Antigenic variability in Trichuris trichiura populations

Parasitology ◽  
1998 ◽  
Vol 117 (4) ◽  
pp. 347-353 ◽  
Author(s):  
R. M. CURRIE ◽  
C. S. NEEDHAM ◽  
L. J. DRAKE ◽  
E. S. COOPER ◽  
D. A. P. BUNDY

The present study examines antigenic variability for the human whipworm Trichuris trichiura. Recognition by IgG of somatic antigens of individual worms collected from 3 intensely infected children from Jamaica, West Indies has been investigated by immunoblotting. When probed with 1 plasma sample, significant differences in recognition of 2 selected antigens among worm populations and between male and female worms was observed. In addition, there was evidence for antigenic variability within worm populations at the individual worm level. Such variation may have considerable implications for the development of immunity to parasitic nematodes.

1985 ◽  
Vol 54 (02) ◽  
pp. 515-517 ◽  
Author(s):  
E A Loeliger ◽  
L Poller ◽  
M Samama ◽  
J M Thomson ◽  
A M H P Van den Besselaar ◽  
...  

SummaryOne of the reasons why oral anticoagulants fell into disrepute is the absence of internationally accepted standardised procedures for controlling the level of anticoagulatiori. This deplorable situation resulted in over- and under-coagulation and uncertainty in the therapeutic range. International conformity can now be obtained by using an International Normalised Ratio (INR) which is derived from the individual result obtained in a given plasma sample and the International Sensitivity Index (ISI) of the tissue thromboplastin reagent used. Any thromboplastin reagent can be calibrated against an international primary or secondary W.H.O. reference preparation, so as to obtain its International Sensitivity Index. The new system of reporting the level of anticoagulation was designed and can only safely be applied in patients taking oral anticoagulants.


Genetika ◽  
2020 ◽  
Vol 52 (3) ◽  
pp. 1009-1019
Author(s):  
Slavko Brankovic ◽  
Dejan Nikolic ◽  
Dragoslav Marinkovic ◽  
Suzana Cvjeticanin

The aim of our study was to evaluate the morphogenetic variability as a marker of smoking dependency in adult smokers versus controls and to investigate the presence and the degree of morphogenetic variability difference between male and female smokers versus same gender controls. The cross-sectional study evaluated 241 smokers and 185 nonsmoker individuals as controls. We analyzed 17 homozygous recessive characteristics (HRC). There was a significant difference in the individual variations of 17 HRCs between the controls and smokers (??2=61.400, p<0.001; for females ??2=79.440, p<0.001; for males ??2=84.972, p<0.001). The mean values of HRCs significantly differed between smokers and controls (MV?SEM(Controls) -4.79?0.13, MV?SEM(Smokers) -5.70?0.12; p<0.001). For males, presence of 6/17 (35.29% genetic homozygosity) HRCs (OR=6.12) was to the certain degree predictor for smoking dependency. Higher degree of genetic homozygosity, changed variability and male gender, might be some among potential numerous factors that could have impact on smoking development and dependence.


Author(s):  
Ranjini Karthikeyan ◽  
Amiya Bhaumik

Body self-relation is a multidimensional construct defined by persons" perceptions of and attitudes about their body. Body image does not simply reflect the biological enrichment of the individual or the feedback received from the significant others. The way you perceive about your body is your cognitive body image. This can lead to excessive concern with body shape and weight. Behaviors in which you relate as a result of your body image encompass your behavioral body image. A study based on the gender differences in body relation relating to young adults rating the comparison in perception of both male and female data. Hundred participants of both male and female took part in answering the by Multidimensional body selfrelations questionnaire (MBSRQ-AS). Results demonstrated by Mann Whitney U test revealed that there is significant difference between male and female young adults in their relation to body self, p<0.05, (2- tailed) in appearance orientation. There is no statistical sig.>0.05 differences in the other dimensions. Therefore, this study rejects the null hypothesis in (dimension) appearance orientation and accepts the null hypothesis (dimensions) in appearance evaluation, body area satisfaction, overweight preoccupation and self-classified weight. Keywords: body self-relation; gender differences


Author(s):  
Dennis Harding

Contemporary studies commonly stress the belief that, even if sex is biologically determined, gender by contrast is a social and cultural construct (Sofaer and Sørensen, 2012). Even biological sex entails varying degrees of male and female attributes in terms of chromosomes and DNA if not in terms of reproductive organs, so that, contrary to the bipolar model of sex, contemporary studies of gender tend to think in terms of a spectrum that includes composite gender or a third gender that is neither male nor female in what Arnold (2006: 155) described as ‘a suprabinary gender system’. In the case of the Byzantine eunuchs or the Indian hijra cited by Croucher (2012: 174–5), these could be regarded as socially constructed, and it is not here suggested that such categories existed in Iron Age Britain or Europe. It is important, however, to be clear that conventional western sexual stereotypes and conceptions of gender roles in child-rearing, food production, and warfare, for example, need not have pertained in non-classical societies in antiquity. Gender issues in the study of funerary archaeology have gained a prominence in the last twenty years not simply as a result of theoretical considerations but also because of more intensive interest in osteological research, as a result of which there has been a greater recognition of the fact that identifying sex may involve evaluation of a spectrum of criteria rather than simple bipolar options. Though pelvic bones remain crucial to assessing sex, the skull and other major bones can also be indicative, and not infrequently the evidence remains equivocal, even where the skeleton is reasonably well preserved. Accordingly, some of the skeletons from the eastern Yorkshire cemeteries were deemed to show ‘contra’ indications, that is male and female characteristics in equal measure, in a gradation of assessment that also included ‘definite’, ‘probable’, and ‘possible’ identifications (Stead, 1991). Furthermore, though sex is biologically determined, osteology may be affected by cultural factors such as the degree of physical exercise that the individual habitually engages in, so that the criteria observed by the osteologist may suggest a physique normally associated with the opposite sex.


Heliyon ◽  
2020 ◽  
Vol 6 (6) ◽  
pp. e04119
Author(s):  
Camille Coomansingh Springer ◽  
Mike Kinsella ◽  
Vishakha Vasuki ◽  
Ravindra Nath Sharma

1970 ◽  
Vol 16 ◽  
pp. 314-329 ◽  

Herbert Leader Hawkins died in Reading on 29 December 1968, having lived and worked there all his life. Spatially, he travelled little prior to visiting the West Indies in his retirement. Intellectually, he was a noted voyageur. Adventurous of mind, kindly, young in heart, vividly imaginative and telling a superb tale, he radiated a genuinely joyful dedication to geology. Outwardly, this inner liveliness beamed through a merry twinkle of eye and ready humour—robust or ribald, sensitive or elegant according to the occasion, which he seldom mistimed or misjudged. A consummate actor on life’s stage, he was for ever transmitting a message or moral. Its essence was, I think, that the materials of scientific enquiry should be loved as well as enjoyed, that feed-back from scientific endeavour to the individual and community mattered pre-eminently; that somewhere behind it all there was a meaning. With him, generations learned to question, as well as respect, things held sacred.


1977 ◽  
Vol 40 (3_suppl) ◽  
pp. 1227-1235 ◽  
Author(s):  
H. Jack Shapiro ◽  
Louis W. Stern

The present study examined the importance of various hierarchical needs, as described by Maslow, to black, white, male, and female business college seniors. Data support the Maslow postulate that the hierarchical needs he proposed are “more universal” for all cultures than are superficial behaviors or desires. The cultural differences between the races begin to be manifest in the magnitude of the individual needs. Data indicate that 58 blacks placed greater importance on most of the needs studied than did the 249 whites regardless of sex.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anne A. Andere ◽  
Meaghan L. Pimsler ◽  
Aaron M. Tarone ◽  
Christine J. Picard

Abstract The production of male and female offspring is often determined by the presence of specific sex chromosomes which control sex-specific expression, and sex chromosomes evolve through reduced recombination and specialized gene content. Here we present the genomes of Chrysomya rufifacies, a monogenic blow fly (females produce female or male offspring, exclusively) by separately sequencing and assembling each type of female and the male. The genomes (> 25X coverage) do not appear to have any sex-linked Muller F elements (typical for many Diptera) and exhibit little differentiation between groups supporting the morphological assessments of C. rufifacies homomorphic chromosomes. Males in this species are associated with a unimodal coverage distribution while females exhibit bimodal coverage distributions, suggesting a potential difference in genomic architecture. The presence of the individual-sex draft genomes herein provides new clues regarding the origination and evolution of the diverse sex-determining mechanisms observed within Diptera. Additional genomic analysis of sex chromosomes and sex-determining genes of other blow flies will allow a refined evolutionary understanding of how flies with a typical X/Y heterogametic amphogeny (male and female offspring in similar ratios) sex determination systems evolved into one with a dominant factor that results in single sex progeny in a chromosomally monomorphic system.


The latter half of the nineteenth century witnessed three events of supreme importance to biology. The first of these consisted in that reasoned theory of the mode of origin of new species with which the name of Charles Darwin will always remain associated. The second lay in the discovery, made by Strasburger in 1875, that the nucleus is not only a permanent organ of the cell, but that certain definite constituents of it are transmitted in unbroken sequence from one cell generation to another. Thirdly, Oscar Hertwig, also in 1875, showed that fertilisation consists not only in the union of male and female cells, but that the union of the two nuclei forms an essential part of the process. At the present time, when evolutionary problems are being attacked at their very roots by the experimental study of variation, results are being accumulated which are capable of being dealt with from a cytological standpoint. Much is to be expected from a joining together of the forces engaged on what are really only different aspects of the same problem. What we really want to know is the nature and mode of working of the machinery which is responsible for the appearance of the characters manifested, as well as inherited, by the organism. We also are concerned with the nature of those inner changes which find their outward expression in what we designate as variation.


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