Community clinic-based lifestyle change for prevention of metabolic syndrome: Rationale, design and methods of the ‘Vida Sana/healthy life’ program

Objective: To our knowledge, no studies have yet looked at how the risk of developing breast cancer (BC) varies with changes in metabolic syndrome (MetS) status. This study aimed to investigate the association between changes in MetS and subsequent BC occurrence. Research Design and Methods: We enrolled 930,055 postmenopausal women aged 40–74 years who participated in a biennial National Health Screening Program in 2009–2010 and 2011–2012. Participants were categorized into four groups according to change in MetS status during the two-year interval screening: sustained non-MetS, transition to MetS, transition to non-MetS, and sustained MetS. We calculated multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for BC incidence using the Cox proportional hazards models. Results: At baseline, MetS was associated with a significantly increased risk of BC (aHR 1.11, 95% CI 1.06–1.17) and so were all of its components. The risk of BC increased as the number of the components increased (aHR 1.46, 95% CI 1.26–1.61 for women with all five components). Compared to the sustained non-MetS group, the aHR (95% CI) for BC was 1.11 (1.04–1.19) in the transition to MetS group, 1.05 (0.96–1.14) in the transition to non-MetS group, and 1.18 (1.12–1.25) in the sustained MetS group. Conclusions: Significantly increased BC risk was observed in the sustained MetS and transition to MetS groups. These findings are clinically meaningful in that efforts to recover from MetS may lead to reduced risk of BC.

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Lipid Abnormalities in the Natural History of Diabetes

Journal of Medicine ◽

10.3329/jom.v16i2.25432 ◽

2015 ◽

Vol 16 (2) ◽

pp. 83-88

Author(s):

Muhammad Hafizur Rahman ◽

Liaquat Ali

Keyword(s):

Metabolic Syndrome ◽

Natural History ◽

Total Cholesterol ◽

Fasting Glucose ◽

Serum Triglyceride ◽

Hdl Cholesterol ◽

Family History Of Diabetes ◽

History Of ◽

Lipid Abnormalities ◽

Design And Methods

Objective: To explore lipid abnormalities in normoglycemic first-degree diabetic relatives (FDRs) and prediabetic and diabetic subjects in the natural history of diabetes.Research design and methods: Thirty six impaired fasting glucose (IFG), 61 isolated impaired glucose tolerance (I-IGT), 64 combined IFG-IGT, 73 diabetic, and 32 FDRs along with 57 normoglycemic healthy controls without family history of diabetes in 1st degree relatives, were selected purposively following 2003 ADA cut-off values and 2006 WHO/IDF grouping. Anthropometry and blood pressure of the subjects were taken. Fasting and 2-h plasma glucose and HbA1C were measured. Fasting plasma triglyceride, total cholesterol and HDL cholesterol were measured by enzymatic colorimetric method.Results: Serum triglyceride was higher in IFG, I-IGT, IFG-IGT, diabetic and FDRs compared to Control [145 (59- 307), 128 (66-584), 166 (68-764), 161 (69-750) and 130 (81-281) vs. 108 (47-219) mg/dl, P<0.01, P<0.01, P<0.001, P<0.001 and P<0.05]. Total cholesterol was raised in IFG-IGT and diabetes compared to Control [185 (105-310), 185 (123-326) vs. 171 (101-235) mg/dl, P<0.05] and FDRs. But HDL did not differ among the groups. Prevalence of metabolic syndrome was higher in IFG, I-IGT, IFG-IGT and diabetes and FDRs than Control [55%, 38%, 57%, 58% and 36% vs. 15%, P<0.001, P<0.01, P<0.001, P<0.001 and P<0.05] and also in IFGIGT and diabetic compared to I-IGT and FDRs (P<0.05).Conclusions: Higher prevalence of metabolic syndrome and raised serum triglyceride is seen among diabetic, prediabetic and 1st degree diabetic-relatives. Total cholesterol and non-HDL cholesterol is raised only in IFG-IGT and diabetes, the more decompensated glycemic states.J MEDICINE July 2015; 16 (2) : 83-88

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Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss

International Journal of Obesity ◽

10.1038/ijo.2008.225 ◽

2008 ◽

Vol 33 (1) ◽

pp. 144-150 ◽

Cited By ~ 18

Author(s):

J D Lundgren ◽

R Malcolm ◽

M Binks ◽

P M O'Neil

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Lifestyle Change ◽

Low Calorie

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Changes in Serum Lipids and Blood Glucose in Non Diabetic Patients with Metabolic Syndrome after Mixed Meals of Different Composition

Journal of Nutrition and Metabolism ◽

10.1155/2012/215052 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Adriana Branchi ◽

Adriana Torri ◽

Cristina Berra ◽

Emanuela Colombo ◽

Domenico Sommariva

Keyword(s):

Metabolic Syndrome ◽

Blood Glucose ◽

Serum Lipids ◽

Hdl Cholesterol ◽

Nutrient Composition ◽

Diabetic Patients ◽

Serum Triglycerides ◽

Different Response ◽

Design And Methods ◽

Usual Diet

Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS−) metabolic syndrome.Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS− consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal.Results. Serum triglycerides increased more in MetS+ (35%, 4:30 hours after the meal) than in MetS− (29%), HDL-cholesterol decreased 2 hours after the meal in both groups (−4% and −5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours after the meal in MetS+ and 17% in MetS−) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 μU/mL, 2 and 4:30 hours after the meal) than in MetS− (46.7 and 21.6 μU/mL). Difference in nutrient composition of the meal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group.Conclusions. As compared with MetS−, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.

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Association of postprandial and fasting triglycerides with traits of the metabolic syndrome in the Metabolic Intervention Cohort Kiel

Acta Endocrinologica ◽

10.1530/eje-09-0446 ◽

2010 ◽

Vol 162 (4) ◽

pp. 719-727 ◽

Cited By ~ 10

Author(s):

Diana Rubin ◽

Ulf Helwig ◽

Michael Nothnagel ◽

Ulrich R Fölsch ◽

Stefan Schreiber ◽

...

Keyword(s):

Metabolic Syndrome ◽

Lipid Metabolism ◽

Cell Function ◽

International Diabetes Federation ◽

Tolerance Test ◽

Oral Glucose ◽

Middle Aged ◽

The Metabolic Syndrome ◽

Β Cell Function ◽

Design And Methods

ObjectivePostprandial (pp) lipid metabolism is associated with insulin resistance and type 2 diabetes. In young men, pp triglycerides (TGs) are more strongly associated with traits of metabolic syndrome (MS) than fasting TGs. We established a cohort of middle-aged men selected for traits of MS and pp lipid metabolism to determine if fasting TGs or pp TGs are more closely related to MS.Research design and methodsA total of 1558 men were characterized for MS. A total of 755 men underwent an oral metabolic tolerance test consisting of a standardized high-fat meal and an oral glucose tolerance test. Blood samples were drawn in the fasting state and hourly until 9 h to determine pp TGs and free fatty acids. Glucose and insulin were analyzed until 5 h pp.ResultsIn the overall cohort, 329 subjects (21.1%) had a complete MS based on the Adult Treatment Panel III criteria, and 650 subjects (41.7%) had a complete MS based on the International Diabetes Federation criteria. The association of pp TGs with MS parameters was not stronger than the association of fasting TGs with them. Pp TGs were independently associated with β-cell function.ConclusionsPp TGs did not show a higher correlation with MS traits than fasting TGs. This finding is probably due to the high incidence of overweight subjects in this middle-aged cohort.

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Focus on lifestyle change and the metabolic syndrome

Endocrinology and Metabolism Clinics of North America ◽

10.1016/j.ecl.2004.03.009 ◽

2004 ◽

Vol 33 (3) ◽

pp. 493-508 ◽

Cited By ~ 16

Author(s):

Neil J. Stone

Keyword(s):

Metabolic Syndrome ◽

Lifestyle Change ◽

The Metabolic Syndrome

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ASSOCIATION OF rs9939609 FTO GENE POLYMORPHISM WITH METABOLIC SYNDROME AND ITS COMPONENTS IN RUSSIAN POPULATION

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2013-19-4-311-319 ◽

2013 ◽

Vol 19 (4) ◽

pp. 311-319 ◽

Cited By ~ 1

Author(s):

N. V. Khromova ◽

O. P. Rotar ◽

A. M. Erina ◽

D. A. Shavshin ◽

N. P. Alexeeva ◽

...

Keyword(s):

Metabolic Syndrome ◽

Deoxyribonucleic Acid ◽

Plasma Lipids ◽

Risk Allele ◽

Polymerase Chain Reaction Method ◽

Peripheral Blood Lymphocytes ◽

Russian Population ◽

Fto Gene ◽

Polymerase Chain ◽

Design And Methods

Objective. To study the association of genetic determinant (A-risk allele of rs9939609 SNP of FTO gene) with prevalence of metabolic syndrome (MS) and its components in residents of different Russian cities.Design and methods. We examined 425 patients with MS or its components from different cities of Russia (St Petersburg, Kursk, Kaliningrad), stratiied by sex and age [175 male (41,2 %) and 250 female (58,8 %), mean age — 47,2 ± 0,6 years]. All subjects were interviewed with special questionnaire. Physical examination included anthropometry (waist and hip circumferences, weight, height), blood pressure and heart rate registration. MS was deined according to NCEP-ATPIII as well as IDF (2005) and JIS (2009) criteria. Fasting plasma lipids and glucose were performed in all patients by Hitachi-902 equipment (Roche reagents). Genomic deoxyribonucleic acid (DNA) was puriied from peripheral blood lymphocytes and genotyping was performed using real time polymerase chain reaction method by allele-speciic probes (Applied Biosystems).Results. Among males with AA genotype waist and hip circumferences and weight were higher, compared to subjects with TA and TT genotypes (p = 0,0002, p = 0,001 and p = 0,01, respectively). There was a tendency to the increase of body mass index (BMI) in the group with AA genotype compared to subjects with TA and TT genotypes (29,7 ± 0,7; 27,6 ± 0,4 and 27,9 ± 0,3 kg/m2, respectively, р = 0,1). In our study AA genotype was associated with higher glucose level compared to TA and TT genotypes (5,6 ± 0,2; 5,0 ± 0,1 and 5,1 ± 0,1 mmol/l, respectively, p = 0,04). There was a tendency to the increase of the proportion of hypertensives among patients with AA genotype compared to TA and TT genotypes (70,5; 65,2 and 57 %, respectively, p = 0,18).Conclusion. In Russian population FTO genepolymorphism rs9969309 is associated not only with abdominal obesity, but also with other components of MS, including hyperglycemia and hypertension.

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REPRODUKSI WACANA METABO LAW DALAM PEMBENTUKAN STEREOTYPE FAT CHARACTER PADA ANIME JEPANG

IZUMI ◽

10.14710/izumi.7.1.11-21 ◽

2018 ◽

Vol 7 (1) ◽

pp. 11

Author(s):

Santi Andayani ◽

Ni Made Savitri Paramita

Keyword(s):

Metabolic Syndrome ◽

Life Style ◽

Japanese Government ◽

The Body ◽

Healthy Life ◽

The Public ◽

The Metabolic Syndrome ◽

Healthy Life Style ◽

Normalization Process ◽

Health Guidance

(Title: The Reproduction Of Metabo Law Discourse In Constructing Fat Characters Stereotype In Japanese Animes) Japanese government through Ministry of Health, Labor and Welfare (MHLW) in 2008 issued the Metabo Law regulation, which is the standard of medical and health guidance that is done specifically with the purpose to decrease the number of obesity which cause the metabolic syndrome. This regulation put the body of each individual to be open to the public. Using Foucault’s perception, this study look how Metabo Law works and how the reproduction of Metabo Law discourses constructing stereotype of fat character in Japanese anime. This study took data from 14 fat character in 13 anime, airing in 2008’s until 2015’s. To complete the data, interview were conducted on 5 Japanese about their understanding about Metabo Law. This study shows that with the normalization process using yearly general checkup and the reproduction of Metabo Law discourses, Japanese government successfully change the Japanese mindset and their behavior in maintained a healthy life style and to stay slim. The stereotype of the fat character that emerge as the product of reproduction of Metabo Law discourses is greedy, careless, cowardly, shy/ have low self-confident, and an otaku.

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