Synthesis and antioxidant properties of gum arabic-stabilized selenium nanoparticles

2014 ◽  
Vol 65 ◽  
pp. 155-162 ◽  
Author(s):  
Huiling Kong ◽  
Jixin Yang ◽  
Yifeng Zhang ◽  
Yapeng Fang ◽  
Katsuyoshi Nishinari ◽  
...  
Keyword(s):  
Antioxidant Properties ◽  
Gum Arabic ◽  
Selenium Nanoparticles

scholarly journals Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells

2020 ◽  
Vol 991 ◽  
pp. 012101
Author(s):  
A Hassani ◽  
S A Hussain ◽  
H H Enezei ◽  
S Saeed ◽  
W N Ibrahim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Antioxidant Properties ◽  
Gum Arabic

scholarly journals Spray Drying ofRhodomyrtus tomentosa(Ait.) Hassk. Flavonoids Extract: Optimization and Physicochemical, Morphological, and Antioxidant Properties

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Pingping Wu ◽  
Qian Deng ◽  
Guangzhi Ma ◽  
Nianghui Li ◽  
Yanyan Yin ◽  
...  
Keyword(s):  
Spray Drying ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Storage Period ◽  
Gum Arabic ◽  
Total Solid ◽  
Solid Content ◽  
Spherical Particles ◽  
Total Solid Content

The optimal condition of spray drying purified flavonoids extract fromR. tomentosaberries was studied by response surface methodology. The optimized condition for microencapsulation was of maltodextrin to gum Arabic ratio 1 : 1.3, total solid content 27.4%, glycerol monostearate content 0.25%, and core to coating material ratio 3 : 7, resulting in EE 91.75%. Prepared at the optimized condition, the flavonoids extract microcapsules (FEMs) were irregularly spherical particles with low moisture content (3.27%), high solubility (92.35%), and high bulk density (0.346 g/cm3). DPPH radical scavenging activity of FEMs was not decreased after spray drying (P>0.05) and higher than those in citric acid and rutin at the same concentration. Moreover, FEMs effectively retarded the oxidation of fresh lard during the 10-day storage period compared with vitamin C, nonencapsulated flavonoids extract, and rutin. Therefore, FEMs produced at the optimized condition could be used as powder ingredients with antioxidant capacities.

scholarly journals Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Abdelkader Hassani ◽  
Mohammad Mahdi Sabaghpour Azarian ◽  
Wisam Nabeel Ibrahim ◽  
Siti Aslina Hussain
Keyword(s):  
Cell Migration ◽  
Cancer Cells ◽  
Gallic Acid ◽  
Cell Lines ◽  
Antioxidant Properties ◽  
Gum Arabic ◽  
Breast Adenocarcinoma ◽  
Therapeutic Effects ◽  
Dependent Manner

Abstract Gallic acid (GA) is a natural phenolic compound with therapeutic effects that are often challenged by its rapid metabolism and clearance. Therefore,  GA was encapsulated using gum arabic into nanoparticles to increase its bioavailability. The formulated nanoparticles (GANPs) were characterized for physicochemical properties and size and were then evaluated for antioxidant and antihypertensive effects using various established in vitro assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide scavenging (NO), β-carotene bleaching and angiotensin-converting enzyme (ACE) inhibitory assays. The GANPs were further evaluated for the in vitro cytotoxicity, cell uptake and cell migration in four types of human cancer cell lines including (MCF-7, MDA-MB231) breast adenocarcinoma, HepG2 hepatocellular cancer, HT-29 colorectal adenocarcinoma, and MCF-10A breast epithelial cell lines. The GANPs demonstrated potent antioxidant effects and have shown promising anti-cancer properties in a dose-dependent manner with a predilection toward HepG2 and MCF7 cancer cells. The uptake of GANPs was successful in the majority of cancer cells with a propensity to accumulate in the nuclear region of the cells. The HepG2 and MCF7 cancer cells also had a significantly higher percentage of apoptosis and were more sensitive to gallic acid nanoparticle treatment in the cell migration assay. This study is the first to confirm the synergistic effects of gum arabic in the encapsulation of gallic acid by increasing the selectivity towards cancer cells and enhancing  the antioxidant properties. The formulated nanoparticles also had remarkably low toxicity in normal cells. Based on these findings, GANPs may have promising therapeutic applications towards the development of more effective treatments with a probable targeting precision in cancer cells.

scholarly journals Gum Arabic/Gelatin and Water-Soluble Soy Polysaccharides/Gelatin Blend Films as Carriers of Astaxanthin—A Comparative Study of the Kinetics of Release and Antioxidant Properties

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1062
Author(s):  
Katarzyna Łupina ◽  
Dariusz Kowalczyk ◽  
Waldemar Kazimierczak
Keyword(s):  
Release Rate ◽  
Antioxidant Properties ◽  
Gum Arabic ◽  
Blocking Agent ◽  
Water Soluble ◽  
Polymer Blending ◽  
Blend Films ◽  
Time Required ◽  
Kinetics Of ◽  
Active Substances

Polymer blending and incorporation of active substances offer a possibility of generation of novel packaging materials with interesting features. Astaxanthin is one of the most powerful antioxidants. Hence, in this study, water-soluble AstaSana astaxanthin (AST) was incorporated into 75/25 gum arabic/gelatin (GAR75/GEL25) and water-soluble soy polysaccharides/gelatin (WSSP75/GEL25) blend films in different concentrations (0, 0.25%, 0.5%, 1%). Microscope images showed good compatibility between the polysaccharides and GEL. Basing on time required for 50% release, the WSSP-based film exhibited an approximately four-fold slower release rate (t50% = 65.16–142.80 min) than the GAR-based film (t50% = 14.64–34.02 min). This result was mainly ascribed to the slower dissolution of the WSSP-based carrier. The faster release rate of the GAR-based films resulted in stronger antioxidant activity (quarter-scavenging time (t25%ABTS) = 0.22–7.51 min) in comparison to the WSSP-based films (t25%ABTS = 0.91–12.94 min). The increase in the AST concentration was accompanied by gradually reduced solubility and the release rate. It is possible that the increasing number of starch granules (from the AST formulation) acted as a dissolution blocking agent. In general, the WSSP75/GEL25 film displayed the most linear (the Zero-order similar) release profile. So, this carrier has potential for release of AST at a quasi-constant speed.

scholarly journals Transcriptome Analysis Identifies Novel Mechanisms Associated with the Antitumor Effect of Chitosan-Stabilized Selenium Nanoparticles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 356
Author(s):  
Hector Estevez ◽  
Estefania Garcia-Calvo ◽  
Jose Rivera-Torres ◽  
María Vallet-Regí ◽  
Blanca González ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Transcriptome Analysis ◽  
Tumor Suppressors ◽  
Antitumor Effect ◽  
Antioxidant Properties ◽  
Selenium Nanoparticles ◽  
Hepatocarcinoma Cells ◽  
Antitumor Properties ◽  
Global Transcriptome ◽  
Human Hepatocarcinoma Cells

Selenium nanoparticles (SeNPs) have been receiving special attention in recent years due to their antioxidant capacity and antitumor properties. However, the mechanisms associated with these properties remain to be elucidated. For this reason, a global transcriptome analysis has been designed in this work and it was carried out using human hepatocarcinoma cells and chitosan-stabilized SeNPs (Ch-SeNPs) to identify new targets and pathways related to the antitumor mechanisms associated with Ch-SeNPs. The results obtained confirm the alteration of the cell cycle and the effect of Ch-SeNPs on different tumor suppressors and other molecules involved in key mechanisms related to cancer progression. Furthermore, we demonstrated the antioxidant properties of these nanoparticles and their capacity to induce senescence, which was further confirmed through the measurement of β-galactosidase activity.

scholarly journals Enhanced Microencapsulation of C-Phycocyanin from Arthrospira by Freeze-Drying with Different Wall Materials

2020 ◽  
Vol 58 (4) ◽  
Author(s):  
Wanida Pan-utai ◽  
Siriluck Iamtham
Keyword(s):  
Thermal Stability ◽  
Antioxidant Activity ◽  
Moisture Content ◽  
Water Activity ◽  
Freeze Drying ◽  
Antioxidant Properties ◽  
Gum Arabic ◽  
Water Soluble ◽  
Freeze Dried ◽  
Wall Materials

Research background. C-phycocyanin (C-PC) as a water-soluble blue pigment was extracted from microalga Arthrospira. C-PC could be a good substitute for synthetic pigments with high antioxidant activity. However, C-PC is unstable due to sensitivity to temperature, light, pH, and oxygen; therefore applications of C-PC in food and other products are limited. Microencapsulation of C-PC using freeze-drying is a solution to this problem and is considered a suitable method for drying heat-sensitive pigment. Experimental approach. C-phycocyanin was extracted from Arthrospira platensis. C-phycocyanin microcapsules were modified by freeze-drying, with different ratios at 0-100 % of maltodextrin (MD) and gum Arabic (GA) used as microencapsulation wall materials. The powders produced were evaluated for physical properties including moisture content and water activity, solubility, hygroscopicity, bulk density, colour appearance, particle morphology and size distribution. Thermal stability and antioxidant activity of freeze-dried C-PC microencapsulated powders were also assessed. Results and conclusions. Freeze-dried C-PC microencapsulated powders with maltodextrin and gum Arabic as wall materials gave high encapsulation efficiency of around 99 %. At higher gum Arabic percentage, moisture content decreased and water activity improved. Maltodextrin gave higher solubility of C-PC powders whereas gum Arabic led to a similar colour of C-PC without microencapsulation. Freeze-dried C-PC microencapsulated powders were composed of different sized microparticles regardless of the combination of wall materials with amorphous glassy shapes. Thermal stability of encapsulated C-PC increased and also showed high antioxidant properties. Novelty and scientific contribution. C-PC microcapsules that maintain colourant stability with high antioxidant levels and resistance to high temperatures can be applied in a wide variety of products and also in the food industry.

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