Traditionally used polyherbals in a southern African therapeutic context

2022 ◽  
pp. 114977
Author(s):  
S.F. Van Vuuren ◽  
K.E. Motlhatlego ◽  
V. Netshia
Keyword(s):  
Therapeutic Context

Metastatic Colorectal Cancer: Prognostic and Predictive Factors

2020 ◽  
Vol 27 (17) ◽  
pp. 2779-2791 ◽  
Author(s):  
Anna Nappi ◽  
Guglielmo Nasti ◽  
Carmela Romano ◽  
Massimiliano Berretta ◽  
Alessandro Ottaiano
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Predictive Factors ◽  
Cancer Biology ◽  
Clinical Course ◽  
Molecular Signatures ◽  
Biological Drugs ◽  
The Third ◽  
Therapeutic Context ◽  
Prognostic And Predictive Factors

: Colorectal cancer represents the third most frequently occurring cancer worldwide. In the last decade, the survival of patients affected by metastatic colorectal cancer (mCRC) has improved through the introduction of biological drugs. However, in this new and dynamic therapeutic context, research about prognostic and predictive factors is important to guide the oncologists to effective therapies as well as to improve the understanding of colorectal cancer biology. Their identification is an intensive area of research and our future goal will be to depict tumour-specific "molecular signatures" in order to predict the clinical course of the disease and the best treatments. : In this report, we describe clinical, pathological and molecular biomarkers that can play a role as prognostic or predictive factors in mCRC.

Imaginative Play in Child Psychotherapy: the Relevance of Merleau-Ponty's Thought

1998 ◽  
Vol 29 (2) ◽  
pp. 231-248 ◽  
Author(s):  
Bertha Mook
Keyword(s):  
Clinical Case ◽  
Child Psychotherapy ◽  
Lived Body ◽  
Therapeutic Value ◽  
The World ◽  
Therapeutic Context ◽  
Imaginative Play ◽  
Play World ◽  
Mode Of Being ◽  
Theoretical Conceptualization

AbstractIn recent years, there has been a marked increase in the use of imaginative play in child psychotherapy, yet the theoretical conceptualization of the meaning of play is lacking behind its application in practice. In search of a deeper understanding of the phenomenon of imaginative play, the author turns to Merleau-Ponty's ontology and to his phenomenology of structure, of the lived body, of perception, and of expression. In light of his work, play is an embodied mode of being in the world and a body-world phenomenon. Imaginative play in particular exemplifies the human order in that it enables the child to create and re-create his own meanings within his play world. In a therapeutic context, the evocation of play imagery and the expressive shaping and reshaping of play meanings lead to surprising insights and new discoveries relevant to the child's life-world. A central therapeutic value of imaginative play lies in its promise for facilitating change and healing. A clinical case illustration of a young boy is provided, and the meaning of his imaginative play is exemplified in light of Merleau-Ponty's thought. Some implications are drawn for the theory of play in child psychotherapy.

scholarly journals Non-Coding RNAs in Invadopodia: New Insights Into Cancer Metastasis

2021 ◽  
Vol 11 ◽  
Author(s):  
Feiya Li ◽  
Burton B. Yang
Keyword(s):  
Clinical Application ◽  
Cancer Metastasis ◽  
Noncoding Rnas ◽  
Anticancer Therapy ◽  
Invasion And Metastasis ◽  
Pathological Conditions ◽  
Open Questions ◽  
New Ideas ◽  
Therapeutic Context ◽  
Non Coding Rnas

Invadopodia are actin-rich structures and their formation is implicated in cancer invasion and metastasis. Growing evidence has shown that noncoding RNAs (ncRNAs) play important roles in pathological conditions, including tumorigenesis and metastasis. Although this is still a new area of research, ncRNAs appear to be promising biomarkers and therapeutic targets for cancer metastasis. However, understanding the roles of ncRNAs in invadopodia is still in the early stages and far from clinical application. In this mini-review, we summarize the roles of ncRNAs in invadopodia functions and discuss them in a therapeutic context. The current challenges and gaps in this field are also raised, and we provide some open questions to facilitate new ideas in targeting invadopodia in anticancer therapy.

scholarly journals Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity

Blood ◽  
2011 ◽  
Vol 117 (5) ◽  
pp. 1614-1621 ◽  
Author(s):  
Marc N. Offman ◽  
Marcin Krol ◽  
Naina Patel ◽  
Shekhar Krishnan ◽  
JiZhong Liu ◽  
...  
Keyword(s):  
Cysteine Proteases ◽  
Hydrogen Bond Network ◽  
Cell Toxicity ◽  
Rational Engineering ◽  
Therapeutic Context ◽  
Bond Network ◽  
The Impact ◽  
Glutaminase Activity ◽  
Protein Macromolecule ◽  
Tetrameric Form

Abstract Using proteins in a therapeutic context often requires engineering to modify functionality and enhance efficacy. We have previously reported that the therapeutic antileukemic protein macromolecule Escherichia coli L-asparaginase is degraded by leukemic lysosomal cysteine proteases. In the present study, we successfully engineered L-asparaginaseto resist proteolytic cleavage and at the same time improve activity. We employed a novel combination of mutant sampling using a genetic algorithm in tandem with flexibility studies using molecular dynamics to investigate the impact of lid-loop and mutations on drug activity. Applying these methods, we successfully predicted the more active L-asparaginase mutants N24T and N24A. For the latter, a unique hydrogen bond network contributes to higher activity. Furthermore, interface mutations controlling secondary glutaminase activity demonstrated the importance of this enzymatic activity for drug cytotoxicity. All selected mutants were expressed, purified, and tested for activity and for their ability to form the active tetrameric form. By introducing the N24A and N24A R195S mutations to the drug L-asparaginase, we are a step closer to individualized drug design.

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