Human campylobacteriosis

Campylobacter ◽  
2017 ◽  
pp. 1-25 ◽  
Author(s):  
Steffen Backert ◽  
Nicole Tegtmeyer ◽  
Tadhg Ó Cróinín ◽  
Manja Boehm ◽  
Markus M. Heimesaat
Keyword(s):  
Human Campylobacteriosis

scholarly journals Immune-Modulatory Effects upon Oral Application of Cumin-Essential-Oil to Mice Suffering from Acute Campylobacteriosis

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 818
Author(s):  
Soraya Mousavi ◽  
Dennis Weschka ◽  
Stefan Bereswill ◽  
Markus Heimesaat
Keyword(s):  
Essential Oil ◽  
Infectious Diseases ◽  
Post Infection ◽  
Apoptotic Cell ◽  
Natural Compounds ◽  
Mesenteric Lymph Nodes ◽  
Beneficial Effects ◽  
Cell Responses ◽  
Food Borne ◽  
Human Campylobacteriosis

Human campylobacteriosis, commonly caused by Campylobacter jejuni, is a food-borne infection with rising prevalence causing significant health and socioeconomic burdens worldwide. Given the threat from emerging antimicrobial resistances, the treatment of infectious diseases with antibiotics-independent natural compounds is utmost appreciated. Since the health-beneficial effects of cumin-essential-oil (EO) have been known for centuries, its potential anti-pathogenic and immune-modulatory effects during acute experimental campylobacteriosis were addressed in the present study. Therefore, C. jejuni-challenged secondary abiotic IL-10-/- mice were treated perorally with either cumin-EO or placebo starting on day 2 post-infection. On day 6 post-infection, cumin-EO treated mice harbored lower ileal pathogen numbers and exhibited a better clinical outcome when compared to placebo controls. Furthermore, cumin-EO treatment alleviated enteropathogen-induced apoptotic cell responses in colonic epithelia. Whereas, on day 6 post-infection, a dampened secretion of pro-inflammatory mediators, including nitric oxide and IFN-γ to basal levels, could be assessed in mesenteric lymph nodes of cumin-EO treated mice, systemic MCP-1 concentrations were elevated in placebo counterparts only. In conclusion, our preclinical intervention study provides first evidence for promising immune-modulatory effects of cumin-EO in the combat of human campylobacteriosis. Future studies should address antimicrobial and immune-modulatory effects of natural compounds as adjunct antibiotics-independent treatment option for infectious diseases.

scholarly journals Integrated management of a human campylobacteriosis outbreak in South Tyrol, Italy

2014 ◽  
Vol 21 ◽  
pp. 182-183 ◽  
Author(s):  
M. Armani ◽  
A. Tavella ◽  
P. Ceschi ◽  
I. Idrizi ◽  
J. Simmerle ◽  
...  
Keyword(s):  
Integrated Management ◽  
South Tyrol ◽  
Human Campylobacteriosis

scholarly journals Antimicrobial Susceptibility Profiles and Strain Type Diversity of Campylobacter jejuni Isolates from Turkeys in Eastern North Carolina

2008 ◽  
Vol 75 (2) ◽  
pp. 474-482 ◽  
Author(s):  
Weimin Gu ◽  
Robin M. Siletzky ◽  
Sandra Wright ◽  
Mohammed Islam ◽  
Sophia Kathariou
Keyword(s):  
North Carolina ◽  
Campylobacter Jejuni ◽  
Drug Of Choice ◽  
Ca 50 ◽  
Strain Type ◽  
Eastern North Carolina ◽  
Susceptibility Profiles ◽  
Genomic Cluster ◽  
Sequence Types ◽  
Human Campylobacteriosis

ABSTRACT Campylobacter jejuni is one of the most common bacterial causes of human gastroenteritis, and recent findings suggest that turkeys are an important reservoir for this organism. In this study, 80 C. jejuni isolates from eastern North Carolina were characterized for resistance to nine antimicrobials, and strain types were determined by fla typing, pulsed-field gel electrophoresis (PFGE) with SmaI and KpnI, and (for 41 isolates) multilocus sequence typing (MLST). PFGE analysis suggested that many of the isolates (37/40 [ca. 93%]) in a major genomic cluster had DNA that was partially methylated at SmaI sites. Furthermore, 12/40 (30%) of the isolates in this cluster were completely resistant to digestion by KpnI, suggesting methylation at KpnI sites. MLST of 41 isolates identified 10 sequence types (STs), of which 4 were new. Three STs (ST-1839, ST-2132 and the new ST-2934) were predominant and were detected among isolates from different farms. The majority of the isolates (74%) were resistant to three or more antimicrobials, and resistance to ciprofloxacin was common (64%), whereas resistance to the other drug of choice for treatment of human campylobacteriosis, erythromycin, was never encountered. Most (33/34) of the kanamycin-resistant isolates were also resistant to tetracycline; however, only ca. 50% of the tetracycline-resistant isolates were also kanamycin resistant. Isolates with certain antimicrobial resistance profiles had identical or closely related strain types. Overall, the findings suggest dissemination of certain clonal groups of C. jejuni isolates in the turkey production industry of this region.

scholarly journals Draft Whole-Genome Sequences of Three Isolates of a Novel Strain of a Campylobacter sp. Isolated from New Zealand Birds and Water

2019 ◽  
Vol 8 (18) ◽  
Author(s):  
David A. Wilkinson ◽  
Anne C. Midwinter ◽  
Errol Kwan ◽  
Samuel J. Bloomfield ◽  
Nigel P. French ◽  
...  
Keyword(s):  
New Zealand ◽  
Intestinal Tract ◽  
Whole Genome ◽  
Genome Sequences ◽  
New Zealand Birds ◽  
Human Campylobacteriosis

Campylobacter spp. are frequently found associated with the avian intestinal tract. Most are commensals, but some can cause human campylobacteriosis.

Survival of Campylobacter jejuni Inoculated in Fresh and Frozen Beef Hamburgers stored under Various Temperatures and Atmospheres

1997 ◽  
Vol 60 (8) ◽  
pp. 903-907 ◽  
Author(s):  
SPYROS G. GRIGORIADIS ◽  
PAVLOS A. KOIDIS ◽  
KYRIAKOS P. VARELTZIS ◽  
CHRISTOS A. BATZIOS
Keyword(s):  
Campylobacter Jejuni ◽  
Modified Atmospheres ◽  
Principal Source ◽  
Human Campylobacteriosis

The viability of Campylobacter jejuni strains FRI-CF 401S and FRI-CF 25 inoculated in fresh and frozen beef hamburgers was investigated. Hamburgers were stored in the following conditions: 100% air at 4°C for 15 days, 100% CO2, and 100% N2 atmospheres at 4°C for 60 days and −18°C for 90 days. The data showed that 100% air was the most toxic atmosphere to C. jejuni strains. The C. jejuni populations decreased significantly faster (P ≤ 0.05) in the inoculated hamburgers in modified atmospheres than in those at −18°C. Fresh or frozen beef hamburgers contaminated by C. jejuni could always be a principal source of human campylobacteriosis.

scholarly journals Campylobacter jejuni from Canine and Bovine Cases of Campylobacteriosis Express High Antimicrobial Resistance Rates against (Fluoro)quinolones and Tetracyclines

Pathogens ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 691
Author(s):  
Sarah Moser ◽  
Helena Seth-Smith ◽  
Adrian Egli ◽  
Sonja Kittl ◽  
Gudrun Overesch
Keyword(s):  
Veterinary Medicine ◽  
Antimicrobial Resistance ◽  
Treatment Options ◽  
Tetracycline Resistance ◽  
Antimicrobial Treatment ◽  
Human Infection ◽  
Quinolone Resistance ◽  
European Program ◽  
Resistance Rates ◽  
Human Campylobacteriosis

Campylobacter (C.) spp. from poultry is the main source of foodborne human campylobacteriosis, but diseased pets and cattle shedding Campylobacter spp. may contribute sporadically as a source of human infection. As fluoroquinolones are one of the drugs of choice for the treatment of severe human campylobacteriosis, the resistance rates of C. jejuni and C. coli from poultry against antibiotics, including fluoroquinolones, are monitored within the European program on antimicrobial resistance (AMR) in livestock. However, much less is published on the AMR rates of C.jejuni and C. coli from pets and cattle. Therefore, C. jejuni and C. coli isolated from diseased animals were tested phenotypically for AMR, and associated AMR genes or mutations were identified by whole genome sequencing. High rates of resistance to (fluoro)quinolones (41%) and tetracyclines (61.1%) were found in C. jejuni (n = 29/66). (Fluoro)quinolone resistance was associated with the known point mutation in the quinolone resistance-determining region (QRDR) of gyrA, and tetracycline resistance was mostly caused by the tet(O) gene. These high rates of resistance, especially to critically important antibiotics in C. jejuni and C. coli, are worrisome not only in veterinary medicine. Efforts to preserve the efficacy of important antimicrobial treatment options in human and veterinary medicine have to be strengthened in the future.

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