Relationship between omega-3 and omega-6 fatty acid ratios and breast cancer

Background: Vitamin C (Vit C) is an important physiological antioxidant with growing applications in cancer. Somatostatin (SST) is a natural peptide with growth inhibitory effect in several mammary cancer models. Objective: The combined effects of SST and Vit C supplementation have never been studied in breast cancer cells so far. Methods: We used MCF-7 and MDA-MB231 breast cancer cells incubated with SST for 24h, in the absence and presence of Vit C, at their EC50 concentrations, to evaluate membrane fatty acid-profiles together with the follow-up of EGFR and MAPK signaling pathways. Results: The two cell lines gave different membrane reorganization: in MCF-7 cells, decrease of omega-6 linoleic acid and increase of omega-3 fatty acids (Fas) occurred after SST and SST+Vit C incubations, the latter also showing significant increases in MUFA, docosapentaenoic acid and mono-trans arachidonic acid levels. In MDA-MB231 cells, SST+Vit C incubation induced significant membrane remodeling with an increase of stearic acid and mono-trans-linoleic acid isomer, diminution of omega-6 linoleic, arachidonic acid and omega-3 (docosapentaenoic and docosadienoic acids). Distinct signaling pathways in these cell lines were studies: in MCF-7 cells, incubations with SST and Vit C, alone or in combination significantly decreased EGFR and MAPK signaling, whereas in MDA-MB231 cells, SST and Vit C incubations, alone or combined, decreased p-P44/42 MAPK levels, and increased EGFR levels. Conclusion: Our results showed that SST and Vit C can be combined to induce membrane fatty acid changes, including lipid isomerization through a specific free radical-driven process, influencing signaling pathways.

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Re: Dietary Modulation of Omega-3/Omega-6 Polyunsaturated Fatty Acid Ratios in Patients With Breast Cancer

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/90.8.629 ◽

1998 ◽

Vol 90 (8) ◽

pp. 629-630 ◽

Cited By ~ 1

Author(s):

Edward N. Siguel

Keyword(s):

Breast Cancer ◽

Fatty Acid ◽

Polyunsaturated Fatty Acid ◽

Omega 3 ◽

Dietary Modulation ◽

Omega 6 ◽

3 Omega

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10 / OMEGA-3 (Ω3) SUPPLEMENTATION VERSUS OMEGA-6 (Ω6) SUPPLEMENTATION FOR PAIN AMONG BREAST CANCER SURVIVORS: A URCC NCORP PHASE II FEASIBILITY RCT

10.26226/morressier.5afadd8af314ac000849b344 ◽

2018 ◽

Author(s):

Luke Peppone

Keyword(s):

Breast Cancer ◽

Cancer Survivors ◽

Phase Ii ◽

Breast Cancer Survivors ◽

Omega 3 ◽

Omega 6 ◽

Feasibility Rct

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EFFECT OF GINGER, LEMURU FISH OIL SAPONIFICATION AND OLIVE OIL ON COMPOSITION FATTY ACID OF BEEF

Jurnal Agroindustri ◽

10.31186/j.agroind.4.1.31-39 ◽

2014 ◽

Vol 4 (1) ◽

pp. 31-39

Author(s):

Siwitri Kadarsih

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Fish Oil ◽

Olive Oil ◽

Rice Bran ◽

Dry Matter ◽

Unsaturated Fatty Acids ◽

Saturated Fatty Acids ◽

Omega 3 ◽

Omega 6

The objective was to get beef that contain unsaturated fatty acids (especially omega 3 and 6), so as to improve intelligence, physical health for those who consume. The study design using CRD with 3 treatments, each treatment used 4 Bali cattle aged approximately 1.5 years. Observations were made 8 weeks. Pasta mixed with ginger provided konsentrat. P1 (control); P2 (6% saponification lemuru fish oil, olive oil 1%; rice bran: 37.30%; corn: 62.70%; KLK: 7%, ginger paste: 100 g); P3 (lemuru fish oil saponification 8%, 2% olive oil; rice bran; 37.30; corn: 62.70%; KLK: 7%, ginger paste: 200 g). Konsentrat given in the morning as much as 1% of the weight of the cattle based on dry matter, while the grass given a minimum of 10% of the weight of livestock observation variables include: fatty acid composition of meat. Data the analyzies qualitative. The results of the study showed that the composition of saturated fatty acids in meat decreased and an increase in unsaturated fatty acids, namely linoleic acid (omega 6) and linolenic acid (omega 3), and deikosapenta deikosaheksa acid.Keywords :

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Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study

Scientific Reports ◽

10.1038/s41598-021-93846-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Rima Irwinda ◽

Rabbania Hiksas ◽

Aprilia Asthasari Siregar ◽

Yudianto Budi Saroyo ◽

Noroyono Wibowo

Keyword(s):

Fatty Acid ◽

Preterm Birth ◽

Cross Sectional Study ◽

Severe Preeclampsia ◽

Chain Polyunsaturated Fatty Acid ◽

Omega 3 ◽

Sectional Study ◽

Cross Sectional ◽

Omega 6 ◽

Long Chain

AbstractLong-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status.

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Omega-3 fatty acid use for obese breast cancer patients with aromatase inhibitor-related arthralgia (SWOG S0927)

Breast Cancer Research and Treatment ◽

10.1007/s10549-018-4946-0 ◽

2018 ◽

Vol 172 (3) ◽

pp. 603-610 ◽

Cited By ~ 10

Author(s):

Sherry Shen ◽

Joseph M. Unger ◽

Katherine D. Crew ◽

Cathee Till ◽

Heather Greenlee ◽

...

Keyword(s):

Breast Cancer ◽

Fatty Acid ◽

Aromatase Inhibitor ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Omega 3 ◽

Omega 3 Fatty Acid

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The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected

International Journal of Pediatrics ◽

10.1155/2017/6424186 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

C. Castro-Correia ◽

S. Sousa ◽

S. Norberto ◽

C. Matos ◽

V. F. Domingues ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Control Group ◽

Healthy Children ◽

Omega 3 ◽

Alpha Linolenic Acid ◽

Diabetes Group ◽

Diabetic Children ◽

Omega 6 ◽

Diagnosed Diabetes

Context. Several studies have shown a link between proinflammatory activity and the presence or deficit of some fatty acids. Inflammation is associated with several diseases including diabetes.Objective. To characterize and compare the fatty acids profiles in children with inaugural type 1 diabetes, diabetic children (at least 1 year after diagnosis), and healthy children.Design. Plasma fatty acids profiles in children with inaugural diabetes, children with noninaugural diabetes, and controls, all of whom were prepubescent with a BMI < 85th percentile, were evaluated.Results. Omega-3 fatty acid levels were higher in recently diagnosed subjects with diabetes than in controls. The ratio of omega-6/omega-3 fatty acids was higher in the control population. Omega-6 fatty acid levels were higher in the nonrecent diabetic subjects than in the children with recently diagnosed diabetes, and the levels were higher in the nonrecent diabetes group compared to the control group.Conclusion. Our findings showed higher levels of alpha-linolenic acid, EPA, and DHA, as well as mono- and polyunsaturated fatty acids, in diabetic children. These findings reinforce the importance of precocious nutritional attention and intervention in the treatment of diabetic children.

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