Labors slow in older women?Cohen W, Newman L, Friedman E: Risk of labor abnormalities with advancing maternal age. Obstet Gybecik 55:414, 1980

1980 ◽  
Vol 25 (5) ◽  
pp. 46-47
Keyword(s):  
Older Women ◽  
Maternal Age ◽  
Labor Abnormalities

scholarly journals Factors Associated with Recent Increase of Multiple Births in Spain

2008 ◽  
Vol 11 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Vicente Fuster ◽  
Pilar Zuluaga ◽  
Sonia Colantonio ◽  
Clemente de Blas
Keyword(s):  
Older Women ◽  
Maternal Age ◽  
Reference Group ◽  
Population Based ◽  
Factors Associated ◽  
Relative Contribution ◽  
High Incidence ◽  
Spanish Women ◽  
Opposite Sex ◽  
Mother’S Age

AbstractThe increased incidence of multiple deliveries in Spain, in addition to changes in age at maternity and parity, is attributed to assisted reproductive treatments, but the relative contribution of the latter to this rise remains uncertain, due to the scarce information provided by clinics practicing those treatments. Population based data (1984–2004), including information on mother's age, nationality, marital status, date of delivery, and the characteristics of each (parity, single or multiple), and sex of newborns were provided by the Spanish Institute of Statistics. Twinning and triplet deliveries relate to maternal age, parity, and nationality. For younger ages (≤ 19, 20–24, 25–29) rates remained constant over time, but for older women (30–34, 35–39, ≥ 40) rates increased after 1994. From 1984 to 2004 the percentage of twins of opposite sex increased from 24.31 to 36.58 per cent. Since 1997, Spanish and non-Spanish mothers differentiate with respect to multiple maternity at ages over 30. In addition to unmarried Spanish women, immigrants constitute a reliable reference group that determines the convenience of segregating information on multiple deliveries respecting origin. The proportion of twins and triplets of opposite sex, maternal age, and parity patterns observed are concordant with a differential access to reproductive treatments depending on the woman's age. The present norm regulating the maximum number of fertilizations per cycle and the demand for these treatments explain the high incidence of multiple deliveries in Spain. A modified logistic curve predicts a stabilization of multiple deliveries, which will probably continue to be high in Spain.

Maternal Age and Preeclampsia Outcomes during Delivery Hospitalizations

2019 ◽  
Vol 37 (01) ◽  
pp. 044-052 ◽  
Author(s):  
Jean-Ju Sheen ◽  
Yongmei Huang ◽  
Maria Andrikopoulou ◽  
Jason D. Wright ◽  
Dena Goffman ◽  
...  
Keyword(s):  
Older Women ◽  
Maternal Age ◽  
Primary Outcome ◽  
Temporal Trends ◽  
Adverse Outcomes ◽  
Dependent Manner ◽  
Age Group ◽  
National Inpatient Sample ◽  
Secondary Outcomes ◽  
Dose Dependent

Abstract Objective To characterize risk and temporal trends for preeclampsia and related outcomes by maternal age. Study Design Deliveries to women aged 15 to 54 years in the 1998 to 2014 National Inpatient Sample who had a diagnosis of preeclampsia, eclampsia, or both were included in the analysis. Age was categorized as 15 to 17, 18 to 24, 25 to 29, 30 to 34, 35 to 39, 40 to 44, and 45 to 54 years. The primary outcome was temporal trends in preeclampsia based on maternal age. Secondary outcomes analyzed included risk for severe maternal morbidity. Results The proportion of women with preeclampsia aged 15 to 24 years decreased from 42.3% in 1998 to 30.1% in 2014, while preeclampsia among those 30 to 54 years increased from 32.9 to 43.7%. Preeclampsia risk increased for all groups over the study period. Risk for severe morbidity by age group with and without transfusion was “U-shaped,” with risk highest for women 18 to 24 and 40 to 54 years. The risk for abruption, acute renal failure, acute heart failure or pulmonary edema, and stroke was lowest for women aged 15 to 24 years and increased in a “dose-dependent” manner with increasing maternal age. In contrast, eclampsia risk was highest for women aged 15 to 17 years. Conclusion With a changing demographic profile of preeclampsia, older women accounted for an increasing proportion of preeclampsia and related adverse outcomes.

SIZE OF NEWBORN AND CAESAREAN SECTION DELIVERIES AMONG TEENAGERS IN SUB-SAHARAN AFRICA: EVIDENCE FROM DHS

2006 ◽  
Vol 39 (2) ◽  
pp. 175-187 ◽  
Author(s):  
MONICA MAGADI ◽  
ALFRED AGWANDA ◽  
FRANCIS OBARE ◽  
NEGUSSIE TAFFA
Keyword(s):  
Caesarean Section ◽  
Older Women ◽  
Maternal Age ◽  
Sub Saharan Africa ◽  
Regression Analyses ◽  
Pooled Data ◽  
Country Level ◽  
Individual Probability ◽  
Sub Saharan ◽  
Socioeconomic And Demographic Factors

Summary.This paper uses DHS data from 20 countries in sub-Saharan Africa, collected in the late 1990s and early 2000s, to examine perceived size of newborn and Caesarean section deliveries among teenagers in the region. A comparison between teenagers and older women, based on logistic regression analyses for individual countries, as well as multilevel logistic analyses applied to pooled data across countries, and controlling for the effects of important socioeconomic and demographic factors, shows that in general, births to teenagers are more likely to be small in size but are less likely to be delivered by Caesarean section compared with births among older women. An examination of the country-level variations shows significant differences in perceived size of newborn and Caesarean section deliveries between countries. However, the observed pattern by maternal age does not vary significantly between countries, suggesting that these patterns are generalizable for the region. For teenagers with characteristics associated with higher odds of Caesarean section, being in a country with an overall higher rate particularly amplifies their individual probability.

Pregnancy and neonatal outcomes of twin pregnancies – the role of maternal age

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Shlomi Toussia-Cohen ◽  
Aya Mohr-Sasson ◽  
Abraham Tsur ◽  
Gabriel Levin ◽  
Raoul Orvieto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Older Women ◽  
Maternal Age ◽  
Younger Women ◽  
Cesarean Deliveries ◽  
Women Groups ◽  
Twin Pregnancies

Abstract Objectives We aim to study the association of maternal age with maternal and neonatal complications in twin pregnancies. Methods A retrospective cohort study of dichorionic–diamniotic twin pregnancies stratified into three groups according to maternal age (“A” <25, “B” 25–34 and “C” 35–44 years old). Outcome measures included pregnancy, delivery and neonatal complications. A sub-analysis of in vitro fertilization pregnancies only was conducted. Results Compared with younger women (groups A [n=65] and B [n=783]), older women [group C (n=392)] demonstrated significantly higher rates of gestational diabetes mellitus (B 6.6% vs. A 0%, p =0.027, C 10.2% vs. B 6.6%, p =0.032), were more likely to undergo cesarean deliveries (C 66.6%, B 57.6%, A 52.3%, p =0.007), and were at increased risk of having more than 20% difference in weight between the twins (C 24.5%, B 17.4%, A 16.9%, p =0.013). Other outcomes, including preeclampsia, did not differ between the groups. A sub-analysis of the in vitro fertilization only pregnancies was performed. Compared with younger women (groups A [n=18] and B [n=388]), older women (group C [n=230]) underwent more cesarean deliveries (p=0.004), and had more than 20% difference in weight between the twins (p<0.004). Other outcomes, including gestational diabetes mellitus rates and preeclampsia, did not differ between the groups. Conclusions Women at advanced maternal age with dichorionic twin pregnancies had significantly higher rates of gestational diabetes mellitus, cesarean deliveries and fetal weight discordancy as compared with younger women. In contrast, the incidence of preeclampsia was not affected by maternal age.

scholarly journals The influence of demographic change and cumulative risk of pelvic inflammatory disease on the incidence of ectopic pregnancy

1997 ◽  
Vol 119 (1) ◽  
pp. 49-52 ◽  
Author(s):  
I. SIMMS ◽  
P. A. ROGERS ◽  
A. NICOLL
Keyword(s):  
Retrospective Study ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Older Women ◽  
Inflammatory Disease ◽  
Maternal Age ◽  
Cumulative Risk ◽  
Positive Association ◽  
Significant Positive Association ◽  
Over Time

A retrospective study was carried out to determine the recent epidemiology of ectopic pregnancy in England between the biennial years 1988/9 and 1992/3. The number of ectopic pregnancy cases were combined with numbers of conceptions and the rates analysed for trend over time. The incidence of ectopic pregnancy rose significantly (P=0·05) over this period. However, this could be entirely explained by increasing numbers of births in older women and a highly significant positive association was found between risk of ectopic pregnancy and maternal age (P<0·0001). Over the study period the incidence of ectopic pregnancy in women aged 40 years or more was over 14 times that observed in those under 16 years of age. It is suggested that this reflects cumulative risk of acquiring pelvic inflammatory disease. The surveillance of ectopic pregnancy provides a useful indicator of the level of reproductive morbidity in women.

Days of sick leave and inpatient care at the time of pregnancy and childbirth in relation to maternal age

2017 ◽  
Vol 45 (3) ◽  
pp. 222-229 ◽  
Author(s):  
Lovisa Brehmer ◽  
Kristina Alexanderson ◽  
Erica Schytt
Keyword(s):  
Sick Leave ◽  
Older Women ◽  
Inpatient Care ◽  
Maternal Age ◽  
Mean Values ◽  
Younger Women ◽  
Pregnancy And Childbirth ◽  
Nulliparous Women ◽  
Starting Point ◽  
Delivery Date

Aims: To explore whether older women differ from younger women with respect to sick leave and inpatient care at the time around their first pregnancy and delivery. Methods: This was a descriptive population-based cohort study. The study population included all 236,176 nulliparous women registered as living in Sweden who gave birth to their first singleton infant in 2006–2010. Data from nationwide Swedish registers were used. Maternal age was categorized in five-year intervals. Time was calculated in years with the delivery date as the starting point, from two years before and up to three years after delivery. Descriptive statistics were used to calculate mean values and ANOVA tables were used to obtain the 95% confidence intervals of the means. Restriction was used to reduce potential confounding. Results: Women aged ⩾35 years had a higher annual mean number of sick leave days from two years before to one year after their delivery date compared with younger women. The range for all age categories in the year before the delivery date, including pregnancy, was 15.3–37.4 mean sick leave days. The mean number of inpatient days increased with each age category during the year after the date of delivery in the range 1.4–4.3 days. Conclusions: This first explorative study indicates the need for more knowledge on morbidity among older primiparous women. They had a higher number of days with sick leave and hospitalization in the year before and after their delivery date. This might reflect higher health risks during pregnancy and childbirth among older women; however, social factors and reverse causation might also be influential.

scholarly journals Optimal Endometrial Preparation Protocols for Frozen-thawed Embryo Transfer Cycles by Maternal Age

2020 ◽  
Author(s):  
Qizhen Zheng ◽  
Hongzhan Zhang ◽  
Shiru Xu ◽  
Shan Xiao ◽  
Xuejin Wang ◽  
...  
Keyword(s):  
Older Women ◽  
Embryo Transfer ◽  
Live Birth ◽  
Pregnancy Outcomes ◽  
Maternal Age ◽  
Independent Effect ◽  
Miscarriage Rate ◽  
Younger Women ◽  
Endometrial Preparation ◽  
Early Miscarriage

Abstract Background: It is paramount to consider the appropriate preparation of the endometrium to receive the transferred embryos as the amount of frozen embryo transfer (FET) cycles is increasing worldwide. However, there remains lack of evidence about what is the most optimal protocol of endometrial preparation regarding pregnancy outcomes in different subgroup of infertile women. This retrospective cohort study was aim to explore the best endometrial preparation protocols among different maternal age groups.Methods: A total of 16870 FET cycles were categorized into three groups based on endometrial preparation protocols: Natural cycle (NC n=3893), artificial cycles (AC, n=11459) and AC with pretreatment with GnRH-a (AC+GnRH-a, n=1518). Logistic regression was performed to investigate the independent effect of endometrial preparation protocols on IVF pregnancy outcomes. Subgroup analyses were conducted to evaluate the most optimal endometrial preparation protocols for different maternal age groups.Results: In overall populations, after controlling for potential confounders, the incidence of live birth (NC as reference; AC: adjusted odds ratio (aOR) =0.840, 95%CI 0.774-0.912; AC+GnRHa: aOR=0.907, 95%CI 0.795-1.034) in NC was significantly higher than that of AC, while comparable to that of AC+GnRH-a. The early miscarriage rate (AC: aOR=1.413, 95%CI 1.220-1.638; AC+GnRHa: aOR=1.537, 95%CI 1.232-1.919) was significantly lower in NC compared to either AC group. In younger women, the live birth rates (AC: aOR=0.894, 95%CI 0.799-1.001; AC+GnRHa: aOR=1.111, 95%CI 0.923-1.337) were comparable between the three groups, with a slightly higher in AC+GnRH-a. Early miscarriage rate was only significantly lower in NC compared to that of AC without GnRH-a (aOR=1.452, 95%CI 1.159-1.820). While in older women, the incidence of live birth (AC: aOR=0.811, 95%CI 0.718-0.916; AC+GnRHa: aOR=0.760, 95%CI 0.626-0.923) was significantly higher, and early miscarriage (AC: aOR=1.358, 95%CI 1.114-1.655; AC+GnRHa: aOR=1.717, 95%CI 1.279-2.305) was significantly lower in NC compared to those of two AC groups.Conclusions: NC protocol is associated with lower early miscarriage late in overall IVF population. There is a mild favor of AC+GnRH-a in younger women, while the priority of NC is remarkable in older women. Maternal age should be a considerable factor when determine endometrial preparation method for FET.

WHAT IS THE RIGHT AGE TO REPRODUCE?

2006 ◽  
Vol 17 (3) ◽  
pp. 185-204 ◽  
Author(s):  
M NWANDISON ◽  
S BEWLEY
Keyword(s):  
Older Women ◽  
Maternal Age ◽  
Biological Clock ◽  
Point Of View ◽  
Demographic Shift ◽  
Younger Women ◽  
The Past ◽  
Healthy Mother ◽  
Human Reproductive ◽  
The Right

This article examines the question as to what is the right age to reproduce from the biological point of view of its purpose; that of achieving a healthy mother and baby. We start with an assumption that issues surrounding sex, fertility, pregnancy, miscarriage, abortion and childbearing are private and emotionally laden. We are not looking at, nor judging, individual reproductive choices; what might be “right” for one person, or couple, in one context will be unsuitable for another. It is traditional obstetric and gynaecological teaching that human reproductive outcomes are worse at the extremes of maternal age. Yet the advice given in a recent BMJ editorial entitled “Which career first? The securest age for childbearing remains 20–35” appeared to be controversial. The ensuing scientific and media interest raised such headlines as “Horns of the dilemma”, “A sinister article”, “Late mums face baby misery” and “Are we having children too late? IVF not the answer, say docs”. Products have recently appeared on the market offering kits to women to indicate the time left on their ‘biological clock’ so they can choose whether to continue pursuing their career or try for a baby. Why is there so much interest in the right time to reproduce? Are women (and men) doing something differently compared to the past? If there has been a demographic shift in the age women reproduce (hitherto unexplained), there are important and specific risks older women may face as compared to younger women.

scholarly journals Advanced Maternal Age Deteriorates the Developmental Competence of Vitrified Oocytes in Mice

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1563
Author(s):  
Ju Hee Lee ◽  
Jae Kyun Park ◽  
Sook Young Yoon ◽  
Eun A. Park ◽  
Jin Hyun Jun ◽  
...  
Keyword(s):  
Older Women ◽  
Maternal Age ◽  
Developmental Outcomes ◽  
Advanced Maternal Age ◽  
Reproductive Technology ◽  
Developmental Competence ◽  
Autophagosome Formation ◽  
Oocyte Vitrification ◽  
Young Females ◽  
Molecular Features

Advanced maternal age (AMA) is known to be related to the decrease in the quality and quantity of oocytes. Oocyte vitrification is now considered an established assisted reproductive technology for fertility preservation. However, it remains unclear whether the oocytes in older women are more sensitive to various insults during vitrification. Thus, we evaluated whether AMA affects cellular and molecular features and developmental outcomes of oocytes after vitrification in mice. The oocytes were grouped as young fresh (YF), young vitrified/warmed (YV), aged fresh (AF), and aged vitrified/warmed (AV). The survival rate of AV oocytes was significantly lower than that of YV oocytes. The rates of fertilization, cleavage, and blastocyst formation of AV oocytes were significantly lower than those of other groups. AV oocytes were represented as aberrations in mitochondria distribution, microvacuole size, and autophagosome formation, leading to delayed embryo development in mice. This delay was associated with a reduced number of total cells and trophectoderm in the blastocyst developed from AV oocytes. Collectively, AMA exaggerates the vulnerability of oocytes to cryo-damage that occurs during vitrification in mice, suggesting that the current vitrification protocols optimized for oocytes from young females should be modified for oocytes from aged women.

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