scholarly journals Alcohol-Related Liver Disease Is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide

2019 ◽  
Vol 17 (11) ◽  
pp. 2320-2329.e12 ◽  
Author(s):  
Neil D. Shah ◽  
Meritxell Ventura-Cots ◽  
Juan G. Abraldes ◽  
Mohamed Alboraie ◽  
Ahmad Alfadhli ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Early Stages ◽  
Related Liver Disease

scholarly journals Impact of Sarcopenia and Myosteatosis in Non-Cirrhotic Stages of Liver Diseases: Similarities and Differences across Aetiologies and Possible Therapeutic Strategies

Biomedicines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 182
Author(s):  
Annalisa Cespiati ◽  
Marica Meroni ◽  
Rosa Lombardi ◽  
Giovanna Oberti ◽  
Paola Dongiovanni ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Early Stage ◽  
Alcoholic Fatty Liver ◽  
Early Stages ◽  
Advanced Stages ◽  
Related Liver Disease ◽  
And Function ◽  
The Relationship

Sarcopenia is defined as a loss of muscle strength, mass and function and it is a predictor of mortality. Sarcopenia is not only a geriatric disease, but it is related to several chronic conditions, including liver diseases in both its early and advanced stages. Despite the increasing number of studies exploring the role of sarcopenia in the early stages of chronic liver disease (CLD), its prevalence and the relationship between these two clinical entities are still controversial. Myosteatosis is characterized by fat accumulation in the muscles and it is related to advanced liver disease, although its role in the early stages is still under researched. Therefore, in this narrative review, we firstly aimed to evaluate the prevalence and the pathogenetic mechanisms underlying sarcopenia and myosteatosis in the early stage of CLD across different aetiologies (mainly non-alcoholic fatty liver disease, alcohol-related liver disease and viral hepatitis). Secondly, due to the increasing prevalence of sarcopenia worldwide, we aimed to revise the current and the future therapeutic approaches for the management of sarcopenia in CLD.

Spectrum of liver diseases occurring solely in pregnancies carrying male fetuses: A case series

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Eva koulaymi ◽  
◽  
Mayssaloun khairallah ◽  
Zeinab Haroun ◽  
Jihad Al Hassan ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mortality Rate ◽  
High Mortality ◽  
Liver Diseases ◽  
Case Series ◽  
Specific Effect ◽  
Related Liver Disease ◽  
Insight Into

Liver disease affects nearly 3% of pregnancies. It is a challenging topic for obstetricians as it can be fatal for both, the mother and the fetus. They carry a high mortality rate reaching 25%. Sex-specific effect on the expression of pregnancy-related liver diseases is largely unknown. We present several cases of familial pregnancy-related liver diseases that were expressed solely when the mothers had male fetuses, ending with deleterious outcomes. Liver disease was not expressed when they had female fetuses. These cases provide a novel insight into the diversity of pregnancy-related liver disease complications expression among sex.

scholarly journals Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions

2019 ◽  
Vol 20 (20) ◽  
pp. 5029 ◽  
Author(s):  
Shengmin Yan ◽  
Bilon Khambu ◽  
Honghai Hong ◽  
Gang Liu ◽  
Nazmul Huda ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Hepatic Metabolism ◽  
Pathological Changes ◽  
Hepatic Cells ◽  
Nuclear Factors ◽  
Non Coding Rnas ◽  
Related Liver Disease

Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases.

scholarly journals Long non-coding RNAs in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease

2020 ◽  
Vol 26 (4) ◽  
pp. 705-714
Author(s):  
Sen Han ◽  
Ting Zhang ◽  
Praveen Kusumanchi ◽  
Nazmul Huda ◽  
Yanchao Jiang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Liver Diseases ◽  
Current Knowledge ◽  
Cholestatic Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Non Coding Rnas ◽  
Related Liver Disease

Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.

scholarly journals Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation

2021 ◽  
Vol 14 ◽  
pp. 175628482110313
Author(s):  
Paul Middleton ◽  
Nikhil Vergis
Keyword(s):  
Liver Disease ◽  
Mitochondrial Dysfunction ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Alcoholic Fatty Liver ◽  
Mitochondrial Defects ◽  
Related Liver Disease ◽  
Species Production ◽  
Alcoholic Fatty Liver Disease

Mitochondria are key organelles involved in energy production as well as numerous metabolic processes. There is a growing interest in the role of mitochondrial dysfunction in the pathogenesis of common chronic diseases as well as in cancer development. This review will examine the role mitochondria play in the pathophysiology of common liver diseases, including alcohol-related liver disease, non-alcoholic fatty liver disease, chronic hepatitis B and hepatocellular carcinoma. Mitochondrial dysfunction is described widely in the literature in studies examining patient tissue and in disease models. Despite significant differences in pathophysiology between chronic liver diseases, common mitochondrial defects are described, including increased mitochondrial reactive oxygen species production and impaired oxidative phosphorylation. We review the current literature on mitochondrial-targeted therapies, which have the potential to open new therapeutic avenues in the management of patients with chronic liver disease.

Assessment Of Nutritional Status Among Patients Suffering From HCV Visiting Public Hospitals Of Lahore

2020 ◽  
pp. 54-60
Author(s):  
OJS Admin
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Nutritional Status ◽  
Liver Diseases ◽  
Public Hospitals ◽  
Early Stages

Hepatitis C virus is an infectious liver disease. The infection is generally asymptomatic commonly in its early stages but when it's confirmed, it can lead to advanced liver diseases such as liver fibrosis and thencirrhosis.

Jaundice syndrome in patient with alcoholic liver disease in therapeutic practice

2020 ◽  
pp. 5-10
Author(s):  
A. L. Vertkin ◽  
Yu. V. Sedyakina ◽  
E. G. Silina ◽  
M. M. Shamuilova ◽  
E. I. Vovk
Keyword(s):  
Liver Disease ◽  
Research Methods ◽  
Alcoholic Liver Disease ◽  
Liver Diseases ◽  
Additional Research ◽  
Initial Examination ◽  
Therapeutic Practice ◽  
Early Stages

With liver diseases, jaundice syndrome is one of the most common. It is extremely important for the doctor to suspect and identify this syndrome in the early stages of the disease, as well as decide which hospital to hospitalize the patient: infectious, surgical or therapeutic. The detection of jaundice syndrome during the initial examination, as a rule, does not require therapeutic additional research methods, but a common pathology accompanied by jaundice syndrome is an alcoholic liver disease.

Addiction and Liver Disease

2014 ◽  
Vol 25 (2) ◽  
pp. 75-83
Author(s):  
Md Akmat Ali ◽  
Farida Yeasmin ◽  
MN Nag
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Drug Users ◽  
Harmful Effect ◽  
Main Role ◽  
Drug Induced ◽  
Mortality And Morbidity ◽  
Other Substances ◽  
Excessive Alcohol ◽  
Medicine Today

Drug induced liver disease is a global problem. The aims of the study are to know the recreational drugs causing harmful effect on liver, epidemiology of addiction; pathophysiology and their consequences. The major findings published to date concerning different agents causing addiction and liver disease, their implications with regard to understanding disease mechanisms and their amplitude or spectrum are described. Addiction not only invites lot of sufferings to the family and the country, but also responsible for different types of liver disease including fatty liver, hepatitis and liver failure; responsible for mortality and morbidity. Among the addiction causing substances alcohol playing the main role for liver disease worldwide. Indirect effects of addiction on liver are hepatitis B, hepatitis C and their complication, mainly due to contamination of sharing needle. Majority of people in Bangladesh are life long abstainer. Excessive alcohol beverages and other substances like heroin, amphetamine are not harmless, rather they can cause serious liver diseases. There are some differences in prevalence of addiction and liver diseases among countries. Intravenous drug users are affected both directly and indirectly due to contaminated needle sharing . DOI: http://dx.doi.org/10.3329/medtoday.v25i2.17926 Medicine Today 2013 Vol.25(2): 75-83

Sign in / Sign up

Export Citation Format

Share Document