A specific plasma lipid signature associated with high triglycerides and low HDL cholesterol identifies residual CAD risk in patients with chronic coronary syndrome

Objective: Acute coronary syndrome is frequently complicated by rhythm disturbances, yet any association between high-density lipoprotein (HDL) cholesterol levels and arrhythmias in the setting of non-ST-segment elevation myocardial infarction (non-STEMI) is uncertain. The goal of this study was to evaluate any association between HDL-cholesterol levels and arrhythmias in the setting of non-STEMI. Methods: Retrospective data from Phoenix Veterans Affair Medical Center records were utilized for our study. A total of 6881 patients were found who presented during 2000 to 2003 with non-STEMI with available fasting lipid panels collected within the first 24 hours of admission. Patients were followed for the development of rhythm disturbances up to 6 years after initial presentation, with a mean follow up of 1269 days. Results: We found that high triglycerides/HDL and low-density lipid/HDL ratios were predictive of arrhythmias. However, low HDL levels had strongest association with highest odds ratio (OR) for development of arrhythmias (for HDL <31 mg/dL, OR = 3.72, 95% confidence interval [CI] = 2.55-5.44, P < .05) in patients with diabetes and (for HDL < 31 mg/dL, OR = 3.69, 95% CI = 2.85-4.71, P < .05) in patients without diabetes. Using multivariate analysis adjusting for comorbidities, low HDL level remained independently associated with arrhythmias. Conclusions: Patients with low HDL levels during hospitalization with non-STEMI have a greater risk of developing cardiac rhythm disturbances independent of other risk factors. These data suggest a possible protective role of HDL in preventing arrhythmias in the setting of acute coronary syndrome.

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Association of HDL Cholesterol with In-Hospital Outcome of Patients with Acute Coronary Syndrome

Bangladesh Heart Journal ◽

10.3329/bhj.v32i2.36098 ◽

2018 ◽

Vol 32 (2) ◽

pp. 114-118

Author(s):

Chowdhury Muhammad Omar Faruque ◽

Abdul Wadud Chowdhury ◽

Miftaul Jannath Chowdhury ◽

Abu Thaher Mohammad Mahfuzul Hoque ◽

Md Solaiman Mia ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Cross Sectional ◽

Hospital Outcome ◽

Coronary Syndrome ◽

Group I ◽

Low Hdl ◽

Biochemical Evaluation ◽

Cardiac Emergency

Background:Acute coronary syndrome is a cardiac emergency. It is increasing dramatically and becoming a major burden in our health care system. Relation between serum lipid profile and acute coronary syndrome is well established. Our study tried to reveal association of high density lipoprotein cholesterol (HDL-C) with in-hospital outcome of patients with acute coronary syndrome.Methods: The study was a cross sectional comparative study. Clinical & biochemical evaluation was done in hospital settings. A total number of 271 patients were included in the study and divided into two groups. Patients with low HDL-C level were in group I and patients with normal HDL-C were in group II.Results: Group I populations had more complications & more in- hospital stay than group II (74.3% vs 28.9%, P<0.001 and 6.65±2.04 days vs 5.09±1.44 days, p<0.001 respectively).Conclusion: The study revealed significant association of HDL-C with outcome of acute coronary syndrome patients. Complications of acute coronary syndrome were more in patients with low HDLC level.Bangladesh Heart Journal 2017; 32(2) : 114-118

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Favourable impact of low-calorie cranberry juice consumption on plasma HDL-cholesterol concentrations in men

British Journal Of Nutrition ◽

10.1079/bjn20061814 ◽

2006 ◽

Vol 96 (2) ◽

pp. 357-364 ◽

Cited By ~ 86

Author(s):

Guillaume Ruel ◽

Sonia Pomerleau ◽

Patrick Couture ◽

Simone Lemieux ◽

Benoît Lamarche ◽

...

Keyword(s):

Multivariate Analyses ◽

Plasma Lipid ◽

Hdl Cholesterol ◽

Polyphenolic Compounds ◽

Cholesterol Concentration ◽

Cranberry Juice ◽

Low Calorie ◽

Vldl Cholesterol ◽

Low Hdl ◽

Metabolic Variables

A low HDL-cholesterol concentration is an independent risk factor for CVD. Studies have suggested that flavonoid consumption may be cardioprotective, and a favourable impact on circulating HDL-cholesterol concentrations has been suggested to partially explain this association. The aim of the present study was to determine the effect of consuming increasing daily doses of low-calorie cranberry juice cocktail (CJC) on the plasma lipid profile of abdominally obese men. For that purpose, thirty men (mean age 51 (SD 10) years) consumed increasing doses of CJC during three successive periods of 4 weeks (125ml/d, 250ml/d, 500ml/d). Before the study and after each phase, we measured changes in physical and metabolic variables. We noted a significant increase in plasma HDL-cholesterol concentration after the consumption of 250ml CJC/d (+8·6±14·0% v. 0ml CJC/d; P<0·01), an effect that plateaued during the last phase of the study (500ml CJC/d: +8·1±10·0% v. 0ml CJC/d; P<0·0001). Multivariate analyses revealed that changes in plasma apo A-I (IR2=48%, P<0·0001) and triacylglycerol (R2=16%, P<0·005) concentrations were the only variables significantly contributing to the variation in plasma HDL-cholesterol concentration noted in response to the intervention. No variation was observed in total as well as in LDL and VLDL cholesterol. The present results show that daily CJC consumption is associated with an increase in plasma HDL-cholesterol concentrations in abdominally obese men. We hypothesise that polyphenolic compounds from cranberries may be responsible for this effect, supporting the notion that the consumption of flavonoid-rich foods can be cardioprotective.

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Abstract 632: Lipoprotein Lipase Activators: A New Potent Drug Class for Treatment of Dyslipidemia

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.34.suppl_1.632 ◽

2014 ◽

Vol 34 (suppl_1) ◽

Author(s):

Madelene Ericsson ◽

Mikael Larsson ◽

Remi Caraballo ◽

Per-Anders Enquist ◽

Mikael Elofsson ◽

...

Keyword(s):

Lipoprotein Lipase ◽

De Novo ◽

Plasma Lipid ◽

Hdl Cholesterol ◽

Residual Risk ◽

Lipid Response ◽

Low Hdl ◽

Specific Tissue ◽

Potent Drug ◽

Subcutaneous Adipose

Aim: Elevated plasma TG and low HDL-cholesterol are part of CVD residual risk. Lipoprotein lipase (LPL) is the central enzyme controlling plasma TG hydrolysis and affecting de novo HDL formation. Thus LPL is an attractive target for correcting dyslipidemia and reduction of CVD residual risk. We have identified a novel first-in-class small molecule LPL activator - LP071. The objective with this study was to characterize the plasma lipid metabolism in LPL activator treated mice. Methods: ApoE3L:CETP mice were treated week with LP071. Plasma lipid profiles were analyzed using FPLC fractioning. LPL activity was investigated systemically and in specific tissue. Using triton WR1339 blockade chylomicron and VLDL secretion were assessed. Functional lipid clearance test were performed by oral fat tolerance tests. Results: Fasting plasma TG levels decreased with 97 % in apoE3L:CETP mice treated with LP071; HDL-c were increased by 116 % and (V)LDL-c were decreased with 91 %. Plasma free glycerol and NEFA were significantly lowered, 26 % and 22 % respectively. After an oral lipid load the plasma lipid response was significantly blunted in LP071 treated mice compared to controls. LPL activity in subcutaneous adipose tissue was increased 1500 % and in BAT LPL was increased by 100% at 3 h after a lipid gavage in WT mice treated with LP071. Conclusions: LP071 is a potent compound that can improve plasma lipid levels to a less atherogenic profile. The LP-class LPL activators can potentially help battle CVD residual risk in the future.

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Low HDL and high triglycerides predict COVID-19 severity

Scientific Reports ◽

10.1038/s41598-021-86747-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Lluís Masana ◽

◽

Eudald Correig ◽

Daiana Ibarretxe ◽

Eva Anoro ◽

...

Keyword(s):

Lipid Profile ◽

Plasma Lipid ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Infection Process ◽

Plasma Lipid Profile ◽

Cross Sectional ◽

Cholesterol Levels ◽

Atherogenic Dyslipidaemia ◽

Low Hdl

AbstractLipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.

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Prevalence of metabolic syndrome and its different components in patients with acute coronary syndrome

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20195664 ◽

2019 ◽

Vol 7 (1) ◽

pp. 161

Author(s):

Gaurav Jain ◽

Balaji D. More

Keyword(s):

Metabolic Syndrome ◽

Acute Coronary Syndrome ◽

International Diabetes Federation ◽

Hdl Cholesterol ◽

Coronary Syndrome ◽

The Metabolic Syndrome ◽

High Prevalence ◽

Low Hdl ◽

Male Patients ◽

Very High

Background: Several components of the Metabolic Syndrome (MetS) are risk factor for cardiovascular diseases. So, this study was conducted to evaluate the prevalence of MetS and its components in patients with CAD.Methods: Author included all patients admitted with Acute Coronary Syndrome (ACS), who had CAD confirmed by coronary angiography. They were divided into two groups according to presence or absence of MetS based on International Diabetes Federation criteria. The prevalence of MetS and its individual components was estimated.Results: It was observed that there is a high prevalence of MetS (66%) in patients admitted with ACS. Metabolic syndrome is more prevalent in female patients (82.4%) than in male patients (57.6%) with ACS. Hypertension is the most prevalent (87.9) component of MetS. Diabetes Mellitus (DM) is the 2nd most prevalent (83.3%) component of MetS. About 65.2% patients with MetS had abnormally raised triglyceride levels and 32(48.5%) had abnormally low HDL-cholesterol level. Among the MetS 38(57.6%) had abnormal waist circumference. Among the study group, the most common triad of MetS components was DM + HTN + abnormal TG. There is significant association between MetS and microalbuminuria, with incidence of 22(33.3%) in this study. Similarly, a significant association between DM and microalbuminuria, 23(33.8%) was observed.Conclusions: This study confirms a very high prevalence of MetS in Indian patients with CAD. The prevalence of the risk factors was higher in CAD patients with MetS.

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476 ACUTE CORONARY SYNDROME AND LOW-HDL CHOLESTEROL. RELATIONSHIP WITH LIPOPROTEIN (A)

Atherosclerosis Supplements ◽

10.1016/s1567-5688(11)70477-9 ◽

2011 ◽

Vol 12 (1) ◽

pp. 101

Author(s):

R. Toro ◽

P. Gomez ◽

C. Rodriguez ◽

I. Tinoco ◽

D. Biedma ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Hdl Cholesterol ◽

Lipoprotein A ◽

Coronary Syndrome ◽

Low Hdl

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Acute Coronary Syndrome in the Young: Clinical Characteristics, Risk Factors and Prognosis

The Open Cardiovascular Medicine Journal ◽

10.2174/1874192401408010061 ◽

2014 ◽

Vol 8 (1) ◽

pp. 61-67 ◽

Cited By ~ 14

Author(s):

Marcos R Esteban ◽

Sara M Montero ◽

José J. A Sánchez ◽

Horacio P Hernández ◽

José J. G Pérez ◽

...

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Ejection Fraction ◽

Odds Ratio ◽

Hdl Cholesterol ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Ventricular Ejection Fraction ◽

Coronary Syndrome ◽

Low Hdl

Background: To describe the characteristics of patients ≤40 years of age hospitalized for acute coronary syndrome, analyze the risk factors and identify the variables associated with prognosis. Methods: Case series of patients admitted between 2003 and 2012 inclusive in a tertiary hospital (123 consecutive cases admitted between 2003 and 2012), and case-control study (369 controls selected from the general population matched for sex and age with cases, at a ratio of 3:1). Outcome variables: Mortality, likelihood of survival without readmission for heart-related problems, extent of coronary disease as determined by coronary angiography and cardiovascular risk factors. Results: Mean age was 35.4±4.8 years and 83.7% of the participants were men. Myocardial infarction with abnormal Q wave (48%) and single-vessel involvement (44.7%) predominated. Intrahospital mortality was 1.6%. For the 108 patients eventually included in the follow-up, likelihood of readmission-free survival after 60 months was 69.3±4.8%. In the case group 36% of the patients admitted to using cocaine. Compared to controls, the prevalence in patients was higher for smoking (74.8 vs 33.1%, p<0001), diabetes (14.6% vs 5.1%, p=0.001), low HDL-cholesterol (82.9 vs 34.1%, p<0.001) and obesity (30.0 vs 20.3%, p=0.029). Decreased left ventricular ejection fraction (odds ratio=2.2, p=0.033) and smoking (odds ratio=7.8, p=0.045) were associated with readmission for coronary syndrome. Conclusion: Acute coronary syndrome in people younger than 40 years is associated with diabetes and unhealthy lifestyle: smoking, sedentary behavior (low HDL-cholesterol), cocaine use and obesity. The readmission rate is high, and readmission is associated with smoking and decreased ejection fraction.

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200 ARE HDL PARTICLES DYSFUNCTIONAL IN ACUTE CORONARY SYNDROME PATIENTS WITH STEMI AND LOW HDL-CHOLESTEROL LEVELS: IMPACT OF STATIN?

Atherosclerosis Supplements ◽

10.1016/s1567-5688(11)70201-x ◽

2011 ◽

Vol 12 (1) ◽

pp. 44-45

Author(s):

F.H. Rached ◽

C.V. Serrano ◽

L. Camont ◽

A.L. Pinto ◽

M. Barros ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Hdl Cholesterol ◽

Coronary Syndrome ◽

Cholesterol Levels ◽

Low Hdl

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GAMBARAN PROFIL LIPID PADA PENDERITA SINDROM KORONER AKUT DI RSUP. PROF. DR. R. D. KANDOU PERIODE JANUARI – SEPTEMBER 2015

e-CliniC ◽

10.35790/ecl.4.1.2016.11023 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Eva Nur Faridah ◽

Janry A. Pangemanan ◽

Starry H. Rampengan

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Ldl Cholesterol ◽

Plaque Rupture ◽

Hdl Cholesterol ◽

St Elevation Myocardial Infarction ◽

Coronary Syndrome ◽

Cholesterol Levels ◽

Low Hdl ◽

St Elevation

Abstract: Acute coronary syndrome (ACS) is due to plaque rupture or erosion of atherosklerosis, including unstable angina pectoris, non-ST elevation myocardial infarction, and ST-elevation myocardial infarction. In indonesia, ACS is still regarded as the highest death contributor. One of the risk factors of ACS is dyslipidemia, that is abnormality condition of lipid in blood. Objective: This study aims to determine description of lipid profile in patients with acute coronary syndrome. Methods: This was a descriptive observational method, based on the secondary data from patients in CVBC Prof. Dr. R. D. Kandou Hospital during January to September 2015. Result: The result showed that from 80 patients of ACS were 37 patients (46,25%) with high total cholsterol levels (≥ 200 mg/dL), 70 patients (87,5%) with low HDL cholesterol levels (≤ 40 - 50 mg/dL), there are 58 patients (72,5%) with high LDL cholesterol levels (> 100 mg/dL) and 32 patients (40%) with high triglycerides levels (≥ 150 mg/dL). Conclusion: Most of ACS patients in this research had high LDL cholesterol levels and low HDL cholesterol levels.Keywords: Acute coronary syndrome, dyslipidemia, lipid profileAbstrak: Sindrom koroner Akut ( SKA ) terjadi karena adanya ruptur atau erosi dari plak aterosklerosis, termasuk angina pektoris tidak stabil, non-ST elevasi miokard infark, dan ST elevasi miokard infark. Di Indonesia, SKA masih di anggap sebagai penyumbang angka kematian tertinggi. Salah satu faktor risiko SKA adalah dislipidemia, yaitu berupa gangguan metabolisme lipid. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran profil lipid pada penderita sindrom koroner akut. Metode: Penelitian ini bersifat deskriptif observasional dengan menggunakan data sekunder dari penderita SKA di CVBC RSUP. Prof. Dr. R. D. Kandou periode januari – september 2015. Hasil: Hasil penelitian ini menunjukkan dari 80 penderita SKA didapatkan 37 orang (46,25%) adalah penderita yang memiliki kadar kolesterol total tinggi (≥ 200 mg/dL), sebanyak 70 orang (87,5%) memiliki kadar HDL rendah (≤ 40 – 50 mg/dL), adapun yang memiliki kadar LDL tinggi (> 100 mg/dL) yaitu 58 orang (72,5%) dan 32 orang (40%) adalah penderita yang memiliki kadar trigliserida tinggi (≥ 150 mg/dL). Kesimpulan: Penderita sindrom koroner akut dalam penelitian ini sebagian besar memiliki kadar kolesterol LDL yang tinggi dan kadar kolesterol HDL yang rendah.Kata kunci: Sindrom koroner akut, dislipidemia, profil lipid

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