Valorization of sage extracts (Salvia officinalis L.) obtained by high voltage electrical discharges: Process control and antioxidant properties

2020 ◽  
Vol 60 ◽  
pp. 102284 ◽  
Author(s):  
Marinela Nutrizio ◽  
Jasenka Gajdoš Kljusurić ◽  
Marija Badanjak Sabolović ◽  
Danijela Bursać Kovačević ◽  
Filip Šupljika ◽  
...  
Keyword(s):  
Process Control ◽  
High Voltage ◽  
Antioxidant Properties ◽  
Salvia Officinalis ◽  
Electrical Discharges ◽  
Salvia Officinalis L

scholarly journals Salvia officinalis L. from Italy: A Comparative Chemical and Biological Study of Its Essential Oil in the Mediterranean Context

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5826
Author(s):  
Rosa Tundis ◽  
Mariarosaria Leporini ◽  
Marco Bonesi ◽  
Simone Rovito ◽  
Nicodemo G. Passalacqua
Keyword(s):  
Gas Chromatography ◽  
Essential Oil ◽  
Antioxidant Properties ◽  
Salvia Officinalis ◽  
Biologically Active ◽  
In Vitro Assays ◽  
Biological Study ◽  
Reducing Ability ◽  
The Mediterranean ◽  
Salvia Officinalis L

Salvia officinalis L. (sage) is one of the most appreciated plants for its plethora of biologically active compounds. The objective of our research was a comparative study, in the Mediterranean context, of chemical composition, anticholinesterases, and antioxidant properties of essential oils (EOs) from sage collected in three areas (S1–S3) of Southern Italy. EOs were extracted by hydrodistillation and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory properties were investigated by employing Ellman’s method. Four in vitro assays, namely, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric-reducing ability power (FRAP), and β-carotene bleaching tests, were used to study the antioxidant effects. Camphor (16.16–18.92%), 1,8-cineole (8.80–9.86%), β-pinene (3.08–9.14%), camphene (6.27–8.08%), and α-thujone (1.17–9.26%) are identified as the most abundant constituents. However, the content of these constituents varied depending on environmental factors and pedoclimatic conditions. Principal component analysis (PCA) was performed. Based on Relative Antioxidant Capacity Index (RACI), S2 essential oil exhibited the highest radical potential with an IC50 value of 20.64 μg/mL in ABTS test and presented the highest protection of lipid peroxidation with IC50 values of 38.06 and 46.32 μg/mL after 30 and 60 min of incubation, respectively. The most promising inhibitory activity against BChE was found for S3 sample (IC50 of 33.13 μg/mL).

scholarly journals COMPARATIVE STUDY OF ANTIOXIDANT ACTIVITY, PHENOLIC COMPOUNDS AND FLAVONOIDS OF LINDEN-SHAPED FLOWERS OF THE HEART (TILIA CORDATA MILL.), MEDICINAL SAGE (SALVIA OFFICINALIS L.), MEDICINAL SWEET CLOVER (MELILOTUS OFFICINALIS L.), CURRANT LEAVES (RIBES NIGR

2019 ◽  
pp. 153-159 ◽  
Author(s):  
Sof'ya Anatol'yevna Aleksashina ◽  
Nadezhda Viktorovna Makarova
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
Salvia Officinalis ◽  
Biologically Active ◽  
Tilia Cordata ◽  
Restoring Force ◽  
Antioxidant Power ◽  
Melilotus Officinalis ◽  
Wild Strawberry ◽  
Salvia Officinalis L

A reliable source of increased intake of vitamins and biologically active substances are not only berries and fruits, but also herbs. This article is devoted to the analysis of plant samples for antioxidant activity. The objects of study were selected herbs and flowering woody plants of the Samara region: small-leaved linden color (Tilia cordata), medicinal sage (Salvia officinalis L.), medicinal clover (Melilоtus officinalis), currant leaf (Folium Ribes nigrum), wild strawberry (Fragum folium silvam), grapes (Vitis labrusca). Plant material collected in the phase of mass flowering. Aqueous alcoholic extracts (1 : 1 ratio) were obtained from the samples at 37 °C for 2 hours. Anti-radical activity was tested using the free radical DPPH (2,2-diphenyl-1-pilkrilgidrazil), restoring force the FRAP method (Ferric Reduction Antioxidant Power), antioxidant activity in the linoleic acid system and the content of phenols, flavonoids. Analyzing the results obtained in this work, we can conclude about the presence of antioxidant properties. The leader in anti-radical activity and regenerative power was a currant leaf, a high content of phenols has linden color, the maximum content of flavonoids was also recorded in a currant leaf.

Chemical composition of essential oils from leaves and twigs with leaves of two new varieties of common sage (Salvia officinalis L.)

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
A Aprotosoaie ◽  
E Gille ◽  
A Spac ◽  
M Gonceariuc ◽  
M Hancianu ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oils ◽  
Salvia Officinalis ◽  
New Varieties ◽  
Salvia Officinalis L

Contribution to the Optimization of a Gas Chromatographic Method by QbD Approach used for Analysis of Essential Oils from Salvia officinalis

2019 ◽  
Vol 70 (6) ◽  
pp. 2015-2020
Author(s):  
Silvia Robu ◽  
Aurelia Romila ◽  
Olimpia Dumitriu Buzia ◽  
Adrian Florin Spac ◽  
Camelia Diaconu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Plant Material ◽  
Mobile Phase ◽  
Chromatographic Method ◽  
Salvia Officinalis ◽  
Salvia Officinalis L ◽  
Gas Chromatographic Method

Numerous articles on Salvia officinalis L. have been published regarding the composition of their essential oil. The considerable variation found may be due to the quality of the plant material as well as to the methods used for analysis. A simple GC-MS method was developed and optimized in the QbD approach, for the determination of sage essential oils. The optimization of GC-MS analysis was performed using different mobile phase flows, injection volumes, split ratios and temperature programs. The optimized method proved to be simple and can be successfully applied for the determination of sage essential oils.

Therapeutic Properties of Several Chemical Compounds from Salvia officinalis L. in Alzheimer’s Disease

2020 ◽  
Vol 21 ◽  
Author(s):  
Georgiana Uță ◽  
Denisa Ștefania Manolescu ◽  
Speranța Avram
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Side Effects ◽  
Chemical Compounds ◽  
Natural Compounds ◽  
Salvia Officinalis ◽  
Chemical Structures ◽  
In Silico Studies ◽  
Wide Range ◽  
Salvia Officinalis L

Background.: Currently, the pharmacological management in Alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate (NMDA) receptor ligands, with still unclear molecular mechanisms, but severe side effects. For this reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side effects. Recently, the natural compounds, in particular certain chemical compounds identified in the essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible therapeutics. Objectives.: In this paper, we have summarized data from the recent literature, on several chemical compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease. Methods.: In addition to the wide range of experimental methods performed in vivo and in vitro, also we presented some in silico studies of medicinal compounds. Results. Through this mini-review, we present the latest information regarding the therapeutic characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease. Conclusion.: Thus, based on the information presented, we can say that phytotherapy is a reliable therapeutic method in a neurodegenerative disease.

Identification and Determination of the Components of Garden Sage (Salvia officinalis L.) Essential Oil, Isolated by Different Extraction Methods

2020 ◽  
Vol 75 (11) ◽  
pp. 1451-1460
Author(s):  
Z. A. Temerdashev ◽  
V. V. Milevskaya ◽  
L. P. Ryabokon’ ◽  
N. N. Latin ◽  
N. V. Kiseleva ◽  
...  
Keyword(s):  
Essential Oil ◽  
Extraction Methods ◽  
Salvia Officinalis ◽  
Salvia Officinalis L

scholarly journals Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.)

2021 ◽  
Vol 22 (14) ◽  
pp. 7382
Author(s):  
Nancy Chiang ◽  
Shahla Ray ◽  
Jade Lomax ◽  
Sydney Goertzen ◽  
Slavko Komarnytsky ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Neurotrophic Factor ◽  
High Performance ◽  
Memory Function ◽  
Brain Derived Neurotrophic Factor ◽  
Salvia Officinalis ◽  
C6 Glioma Cells ◽  
Medicinal Uses ◽  
Bdnf Signaling ◽  
Salvia Officinalis L

Culinary sage (Salvia officinalis L.) is a common spice plant in the mint family (Lamiaceae) well known for its distinctive culinary and traditional medicinal uses. Sage tea has been used traditionally as a brain-enhancing tonic and extracts from sage have been reported to have both cognitive and memory enhancing effects. Brain-derived neurotrophic factor (BDNF) is an endogenous signaling molecule involved in cognition and memory function. In this study, activity-guided fractionation employing preparative reverse-phase high performance liquid chromatography (RP-HPLC) of culinary sage extracts led to the discovery of benzyl 6-O-β-D-apiofuranosyl-β-D-glucoside (B6AG) as a natural product that upregulates transcription of neurotrophic factors in C6 glioma cells. Purified B6AG showed a moderate dose response, with upregulation of BDNF and with EC50 at 6.46 μM. To better understand the natural variation in culinary sage, B6AG was quantitated in the leaves of several commercial varieties by liquid chromatography-mass spectrometry (LC-MS). The level of B6AG in dried culinary sage was found to range from 334 ± 14 to 698 ± 65 μg/g. This study provided a foundation for future investigations, including quantitative inquiries on the distribution of B6AG within the different plant organs, explorations in optimizing post-harvest practices, and aid in the development of sage varieties with elevated levels of B6AG.

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