Toward the biomimetic implant surface: Biopolymers on titanium-based implants for bone regeneration

2014 ◽  
Vol 39 (7) ◽  
pp. 1406-1447 ◽  
Author(s):  
Ricardo Tejero ◽  
Eduardo Anitua ◽  
Gorka Orive
Keyword(s):  
Bone Regeneration ◽  
Implant Surface ◽  
Surface Biopolymers

scholarly journals The Effect of Diclofenac Sodium-Loaded Poly(Lactide-co-Glycolide) Rods on Bone Formation and Inflammation: A Histological and Histomorphometric Study in the Femora of Rats

Micromachines ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1098
Author(s):  
Karoline M. Reich ◽  
Petrus Viitanen ◽  
Ehsanul Hoque Apu ◽  
Stefan Tangl ◽  
Nureddin Ashammakhi
Keyword(s):  
Bone Regeneration ◽  
Diclofenac Sodium ◽  
Giant Cells ◽  
Host Tissue ◽  
Negative Effects ◽  
Implant Surface ◽  
Histomorphometric Study ◽  
Tissue Reactions ◽  
Local Release ◽  
The Impact

Implants made of poly(lactide-co-glycolide) (PLGA) are biodegradable and frequently provoke foreign body reactions (FBR) in the host tissue. In order to modulate the inflammatory response of the host tissue, PLGA implants can be loaded with anti-inflammatory drugs. The aim of this study was to analyze the impact of PLGA 80/20 rods loaded with the diclofenac sodium (DS) on local tissue reactions in the femur of rats. Special emphasis was put on bone regeneration and the presence of multinucleated giant cells (MGCs) associated with FBR. PLGA 80/20 alone and PLGA 80/20 combined with DS was extruded into rods. PLGA rods loaded with DS (PLGA+DS) were implanted into the femora of 18 rats. Eighteen control rats received unloaded PLGA rods. The follow-up period was of 3, 6 and 12 weeks. Each group comprised of six rats. Peri-implant tissue reactions were histologically and histomorphometrically evaluated. The implantation of PLGA and PLGA+DS8 rods induced the formation of a layer of newly formed bone islands parallel to the contour of the implants. PLGA+DS rods tended to reduce the presence of multi-nucleated giant cells (MGCs) at the implant surface. Although it is known that the systemic administration of DS is associated with compromised bone healing, the local release of DS via PLGA rods did not have negative effects on bone regeneration in the femora of rats throughout 12 weeks.

scholarly journals The Role of Epigenetic Functionalization of Implants and Biomaterials in Osseointegration and Bone Regeneration—A Review

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5879
Author(s):  
Farah Asa’ad ◽  
Goda Pelanyte ◽  
Jincy Philip ◽  
Christer Dahlin ◽  
Lena Larsson
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Inflammatory Diseases ◽  
Standards Of Care ◽  
Epigenetic Mechanisms ◽  
Implant Surface ◽  
The Past ◽  
Need To Evaluate ◽  
Specific Search

The contribution of epigenetic mechanisms as a potential treatment model has been observed in cancer and autoimmune/inflammatory diseases. This review aims to put forward the epigenetic mechanisms as a promising strategy in implant surface functionalization and modification of biomaterials, to promote better osseointegration and bone regeneration, and could be applicable for alveolar bone regeneration and osseointegration in the future. Materials and Methods: Electronic and manual searches of the literature in PubMed, MEDLINE, and EMBASE were conducted, using a specific search strategy limited to publications in the last 5 years to identify preclinical studies in order to address the following focused questions: (i) Which, if any, are the epigenetic mechanisms used to functionalize implant surfaces to achieve better osseointegration? (ii) Which, if any, are the epigenetic mechanisms used to functionalize biomaterials to achieve better bone regeneration? Results: Findings from several studies have emphasized the role of miRNAs in functionalizing implants surfaces and biomaterials to promote osseointegration and bone regeneration, respectively. However, there are scarce data on the role of DNA methylation and histone modifications for these specific applications, despite being commonly applied in cancer research. Conclusions: Studies over the past few years have demonstrated that biomaterials are immunomodulatory rather than inert materials. In this context, epigenetics can act as next generation of advanced treatment tools for future regenerative techniques. Yet, there is a need to evaluate the efficacy/cost effectiveness of these techniques in comparison to current standards of care.

Bone Regeneration around Dental Implants as a Treatment for Peri-Implantitis: A Review of the Literature

2011 ◽  
Vol 11 ◽  
pp. 21-33 ◽  
Author(s):  
Karthikeyan Subramani ◽  
Reji Mathew ◽  
Hossein Hosseinkhani ◽  
Mohsen Hosseinkhani
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Bone Morphogenetic Protein 2 ◽  
Surgical Approaches ◽  
Autogenous Bone ◽  
Implant Surface ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Bone Substitute Materials ◽  
Substitute Materials

This manuscript discusses peri-implantitis around dental implants and the current methodologies of surgical and non-surgical approaches towards treating peri-implantitis. Mechanical, chemical cleansing and reactivation of infected implant surface along with recent advances like the use of Laser and Photodynamic therapy (PDT) have also been reviewed in this literature. Bone regenerative treatment methods for the treatment of peri-implantitis using non-resorbable membranes (Guided Bone Regeneration), autogenous bone grafts and bone substitute materials with recombinant human bone morphogenetic protein-2 (rhBMP-2) and other growth factors have also been reviewed in this manuscript.

Hydrophilic Nanotube Coating of Ti Implant Materials for Potential Rapid Bone Regeneration

2010 ◽  
Author(s):  
Tolou Shokuhfar ◽  
C. K. Choi ◽  
Craig Friedrich
Keyword(s):  
Bone Regeneration ◽  
Low Cost ◽  
Titanium Implant ◽  
Electrochemical Technique ◽  
Ti Alloy ◽  
Surface Oxide Film ◽  
Implant Surface ◽  
Implant Materials ◽  
Materials Used

The properties of implant materials used in humans may have important influences on the outcomes of clinical treatments. Recently, titanium and titanium alloys have been extensively employed as in-vivo implant materials, due to their generally favorable biocompatibility, high resistance to corrosion, and relatively low cost. On the other hand, even when using chemically identical materials, the biocompatibility of an implant or its stability depends heavily on its surface structure, as well as the thickness and properties of the surface oxide film. As the characteristics of the implant surface have been reported to play an important role in the in-vivo reactions of implants, a great deal of interest has recently been focused on different surface treatment methods. Currently, there are a variety of methods with which titanium implant surfaces are treated. The anodizing method is an electrochemical technique, which forms a rough, thick oxidized capsule with nanotubular structures on the implant surface. To increase the biocompatibility and bone regeneration and to improve the current shortcomings of Ti and Ti alloy (Ti6Al4V)implants, we applied a uniquely fabricated nanotubular coating over the surface of such implants.

An Oxidized Implant Surface May Improve Bone-to-Implant Contact in Pristine Bone and Bone Defects Treated With Guided Bone Regeneration: An Experimental Study in Dogs

2008 ◽  
Vol 79 (7) ◽  
pp. 1225-1231 ◽  
Author(s):  
Bruno César de Vasconcelos Gurgel ◽  
Patrícia Furtado Gonçalves ◽  
Suzana Peres Pimentel ◽  
Francisco Humberto Nociti ◽  
Enilson Antonio Sallum ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
Implant Surface ◽  
Bone To Implant Contact

scholarly journals A Mini Review on Non-augmentative Surgical Therapy of Peri-Implantitis—What Is Known and What Are the Future Challenges?

2021 ◽  
Vol 2 ◽  
Author(s):  
Kristina Bertl ◽  
Andreas Stavropoulos
Keyword(s):  
Surgical Treatment ◽  
Bone Loss ◽  
Bone Regeneration ◽  
Surgical Therapy ◽  
Treatment Approach ◽  
Future Research ◽  
Implant Surface ◽  
Research Challenges ◽  
Future Challenges ◽  
Open Flap Debridement

Non-augmentative surgical therapy of peri-implantitis is indicated for cases with primarily horizontal bone loss or wide defects with limited potential for bone regeneration and/or re-osseointegration. This treatment approach includes a variety of different techniques (e.g., open flap debridement, resection of peri-implant mucosa, apically positioned flaps, bone re-contouring, implantoplasty, etc.) and various relevant aspects should be considered during treatment planning. The present mini review provides an overview on what is known for the following components of non-augmentative surgical treatment of peri-implantitis and on potential future research challenges: (1) decontamination of the implant surface, (2) need of implantoplasty, (3) prescription of antibiotics, and (4) extent of resective measures.

scholarly journals Crestal Bone Regeneration in Defective Bone Implants

2014 ◽  
Vol 3 (2) ◽  
pp. 95-97
Author(s):  
Mohammed Jasim Aljuboori
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Alveolar Bone ◽  
Medical Condition ◽  
Collagen Membrane ◽  
Bone Implants ◽  
Implant Surface ◽  
Primary Wound Closure ◽  
Narrow Ridge ◽  
Defective Bone

ABSTRACT Implant placement in narrow alveolar bone ridges end with buccal bone dehiscence and implant thread exposure. In this conditions, bone graft need to be placed in a addition to the collagen membrane to cover the dehiscence with primary wound closure. This paper presents an implant case with a medical history of diabetic type II and smoker patient. Implant placed in narrow ridge and three coronal threads of the fixture exposed when the implant torque into the final position. After 3 months healing period, the implant site exposed with complete bone formation and coverage of the threads. From this case, one might conclude that: first the type of the implant surface may enhance bone formation, second the periosteum may contribute in the bone regeneration. Third the medical condition of the patient may has no local influence on the implant site. How to cite this article Aljuboori MJ, Saini R. Crestal Bone Regeneration in Defective Bone Implants. Int J Experiment Dent Sci 2014;3(2):95-97.

Management of Retrograde Peri-implantitis: A Clinical Case Report

2006 ◽  
Vol 32 (6) ◽  
pp. 308-312 ◽  
Author(s):  
Khurram Ataullah ◽  
Loh Fun Chee ◽  
Lim Lum Peng ◽  
Henry Ho Kim Lung
Keyword(s):  
Case Report ◽  
Bone Loss ◽  
Bone Regeneration ◽  
Dental Implants ◽  
Clinical Case ◽  
Guided Bone Regeneration ◽  
Surgical Debridement ◽  
Implant Surface ◽  
Exact Etiology ◽  
Current Article

Abstract The term retrograde peri-implantitis has been commonly used to describe lesions in the periapical region of dental implants. There are very few reports on this condition, and the exact etiology and pathogenesis are subject to speculation. Management of retrograde peri-implantitis is even more scarcely discussed in the literature. The current article briefly reviews the literature on this subject and presents a case report of retrograde peri-implantitis. Special emphasis is placed on the management of the condition, and different strategies are critically evaluated. If the fixture is stable despite bone loss in the periapical region, it is suggested that surgical debridement be carried out with the use of a surface antiseptic like chlorhexidine. Also all possible efforts should be made to prevent damage to the implant surface. Bone loss due to this condition may be regenerated on the basis of the principle of guided bone regeneration.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

Sign in / Sign up

Export Citation Format

Share Document