Slow-release lubrication of artificial joints using self-healing polyvinyl alcohol/polyethylene glycol/ graphene oxide hydrogel

One of the most common problems encountered by patients using artificial joints is the high wear rate. In this study, a polyvinyl alcohol/polyethylene glycol (PVA/PEG) gel was prepared through the cross-linking reaction between polyvinyl alcohol (PVA) and polyethylene glycol (PEG) solutions. This gel can lubricate artificial joints, thereby lowering their coefficient of friction (COF) and increasing their service life. Various techniques, such as Fourier transform infrared spectroscopy, X-ray diffraction, Raman spectra, X-ray photon spectroscopy, and thermogravimetric analyses, were used to analyze the structure of this synthetic gel. The tribological results indicated that the synthetic gel’s lubrication effect was the most optimum when it contained PVA (10 wt%) and PEG (15 wt%). An average COF of 0.05 was obtained under a load of 10 N and at a speed of 1.0 cm/s. In addition, the wear rate was reduced in comparison to distilled water. Furthermore, the biological tests proved that the PVA/PEG gel was highly biocompatible. Thus, this study introduces a novel technique to prepare PVA/PEG gels that improve the tribological performance of artificial joints.

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Phase change-induced tunable dielectric permittivity of poly(vinylidene fluoride)/polyethylene glycol/graphene oxide composites

Composites Part B Engineering ◽

10.1016/j.compositesb.2019.106920 ◽

2019 ◽

Vol 173 ◽

pp. 106920 ◽

Cited By ~ 4

Author(s):

Junyang Tu ◽

Hairong Li ◽

Ziqing Cai ◽

Jingjing Zhang ◽

Xiang Hu ◽

...

Keyword(s):

Graphene Oxide ◽

Polyethylene Glycol ◽

Dielectric Permittivity ◽

Phase Change ◽

Vinylidene Fluoride ◽

Poly Vinylidene Fluoride ◽

Oxide Composites

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Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Molecules ◽

10.3390/molecules26113067 ◽

2021 ◽

Vol 26 (11) ◽

pp. 3067

Author(s):

Mustafa A. Jihad ◽

Farah T. M. Noori ◽

Majid S. Jabir ◽

Salim Albukhaty ◽

Faizah A. AlMalki ◽

...

Keyword(s):

Drug Delivery ◽

Grain Size ◽

Cell Wall ◽

Graphene Oxide ◽

Polyethylene Glycol ◽

Nucleic Acid ◽

Drug Delivery System ◽

Delivery System ◽

Nigella Sativa ◽

Seed Extract

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.

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