scholarly journals Effect of Graphene Oxide on the Performance of Cellulose Acetate/ Polyethylene Glycol Membrane with Blending Method for Desalination of Brackish Water

2021 ◽  
Vol 1143 (1) ◽  
pp. 012059
Author(s):  
R D Nyamiati ◽  
B C Devi ◽  
B A Febriansyah ◽  
A Ramadhani ◽  
Y Rahmawati ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Cellulose Acetate ◽  
Brackish Water ◽  
Blending Method

scholarly journals Polyethylene glycol grafted with carboxylated graphene oxide as a novel interface modifier for polylactic acid/graphene nanocomposites

2020 ◽  
Vol 7 (7) ◽  
pp. 192154
Author(s):  
Mingjun Niu ◽  
Hao Wang ◽  
Jing Li ◽  
Hongyan Chen ◽  
Lin Li ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Polylactic Acid ◽  
Melt Blending ◽  
Elongation At Break ◽  
Graphene Nanocomposites ◽  
Practical Strategy ◽  
Blending Method ◽  
Synthesis Procedure

Strength and toughness are both of great importance for the application of polylactic acid (PLA). Unfortunately, these two properties are often contradictory. In this work, an effective and practical strategy is proposed by using carboxylated graphene oxide (GC) grafted with polyethylene glycol (PEG), i.e. GC-g-PEG. The synthesis procedure of GC-g-PEG is firstly optimized. Then, a series of PLA nanocomposites were prepared by the melt blending method via masterbatch. In comparison to that achieved over pure PLA, these nanocomposites are of higher crystallinity, thermal stability and mechanical strength. This is mainly attributed to well-tailored interface and good dispersion. Especially, while retaining the tensile strength of the original PLA, the elongation at break increases by seven times by adding 0.3 wt% GC-g-PEG.

Development, Evaluation and Optimization of Osmotic Controlled Tablets of Aceclofenac for Rheumatoid Arthritis Management

2019 ◽  
Vol 9 (1) ◽  
pp. 29-36
Author(s):  
Bijaya Ghosh ◽  
Niraj Mishra ◽  
Preeta Bose ◽  
Moumita D. Kirtania
Keyword(s):  
Rheumatoid Arthritis ◽  
Polyethylene Glycol ◽  
Sodium Chloride ◽  
Cellulose Acetate ◽  
Hydroxypropyl Methylcellulose ◽  
Release Profile ◽  
Polyethylene Glycol 400 ◽  
Permeable Membrane ◽  
Cumulative Release ◽  
The Core

Objective: Rheumatoid arthritis is a dreaded disease, characterized by pain, inflammation and stiffness of joints, leading to severe immobility problems. The disease shows circadian variation and usually gets aggravated in early morning hours. Aceclofenac, a BCS Class II compound is routinely used in the treatment of pain and inflammation associated with rheumatoid arthritis. The objective of this study was to develop an osmotic delivery system of Aceclofenac that after administration at bedtime would deliver the drug in the morning hours. </P><P> Methods: A series of osmotically controlled systems of aceclofenac was developed by using lactose, sodium chloride and hydroxypropyl methylcellulose K100M as osmogens. Cellulose acetate (2% w/v in acetone) with varying concentrations of polyethylene glycol-400 was used as the coating polymer to create semi permeable membrane and dissolution was carried out in 290 mOsm phosphate buffer. Formulation optimization was done from four considerations: cumulative release at the end of 6 hours (lag time), cumulative release at the end of 7 hours (burst time), steady state release rate and completeness of drug release. </P><P> Results: A formulation having swelling polymer hydroxypropyl methylcellulose in the core and lactose and sodium chloride as osmogens, polyethylene glycol-400 (16.39 %) as pore former, with a coating weight of 5% was a close fit to the target release profile and was chosen as the optimum formulation. Conclusion: Aceclofenac tablets containing lactose, HPMC and sodium chloride in the core, given a coating of cellulose acetate and PEG-400 (5% wt gain), generated a release profile for optimum management of rheumatoid arthritic pain.

scholarly journals Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3067
Author(s):  
Mustafa A. Jihad ◽  
Farah T. M. Noori ◽  
Majid S. Jabir ◽  
Salim Albukhaty ◽  
Faizah A. AlMalki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Grain Size ◽  
Cell Wall ◽  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Nucleic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nigella Sativa ◽  
Seed Extract

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.

Graphene oxide/polyethylene glycol aerogel reinforced with grape seed extracts as wound dressing

2021 ◽  
Author(s):  
Jessica Borges-Vilches ◽  
Javiera Poblete ◽  
Fernando Gajardo ◽  
Claudio Aguayo ◽  
Katherina Fernández
Keyword(s):  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Wound Dressing ◽  
Grape Seed ◽  
Grape Seed Extracts ◽  
Seed Extracts

Preparation and disinfection properties of graphene oxide/trichloroisocyanuric acid disinfectant

2021 ◽  
Author(s):  
li li jiang ◽  
Su Xu ◽  
Haitao Yu ◽  
Qi Cui ◽  
Rui Cao
Keyword(s):  
Electron Microscopy ◽  
Graphene Oxide ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Kinetic Curve ◽  
X Ray ◽  
Bacterial Inhibition ◽  
E Coli ◽  
Blending Method ◽  
Trichloroisocyanuric Acid

Abstract In this study, graphene oxide (GO) was first prepared by the modified Hummer method. Then, the GO/trichloroisocyanuric acid (TCCA) composite was prepared by loading TCCA into GO with the blending method. X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and atomic force microscopy were used to characterize the composite. The results showed that TCCA was successfully loaded on the surface of GO or intercalated among GO layers. Next, the antibacterial performance of the composite against Escherichia coli and Staphylococcus aureus was tested by the 96-well plate assay. A bactericidal kinetic curve, bacterial inhibition tests, and the mechanism of bacterial inhibition is discussed. The results showed that the minimum inhibitory concentration of the GO/TCCA composite (GO:TCCA ratio = 1:50) was 327.5 µg/mL against E. coli and 655 µg/mL against S. aureus. At the minimum inhibitory concentration, the inhibition rate of the GO/TCCA composite exceeded 99.46% against E. coli and 99.17% against S. aureus. The bactericidal kinetic curves indicate that the GO/TCCA composite has an excellent bactericidal effect against E. coli and S. aureus.

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