Inflammatory responses to parasites

Parasitology ◽  
1987 ◽  
Vol 94 (S1) ◽  
pp. S9-S28 ◽  
Author(s):  
C. D. Mackenzie ◽  
A. J. Gatrill ◽  
A. J. Luty ◽  
D. G. Manyasi ◽  
C. Moore ◽  
...  

The patients we are concerned about in tropical medicine are unfortunately affected by a wide range of conditions, not only those seen and studied extensively in the West, such as cancer, cardiovascular diseases and viral or bacterial infections, but also the major protozoan and metazoan conditions – the parasitic diseases. It is with this spectrum of pathophysiological changes that occurs in this last group that we are presently concerned and this communication is intended to present an overview of the subject.

1976 ◽  
Vol 1 (15) ◽  
pp. 143 ◽  
Author(s):  
John Dorrington Mettam

In March 1972 the author's firm in association with two Portuguese firms of consulting engineers, Consulmar and Lusotecna, were appointed by the Portuguese Government agency Gabinete da Area de Sines to prepare designs for the construction of a new harbour at Sines on the west coast of Portugal. The location is shown in Figure 1. The main breakwater, which is the subject of this paper, is probably the largest breakwater yet built, being 2 km long and in depths of water of up to 50 m. It is exposed to the North Atlantic and has been designed for a significant wave height of 11 m. Dolos units invented by Merrifield (ref. 1) form the main armour. The project programme required that studies be first made of a wide range of alternative layouts for the harbour. After the client had decided on the layout to be adopted, documents were to be prepared to enable tenders for construction to be invited in January 1973. This allowed little time for the design to be developed and only one series of flume tests, using regular waves, was completed during this period. Further tests in the regular flume were completed during the tender period and a thorough programme of testing with irregular waves was commenced later in the year, continuing until August 1974 when the root of the breakwater was complete and the construction of the main cross-section was about to start. The model tests, which were carried out at the Laboratorio Nacional de Engenharia Civil in Lisbon, were reported by Morals in a paper presented to the 14th International Coastal Engineering Conference in 1974. (ref. 2)


Art History ◽  
2021 ◽  
Author(s):  
Patricia J. Graham ◽  
Frank L. Chance

Literati painting in Japan is generally referred to as Bunjinga (literati painting; Ch. Wen ren hua) or Nanga (Southern School painting; Ch. nan zong hua), both terms borrowed from China. Wen ren hua refers to the status of artists who belonged to the scholar-gentleman class. Nan zong hua was coined by the Chinese painter and theorist Dong Qichang (b. 1555–d. 1636), who used it to describe art by literati, ostensibly amateurs, whose paintings were indebted to their mastery of calligraphy, expressed their inner feelings, and sought to capture the spiritual essence of their subjects. He deemed Nan zong hua superior to that of another so-called “school” of painters he invented, the “northern school,” professionals whose work he declared to be superficial and decorative. In relation to Japanese literati painters, however, this distinction between the southern and northern schools is largely irrelevant. The diverse and very large group of artists defined as literati painters were variously amateurs and professionals who worked in styles inspired by a wide range of Chinese pictorial approaches, which the Japanese learned from imported woodblock-printed painting books, actual paintings, and Chinese and Korean artists and calligraphers who visited or emigrated to Japan, including professional painters, Confucian scholars, and Chan (Zen) Buddhist monks. Some Japanese literati painters were samurai, others commoners. Their commonality is a dedication to and deep knowledge of Sinophile literati culture—particularly Chinese poetry—and their use of Chinese literati painting subjects, especially ink landscapes and themes, such as bamboo, in response to the market demands of Japanese consumers fascinated by Chinese culture. Many also brushed polished and colorful bird-and-flower paintings modeled after the work of Chinese professional painters, and their art was also impacted by native styles then in vogue and by naturalistic rendering drawn from exposure to imported Western art. Some literati artists earned their living as Confucian scholars or writers and painted as an avocation; others worked as professional painters, presiding over independent ateliers with legions of disciples. Although the literati painting movement began in the Kyoto region, it was quickly embraced by artists throughout the country who often traveled and shared ideas. The first writings on the subject date to the early 20th century, but the heyday of scholarship occurred in the 1970s and 1980s, and resulted, in the West, in a large number of dissertations, with the majority dating from the late 1970s through early 1990s. Those that were subsequently revised as published monographs have been omitted from this bibliography.


2011 ◽  
Vol 31 (04) ◽  
pp. 264-268 ◽  
Author(s):  
K. J. Clemetson

SummaryMany more platelets are present in healthy mammals than are necessary for routine haemostasis. Thus, they could have other functions. Platelets have many of the attributes of innate immune function including Toll-like receptors. They also contain a wide range of anti-microbial peptides in storage granules. Platelets play an important role in bacterial infections, both in disease progress and in defence mechanisms depending on circumstances. Similar mechanisms are used in defence against fungi. Platelets are also involved in viral diseases, either in protecting from the immune system or in killing viruses that activate platelets. Finally, platelets have a role in defence against parasitic diseases, in particular malaria, that should not be ignored, and may aggravate some of the worst aspects. Platelets also have receptors for IgE and are implicated via parasitic disorders in development and problems of allergy.


Author(s):  
Ato Quayson

The term ‘postcolonialism’ is sometimes spelled with a hyphen – post-colonial – and sometimes without. There is no strict general practice, but the hyphenated version is often used to refer to the condition of life after the end of colonialism while the non-hyphenated version denotes the theory that attempts to make sense of this condition. The term is regularly used to denote both colonialism and imperialism even though these refer to different historical realities. Like postmodernism and poststructuralism, postcolonialism designates a critical practice that is highly eclectic and difficult to define. It involves a studied engagement with the experience of colonialism and its past and present effects at the levels of material culture and of representation. Postcolonialism often involves the discussion of experiences such as those of slavery, migration, suppression and resistance, difference, race, gender, place and analysis of the responses to the discourses of imperial Europe, such as history, philosophy, anthropology and linguistics. Since conditions under imperialism and colonialism proper are as much the subject of postcolonialism as those coming after the historical end of colonialism, postcolonialism allows for a wide range of applications and a constant interplay between the sense of a historical transition, a cultural location and an epochal condition. Postcolonialism is seen to pertain as much to conditions of existence in former colonies as to conditions in diaspora. Both are frequently linked to the continuing power and authority of the West in the global political, economic and symbolic spheres and the ways in which resistance to, appropriation of and negotiation with the West’s order are prosecuted. However the term is construed, there is as much focus on the discourse and ideology of colonialism as on the material effects of colonial subjugation. Because it has its source in past and continuing oppression, postcolonialism furthermore has affinities with multicultural, feminist, and gay and lesbian studies.


Author(s):  
R J Hawker ◽  
Carolyn E Hall

Mixed cell,leucocyte or platelet preparations labelled with 111-Indium oxine have been used to visualise septic foci, renal rejection and venous and arterial thrombosis. Pure polymorphonuclear leucocyte preparations are difficult to prepare without modification of cellular activity and are generally contaminated with platelets. Up to 27% of the Indium label is associated with platelets when a granulocyte preparation contains as little as 2% of the original platelet population.Under conditions of limiting Indium-oxine,uptake by platelets is 16.8 and 17.5 times more effective than granulocytes or erythrocytes per unit area of membrane; the accumulation by these latter cell types is related to their surface area with a ratio of 4.7:1. This data is further evidence for a facilitated mechanism for the uptake of Indium by platelets.Labelled platelets have been used for visualisation of sterile and septic abscesses in animals, and in man minor inflammatory responses can be detected. 99.8% pure platelet preparations are simple to prepare and label. These cells which have a more efficient uptake of Indium and long biological survival (up to 9 days) are capable of detecting a wide range of lesions. The use of labelled granulocytes with a short biological survival (about 4 hours) is restricted to haematological investigations and diagnosis of acute bacterial infections or necrosis.


Author(s):  
Denis Tikhomirov

The purpose of the article is to typologize terminological definitions of security, to find out the general, to identify the originality of their interpretations depending on the subject of legal regulation. The methodological basis of the study is the methods that made it possible to obtain valid conclusions, in particular, the method of comparison, through which it became possible to correlate different interpretations of the term "security"; method of hermeneutics, which allowed to elaborate texts of normative legal acts of Ukraine, method of typologization, which made it possible to create typologization groups of variants of understanding of the term "security". Scientific novelty. The article analyzes the understanding of the term "security" in various regulatory acts in force in Ukraine. Typological groups were understood to understand the term "security". Conclusions. The analysis of the legal material makes it possible to confirm that the issues of security are within the scope of both legislative regulation and various specialized by-laws. However, today there is no single conception on how to interpret security terminology. This is due both to the wide range of social relations that are the subject of legal regulation and to the relativity of the notion of security itself and the lack of coherence of views on its definition in legal acts and in the scientific literature. The multiplicity of definitions is explained by combinations of material and procedural understanding, static - dynamic, and conditioned by the peculiarities of a particular branch of legal regulation, limited ability to use methods of one or another branch, the inter-branch nature of some variations of security, etc. Separation, common and different in the definition of "security" can be used to further standardize, in fact, the regulatory legal understanding of security to more effectively implement the legal regulation of the security direction.


2020 ◽  
Vol 48 (3-4) ◽  
pp. 13-26
Author(s):  
Brandon W. Hawk

Literature written in England between about 500 and 1100 CE attests to a wide range of traditions, although it is clear that Christian sources were the most influential. Biblical apocrypha feature prominently across this corpus of literature, as early English authors clearly relied on a range of extra-biblical texts and traditions related to works under the umbrella of what have been called “Old Testament Pseudepigrapha” and “New Testament/Christian Apocrypha." While scholars of pseudepigrapha and apocrypha have long trained their eyes upon literature from the first few centuries of early Judaism and early Christianity, the medieval period has much to offer. This article presents a survey of significant developments and key threads in the history of scholarship on apocrypha in early medieval England. My purpose is not to offer a comprehensive bibliography, but to highlight major studies that have focused on the transmission of specific apocrypha, contributed to knowledge about medieval uses of apocrypha, and shaped the field from the nineteenth century up to the present. Bringing together major publications on the subject presents a striking picture of the state of the field as well as future directions.


2019 ◽  
Vol 9 (4) ◽  
pp. 193-198
Author(s):  
Lyudmila S. Timofeeva ◽  
Albina R. Akhmetova ◽  
Liliya R. Galimzyanova ◽  
Roman R. Nizaev ◽  
Svetlana E. Nikitina

Abstract The article studies the existence experience of historical cities as centers of tourism development as in the case of Elabuga. The city of Elabuga is among the historical cities of Russia. The major role in the development of the city as a tourist center is played by the Elabuga State Historical-Architectural and Art Museum-Reserve. The object of the research in the article is Elabuga as a medium-size historical city. The subject of the research is the activity of the museum-reserve which contributes to the preservation and development of the historical look of Elabuga and increases its attractiveness to tourists. The tourism attractiveness of Elabuga is obtained primarily through the presence of the perfectly preserved historical center of the city with the blocks of integral buildings of the 19th century. The Elabuga State Historical-Architectural and Art Museum-Reserve, which emerged in 1989, is currently an object of historical and cultural heritage of federal importance. Museum-reserves with their significant territories and rich historical, cultural and natural heritage have unique resources for the implementation of large partnership projects. Such projects are not only aimed at attracting a wide range of tourists, but also stimulate interest in the reserve from the business elite, municipal and regional authorities. The most famous example is the Spasskaya Fair which revived in 2008 in Elabuga. It was held in the city since the second half of the 19th century, and was widely known throughout Russia. The process of the revival and successful development of the fair can be viewed as the creation of a special tourist event contributing to the formation of new and currently important tourism products.


2018 ◽  
Vol 7 (4) ◽  
pp. 13-21
Author(s):  
Todd Backes ◽  
Charlene Takacs

There are a wide range of options for individuals to choose from in order to engage in aerobic exercise; from outdoor running to computer controlled and self-propelled treadmills. Recently, self-propelled treadmills have increased in popularity and provide an alternative to a motorized treadmill. Twenty subjects (10 men, 10 women) ranging in age from 19-23 with a mean of 20.4 ± 0.8 SD were participants in this study. The subjects visited the laboratory on three occasions. The purpose of the first visit was to familiarize the subject with the self-propelled treadmill (Woodway Curve 3.0). The second visit, subjects were instructed to run on the self-propelled treadmill for 3km at a self-determined pace. Speed data were collected directly from the self-propelled treadmill. The third visit used speed data collected during the self-propelled treadmill run to create an identically paced 3km run for the subjects to perform on a motorized treadmill (COSMED T150). During both the second and third visit, oxygen consumption (VO2) and respiratory exchange ratio (R) data were collected with COSMED’s Quark cardiopulmonary exercise testing (CPET) metabolic mixing chamber system. The VO2 mean value for the self-propelled treadmill (44.90 ± 1.65 SE ml/kg/min) was significantly greater than the motorized treadmill (34.38 ± 1.39 SE ml/kg/min). The mean R value for the self-propelled treadmill (0.91 ± 0.01 SE) was significantly greater than the motorized treadmill (0.86 ± 0.01 SE). Our study demonstrated that a 3km run on a self-propelled treadmill does elicit a greater physiological response than a 3km run at on a standard motorized treadmill. Self-propelled treadmills provide a mode of exercise that offers increased training loads and should be considered as an alternative to motorized treadmills.


2020 ◽  
pp. 301-323
Author(s):  
Natalya I. Kikilo ◽  

In the Macedonian literary language the analytic da-construction used in an independent clause has a wide range of possible modal meanings, the most common of which are imperative and optative. The present article offers a detailed analysis of the semantics and functions of the Macedonian optative da-construction based on fiction and journalistic texts. The first part of the article deals with the specificities of the optative as a category which primarily considers the subject of a wish. In accordance with the semantic characteristics of this category, optative constructions are used in those discourse text types where the speakers are explicitly designated (the most natural context for the optative is the dialogue). The analysis of the Macedonian material includes instances of atypical usage of the optative da-construction, in which the wish of the subject is not apparent and thereby produces new emotional tonalities perceptible to the reader of a fiction/journalistic text. The study describes Macedonian constructions involving two different verb forms: 1) present tense form (da + praes) and 2) imperfective form (da + impf). These constructions formally designate the hypothetical and counterfactual status of the optative situation, respectively. Thus, the examples in the analysis are ordered according to two types of constructions, which reflect the speaker’s view on the probability of the realisation of his/her wish. Unrealistic wishes can be communicated through the present da-construction, while the imperfective construction denotes situations in which the wish can be realised in the future. The second part of the article is devoted to performative optative da-constructions, which express formulas of speech etiquette, wishes and curses. The analysis demonstrates that these constructions lose their magical functions, when used outside of the ritual context, and begin to function as interjections.


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