Recurrence risk of preeclampsia in a linked population-based cohort: Effects of first pregnancy maximum diastolic blood pressure and gestational age

Abstract Context: The association between thyroid function and blood pressure is insufficiently studied. Objective: The objective of the investigation was to study the association between TSH within the reference range and blood pressure. Design and Setting: This was a cross-sectional, population-based study. Subjects: A total of 30,728 individuals without previously known thyroid disease were studied. Main Outcome Measures: The main outcome measures were mean systolic and diastolic blood pressure and pulse pressure and odds ratio for hypertension (>140/90 mm Hg or current or previous use of antihypertensive medication), according to categories of TSH. Results: Within the reference range of TSH (0.50–3.5 mU/liter), there was a linear increase in blood pressure with increasing TSH. The average increase in systolic blood pressure was 2.0 mm Hg [95% confidence interval (CI) 1.4–2.6 mm Hg] per milliunit per liter increase in TSH among men, and 1.8 mm Hg (95% CI 1.4–2.3 mm Hg) in women. The corresponding increase in diastolic blood pressure was 1.6 mm Hg (95% CI 1.2–2.0 mm Hg) in men and 1.1 mm Hg (95% CI 0.8–1.3 mm Hg) in women. Comparing TSH of 3.0–3.5 mU/liter (upper part of the reference) with TSH of 0.50–0.99 mU/liter (lower part of the reference), the odds ratio for hypertension was 1.98 (95% CI 1.56–2.53) in men and 1.23 (95% CI 1.04–1.46) in women. Conclusion: Within the reference range of TSH, we found a linear positive association between TSH and systolic and diastolic blood pressure that may have long-term implications for cardiovascular health.

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Serum kallistatin level is decreased in women with preeclampsia

Journal of Perinatal Medicine ◽

10.1515/jpm-2020-0142 ◽

2021 ◽

Vol 49 (1) ◽

pp. 60-66

Author(s):

Onur Güralp ◽

Nevin Tüten ◽

Koray Gök ◽

Kübra Hamzaoglu ◽

Huri Bulut ◽

...

Keyword(s):

Blood Pressure ◽

Diastolic Blood Pressure ◽

Gestational Age ◽

Late Onset ◽

Serine Proteinase ◽

Serum Levels ◽

Control Group ◽

Positive Correlation ◽

Uncomplicated Pregnancy ◽

Appropriate For Gestational Age

AbstractObjectivesTo evaluate the serum levels of the serine proteinase inhibitor kallistatin in women with preeclampsia (PE).MethodsThe clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and 55 consecutive women with late-onset PE (LOPE) were compared with 110 consecutive gestational age (GA)-matched (±1 week) pregnant women with an uncomplicated pregnancy and an appropriate for gestational age fetus.ResultsMean serum kallistatin was significantly lower in women with PE compared to the GA-matched-controls (27.74±8.29 ng/mL vs. 37.86±20.64 ng/mL, p<0.001); in women with EOPE compared to that of women in the control group GA-matched for EOPE (24.85±6.65 ng/mL vs. 33.37±17.46 ng/mL, p=0.002); and in women with LOPE compared to that of women in the control group GA-matched for LOPE (30.87±8.81 ng/mL vs. 42.25±22.67 ng/mL, p=0.002). Mean serum kallistatin was significantly lower in women with EOPE compared to LOPE (24.85±6.65 ng/mL vs. 30.87±8.81 ng/mL, p<0.001). Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth.ConclusionsSerum kallistatin levels are decreased in preeclamptic pregnancies compared to the GA-matched-controls. This decrease was also significant in women with EOPE compared to LOPE. Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.

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The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index

Journal of Cellular Biochemistry ◽

10.1002/jcb.27934 ◽

2018 ◽

Vol 120 (4) ◽

pp. 6441-6448 ◽

Cited By ~ 7

Author(s):

Negin Rezavand ◽

Saba Tabarok ◽

Ziba Rahimi ◽

Asad Vaisi‐Raygani ◽

Ehsan Mohammadi ◽

...

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Gestational Age ◽

Gene Polymorphisms ◽

Vdr Gene ◽

Vdr Gene Polymorphisms ◽

Risk Of Preeclampsia

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Maternal first-trimester dietary intake and childhood blood pressure: the Generation R Study

British Journal Of Nutrition ◽

10.1017/s0007114513000676 ◽

2013 ◽

Vol 110 (8) ◽

pp. 1454-1464 ◽

Cited By ~ 12

Author(s):

Leontine C. L. van den Hil ◽

H. Rob Taal ◽

Layla. L. de Jonge ◽

Denise H. M. Heppe ◽

Eric A. P. Steegers ◽

...

Keyword(s):

Blood Pressure ◽

Dietary Intake ◽

Diastolic Blood Pressure ◽

Multiple Testing ◽

Daily Intake ◽

Later Life ◽

First Trimester ◽

Population Based ◽

Vitamin B ◽

Standard Deviation Increase

Suboptimal maternal dietary intake during pregnancy might lead to fetal cardiovascular adaptations and higher blood pressure in the offspring. The aim of the present study was to investigate the associations of maternal first-trimester dietary intake with blood pressure in children at the age of 6 years. We assessed first-trimester maternal daily dietary intake by a FFQ and measured folate, homocysteine and vitamin B12 concentrations in the blood, in a population-based prospective cohort study among 2863 mothers and children. Childhood systolic and diastolic blood pressure was measured using a validated automatic sphygmomanometer. First-trimester maternal daily intake of energy, fat, protein and carbohydrate was not associated with childhood blood pressure. Furthermore, maternal intake of micronutrients was not associated with childhood blood pressure. Also, higher maternal vitamin B12 concentrations were associated with a higher diastolic blood pressure (0·31 mmHg per standard deviation increase in vitamin B12 (95 % CI 0·06, 0·56)). After taking into account multiple testing, none of the associations was statistically significant. Maternal first-trimester folate and homocysteine concentrations were not associated with childhood blood pressure. The results from the present study suggest that maternal Fe intake and vitamin B12 concentrations during the first trimester of pregnancy might affect childhood blood pressure, although the effect estimates were small and were not significant after correction for multiple testing. Further studies are needed to replicate these findings, to elucidate the underlying mechanisms and to assess whether these differences in blood pressure persist in later life.

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Diagnostic Methods for Pregnancy Hypertension: Significance of Standardized Conditions

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462300012939 ◽

1992 ◽

Vol 8 (S1) ◽

pp. 72-74 ◽

Cited By ~ 1

Author(s):

Anders Åberg

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Diastolic Blood Pressure ◽

Home Monitoring ◽

Upright Position ◽

Diagnostic Methods ◽

Pressure Measurements ◽

Pregnancy Hypertension ◽

Measure Blood Pressure ◽

Risk Of Preeclampsia

AbstractStandardized conditions for blood pressure measurements and strict definitions of systolic and diastolic blood pressure are essential for a consequent management of hypertension during pregnancy. In Sweden, it has been agreed to measure blood pressure with the pregnant women sitting in upright position. Home-monitoring of blood pressure is recommended in women at risk of preeclampsia.

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Blood Pressure Variability and Incidence of New-Onset Atrial Fibrillation

Hypertension ◽

10.1161/hypertensionaha.119.13708 ◽

2020 ◽

Vol 75 (2) ◽

pp. 309-315 ◽

Cited By ~ 6

Author(s):

So-Ryoung Lee ◽

You-Jung Choi ◽

Eue-Keun Choi ◽

Kyung-Do Han ◽

Euijae Lee ◽

...

Keyword(s):

Atrial Fibrillation ◽

Blood Pressure ◽

Diastolic Blood Pressure ◽

Blood Pressure Variability ◽

Blood Pressure Measurement ◽

Population Based ◽

Increased Risk ◽

Complete Set ◽

The Impact ◽

Fourth Quartile

Blood pressure variability is a well-known risk factor for cardiovascular disease, but its association with atrial fibrillation (AF) is uncertain. We aimed to evaluate the association between visit-to-visit blood pressure variability and incident AF. This population-based cohort study used database from the Health Screening Cohort, which contained a complete set of medical claims and a biannual health checkup information of the Koran population. A total of 8 063 922 individuals who had at least 3 health checkups with blood pressure measurement between 2004 and 2010 were collected after excluding subjects with preexisting AF. Blood pressure variability was defined as variability independence of the mean and was divided into 4 quartiles. During a mean follow-up of 6.8 years, 140 086 subjects were newly diagnosed with AF. The highest blood pressure variability (fourth quartile) was associated with an increased risk of AF (hazard ratio, 95% CI; systolic blood pressure: 1.06, 1.05–1.08; diastolic blood pressure: 1.07, 1.05–1.08) compared with the lowest (first quartile). Among subjects in the fourth quartile in both systolic and diastolic blood pressure variability, the risk of AF was 7.6% higher than those in the first quartile. Moreover, this result was consistent in both patients with or without prevalent hypertension. In subgroup analysis, the impact of high blood pressure variability on AF development was stronger in high-risk subjects, who were older (≥65 years), with diabetes mellitus or chronic kidney disease. Our findings demonstrated that higher blood pressure variability was associated with a modestly increased risk of AF.

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Adverse Outcomes with Maternal Blood Pressure Less than 140/90 in Pregnancy Complicated by Hypertension

American Journal of Perinatology ◽

10.1055/s-0038-1677474 ◽

2019 ◽

Vol 36 (13) ◽

pp. 1394-1400 ◽

Cited By ~ 1

Author(s):

Courtney J. Mitchell ◽

Alan Tita ◽

Sarah B. Anderson ◽

Daniel N. Pasko ◽

Lorie M. Harper

Keyword(s):

Blood Pressure ◽

Preterm Birth ◽

Systolic Blood Pressure ◽

Diastolic Blood Pressure ◽

Gestational Age ◽

Small For Gestational Age ◽

Maternal Blood ◽

Adverse Outcomes ◽

Chronic Hypertension ◽

Increased Risk

Objective We assessed the risk of small for gestational age and other outcomes in pregnancies complicated by chronic hypertension with blood pressure <140/90 mm Hg. Study Design Retrospective cohort of singletons with hypertension at a single institution from 2000 to 2014. Mean systolic blood pressure and mean diastolic blood pressure were analyzed as continuous and dichotomous variables (<120/80 and 120–139/80–89 mm Hg). The primary outcome was small for gestational age. Secondary outcomes included birth weight, preeclampsia, preterm birth <35 weeks, and a composite of adverse neonatal outcomes. Results Small for gestational age was not increased with a mean systolic blood pressure <120 mm Hg compared with a mean systolic blood pressure 120 to 129 mm Hg (adjusted odds ratio [AOR] 1.6; 95% confidence interval [CI] 0.92–2.79). Mean diastolic blood pressure <80 mm Hg was associated with a decrease in the risk preeclampsia (AOR 0.57; 95% CI 0.35–0.94), preterm birth <35 weeks (AOR 0.35; 95% CI 0.20–0.62), and the composite neonatal outcome (AOR 0.42; 95% CI 0.22–0.81). Conclusion Mean systolic blood pressure <120 mm Hg and mean diastolic blood pressure <80 mm Hg were not associated with increased risk of small for gestational age when compared with higher, normal mean systolic and diastolic blood pressures.

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