate logistic regression models and multiple regression models were used in risk factor analysis. Kruskal-Wallis H test were used to test the correlation. Results Lifestyle habits including exercise, smoking, sleep and physical activity can significantly affect the probability of getting COVID-19(P < 0.05). The MET (Metabolic Equivalent) intensity classification and sleep status are found to be the potential influencing factors of prognosis in both all infects and symptomatic patients. In all infects, taking the high MET intensity level as a reference, inpatient days would increase by 1.812 times (95% CI: 0.887–3.701) with no significance when the level is moderate (P > 0.05) and significantly increase by 6.674 times (95% CI: 1.613–27.613) when the level is low (P < 0.05). Kruskal-Wallis H test results showed moderate activity MET*min promoted shorter hospital stay (P < 0.05) mainly. Conclusions Sleep status and physical activity influenced the susceptibility and prognosis of COVID-19. Lack of sleep and low MET intensity level may prolong the hospital stay, which means a relatively slow recovery. This encourages the public to have moderate physical activity and adequate sleep to respond to the COVID-19 pandemic actively.

scholarly journals Impact of Physical Activity and Exercise on the Epigenome in Skeletal Muscle and Effects on Systemic Metabolism

Biomedicines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 126
Author(s):  
Julio Plaza-Diaz ◽  
David Izquierdo ◽  
Álvaro Torres-Martos ◽  
Aiman Tariq Baig ◽  
Concepción M. Aguilera ◽  
...  
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Gene Transcription ◽  
Histone Modifications ◽  
Epigenetic Modification ◽  
Epigenetic Modifications ◽  
Late Response ◽  
Transcriptional Responses ◽  
Response To Exercise ◽  
The Impact

Exercise and physical activity induces physiological responses in organisms, and adaptations in skeletal muscle, which is beneficial for maintaining health and preventing and/or treating most chronic diseases. These adaptations are mainly instigated by transcriptional responses that ensue in reaction to each individual exercise, either resistance or endurance. Consequently, changes in key metabolic, regulatory, and myogenic genes in skeletal muscle occur as both an early and late response to exercise, and these epigenetic modifications, which are influenced by environmental and genetic factors, trigger those alterations in the transcriptional responses. DNA methylation and histone modifications are the most significant epigenetic changes described in gene transcription, linked to the skeletal muscle transcriptional response to exercise, and mediating the exercise adaptations. Nevertheless, other alterations in the epigenetics markers, such as epitranscriptomics, modifications mediated by miRNAs, and lactylation as a novel epigenetic modification, are emerging as key events for gene transcription. Here, we provide an overview and update of the impact of exercise on epigenetic modifications, including the well-described DNA methylations and histone modifications, and the emerging modifications in the skeletal muscle. In addition, we describe the effects of exercise on epigenetic markers in other metabolic tissues; also, we provide information about how systemic metabolism or its metabolites influence epigenetic modifications in the skeletal muscle.

scholarly journals Interaction of physical activity and diet: implications for haemostatic factors

1999 ◽  
Vol 2 (3a) ◽  
pp. 383-390 ◽  
Author(s):  
Rainer Rauramaa ◽  
SB Väisänen
Keyword(s):  
Physical Activity ◽  
Blood Coagulation ◽  
Lifestyle Changes ◽  
Regular Physical Activity ◽  
Moderate Intensity ◽  
Moderate Physical Activity ◽  
Platelet Aggregability ◽  
Moderate Intensity Physical Activity ◽  
Intensity Physical Activity ◽  
The Impact

AbstractRegular moderate intensity physical activity and habitual diet providing no more than one third of energy from fats have been recommended for the prevention of atherosclerotic diseases. The background for these guidelines is the key role of plasma lipids. However, the importance of thrombogenesis in acute myocardial infarction has become obvious during the last decade. Hyperlipidaemia and excess of adipose tissue increase platelet aggregability and blood coagulation, and decrease fibrinolysis. Both regular physical activity and dietary fat reduction decrease blood lipids and body fat thereby diminishing the risk of thrombosis. Currently, data on interactions between physical activity and diet on haemostasis are scarce, and the few studies available have not demonstrated additional effects when these two lifestyle modifications have been combined. This paper is restricted only to studies using controlled randomized design. Regular moderate intensity physical activity as well as diet rich in omega-3 fatty acids decrease platelet aggregability. The effects of regular physical activity on plasma fibrinogen remain contradictory, while the impact of diet is even less clear. Plasminogen activator inhibitor-1, a possible link between insulin resistance syndrome and coronary heart disease, may decrease due to physical training or low fat diet. It can be hypothesized that moderation in physical activity and diet carries a more powerful impact on blood coagulation and fibrinolysis than either lifestyle modification alone. Studies focusing on the interactions of regular moderate physical activity and fat-modified diet are needed in efforts to optimize the preventive actions by lifestyle changes.

Impact of Social Isolation on Physical Activity and Factors Associated With Sedentary Behavior in Older Adults During the COVID-19 Pandemic

2021 ◽  
pp. 1-5
Author(s):  
Giovana Z. Mazo ◽  
Felipe Fank ◽  
Pedro S. Franco ◽  
Bruna da Silva Vieira Capanema ◽  
Franciele da Silva Pereira
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Sedentary Behavior ◽  
Social Isolation ◽  
Low Income ◽  
Low Income Countries ◽  
Moderate Physical Activity ◽  
Cross Sectional ◽  
Factors Associated ◽  
The Impact

The objective was to analyze the impact of social isolation on moderate physical activity and factors associated with sedentary behavior of older adults during the COVID-19 pandemic. This was a cross-sectional study involving 111 older adults (aged 71.0 ± 6.87 years). The data were collected at two time points: in November 2019 and in June 2020. There was a decline in moderate physical activity when the minutes/week were compared before and during social isolation (p < .001). Sedentary behavior was associated with the condition of living alone. Older adults who lived alone were 3.29 times more likely to spend 4 hr or more in sedentary behavior than those who lived with a partner (95% confidence interval [1.01, 10.74]). Government agencies must establish PA-related health promotion strategies, especially in developing and low-income countries. Therefore, home exercises need to be encouraged to prevent the consequences of this pandemic period.

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