Type D personality and metabolic syndrome in patients with depression

2017 ◽  
Vol 41 (S1) ◽  
pp. S533-S533
Author(s):  
M. Martinac ◽  
D. Babić ◽  
M. Pavlović

IntroductionPathogenesis of metabolic syndrome (MS) and depression (MDD) is complex and insufficiently explored. In addition to chronic stress, psychotrauma, hypercortisolemia and immunological factors, some personality features may have an impact. Type D personality, most influential personality type in psychosomatic medicine, consists of two dimensions: negative affect (NA) and social inhibition (SI). Individuals with type D personality are more anxious, irritable and depressed and they do not share these emotions with others because of their fear of rejection. Type D personality was proven to be a risk factor for some MS components, as well as for the occurrence of depressive symptoms in cardiac patients.AimTo investigate the association of type D personality with MS and its components in MDD patients.MethodsCross-sectional study was conducted on the sample of 80 patients with depression and 40 healthy subjects as the control group. Mini International Neuropsychiatric Interview (MINI questionnaire) and Hamilton Rating Scale for Depression (HDRS-17) were used for the diagnosis of depression. Type D personality was determined by DS14 questionnaire. The MS diagnosis was made according to ATP III criteria.ResultsThe presence of type D personality did not significantly contribute to the probability of developing MS in patients with depression. NA was associated with abdominal obesity, low HDL-cholesterol and hypertension.ConclusionNegative affect was proven to be an independent risk factor in the pathogenesis of obesity, hypertension, and reduced level of HDL-cholesterol, while type D personality in general did not have predictive value for the MS development.Disclosure of interestThe authors have not supplied their declaration of competing interest.

2011 ◽  
Vol 4 (1) ◽  
Author(s):  
Dimitrios Tziallas ◽  
Michael S Kostapanos ◽  
Petros Skapinakis ◽  
Haralampos J Milionis ◽  
Thanos Athanasiou ◽  
...  

2021 ◽  
Vol 17 (3) ◽  
pp. 214-218
Author(s):  
Emine Duygu Boz ◽  
Refik Demirtunç ◽  
Mehmet Sözen

Background. Gallbladder polyps are usually benign lesions originating from the mucosa and are usually detected incidentally during radiological examinations or after cholecystectomy. Gallbladder polyps are common and may have malignant risk. In this study, it was investigated whether metabolic syndrome (MS) is a risk factor for gallbladder polyps. This study aimed to determine the prevalence of MS and its components in patients with gallbladder polyps. Materials and methods. We conducted a retrospective, cross-sectional study. We investigated the age, gender and past medical history of 90 adults (45 with polyps, 45 without polyps). Body height and weight, body mass index, waist circumference and laboratory data were obtained from the hospital data processing system. National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Foundation (IDF) MS diagnostic criterion were used for the diagnosis of MS. Results. 51.1 % (n = 46) of the subjects participating in the study were female and 48.8 % (n = 44) were male. The mean age was 58.79 ± 15.70 years. MS was found in 56.7 % (n = 51) of the cases according to the criteria of NCEP-ATP III and, in 64.4 % (n = 58) of the cases according to the IDF criteria. In patients with a gallbladder polyp, MS was detected in 55.55 % according to the criteria of NCEP-ATP III and in 66.66 % according to the IDF criteria. The rates of MS were not similar in the gallbladder polyp group and control group (p > 0.01). Abdominal obesity was found to be a risk factor for the development of gallbladder polyp (odds ratio: 14.23, 95% CI: 1.751–15.722; p < 0.01). Although it was not statistically significant, low HDL and hypertension were detected approximately 2 times higher in patients with gallbladder polyps than in the control group. Conclusions. While MS is not associated with the development of gallbladder polyp, obesity is seen as a sole risk factor.


2019 ◽  
pp. 68-73
Author(s):  
Trong Nghia Nguyen ◽  
Thi Nhan Nguyen ◽  
Thi Dua Dao

Background: The metabolic syndrome is a constellation of cardiometabolic risk factors that tend to cluster together in affected individuals more often than predicted by chance. The presence of the metabolic syndrome substantially increases the risk of developing type 2 diabetes and cardiovascular disease, and is associated with a range of adverse clinical outcomes, many of which are closely associated with aging. Current estimates suggest that approximately 20 - 25% of the world’s population is affected by the metabolic syndrome. The prevalence of the metabolic syndrome rises with age and more than 45% of people aged over 60 years have the metabolic syndrome. Recent studies show that low vitamin D status is very common in the world and this is a risk factor of metabolic syndrome. Objective: (1) Plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome. (2) Cut off value of plasma 25-hydroxyvitamin D concentration for predicting metabolic syndrome. Material and method: A cross-sectional study with control group on 318 adult subjects for health examinations at International Medical Center at Hue Central Hospital, including 139 subjects with metabolic syndrome and control group of 179 healthy subjects. Metabolic syndrome was defined according to the IDF, NHLBI, AHA, WHF, IAS, IASO (2009). Plasma hydroxyvitamin D concentration was measured using chemiluminescent microparticle immunoassay. Reciever operating characteristic (ROC) curve were generated to assess sensitivity and specificity for different cut off value of 25-hydroxyvitamin D concentration for predicting metabolic syndrome. Results: Plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome was 26.4 ng/ml, incidence of plasma 25-hydroxyvitamin D deficiency (59.7%) was significantly higher than in control group (23.5%) (p < 0.001). The optimal cut off point for 25-OH-D concentration for predictor of metabolic syndrome as 26.4 ng/ml (AUC=0.657, sensitivity=53.4%, specificity=71.6%). Conclusion: In 139 subjects with metabolic syndrome, the plasma 25-hydroxyvitamin D concentration was 26.4 ng/ml and the incidence of 25-hydroxyvitamin D deficiency in the metabolic syndrome group was 59.7%. The optimal cut off point for plasma 25-hydroxyvitamin D concentration for predictor of metabolic syndrome as 26.4 ng/ml. Key words: Metabolic syndrome, 25-hydroxyvitamin D


Author(s):  
Seung Won Lee ◽  
Sung-In Jang

This study examined the association of alcohol drinking patterns with metabolic syndrome (MetS) and its components in a nationally representative sample of South Korean adults. The cross-sectional study included 12,830 current drinkers (6438 men and 6392 women) who were at least 20 years old. Measures of alcohol drinking patterns included average drinking frequency, usual quantity, and binge drinking frequency over the past year. Multivariate logistic regression was performed to estimate odds ratios and 95% confidence intervals for MetS and its components according to alcohol drinking patterns, and also to examine linear trends in these relationships. The prevalence of MetS was 1822 (26.2%) in men and 1313 (17.5%) in women. After adjusting for potential confounding factors, drinking quantity and binge drinking frequency were positively associated with MetS in both sexes. Regarding components of MetS, while the risk of low HDL cholesterol decreased as drinking frequency increased, other MetS components (abdominal obesity, high blood pressure, and impaired fasting glucose) worsened. Our results suggest that separate management of each component of MetS will be required to protect cardio-metabolic health, and a healthy drinking culture that refrains from binge drinking should be established in the context of public health.


2021 ◽  
Vol 10 (13) ◽  
pp. 2907
Author(s):  
Alba Martínez-Escudé ◽  
Guillem Pera ◽  
Anna Costa-Garrido ◽  
Lluís Rodríguez ◽  
Ingrid Arteaga ◽  
...  

Thyroid hormones may be a risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and its progression to liver fibrosis. The aim of this study is to investigate the relationship between thyroid stimulating hormone (TSH) levels, NAFLD, and liver fibrosis in the general population. A descriptive cross-sectional study was performed in subjects aged 18–75 years randomly selected from primary care centers between 2012 and 2016. Each subject underwent clinical evaluation, physical examination, blood tests and transient elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with NAFLD and fibrosis. We included 2452 subjects (54 ± 12 years; 61% female). Subjects with TSH ≥ 2.5 μIU/mL were significantly associated with obesity, atherogenic dyslipidemia, metabolic syndrome (MetS), hypertransaminasemia and altered cholesterol and triglycerides. The prevalence of NAFLD and liver fibrosis was significantly higher in subjects with TSH ≥ 2.5 (μIU/mL). We found a 1.5 times increased risk of NAFLD, 1.8 and 2.3 times increased risk of liver fibrosis for cut-off points of ≥ 8.0 kPa and ≥ 9.2 kPa, respectively, in subjects with TSH ≥ 2.5 μIU/mL compared with TSH < 2.5 μIU/mL (control group), independent of the presence of MetS. These findings remained significant when stratifying TSH, with values ≥ 10 μIU/mL.


2020 ◽  
Vol 4 (3) ◽  
pp. 191
Author(s):  
Rendi Aji Prihaningtyas ◽  
Nur Aisiyah Widjaja ◽  
Meta Herdiana Hanindita ◽  
Roedi Irawan

ABSTRACTBackground : The prevalence of obesity in adolescents is increasing and causes metabolic syndrome at a young age. Metabolic syndrome results from the interaction of environmental, genetic, and dietary factors. The purpose of this study was to determine the diet profile of obese adolescents suffering from metabolic syndrome.Methods: This study was a cross-sectional study of obese adolescents who visited the Pediatric Nutrition and Metabolic Disease in Dr. Soetomo General Hospital, Surabaya. The anthropometry examination (weight, height and waist circumference), blood pressure, and blood tests (HDL cholesterol, triglycerides and blood glucose levels) were measured. The diagnosis of metabolic syndrome was based on the International Diabetes Federation. Food consumption data was obtained through direct interviews using data collection sheets. Analysis of dietary differences in obese adolescents suffering from metabolic syndrome was performed by chi square using SPSS.Results and Discussions: A total of 59 obese adolescents aged 13-16 years were involved in this study. A total of 27 subjects (45.8%) suffered from metabolic syndrome and 32 subjects (54.2%) did not suffer from metabolic syndrome. The level of the consumption of fish, vegetables, and fruit in obese adolescents were still low. There was no significant difference in the diet profile between obese adolescents who suffer from metabolic syndrome or not.Conclusion: Prevention strategies through food consumption patterns are needed in obese adolescents to control metabolic stress processes and prevent metabolic syndrome in the future. Diet knowledge in obese adolescents needs to be given early to prevent further complications. Increasing foods that contain anti-oxidants, such as fruits and vegetables, is one of the strategies to prevent metabolic syndrome in obese adolescents.ABSTRAKLatar Belakang : Prevalensi obesitas pada remaja semakin meningkat dan menyebabkan sindrom metabolik di usia muda. Sindrom metabolik terjadi akibat interaksi faktor lingkungan, genetik, dan diet. Tujuan dari penelitian ini adalah mengetahui profil diet pada remaja obesitas yang menderita sindrom metabolik.Metode : Penelitian ini merupakan penelitian potong lintang pada remaja obesitas yang berkunjung di Poli Nutrisi dan Penyakit Metabolik Anak di RSUD Dr. Soetomo, Surabaya. Pada subyek dilakukan pemeriksaan antropometri (berat badan, tinggi badan, dan lingkar pinggang), pemeriksaan tekanan darah, dan pemeriksaan darah (kolesterol HDL, trigliserida, dan kadar glukosa darah). Diagnosis sindrom metabolik ditegakkan berdasarkan International Diabetes Federation. Data konsumsi makanan didapatkan melalui wawancara langsung dengan menggunakan lembar pengumpul data. Analisis perbedaan diet pada remaja obesitas yang menderita sindrom metabolik dilakukan dengan chi square menggunakan SPSS.Hasil dan Pembahasan : Sebanyak 59 remaja obesitas yang berusia 13-16 tahun terlibat dalam penelitian ini. Sebanyak 27 subyek (45,8%) menderita sindrom metabolik dan sebanyak 32 subyek (54,2%) tidak menderita sindrom metabolik. Tingkat konsumsi ikan, sayur, dan buah pada remaja obesitas masih rendah. Tidak ada perbedaan yang bermakna pada profil diet antara remaja obesitas yang menderita sindrom metabolik maupun tidak.Kesimpulan : Strategi pencegahan melalui pola konsumsi makanan diperlukan pada remaja obesitas untuk mengontrol proses stres metabolik sehingga dapat mencegah sindrom metabolik di masa datang. Pengetahuan diet pada remaja obesitas perlu diberikan sejak dini untuk mencegah komplikasi lebih lanjut. Memperbanyak makanan yang mengandung anti-oksidan, seperti buah dan sayur merupakan salah satu strategi mencegah sindrom metabolik pada remaja obesitas.


2009 ◽  
Vol 13 (4) ◽  
pp. 488-495 ◽  
Author(s):  
Ahmet Selçuk Can ◽  
Emine Akal Yıldız ◽  
Gülhan Samur ◽  
Neslişah Rakıcıoğlu ◽  
Gülden Pekcan ◽  
...  

AbstractObjectiveTo identify the optimal waist:height ratio (WHtR) cut-off point that discriminates cardiometabolic risk factors in Turkish adults.DesignCross-sectional study. Hypertension, dyslipidaemia, diabetes, metabolic syndrome score ≥2 (presence of two or more metabolic syndrome components except for waist circumference) and at least one risk factor (diabetes, hypertension or dyslipidaemia) were categorical outcome variables. Receiver-operating characteristic (ROC) curves were prepared by plotting 1 − specificity on the x-axis and sensitivity on the y-axis. The WHtR value that had the highest Youden index was selected as the optimal cut-off point for each cardiometabolic risk factor (Youden index = sensitivity + specificity − 1).SettingTurkey, 2003.SubjectsAdults (1121 women and 571 men) aged 18 years and over were examined.ResultsAnalysis of ROC coordinate tables showed that the optimal cut-off value ranged between 0·55 and 0·60 and was almost equal between men and women. The sensitivities of the identified cut-offs were between 0·63 and 0·81, the specificities were between 0·42 and 0·71 and the accuracies were between 0·65 and 0·73, for men and women. The cut-off point of 0·59 was the most frequently identified value for discrimination of the studied cardiometabolic risk factors. Subjects classified as having WHtR ≥ 0·59 had significantly higher age and sociodemographic multivariable-adjusted odds ratios for cardiometabolic risk factors than subjects with WHtR < 0·59, except for diabetes in men.ConclusionsWe show that the optimal WHtR cut-off point to discriminate cardiometabolic risk factors is 0·59 in Turkish adults.


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