scholarly journals Effect of the protein:carbohydrate ratio in hypoenergetic diets on metabolic syndrome risk factors in exercising overweight and obese women

2012 ◽  
Vol 108 (9) ◽  
pp. 1658-1671 ◽  
Author(s):  
Dawn D. Campbell ◽  
Kelly A. Meckling
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
G Protein ◽  
Disease Risk ◽  
Exercise Programme ◽  
Overweight And Obesity ◽  
Energy Restriction ◽  
Obese Women ◽  
The Metabolic Syndrome

Overweight and obesity are growing problems both in Canada and around the world. Obesity is associated with a number of chronic diseases including type 2 diabetes and CVD, which puts a tremendous burden on the health care systems in place. The present study sought to investigate whether there were differences in the effectiveness of three low-fat, hypo- and isoenergetic diets differing in protein:carbohydrate ratio, low protein (LP, 1 g protein:4 g carbohydrate), normal protein (NP, 1 g protein:2 g carbohydrate) or high protein (HP, 1 g protein:1 g carbohydrate), on weight loss and markers of the metabolic syndrome (MetS) in overweight women. Subjects were randomly assigned to receive one of three intervention diets, all of which included a 60 min exercise programme three times/week for 12 weeks. Of the total subjects, fifty-four overweight and obese local women with MetS risk factors completed the study. All groups had similar improvements in body weight, insulin sensitivity, lipid profile, blood pressure and fitness. Subjects reported that the NP diet was easier to comply with and achieved better improvements in body fat, waist circumference and waist:hip ratio, and preservation of lean mass compared with the other two diets. In conclusion, energy restriction and exercise both facilitate weight loss in overweight and obese subjects and reduce symptoms of the MetS. A diet with a 1:2 protein:carbohydrate ratio promoted better improvements than either the LP or HP diets, and may be superior in reducing long-term chronic disease risk in this population.

scholarly journals Effects of time-restricted feeding in weight loss, metabolic syndrome and cardiovascular risk in obese women

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jéssica D. Schroder ◽  
Hugo Falqueto ◽  
Aline Mânica ◽  
Daniela Zanini ◽  
Tácio de Oliveira ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Body Composition ◽  
Cardiovascular Risk ◽  
Overweight And Obesity ◽  
Controlled Clinical Trial ◽  
Restricted Feeding ◽  
Obese Women ◽  
Blood Biomarkers ◽  
The Metabolic Syndrome

Abstract Background The increasing prevalence of overweight and obesity among the worldwide population has been associated with a range of adverse health consequences such as Type 2 diabetes and cardiovascular diseases. The metabolic syndrome (MetS) is a cluster of cardiometabolic abnormalities that occur more commonly in overweight individuals. Time-restricted feeding (TRF) is a dietary approach used for weight loss and overall health. TRF may be an option for those subjects who struggle with extreme restriction diets with foods that generally do not belong to an individual's habits. Objective The purpose of this study was to determine the effect of TRF on body composition and the association of weight loss with metabolic and cardiovascular risks in obese middle-aged women. Methods A non-randomized controlled clinical trial was performed over 3 months in obese women (TRF group, n = 20, BMI 32.53 ± 1.13 vs. Control n = 12, BMI 34.55 ± 1.20). The TRF protocol adopted was 16 h without any energy intake followed by 8 h of normal food intake. Main outcomes and measures Anthropometric measurements, body composition, blood biomarkers, cardiovascular risk in 30 years (CVDRisk30y), and quality of life were evaluated at baseline and after the 3 months. Results TRF was effective in reducing weight (~ 4 kg), BMI, % of body fat (%BF), waist circumference from baseline without changes in blood biomarkers associated with MetS. TRF promoted a reduction in CVDRisk30y (12%) wich was moderately correlated with %BF (r = 0.62, n = 64, p < 0.001) and %MM (r = − 0.74, n = 64, p < 0.001). Conclusions TRF protocol reduces body weight without changes in biomarkers related to MetS. In addition, the anthropometric evaluation that predicts %BF and %MM could be used as an approach to follow individuals engaged in the TRF regimen since they correlate with cardiovascular risk.

scholarly journals Reversal Rate of Clustering of Cardiovascular Disease Risk Factors of Metabolic Syndrome in the General Population: The Niigata Preventive Medicine Study

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Shinsuke Okada ◽  
Akiko Suzuki ◽  
Hiroshi Watanabe ◽  
Toru Watanabe ◽  
Yoshifusa Aizawa
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Disease Risk ◽  
Fasting Blood Glucose ◽  
Reversal Rate ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
The Metabolic Syndrome

The reversal rate from clustering of cardiovascular disease (CVD) risk factors—components of the metabolic syndrome (MetS) is not known.Methods and Results. Among 35,534 subjects who received the annual health examinations at the NiigataHealth Foundation (Niigata, Japan), 4,911 subjects had clustering of 3 or more of the following CVD risk factors: (1) body mass index (BMI) ≥25 Kg/m2, (2) blood pressure ≥130 mm Hg in systolic and/or ≥85 mm Hg in diastolic, (3) triglycerides ≥150 mg/dL, (4) high-density lipoprotein cholesterol ≤40 mg/dL in men, ≤50 mg/dL in women, and (5) fasting blood glucose ≥100 mg/dL. After 5 years 1,929 subjects had a reversal of clustering (39.4%). A reversal occurred more often in males. The subjects with a reversal of clustering had milder level of each risk factor and a smaller number of risk factors, while BMI was associated with the least chance of a reversal.Conclusion. We concluded that a reversal of clustering CVD risk factors is possible in 4/10 subjects over a 5-year period by habitual or medical interventions. Gender and each CVD risk factor affected the reversal rate adversely, and BMI was associated with the least chance of a reversal.

scholarly journals Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome

2011 ◽  
Vol 107 (5) ◽  
pp. 705-711 ◽  
Author(s):  
Caroline Richard ◽  
Patrick Couture ◽  
Sophie Desroches ◽  
Suzanne Benjannet ◽  
Nabil G. Seidah ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Body Weight ◽  
Control Diet ◽  
Cholesterol Absorption ◽  
Energy Restriction ◽  
Surrogate Markers ◽  
The Metabolic Syndrome ◽  
The Mediterranean ◽  
The Impact

The mechanisms implicated in the LDL-cholesterol (LDL-C)-lowering effects of the Mediterranean-type diet (MedDiet) are unknown. The present study assessed the impact of the MedDiet consumed under controlled feeding conditions, with and without weight loss, on surrogate markers of cholesterol absorption, synthesis and clearance using plasma phytosterols, lathosterol and proprotein convertase subtilisin/kexin-9 (PCSK9) concentrations, respectively, in men with the metabolic syndrome. The subjects' diet (n19, 24–62 years) was first standardised to a baseline North American control diet (5 weeks) followed by a MedDiet (5 weeks), both under weight-maintaining isoenergetic feeding conditions. The participants then underwent a 20-week free-living energy restriction period (10 (sd3) % reduction in body weight,P < 0·01), followed by the consumption of the MedDiet (5 weeks) under controlled isoenergetic feeding conditions. The LDL-C-lowering effect of the MedDiet in the absence of weight loss ( − 9·9 %) was accompanied by significant reductions in plasma PCSK9 concentrations ( − 11·7 %,P < 0·01) and in the phytosterol:cholesterol ratio ( − 9·7 %,P < 0·01) compared with the control diet. The addition of weight loss to the MedDiet had no further impact on plasma LDL-C concentrations and on these surrogate markers of LDL clearance and cholesterol absorption. The present results suggest that the MedDiet reduces plasma LDL-C concentrations primarily by increasing LDL clearance and reducing cholesterol absorption, with no synergistic effect of body weight loss in this process.

scholarly journals Short term effects of energy restriction and dietary fat sub-type on weight loss and disease risk factors

2010 ◽  
Vol 20 (5) ◽  
pp. 317-325 ◽  
Author(s):  
L. Tapsell ◽  
M. Batterham ◽  
X.F. Huang ◽  
S.-Y. Tan ◽  
G. Teuss ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Dietary Fat ◽  
Disease Risk ◽  
Energy Restriction ◽  
Short Term ◽  
Short Term Effects

Dietary Approaches to Stop Hypertension (DASH): potential mechanisms of action against risk factors of the metabolic syndrome

2019 ◽  
Vol 33 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Masoumeh Akhlaghi
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Saturated Fat ◽  
Hdl Cholesterol ◽  
Reduce Blood Pressure ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Dash Diet ◽  
The Metabolic Syndrome

AbstractThe metabolic syndrome is a cluster of disorders dominated by abdominal obesity, hypertriacylglycerolaemia, low HDL-cholesterol, high blood pressure and high fasting glucose. Diet modification is a safe and effective way to treat the metabolic syndrome. Dietary Approaches to Stop Hypertension (DASH) is a dietary pattern rich in fruits, vegetables and low-fat dairy products, and low in meats and sweets. DASH provides good amounts of fibre, K, Ca and Mg, and limited quantities of total fat, saturated fat, cholesterol and Na. Although DASH was initially designed for the prevention or control of hypertension, using a DASH diet has other metabolic benefits. In the present review, the effect of each dietary component of DASH on the risk factors of the metabolic syndrome is discussed. Due to limited fat and high fibre and Ca content, individuals on the DASH diet are less prone to overweight and obesity and possess lower concentrations of total and LDL-cholesterol although changes in TAG and HDL-cholesterol have been less significant and available evidence in this regard is still inconclusive. Moreover, high amounts of fruit and vegetables in DASH provide great quantities of K, Mg and fibre, all of which have been shown to reduce blood pressure. K, Mg, fibre and antioxidants have also been effective in correcting glucose and insulin abnormalities. Evidence is provided from cross-sectional investigations, cohort studies and randomised controlled trials, and, where available, from published meta-analyses. Mechanisms are described according to human studies and, in the case of a lack of evidence, from animal and cell culture investigations.

scholarly journals Impact of body mass decrease of patients with metabolic syndrome on cardiovascular risk factors and reproductive function

2015 ◽  
Vol 12 (2) ◽  
pp. 14-18 ◽  
Author(s):  
Ol'ga Borisovna Kalinkina
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Disease Risk ◽  
Reproductive Age ◽  
Atherogenic Index ◽  
High Density Lipoproteins ◽  
Human Organism ◽  
Special Importance ◽  
Childbearing Age

The obesity pandemia linked metabolic syndrome (MS) connected with it acquires not only medical, but also increasing social importance. This state has unfavorable action on human organism and is the serious diseases risk factor. Special importance MS available in the women of childbearing age. There are described some literature data about the special features of MS pathogenesis in women and the possibilities of its correction with sibutramine and by the combined medication Reduxin® (sibutramine + cellulose microcrystalline). Our own data of the experience of treatment by the Reduxin® 53 women in reproductive age with MS are cited, opsomenorrhea and with a formation of polycystic ovarian syndrome. Patients took the medication during 12 weeks. Mean body weight loss was 13% and 27 patients had weight loss more than 5% at the end the period of observation. Circle of waist was also the decreased on the average on 6±2 cm. 43 women had a normalization of rhythm, duration and intensity of menstrual hemorrhages. Remaining patients it was required the designation of gestagen in the cyclic regime. An improvement of the blood lipid profile was detect: the average value of atherogenic index triglycerides/ high density lipoproteins cholesterol was improved to 35,8%. The maximum decrease of the cardiovascular disease risk factors was marked in the patients, who had weight loss more than 10%.

scholarly journals Salud electrónica para el autocuidado de pacientes con factores de riesgo asociados al síndrome metabólico

2016 ◽  
Vol 18 (1) ◽  
pp. 170 ◽  
Author(s):  
Consuelo Vélez Álvarez ◽  
José Armando Vidarte Claros ◽  
Rosa Elvira Álvarez Rosero ◽  
Jully Andrea García Navarro
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Overweight And Obesity ◽  
World Health ◽  
Factors Associated ◽  
The Metabolic Syndrome ◽  
Síndrome Metabólico ◽  
Factores De Riesgo

ResumenEl propósito de esta revisión, es identificar la evidencia científica sobre el uso de estrategias de salud electrónica en las intervenciones dirigidas a mejorar el autocuidado de pacientes con factores de riesgo cardiovascular asociado con la presencia de síndrome metabólico. Los artículos analizados fueron identificados en las bases de datos PubMed, Science Direct, Embase, Elsevier, Scielo, Adicional a esto se revisaron publicaciones estadísticas de la Organización Mundial de la Salud, La Federación Internacional de Diabetes, Guía de Síndrome Metabólico 2009 y ICT Facts and Figures World in 2013. Se tuvieron en cuenta 51 publicaciones realizadas entre los años 2009 y 2015, encontrándose mayor información en la intervención basada en el control del sobrepeso y la obesidad, como principal factor de riesgo para el desarrollo del síndrome metabólico. La evidencia encontrada en la literatura científica muestra la utilidad de la salud electrónica en el manejo de los factores de riesgo cardiovasculares asociados al síndrome metabólico, y el impacto de esta en la calidad de vida cuando son aplicadas con un adecuado protocolo.  AbstractThe purpose of this review is to identify the scientific evidence on the use of electronic health strategies in interventions aimed at improving self-care of patients with cardiovascular risk factors associated with the presence of metabolic syndrome. The articles analyzed were identified in the databases PubMed, Science Direct, Embase, Elsevier and Scielo. In addition, statistical publications from the World Health Organization, the International Diabetes Federation, Metabolic Syndrome Guide 2009 and ICT Facts and Figures World in 2013 were reviewed. 51 publications between the years 2009 and 2015 were considered, where there were more information about the intervention based on the control of overweight and obesity as a major risk factor for the development of the metabolic syndrome. The evidence found in the scientific literature shows the usefulness of e-health in the management of cardiovascular risk factors associated with metabolic syndrome, and its impact on the quality of life when they are applied with a suitable protocol.

Adipokines and Systemic Lupus Erythematosus: Relationship with Metabolic Syndrome and Cardiovascular Disease Risk Factors

2009 ◽  
Vol 36 (2) ◽  
pp. 295-297 ◽  
Author(s):  
MARTA VADACCA ◽  
DOMENICO MARGIOTTA ◽  
AMELIA RIGON ◽  
FABIO CACCIAPAGLIA ◽  
GIUSY COPPOLINO ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Lupus Erythematosus ◽  
Disease Risk ◽  
Activity Index ◽  
Cardiovascular Disease Risk ◽  
Systemic Lupus ◽  
The Metabolic Syndrome

Objective.To study concentrations of adipokines in patients with systemic lupus erythematosus (SLE) and the relationship among adipokines, the metabolic syndrome (MeS), and cardiovascular disease (CVD) risk factors.Methods.We enrolled 50 SLE patients and 26 controls, all women. Leptin, resistin, visfatin, and adiponectin were measured by commercial ELISA kits.Results.MeS prevalence was increased among subjects with SLE. Leptin levels were higher in patients with SLE than controls. Among SLE patients, independent determinants of leptin were insulin levels (p < 0.0001), triglycerides (p = 0.03), body mass index (p = 0.02), corticosteroid dosage (p = 0.02), and SLE Disease Activity Index (p = 0.005). Other adipokines did not differ between SLE patients and controls.Conclusion.Leptin was increased in SLE patients and could play a role in SLE-related cardiovascular diseases.

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