Effect of quinestrol on body weight, vital organs, biochemicals and genotoxicity in adult male lesser bandicoot rat, Bandicota bengalensis

2020 ◽  
Vol 165 ◽  
pp. 104544
Author(s):  
Ajooni Sidhu ◽  
Neena Singla ◽  
Milindmitra Lonare ◽  
Amrit Kaur Mahal
Keyword(s):  
Body Weight ◽  
Adult Male ◽  
Bandicota Bengalensis

Dietary fat and adiposity: a dose-response relationship in adult male rats fed isocalorically

1995 ◽  
Vol 268 (4) ◽  
pp. E546-E550 ◽  
Author(s):  
C. N. Boozer ◽  
G. Schoenbach ◽  
R. L. Atkinson
Keyword(s):  
Body Weight ◽  
Body Fat ◽  
Adult Male ◽  
Dietary Fat ◽  
Male Rats ◽  
Control Group ◽  
Low Fat Diet ◽  
Mesenteric Fat ◽  
Total Body Fat ◽  
Total Body

This study examined the effects of increasing levels of dietary fat fed isocalorically on body weight, body composition, and adipose distribution. Adult male rats were weight matched into four groups. One group that was fed a low-fat diet (12%) served as reference controls. The other three groups were fed diets of 24, 36, or 48% fat in amounts to equal the energy intake of the control group. After 6 wk, body weights of the four groups were not significantly different. Intrascapular brown fat did not differ between groups. Total body fat and adipose depot weights, however, increased in proportion to the level of fat in the diet. Total body fat and retroperitoneal and mesenteric depot weights of the 48% fat group were greater than controls (P < 0.05). Mesenteric fat in this group was also significantly increased over all other groups (P < 0.05). These results show that high-fat diets fed to adult animals cause increased body fat in the absence of significant changes in body weight and that mesenteric fat is increased disproportionately.

scholarly journals In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat

2000 ◽  
pp. 406-410 ◽  
Author(s):  
M Tena-Sempere ◽  
L Pinilla ◽  
LC Gonzalez ◽  
J Navarro ◽  
C Dieguez ◽  
...  
Keyword(s):  
Body Weight ◽  
Adult Male ◽  
Body Weight Gain ◽  
Biologically Active ◽  
Male Rats ◽  
Male Rat ◽  
Gh Secretion ◽  
Adult Rat ◽  
Testosterone Secretion

The obese gene (ob) product, leptin, has recently emerged as a key element in body weight homeostasis, neuroendocrine function and fertility. Identification of biologically active, readily synthesized fragments of the leptin molecule has drawn considerable attention, as they may provide a powerful tool for detailed characterization of the biological actions of leptin in different experimental settings. Recently, a fragment of mouse leptin protein comprising amino acids 116-130, termed leptin(116-130) amide, was shown to mimic the effects of the native molecule in terms of body weight gain and food intake, and to elicit LH and prolactin (PRL) secretion in vivo. As a continuation of our previous experimental work, the present study reports on the effects of leptin(116-130) amide on basal and stimulated testosterone secretion by adult rat testis in vitro. In addition, a comparison of the effects of human recombinant leptin and leptin(116-130) amide at the pituitary level on the patterns of LH, FSH, PRL and GH secretion is presented. As reported previously by our group, human recombinant leptin(10(-9)-10(-7)M) significantly inhibited both basal and human chorionic gonadotrophin (hCG)-stimulated testosterone secretion in vitro. Similarly, incubation of testicular tissue in the presence of increasing concentrations of leptin(116-130) amide (10(-9)-10(-5)M) resulted in a dose-dependent inhibition of basal and hCG-stimulated testosterone secretion; a reduction that was significant from a dose of 10(-7)M upwards. In addition, leptin(116-130) amide, at all doses tested (10(-9)-10(-5)M), significantly decreased LH and FSH secretion by incubated hemi-pituitaries from adult male rats. In contrast, in the same experimental protocol, recombinant leptin(10(-9)-10(-7)M) was ineffective in modulating LH and FSH release. Finally, neither recombinant leptin nor leptin(116-130) amide were able to change basal PRL and GH secretion in vitro. Our results confirm the ability of leptin, acting at the testicular level, to inhibit testosterone secretion, and map the effect to a domain of the leptin molecule that lies between amino acid residues 116 and 130. In addition, we provide evidence for a direct inhibitory action of leptin(116-130) amide on pituitary LH and FSH secretion, a phenomenon not observed for the native leptin molecule, in the adult male rat.

Effects of Insulin, Metrazol, and Electroconvulsive Shocks upon Learning to Learn 30 Successive Reversal Problems by Rats

1970 ◽  
Vol 26 (2) ◽  
pp. 551-558 ◽  
Author(s):  
Loh Seng Tsai ◽  
Vernon J. Perez ◽  
Jefferson M. Koonce
Keyword(s):  
Body Weight ◽  
Potassium Chloride ◽  
Electric Current ◽  
Adult Male ◽  
Male Rats ◽  
Learning To Learn ◽  
Successive Reversal ◽  
Insulin Group ◽  
Weight One ◽  
Better Than

To determine the relative effects of insulin, metrazol and electroconvulsive shocks upon learning to learn 30 successive reversal problems by rats, an enclosed square T-maze was used, with water as incentive after 23 hr. of deprivation. S had to achieve 9 correct out of 10 daily trials before a problem was reversed. 40 adult male rats were equally divided into a control and 3 differently shocked groups. Shocks were administered on 3 alternate days followed by 2 days of rest. Each time, Ss of the 4 groups received respectively 0.5 cc. of saline, 55 mg. of metrazol per kg. of body-weight, one unit of insulin per 20 gm. of body-weight, and an electric current of 50 ma. at 25 v for 150 msec. Convulsion in the insulin group was prevented by an injection of dextrose and potassium chloride. The control was significantly superior to the 3 shocked groups which were remarkably similar or practically identical in their performance during the initial 6 problems. Thereafter, both the non-convulsive (saline and insulin) groups did better than the 2 convulsive groups either in terms of error, day, or one-trial reversal score.

scholarly journals Differential Expression of CD3, TNF-α, and VEGF Induced by Olanzapine on the Spleen of Adult Male Albino Rats and the Possible Protective Role of Vitamin C

Biomedicines ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 39
Author(s):  
Sahar Youssef ◽  
Marwa Salah
Keyword(s):  
Body Weight ◽  
Vitamin C ◽  
Adult Male ◽  
Control Group ◽  
Albino Rats ◽  
White Pulp ◽  
Group Iii ◽  
Group I ◽  
Tnf Α ◽  
Group Ii

Olanzapine is an antipsychotic drug effective in the treatment of stress-associated psychiatric illnesses, but its effect on the spleen remains unclear. Vitamin C is essential for the optimum function of the immune system. We aim to investigate the effect of Olanzapine on spleen structures and to assess the protective effect of vitamin C. Forty adult male albino rats were divided into four groups: group (I), a control; group (II), rats were given vitamin C at 40 mg/kg body weight; group (III), rats were given Olanzapine at 2 mg/kg body weight; and group (IV), rats were given vitamin C and Olanzapine at the same dose of group (II) and group (III) for one month. The hematoxylin and eosin (H&E) of the olanzapine treated group showed focal areas of cellular depletion and a decrease in the size of the white pulp. The red pulp was expanded and showed marked congestion and dilatation of blood sinusoids. Cluster of differentiation 3 (CD3) was significantly reduced, however both tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF) were significantly higher. The administration of vitamin C repaired structural and immunohistochemical changes via increased CD3 and decreased TNF-α and VEGF. Therefore, the oxidative and the inflammatory pathways may be the possible mechanisms underlying olanzapine immunotoxicity. Vitamin C exerted immune modulator and antioxidant effects against olanzapine.

Body weight and lipid reserves of American Black Ducks and Mallards during autumn

1990 ◽  
Vol 68 (10) ◽  
pp. 2098-2104 ◽  
Author(s):  
Alan R. Hanson ◽  
C. Davison Ankney ◽  
Darrell G. Dennis
Keyword(s):  
Body Weight ◽  
Adult Male ◽  
Principal Component ◽  
Abdominal Fat ◽  
Pair Formation ◽  
Eastern North America ◽  
Morphometric Measurements ◽  
Juvenile Female ◽  
Black Duck ◽  
American Black

A comparison of body weight and lipid reserves (weights of mesenteric and abdominal fat) of American Black Ducks (Anas rubripes) and Mallards (Anas platyrhynchos) during autumn was done to provide insight regarding the recent contemporaneous decline in Black Duck and increase in Mallard populations of eastern North America. Data were collected on 350 Black Ducks and 1477 Mallards shot by hunters in southwestern Ontario from September 24 to December 20, 1986. Date shot and fresh body weight were recorded, and the head, a wing, a foot, and the viscera were removed and frozen. Body weight and lipid deposits (weight of mesenteric and abdominal fat) were compared between the two species. The first principal component from an analysis of nine morphometric measurements was used as a covariate in subsequent analysis to remove variation in body weight and lipid deposits caused by differences in structural size. Although all age-sex classes of Mallards and Black Ducks stored lipids during the autumn, adult male and juvenile female Black Ducks stored less lipids than did their Mallard counterparts (P ≤ 0.01). Differences in lipid reserves during fall migration may be a proximal reason for the lower survival of adult male and juvenile Black Ducks compared with Mallards and may also influence the timing of intraspecific, and the rate of interspecifc, pair formation.

The effect of a single injection of estradiol benzoate on thyroid function in intact male rats

1968 ◽  
Vol 46 (4) ◽  
pp. 697-700 ◽  
Author(s):  
K. Brown-Grant
Keyword(s):  
Body Weight ◽  
Thyroid Gland ◽  
Thyroid Function ◽  
Dose Level ◽  
Adult Male ◽  
Single Injection ◽  
Estradiol Benzoate ◽  
Male Rats ◽  
Intact Male ◽  
Federation Proc

The changes observed in the metabolism of radioiodide and radiophosphorus by the thyroid gland of intact adult male rats following a single injection of estradiol benzoate (4 μg/100 g body weight) are consistent with the suggestion (F. Labrie, G. Pelletier, and C. Fortier. Federation Proc. 26, 484 (1967). Abstr.) that at this dose level estrogen causes a hypersecretion of TSH in such animals.

scholarly journals Different types of soluble fermentable dietary fibre decrease food intake, body weight gain and adiposity in young adult male rats

2014 ◽  
Vol 11 (1) ◽  
pp. 36 ◽  
Author(s):  
Clare L Adam ◽  
Patricia A Williams ◽  
Matthew J Dalby ◽  
Karen Garden ◽  
Lynn M Thomson ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Young Adult ◽  
Food Intake ◽  
Adult Male ◽  
Dietary Fibre ◽  
Body Weight Gain ◽  
Male Rats ◽  
Decrease Food Intake ◽  
Different Types
Sign in / Sign up

Export Citation Format

Share Document