scholarly journals Tu1045 PERIOPERATIVE HEPARIN BRIDGING FOR COLORECTAL EMR OR ESD FOR PATIENTS RECEIVING ANTICOAGULATION RESULTED IN A VERY HIGH INCIDENCE OF BLEEDING COMPLICATION

2018 ◽  
Vol 87 (6) ◽  
pp. AB508
Author(s):  
Daisuke Yoshimura ◽  
Toshiaki Ochiai ◽  
Shin-ichiro Fukuda ◽  
Kojiro Niho ◽  
Yusuke Kitagawa ◽  
...  
Keyword(s):  
Bleeding Complication ◽  
High Incidence ◽  
Very High

scholarly journals Immediate rehabilitation with feeding appliance of a three day old neonate with cleft lip and palate- a case report

2017 ◽  
Vol 13 (2) ◽  
pp. 293-295
Author(s):  
Deepika Kapoor ◽  
Deepanshu Garg
Keyword(s):  
Case Report ◽  
Cleft Lip ◽  
Multidisciplinary Approach ◽  
Cleft Lip And Palate ◽  
Facial Growth ◽  
Orofacial Clefts ◽  
High Incidence ◽  
Negative Effect ◽  
Growth Development ◽  
Very High

Orofacial clefts (OFC) are one of the most common congenital problems seen with a very high incidence. It imparts a negative effect on the overall health of the child by hindering in his feeding practices, normal facial growth, development of dentition and hence speech. Infants born with orofacial clefts have oronasal communication which creates a problem with the creation of negative pressure inside the oral cavity required for suckling.The treatment for such patients is with the multidisciplinary approach but the preliminary  concern for the neonate is to help with the feeding for which a feeding appliance is given. This case report presents a case of a 3-day old infant to whom a feeding appliance was given to aid in suckling. 

scholarly journals Prevalence of human papillomavirus DNA sequences in an area with very high incidence of cervical carcinoma

1994 ◽  
Vol 70 (4) ◽  
pp. 694-696 ◽  
Author(s):  
CC Pao ◽  
SM Kao ◽  
G-C Tang ◽  
K Lee ◽  
J Si ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Carcinoma ◽  
Dna Sequences ◽  
High Incidence ◽  
Papillomavirus Dna ◽  
Very High

Abstract WP82: Transcranial Doppler Detection of Microembolic Signals During the Advancement and Deployment of Pipeline Embolization Devices in Unruptured Intracranial Aneurysm Repair

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Andres Hughes ◽  
Mark J Dannenbaum ◽  
Peng R Chen ◽  
Arthur L Day ◽  
Huimahn A Choi ◽  
...  
Keyword(s):  
Transcranial Doppler ◽  
Neurological Complication ◽  
Initial Study ◽  
Relative Safety ◽  
High Incidence ◽  
Device Placement ◽  
The Mean ◽  
Aneurysm Repair ◽  
Very High ◽  
Insight Into

Introduction: Pipeline embolization devices (PED) have become an essential tool in the endovascular treatment of complex intracranial aneurysms. A high-density stent like device, the PED functions to redirect blood flow and facilitate the growth and remodeling of the artery. Postoperative ischemic stroke proves to be the most common neurological complication associated with treatment, ranging from about 3-6% with most occurring within 30 days. Transcranial Doppler (TCD) monitoring has been used in the past to evaluate similar procedures by measuring the occurrence of microembolic signals (MES). Due to the delivery and manipulation of the PED and its thrombotic nature, microembolic events have been postulated to form during device placement and contribute to thromboembolism. Our initial study is the first to detect and measure MES during a PED procedure. Methods: Patients undergoing endovascular PED treatment were simultaneously monitored with TCD. MES were detected, separated from artifacts, and counted for each step. Results: Embolic signals were detected in all patients and were highest during deployment. With 3 PED deployments in the paraophthalmic ICA of 2 patients, the mean MES during PED deployment was 515 +/- 46. Average emboli per second during deployment was 1.62 +/- 0.59 verses 0.30 +/- 0.12 emboli per second observed prior to microcatheter insertion and manipulation. Conclusion: A very high incidence of MES was observed during the procedure and PED deployment. The little success thus far in elucidating a possible mechanism to account for PED’s associated complications warrants more investigation. Determining the occurrence of MES might reveal insight into the relative safety of each step and on the formation of distal thromboembolisms.

Identification of macrotroponin T: findings from a case report and non-reproducible troponin T results

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Leo Lam ◽  
Leah Ha ◽  
Campbell Heron ◽  
Weldon Chiu ◽  
Campbell Kyle
Keyword(s):  
Troponin T ◽  
Protein A ◽  
Cardiac Injury ◽  
High Sensitivity ◽  
High Molecular Weight Complex ◽  
High Incidence ◽  
Laboratory Results ◽  
Clinical Consequences ◽  
Very High ◽  
Biochemical Features

Abstract Objectives Macrotroponin is due to cardiac troponin (cTn) binding to endogenous cTn autoantibodies. While previous studies showed a high incidence of macrotroponin affecting cTnI assays, reports of macrotroponin T, particularly without cTnI reactivity, have been rare. Although the clinical significance of macrotroponin is not fully understood, macroenzymes and complexes are recognised to cause confusion in interpretation of laboratory results. The potential for adverse clinical consequences due to misinterpretation of affected results is very high. Methods We describe four cases of macrotroponin T with persistently low high sensitivity cTnT (hs-cTnT) by the 9 min compared to the 18 min variant of the assay. Three cases were serendipitously identified due to the use of a lot number of Roche hs-cTnT affected by non-reproducible results, necessitating measurement of cTnT in duplicate. We identified and characterised these macrotroponin specimens by immunoglobulin depletion (Protein A and PEG precipitation), mixing studies with EDTA and recombinant cTnT. Results In cases of macro-cTnT, a lower result occurred on the hs-cTnT using the 9 min compared to 18 min variant assay (ratio of 9–18 min hs-cTnT <0.80). Mixing studies with recombinant cTnT or EDTA demonstrated a difference in recovery vs. controls. One of these patients demonstrated a high molecular weight complex for cTnI and cTnT demonstrating a macrocomplex involving both cTn. This patient demonstrated a rise and fall in cTn when measured by several commercial assays consistent with genuine acute cardiac injury. Conclusions We identified several cases of macro-cTnT and described associated clinical and biochemical features.

scholarly journals A Comparison of Caudal Epidural Bupivacaine with Adrenaline and Bupivacaine with Adrenaline and Pethidine for Operative and Postoperative Analgesia in Infants and Children

1993 ◽  
Vol 21 (4) ◽  
pp. 424-428 ◽  
Author(s):  
T. P. Santhosh Kumar ◽  
R. Jacob
Keyword(s):  
Randomised Controlled Trial ◽  
Pain Relief ◽  
Controlled Trial ◽  
Infants And Children ◽  
Epidural Bupivacaine ◽  
High Incidence ◽  
Randomised Controlled ◽  
Very High ◽  
In Infants And Children ◽  
Caudal Epidural

This study compares the effectiveness of two drug combinations–010-(010a) bupivacaine with adrenaline and (b) bupivacaine with adrenaline and pethidine — on operative and postoperative pain relief when administered by the caudal route in infants and children. A randomised controlled trial was conducted on fifty children below the age of twelve years: 25 children were randomly allocated to each group. Both groups had a significant period of analgesia in the postoperative period. None of the children in either group required parenteral analgesia. Though the group with pethidine had a longer duration of analgesia and sedation, the very high incidence of vomiting and delay in urination observed in this group would preclude the use of pethidine routinely. No respiratory depression was seen in either group.

Current Concepts in the Prevention of Alzheimer's Disease

CNS Spectrums ◽  
2003 ◽  
Vol 8 (11) ◽  
pp. 846-853 ◽  
Author(s):  
Mary Sano
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Observational Studies ◽  
Elderly Population ◽  
Primary And Secondary Prevention ◽  
Factors Associated ◽  
Significant Challenge ◽  
High Incidence ◽  
Prevention Studies ◽  
Very High

ABSTRACTAlzheimer's disease represents a significant challenge to the aging population. Since most estimates suggest that AD has a multifactorial etiology, the challenge to find preventative approaches is particularly great. With the aging of the population and the very high incidence from the eighth decade on, the challenge is further enhanced by the need to think of relatively safe interventions given the relative frailty of this elderly population. The need to find safe treatments, or ones with well-understood safety profiles, has led to the examination of known agents for potential dementia-preventing properties. Data supporting these interventions comes from observational studies, laboratory analyses, and clinical trials. Potential mechanisms for prevention of AD include anti-inflammatory and antioxidant approaches. Modulation of risk factors associated with cardiac disease may also reduce the risk of AD. Known agents have been examined for their potential to modify amyloid pathology. Trial designs to address prevention of AD include both primary and secondary prevention studies as well designs to assess slowing disease progression. Information can also be gathered when dementia evaluation is added to ongoing studies. As results from these studies becoming available, we will be able to refine our approach to managing this disease.

Calciphylaxis: The Beginning of the End?

2008 ◽  
Vol 28 (3) ◽  
pp. 268-270 ◽  
Author(s):  
Adrian Fine ◽  
Bunny Fontaine
Keyword(s):  
High Frequency ◽  
Response To Therapy ◽  
Ionized Calcium ◽  
Calcium Salts ◽  
Early Improvement ◽  
Time Period ◽  
High Incidence ◽  
Yearly Incidence ◽  
The Mean ◽  
Very High

Background We previously reported a very high incidence of calciphylaxis, mainly in peritoneal dialysis (PD) patients. Although we identified several risk factors for the condition, including PD, we were unable to identify why our particular unit had such a high frequency of the condition and a reliable treatment. Objectives To assess the apparent changing frequency of the condition and the response to therapy, and to attempt to determine putative factors that might explain our uniquely high incidence of calciphylaxis. Methods A prospective clinical record was kept on all patients that developed calciphylaxis in our center [both PD and hemodialysis (HD) units] between 1998 and 2006. Results Of the 59 patients that developed calciphylaxis, 54 were on PD, 4 were on HD, and 1 was in predialysis. In the PD population, the mean yearly incidence from 1998 to 2003 was 4.5/100 patient-years, falling to 1.3/100 patient-years in 2004 – 2006. The percent of patients not taking calcium salts fell during this time period. Conversion to HD led to marked early improvement. A marked discrepancy between the levels of ionized calcium (routinely used in our center) and corrected serum calcium was found, with most cases of hypercalcemia (corrected) being missed by using ionized values. Conclusions The incidence of calciphylaxis is falling dramatically. This may be related partially to reduction in usage of calcium salts. Conversion to HD is beneficial. Our uniquely high incidence of calciphylaxis may be related to our use of ionized calcium levels to monitor these patients.

scholarly journals Inflorescence blast and flower bud abnormalities of Spiraea × vanhouttei and their causes

2008 ◽  
Vol 43 (No. 4) ◽  
pp. 135-143 ◽  
Author(s):  
V. Kůdela
Keyword(s):  
Seed Production ◽  
Fire Blight ◽  
Erwinia Amylovora ◽  
Small Scale ◽  
Flower Bud ◽  
The Czech Republic ◽  
Hybrid Species ◽  
High Incidence ◽  
The Subject ◽  
Very High

In ornamental gardening, <I>Spiraea × vanhouttei</I> is a frequently planted spirea species in the Czech Republic. In 2003, there arose a suspicion of possible occurrence of fire blight caused by <I>Erwinia amylovora</I> on spirea shrubs in Prague and its environs. This suspicion was disproved for a certainty. The absence of the fire blight pathogen in symptomatic spirea plants stimulates a further effort to tackle the problem of a cause of conspicuous fire blight-like symptoms or inflorescence blast occurring on some spirea shrubs. The subject of this paper is: (i) to describe symptoms, incidence and severity of inflorescence blast, bud and flower abnormalities occurring in <I>Spiraea × vanhouttei</I> shrubs; (ii) to find out differences in the occurrence of blasted inflorescences between <I>Spiraea</I> species and cultivars with the intention of verifying the hypothesis that the blast inflorescence and sterility of some spirea species are associated with hybrid species. Symptoms of inflorescence blast are every growing season. No seed is produced by blasted inflorescences. Besides inflorescence blast, aborted floral buds appeared sporadically on a small scale. Spirea species were split into four categories according to the incidence of blasted inflorescences. Out of 52 species evaluated, 10% showed no or scarce incidence, 52% medium incidence, 27% high incidence and 11% very high incidence. The scarce incidence of blasted inflorescences was connected with the high seed production. And vice versa, very high incidence of blighted inflorescences was closely connected with no or low seed production or with high incidence of sterility. Fifteen out of the evaluated spirea species are the result of hybridization. These hybrids occur in each of the four categories of spirea species distinguished by the incidence of blasted inflorescence. However, it is remarkable that the highest incidence of hybrid spireas occurs in the category with the highest incidence of blasted inflorescence (83.33%). In the remaining three categories of spirea species, the proportion of hybrids ranged from 18 to 21%. It might indicate some connection of spirea hybrids with sterility.

scholarly journals A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment

Nanomedicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 41-54 ◽  
Author(s):  
Xin Jin ◽  
Qing Yang ◽  
Ning Cai ◽  
Zhenhai Zhang
Keyword(s):  
Lung Cancer ◽  
Natural Products ◽  
Betulinic Acid ◽  
Synergistic Action ◽  
Ginsenoside Rh2 ◽  
High Incidence ◽  
High Incidence Rate ◽  
Very High

Aim: Lung cancer has a very high incidence rate, and thus, there is an urgent need for novel and effective therapies. Materials & methods: In this study, we proposed a potential treatment option by combining four natural products in liposome systems. Results: In vitro studies indicated that the combination of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 exhibited a synergistic action. When these four natural products were loaded into liposome systems, we observed an increased effect. The relative action was also observed in vivo. The cisplatin group presented obvious kidney damage, whereas both cocktail therapy and cocktail liposome therapy were safer. Conclusion: Therefore, we propose cocktail liposome systems may provide a more efficient and safer treatment for lung cancer.

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