Using herbal medicine (Cheong-Yeol Sodang-decoction) for fasting blood glucose in patients with diabetes mellitus and pre-diabetes mellitus: a retrospective chart review

Background: This study investigated the effectiveness and safety of switching from Basalin® to Lantus® in Chinese patients with diabetes mellitus (DM). Methods: A retrospective chart review conducted using the electronic medical records of patients hospitalized at the Qingdao Endocrine and Diabetes Hospital from 2005 to 2016. All patients were diagnosed with DM and underwent switching of insulin from Basalin to Lantus during hospitalization. Data collected included fasting (FBG), pre- and post-prandial whole blood glucose, insulin dose, reasons for insulin switching and hypoglycemia. Four study time points were defined as: hospital admission, Basalin initiation, insulin switching (date of final dose of Basalin), and hospital discharge. Blood glucose measurements were imputed as the values recorded closest to the dates of these four time points for each patient. Results: Data from 73 patients (70 patients with type 2 diabetes, 2 with type 1, and 1 undisclosed) were analyzed. At admission, mean glycated hemoglobin (HbA1c) and FBG were 8.9% (SD=1.75) and 9.98 (3.22) mmol/L, respectively. Between Basalin initiation and insulin switch, mean FBG decreased from 9.68 mmol/L to 8.03 mmol/L (p<0.0001), over a mean 10.8 (SD=6.85) days of Basalin treatment, and reduced further to 7.30 mmol/L at discharge (p=0.0116) following a mean 6.6 (7.36) days of Lantus. The final doses of Basalin and Lantus were similar (0.23 vs. 0.24 IU/kg/day; p=0.2409). Furthermore, reductions in pre- and post-prandial blood glucose were also observed between Basalin initiation, insulin switch and hospital discharge. The incidence of confirmed hypoglycemia was low during Basalin (2 [2.4%]) and Lantus (1 [1.2%]) treatment, with no cases of severe hypoglycemia. Conclusion: In this study population, switching from Basalin to Lantus was associated with further reductions in blood glucose, although the dose of insulin glargine did not increase. Further studies are required to verify these findings and determine the reason for this phenomenon.

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PENGARUH JUS LIDAH BUAYA TERHADAP KADAR GLUKOSA DARAH PUASA DAN 2 JAM PP(Post Prandial) PADA PENDERITA DIABETES MELITUS

Jurnal Kesehatan Medika Saintika ◽

10.30633/jkms.v10i1.311 ◽

2019 ◽

Vol 10 (1) ◽

pp. 77

Author(s):

Febria Syafyu Sari ◽

Ridhyalla Afnuhazi

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Fasting Blood Glucose ◽

Aloe Vera ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Patients With Diabetes ◽

Paired T Test ◽

Diabetes Melitus

ABSTRAK Diabetes Melitus merupakan penyakit yang paling menonjol yang disebabkan oleh gagalnya pengaturan gula darah. Lidah buaya berkhasiat untuk menurunkan kadar gula dalam darah bagi penderita diabetes dan dapat mengontrol tekanan darah. Tujuan penelitian untuk mengetahui pengaruh jus lidah buaya (AloeBarbadensis Miller) terhadap penurunan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Desain penelitian merupakan Quasi Eksperimental dengan pendekatan one group pretest – postest design. Sampel terbagi menjadi 14 responden. Data dianalisis dengan paired t-test. Hasil menunjukan rata-rata penurunan glukosa darah puasa pada intervensi (28,42 gr/dl) dan glukosa darah 2 jam pp pada intervensi (40,57 gr/dl). Untuk analisis bivariat terdapat perbedaan antara glukosa puasa dan 2 jam pp dengan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Kesimpulan didapatkanlidah buaya dapat menurunkan kadar glukosa darah.Berdasarkan hasil penelitian jus lidah buaya dapat menjadi salah satu alternatif keperawatan non farmakologi dalam penyakit diabetes melitus. Kata Kunci : Lidah Buaya ; Diabetes Mellitus THE EFFECT OF VEGETABLE VOCATIONAL JUICE ON FAST BLOOD GLUCOSE LEVELS AND 2 HOURS OF PP (Post Prandial) IN DIABETES MELLITUS ABSTRACT Diabetes mellitus is the most prominent disease caused by the failure of blood sugar regulation. Aloe vera is efficacious can to reduce blood sugar levels for diabetics and can control blood pressure. The purpose of this study was to determine the effect of Aloe Barbadensis Miller on the reduction of fasting blood glucose GDP and 2 hours of PP (post prendial) in patients with diabetes mellitus. The research design is Experimental Quasi with one group pretest - postest design approach. The sample is divided into 14 respondents. Data were analyzed by paired t-test. The results showed an average decrease in fasting blood glucose at intervention (28.42 gr / dl) and 2 hours pp blood glucose at intervention (40.57 gr / dl). For bivariate analysis there was a difference between fasting glucose and 2 hours pp with fasting blood glucose GDP) and 2 hours PP (Post Prendial) in patients with diabetes mellitus. The conclusion is that aloe vera can reduce blood glucose levels. Based on the results of research on aloe vera juice can be an alternative non-pharmacological nursing in diabetes mellitus. Keywords: Aloe Vera ; Diabetes Mellitus

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Blood Glucose Level And Candida spp. Growth In Elderly Diabetes Melitus Patients

Medical Laboratory Technology Journal ◽

10.31964/mltj.v4i1.174 ◽

2018 ◽

Vol 4 (1) ◽

pp. 1

Author(s):

Rifqoh Rifqoh ◽

Syaidatul Aslamiah ◽

Jujuk Anton Cahyono ◽

Erpan Roebiakto

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Fasting Blood Glucose ◽

Fasting Blood Glucose Level ◽

Candida Spp ◽

Cross Sectional ◽

Patients With Diabetes ◽

Medium Level

Diabetes mellitus is a presdisposing factor against infection, especially in orofacial area. Infectious diseases are more frequent serious in patients with diabetes mellitus, which potentially increases their morbimortality. The more frequent oral mucosa infection of DM patients is candidiasis which caused by Candida spp. This research is aimed to obtain the correlation between fasting blood glucose level and Candida spp. growth in elderly diabetes mellitus patients. This analytical survey research used cross-sectional design through GOD-PAP methode for fasting blood glucose level test and macroscopic method for total colony of Candida spp. growth. The result of fasting blood glucose level test average 186,06 mg/dl the highest level is 492,90 mg/dl and the lowest one is 72,08 mg/dl. Meanwhile, the result of Candida spp. is 131 at the average and the highest growth is 350 and the lowest one is 12 colonies. The result of the research indicates that there is a rising of Candida spp. to level of fasting blood glucose in elderly diabetes mellitus patients. Based on correlational test of spearman, it gains significant value 0,001 < α = 0,005 of that shows there is a correlation between fasting blood glucose level and Candida spp. growth in diabetes mellitus elderly patients with the strenght relation (r) = 0,572 which means in medium level. Further researches about the influence to the other presdisposing factors of Candida spp. growth are recommended

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Outcomes of Clinical Treatments Among Patients with Diabetes Mellitus in Selangor, Malaysia: A Retrospective Study

Current Diabetes Reviews ◽

10.2174/1573399817999210112191330 ◽

2021 ◽

Vol 17 ◽

Author(s):

Zamalia Mahmud ◽

Syahidatul Alyia Abrahhim ◽

Saperi Sulong

Keyword(s):

Diabetes Mellitus ◽

Retrospective Study ◽

Blood Glucose ◽

Family History ◽

Medical Center ◽

Fasting Blood Glucose ◽

Family History Of Diabetes ◽

Patients With Diabetes ◽

History Of

Background: It is important to assess how well patients respond towards their medical treatments by observing the results appear during the clinical treatments. As such, it is important that the clinical treatments and results obtain information on how effective recommended treatments were for patients with diabetes. Objective: This study examines how patients with Diabetes Mellitus responded towards their clinical treatments, where the probability distribution of patients and the types of treatment received were derived from the Rasch probabilistic model. Methods: This is a retrospective study wherein data were collected from patients’ medical records at a local public hospital in Selangor, Malaysia. Clinical and demographic information such as fasting blood glucose, hemoglobin A1c (HbA1c), family history, type of diabetes (Type 1 or Type 2), types of medication (oral or insulin), compliance with treatments, gender, race and age were chosen as the agents of measurement. Results: The use of Rasch analysis in the present study helped to compare the patients’ responses towards the DM treatments and identify the types of treatment they received. Results from the Wright map show that a majority of the Diabetes Mellitus patients who were diagnosed with Type 2 diabetes have no controlled readings of HbA1c during their first and second visits to the medical center. However, patients with a family history of Diabetes Mellitus who took oral medication have controlled readings of fasting blood glucose based on the probabilistic outcomes of the treatment received by the patients. Conclusion: Controlled readings were found only in the readings of fasting blood glucose during the first and second visits, followed by family history, types of medication received and compliance with the treatment. This study has recommended that Type 2 patients with diabetes without a family history of Diabetes Mellitus need to exercise more control over the readings of HbA1c.

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Stress, Nutritional Status and Blood Glucose Levels among Patients with Diabetes Mellitus Type 2

International Journal of Public Health Science (IJPHS) ◽

10.11591/ijphs.v7i4.14914 ◽

2018 ◽

Vol 7 (4) ◽

pp. 283

Author(s):

Dyah Ayu Kusuma Wardani ◽

Sugiarto Sugiarto ◽

Risya Cilmiaty

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Nutritional Status ◽

Fasting Blood Glucose ◽

Cross Sectional ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Patients With Diabetes ◽

Dm Type 2

Prevalence of diabetes mellitus (DM) was increased significantly. Stress increased cortisol could increase blood glucose levels while obesity could increase insulin resistance. Objective of this study was to examine correlation of stress and nutritional status with blood glucose levels in patients with DM type 2. Design study was cross sectional using 120 samples from patients with DM type 2 at Polyclinic of Internal Disease Dr. Moewardi Hospital Surakarta during April-May 2018. Variables in this study were stress with perceived stress scale 10 items (PSS-10), nutritional status with body mass index (BMI) and blood glucose levels with fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) examination. The results showed that mean of FBG was 152.9±63.66 mg/dL and PPBG was 213.96±70.17 mg/dL. There was no significant correlation between stress and blood glucose levels, by FBG (p=0.389) and PPBG (p=0.202). However, there was significant correlation between nutritional status and PPBG (p=0.016), but FBG was not significant (p=0.209). In conclusion, there was significant correlation between nutritional status and PPBG in patients with DM type 2, but FBG was not significant. However, there was no significant correlation between stress and blood glucose levels in patients with DM type 2.

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Comorbid Diabetes Mellitus was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study

10.1101/2020.03.24.20042358 ◽

2020 ◽

Cited By ~ 11

Author(s):

Yan Zhang ◽

Yanhui Cui ◽

Minxue Shen ◽

Jianchu Zhang ◽

Ben Liu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cohort Study ◽

Blood Glucose ◽

Clinical Laboratory ◽

Invasive Mechanical Ventilation ◽

Fasting Blood Glucose ◽

Incidence Rates ◽

World Health ◽

Established Risk Factor ◽

Patients With Diabetes

ABSTRACTBackgroundThe 2019 novel coronavirus disease (COVID-19) emerged in Wuhan, Hubei province, China, and was characterized as pandemic by the World Health Organization. Diabetes mellitus is an established risk factor for poor clinical outcomes, but the association of diabetes with the prognosis of COVID-19 have not been reported yet.MethodsIn this cohort study, we retrospectively reviewed 258 consecutive hospitalized COVID-19 patients with or without diabetes at the West Court of Union Hospital of Huazhong University of Science and Technology in Wuhan, China, recruited from January 29 to February 12, 2020. The cases were confirmed by real-time PCR and the demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Prognosis was defined as hospitalization, discharged survivor and death, which was followed up until March 12, 2020.ResultsOf the 258 hospitalized patients (63 with diabetes) with COVID-19, the median age was 64 years (range 23-91), and 138 (53.5%) were male. No significant differences in age and sex were identified between patients with and without diabetes. Common symptoms included fever (82.2%), dry cough (67.1%), polypnea (48.1%), and fatigue (38%). Patients with diabetes had significantly higher leucocyte and neutrophil counts, and higher levels of fasting blood glucose, serum creatinine, urea nitrogen and creatine kinase isoenzyme MB at admission compared with those without diabetes. COVID-19 patients with diabetes were more likely to develop severe or critical disease condition with more complications at presentation, and had higher incidence rates of antibiotic therapy, non-invasive and invasive mechanical ventilation, and death (11.1% vs. 4.1%). Cox proportional hazard model showed that diabetes (adjusted hazard ratio [aHR]=3.64; 95% confidence interval [CI]: 1.09, 12.21) and fasting blood glucose (aHR=1.19; 95% CI: 1.08, 1.31) were associated with the fatality of COVID-19, adjusting for potential confounders.ConclusionsDiabetes mellitus is associated with greater disease severity and a higher risk of mortality in patients with COVID-19. Primary and secondary prevention strategies are needed for COVID-19 patients with diabetes.

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Self-monitoring of blood glucose and perceived obstacles in Turkish patients with diabetes mellitus

Endocrine Abstracts ◽

10.1530/endoabs.35.p483 ◽

2014 ◽

Author(s):

Ozlem Turhan Iyidir ◽

Mustafa Unubol ◽

Bulent Ogun Hatipoglu ◽

Ceyla Konca Degertekin

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Self Monitoring ◽

Patients With Diabetes ◽

Turkish Patients

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Neuropathy in the gut. Gut motility disorders in patients with diabetes mellitus

Orvosi Hetilap ◽

10.1556/oh.2012.29360 ◽

2012 ◽

Vol 153 (16) ◽

pp. 607-614

Author(s):

Tibor Wittmann

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Treatment Modalities ◽

Clinical Aspects ◽

Gut Motility ◽

Motility Disorders ◽

The Everyday ◽

Patients With Diabetes ◽

Leading Symptom ◽

Different Parts

The extent and severity of motility disorders remains heterogeneous in the different parts of the gut, and in most cases failures in gut motility do not correspond with the severity of the symptoms. If diarrhea or fecal incontinence is the leading symptom, or the blood glucose level varies frequently and considerably despite the treatment efforts, the motility of the stomach and bowels is seriously disturbed. The clinical aspects, detailed pathogenesis, diagnostic approach and treatment modalities of gastrointestinal motility disorders in diabetes mellitus are reviewed to help and improve the everyday medical practice. Orv. Hetil., 2012, 153, 607–614.

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Anti-Diabetic Effect of a Flavonoid and Sitosterol - Rich Aqueous Extract ofPleurotus tuberregiumSclerotia in Alloxan-Induced Diabetic Rabbits

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666190206213843 ◽

2019 ◽

Vol 19 (8) ◽

pp. 1148-1156 ◽

Cited By ~ 3

Author(s):

Ifeanacho Mercy Onuekwuzu ◽

Ikewuchi Catherine Chidinma ◽

Ikewuchi Jude Chigozie

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Aqueous Extract ◽

Risk Index ◽

Fasting Blood Glucose ◽

Hdl Cholesterol ◽

The Body ◽

Atherogenic Index ◽

Atherogenic Indices ◽

Diabetic Rabbits

Objective:Traditionally prepared infusions and decoctions are commonly used in the management of diabetes mellitus, in southern Nigeria; one of such is the aqueous extract of the sclerotia of Pleurotus tuberregium (“usu” milk). In this study, the effects of the extract on the body weights, tissue/ organ weights, fasting blood glucose, blood/plasma lipid profiles and atherogenic indices were investigated in normal and alloxan-induced diabetic rabbits.Methods:Diabetes mellitus was induced by the injection of alloxan (120 mg/kg body weight) via the marginal ear vein. The extract was administered orally at 100, 200 and 300 mg/kg to normal and diabetic rabbits; while metformin was administered at 50 mg/kg. The crude extract was analyzed by gas chromatography, coupled to flame ionization detector.Results:Thirty-one known flavonoids were detected, consisting mainly of isoquercetin (28.5%), luteolin (24.3%), quercetin (18.8%) and kaempferol (11.3%). Sitosterol (82.0%) and stigmasterol (12.5%) were the most abundant of the seven phytosterols detected. Compared to the diabetic control, the treatment significantly (p<0.05) lowered the weights of the kidney and liver, as well as the levels of blood glucose and triglyceride, plasma VLDL, LDL and non-HDL cholesterol, atherogenic index of plasma, cardiac risk ratio, atherogenic coefficient and Castelli’s risk index II. It, however, significantly (p<0.05) increased plasma HDL cholesterol, without significantly affecting blood total cholesterol levels.Conclusion:This study showed that the extract was hypoglycemic, and improved lipid profile and atherogenic indices, thus highlighting its cardioprotective potential, thereby supporting its use in the management of diabetes mellitus.

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Epigenetic modulation of autophagy genes linked to diabetic nephropathy by administration of isorhamnetin in Type 2 diabetes mellitus rats

Epigenomics ◽

10.2217/epi-2020-0353 ◽

2021 ◽

Author(s):

Marwa Matboli ◽

Doaa Ibrahim ◽

Amany H Hasanin ◽

Mohamed Kamel Hassan ◽

Eman K Habib ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Light And Electron Microscopy ◽

Lipid Profiles ◽

Mirna Regulation ◽

Protein Levels

Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnetin (50 mg/kg/d) for 4 or 8 weeks. Fasting blood glucose, renal and lipid profiles were evaluated. Renal tissues were examined by light and electron microscopy. Autophagy genes ( FYCO1, ULK, TECPR1 and WIPI2) and miR-15b, miR-34a and miR-633 were assessed by qRT-PCR, and LC3A/B by immunoblotting. Results: Isorhamnetin improved fasting blood glucose, renal and lipid profiles with increased autophagosomes in renal tissues. It suppressed miRNA regulation of autophagy genes Conclusion: We propose a molecular mechanism for the isorhamnetin renoprotective effect by modulation of autophagy epigenetic regulators.

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