Cannabis dependence and psychotic symptoms in young people

2003 ◽  
Vol 33 (1) ◽  
pp. 15-21 ◽  
Author(s):  
D. M. FERGUSSON ◽  
L. J. HORWOOD ◽  
N. R. SWAIN-CAMPBELL
Keyword(s):  
Longitudinal Study ◽  
Young People ◽  
Rate Ratio ◽  
Estimating Equation ◽  
Equation Model ◽  
Study Data ◽  
Psychotic Symptoms ◽  
Confounding Factors ◽  
Cannabis Dependence ◽  
Health And Development

Background. The aims of this research were to use data gathered over the course of a 21 year longitudinal study to examine the linkages between cannabis dependence at ages 18 and 21 and rates of psychotic symptoms taking into account previous symptom levels and other confounding factors.Method. Data were gathered during the course of the Christchurch Health and Development Study (CHDS). The CHDS is a longitudinal study of a birth cohort of 1265 children who have been studied from birth to age 21. As part of this study, data were gathered on cannabis dependence and psychotic symptoms at ages 18 and 21.Results. Young people meeting DSM-IV criteria for cannabis dependence had elevated rates of psychotic symptoms at ages 18 (rate ratio = 3.7; 95% CI 2.8–5.0; P<0.0001) and 21 (rate ratio = 2.3; 95% CI 1.7–3.2; P<0.0001). These associations were adjusted for previous psychotic symptoms and a range of other confounding factors using a generalized estimating equation model. This analysis showed that after adjustment for confounding factors, those meeting criteria for cannabis dependence still had an increased rate of psychotic symptoms (rate ratio = 1.8; 95% CI 1.2–2.6; P<0.005).Conclusions. The results show that the development of cannabis dependence is associated with increased rates of psychotic symptoms in young people even when pre-existing symptoms and other background factors are taken into account.

Neuroticism in adolescence and psychotic symptoms in adulthood

2003 ◽  
Vol 33 (6) ◽  
pp. 1089-1097 ◽  
Author(s):  
R. D. GOODWIN ◽  
D. M. FERGUSSON ◽  
L. J. HORWOOD
Keyword(s):  
Longitudinal Study ◽  
Young People ◽  
Mental Disorders ◽  
Childhood Adversity ◽  
Study Data ◽  
Psychotic Symptoms ◽  
Confounding Factors ◽  
Symptom Checklist ◽  
Statistical Adjustment ◽  
Low Levels

Background. The aims of this research were to examine the associations between the personality trait of neuroticism in adolescence and later psychotic symptoms, taking into account potential confounding factors.Method. Data were gathered over the course of a longitudinal study of a birth cohort of New Zealand born young people (N=1265). Over the course of the study, data were gathered on: (a) neuroticism at age 14; (b) psychotic symptoms predominantly subclinical, assessed on the Symptom Checklist (SCL-90), at ages 18 and 21; (c) a range of potential confounding factors including measures of childhood adversity and co-morbid mental disorders.Results. Young people in the highest quartile of neuroticism at age 14 had rates of psychotic symptoms that were two to three times higher than those in the lowest quartile. After statistical adjustment for confounding factors, including childhood adversity and co-morbid mental disorders, the association between neuroticism and later psychotic symptoms reduced but remained statistically significant (P<0·05). After adjustment for confounding, young people with high levels of neuroticism had rates of psychotic symptoms that were between 1·5 to 1·8 times higher than those with low levels of neuroticism.Conclusions. Early neuroticism may be a precursor to the onset of psychotic symptoms. The mechanisms underlying this association are unclear, but may relate to overlapping features between prodromal phases of psychosis and items that measure neuroticism.

Cannabis use and the Mental Health of Young People

2006 ◽  
Vol 40 (2) ◽  
pp. 105-113 ◽  
Author(s):  
Wayne D. Hall
Keyword(s):  
Mental Health ◽  
Young People ◽  
Large Scale ◽  
Illicit Drugs ◽  
Developed Countries ◽  
Cannabis Use ◽  
Psychotic Symptoms ◽  
Cannabis Dependence ◽  
Psychosocial Consequences ◽  
Representative Samples

Objective: To review the evidence on the mental health and psychosocial consequences of rising rates of cannabis use among young people in developed countries. Method: This paper critically reviews epidemiological evidence on the following psychosocial consequences of adolescent cannabis use: cannabis dependence; the use of heroin and cocaine; educational underachievement; and psychosis. Leading electronic databases such as PubMed have been searched to identify large-scale longitudinal studies of representative samples of adolescents and young adults conducted in developed societies over the past 20 years. Results: Cannabis is a drug of dependence, the risk of which increases with decreasing age of initiation. Cannabis dependence in young people predicts increased risks of using other illicit drugs, underperforming in school, and reporting psychotic symptoms. Uncertainty remains about which of these relationships are causal although the evidence is growing that cannabis is a contributory cause of psychotic symptoms. Conclusions: We face major challenges in communicating with young people about the most probable risks of cannabis use (dependence, educational underachievement and psychosis) given uncertainties about these risks and polarized community views about the policies that should be adopted to reduce them.

scholarly journals The Impact of Transitions in Caregiving Status on Depressive Symptoms among Older Family Caregivers: Findings from the Korean Longitudinal Study of Aging

2020 ◽  
Vol 18 (1) ◽  
pp. 42
Author(s):  
Kyungduk Hurh ◽  
Hin Moi Youn ◽  
Yoon Sik Park ◽  
Eun-Cheol Park ◽  
Sung-In Jang
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Family Caregivers ◽  
Depression Scale ◽  
Estimating Equation ◽  
Epidemiologic Studies ◽  
Equation Model ◽  
Significant Difference ◽  
The Impact

This study identifies the effects of transitions in caregiving status on depressive symptoms among middle-aged or older adults who care for family members with limitations in activities of daily living (ADL). Data were collected from the 2006–2018 Korean Longitudinal Study of Aging. A total of 7817 subjects were included. On the basis of their caregiving status transition, participants were categorized into four groups: started caregiving, continued caregiving, stopped caregiving, and noncaregivers. Depressive symptoms were measured using the 10 item Center for Epidemiologic Studies Depression Scale. Analysis using a generalized estimating equation model and subgroup analyses were conducted. Compared to noncaregivers, women who started caregiving showed more depressive symptoms in the following year (β 0.761, p < 0.0001). Regardless of sex, older adults who continued caregiving had more depressive symptoms than noncaregivers did (β 0.616, p < 0.0277 in men, and β 1.091, p < 0.0001 in women). After relinquishing caregiving responsibilities to other caregivers, participants’ depressive symptoms in the following year showed no statistically significant difference from that of noncaregivers. Thus, starting or continuing caregiving was associated with increased depressive symptoms, and those symptoms could be normalized by stopping caregiving. Intervention strategies to reduce family caregivers’ depressive symptoms are needed.

scholarly journals Association between successful aging transitions and depressive symptoms among older Korean adults: findings from the Korean longitudinal study of aging (2006–2018)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fatima Nari ◽  
Bich Na Jang ◽  
Selin Kim ◽  
Wonjeong Jeong ◽  
Sung-In Jang ◽  
...  
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Successful Aging ◽  
Adult Population ◽  
Estimating Equation ◽  
Equation Model ◽  
Longitudinal Association ◽  
Older Adult Population

Abstract Background The importance of SA (Successful aging) has been emphasized in recent years, with focus shifting towards attaining healthier aging rather than longevity. However, the influence of SA and its changes on mental health such as depression remains a relatively unexplored area in gerontology. Therefore, we investigated the longitudinal association between changes in SA and depressive symptoms in Korean older adults. Methods This study comprised a longitudinal sample of older adults aged ≥ 45 years, drawn from the Korean Longitudinal Study of Aging (2006–2018). Changes in SA status was determined using the Rowe and Kahn model over two consecutive years. Using an adjusted generalized estimating equation model, we examined the association between changes in successful aging status, namely SA and NSA (Non-successful aging), and depressive symptoms. Results Compared to the SA→SA group, depressive symptom risk in the NSA→NSA and SA→NSA groups were higher in men [(OR, 1.16; 95 % CI, 1.13–1.18), (OR, 1.11; 95 % CI, 1.08–1.13), respectively] and in women [(OR, 1.15; 95 % CI, 1.13–1.18), (OR, 1.11; 95 % CI, 1.09–1.14), respectively]. Subgroup analysis of the dimensions of successful aging revealed that low or worsening criteria of successful aging status in men and women were associated with depressive symptoms. Conclusions Korean older adults who continuously failed to attain or maintain successful aging status had the highest risk of depressive symptoms. These results could further assist in establishing policies and interventions that promote successful aging and subsequently protect the mental health of the Korean older adult population.

Persistent environmental reservoirs on farms as risk factors forCampylobacterin commercial poultry

2011 ◽  
Vol 140 (5) ◽  
pp. 916-924 ◽  
Author(s):  
J. ELLIS-IVERSEN ◽  
A. RIDLEY ◽  
V. MORRIS ◽  
A. SOWA ◽  
J. HARRIS ◽  
...  
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Estimating Equation ◽  
Equation Model ◽  
The Other ◽  
Generalized Estimating Equation ◽  
Temporal Aspects ◽  
Commercial Poultry ◽  
Developed World ◽  
Generalized Estimating

SUMMARYCampylobacteris the most common known source of human bacterial enteritis in the developed world and poultry is considered the main source. Broilers often become colonized withCampylobacterduring rearing, and then contaminate the farm environment. The objective of this study was to identifyCampylobacter-positive environmental reservoirs on farms, as these pose a risk to broiler flocks becoming colonized withCampylobacter. We considered the temporal aspects of exposure and colonization. A longitudinal study monitored six conventional rearing farms over 2 years. The broiler flocks, catchers' equipment, vehicles, shed surrounds, shed entrance, other equipment, farm entrance, other animals, puddles, dead birds, mains water and drinkers were systematically sampled 2–4 times per flock. A multivariable generalized estimating equation model was used to assess associations between contaminated environmental sites and colonized broiler flocks. The associations were adjusted for confounders and other known risk factors. To further assess temporality of contamination, the sequence of contamination of the different environmental sites and the flocks was established. Contaminated shed entrances and anterooms, contaminated drinkers and shedding ofCampylobacterby other animals such as cattle, dogs, wildlife and rodents were significantly associated with positive flocks. The reservoir of ‘other animals’ was also the reservoir most commonly positive before the flock became colonized. The other sites usually became contaminated after the flock was colonized.

scholarly journals Bullying victimization in adolescence and psychotic symptomatology in adulthood: evidence from a 35-year study

2016 ◽  
Vol 46 (6) ◽  
pp. 1311-1320 ◽  
Author(s):  
J. M. Boden ◽  
S. van Stockum ◽  
L. J. Horwood ◽  
D. M. Fergusson
Keyword(s):  
Sexual Abuse ◽  
Economic Status ◽  
Estimating Equation ◽  
Attention Problems ◽  
Psychotic Symptoms ◽  
Bullying Victimization ◽  
Paranoid Ideation ◽  
Before And After ◽  
Health And Development ◽  
Child Intelligence

BackgroundThere has been considerable recent interest in possible causal linkages between exposure to bullying victimization and later psychotic symptomatology. Prior research in this area has had several limitations which make it difficult to ascertain causality, and to determine the extent to which these effects extend beyond adolescence.MethodData were obtained from the Christchurch Health and Development Study, a 35-year study of a longitudinal birth cohort. This investigation used generalized estimating equation modelling to estimate the associations between bullying victimization (ages 13–16 years) and psychotic symptoms (ages 18–35 years), before and after controlling for possible confounding factors, including: gender; childhood socio-economic status; child intelligence quotient; exposure to sexual abuse in childhood; anxious/withdrawn behaviour and attention problems (ages 7–9 years); and adolescent psychotic symptoms and paranoid ideation (ages 15–16 years).ResultsThere was a significant (p < 0.0001) bivariate association between bullying victimization in adolescence and psychotic symptomatology in adulthood. Successive models controlling for covariation reduced this association to statistical non-significance. After controlling for covariates, those with the highest level of bullying victimization had rates of psychotic symptoms that were 1.21 (95% confidence interval 0.73–1.99) times higher than those who were not victimized.ConclusionsThe association between bullying victimization in adolescence and psychotic symptomatology in adulthood could be largely explained by childhood behavioural problems, and exposure to sexual abuse in childhood. The results suggest that bullying victimization was unlikely to have been a cause of adult psychotic symptoms, but bullying victimization remained a risk marker for these symptoms.

scholarly journals Platelet is the Early Predictor of Bronchopulmonary Dysplasiaa in Very Premature Infants: An Observational Cohort Study

2021 ◽  
Author(s):  
Xiaoling Wang ◽  
Yan Ma ◽  
Shenghui Wang ◽  
Wenbin Dong ◽  
Xiaoping Lei
Keyword(s):  
Cohort Study ◽  
Premature Infants ◽  
Estimating Equation ◽  
Equation Model ◽  
Birth Cohort Study ◽  
Stepwise Logistic Regression ◽  
Confounding Factors ◽  
Distribution Width ◽  
Very Premature Infants ◽  
Early Predictor

Abstract Background: A previous study showed that the lungs are involved in the biogenesis of platelets (PLTs). Thus, the present study aimed to investigate the association between bronchopulmonary dysplasia (BPD), a chronic lung disease, and PLT parameters in very premature infants.Methods: The study subjects were premature infants with a gestational age of < 30 weeks and birth weight of < 1500 g in a preterm birth cohort study recruited between January 1, 2015, and August 31, 2019. BPD was defined as the need for oxygen supplementation more than 28 days after birth. The PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) level were compared between BPD and non-BPD infants. A generalized estimating equation model was used to adjust for confounding factors. A forward stepwise logistic regression model was used to calculate the adjusted odds ratio (OR) for thrombocytopenia in the BPD group.Results: The final study subjects were 134 very premature infants, namely, 64 infants with BPD and 70 infants without BPD. The BPD infants had lower PLT counts (F=25.39, P=0.00) and PCT levels (F=41.16, P=0.00) than the non-BPD infants. However, the MPV (F=37.65, P=0.00) and PDW (F=28.43, P=0.00) were higher in the BPD group. After adjusting for potential confounding factors, the BPD infants had a higher risk of thrombocytopenia than the non-BPD infants (adjusted OR 3.18, 95% CI 1.21, 8.35), and the risk of BPD was increased in very premature infants with a PLT count ≤ 177*109/l (OR 4.74, 95% CI 1.93–11.62) at the end of the second week.Conclusions: Abnormal PLT parameters were observed in BPD infants, and a PLT count ≤ 177*109/l was an early predictor for BPD in very premature infants.

scholarly journals Mechanisms of Moral Disengagement in the Transition from Cybergossip to Cyberaggression: A Longitudinal Study

2021 ◽  
Vol 18 (3) ◽  
pp. 1000 ◽  
Author(s):  
Daniel Falla ◽  
Rosario Ortega-Ruiz ◽  
Eva M. Romera
Keyword(s):  
Longitudinal Study ◽  
Young People ◽  
Moral Disengagement ◽  
Risky Behaviour ◽  
Online Bullying ◽  
Final Sample ◽  
Longitudinal Association ◽  
Online Behaviour ◽  
Responsible Behaviour ◽  
Fine Distinction

The internet is an area where young people establish relationships and develop socially, emotionally and morally, but it also gives rise to certain forms of online behaviour, such as cybergossip, which are associated with cyberaggression and other risky behaviour. The aims of this study were to verify whether a longitudinal association exists between cybergossip and cyberaggression, and to discover which mechanisms of moral disengagement may mediate this relationship. The final sample consisted of 1392 students (50% girls; Mage = 13.47; SD = 0.77), who were surveyed in a three-wave longitudinal study at six-month intervals. The results obtained confirmed a direct, positive relationship between cybergossip, subsequent cyberaggression and the mediation exerted by cognitive restructuring in this transition. We discuss the importance of recognizing and detecting the fine distinction between online gossip and cyberaggression with the intention of doing harm, and focus on the justifications used by young people to normalize online bullying. To sum up, there is a clear need to encourage ethical, responsible behaviour in online interactions in order to achieve well-balanced, more sustainable relationships in classrooms.

Methamphetamine use and psychotic symptoms: findings from a New Zealand longitudinal birth cohort

2021 ◽  
pp. 1-8
Author(s):  
Joseph M. Boden ◽  
James A. Foulds ◽  
Giles Newton-Howes ◽  
Rebecca McKetin
Keyword(s):  
New Zealand ◽  
General Population ◽  
Birth Cohort ◽  
Individual Characteristics ◽  
Psychotic Symptoms ◽  
Confounding Factors ◽  
Long Term Effects ◽  
Methamphetamine Use ◽  
Increased Risk ◽  
Psychosis Risk

Abstract Background This study examined the association between methamphetamine use and psychotic symptoms in a New Zealand general population birth cohort (n = 1265 at birth). Methods At age 18, 21, 25, 30, and 35, participants reported on their methamphetamine use and psychotic symptoms in the period since the previous interview. Generalized estimating equations modelled the association between methamphetamine use and psychotic symptoms (percentage reporting any symptom, and number of symptoms per participant). Confounding factors included childhood individual characteristics, family socioeconomic circumstances and family functioning. Long term effects of methamphetamine use on psychotic symptoms were assessed by comparing the incidence of psychotic symptoms at age 30–35 for those with and without a history of methamphetamine use prior to age 30. Results After adjusting for confounding factors and time-varying covariate factors including concurrent cannabis use, methamphetamine use was associated with a modest increase in psychosis risk over five waves of data (adjusted odds ratio (OR) 1.33, 95% confidence interval (CI) 1.03–1.72 for the percentage measure; and IRR 1.24, 95% CI 1.02–1.50 for the symptom count measure). The increased risk of psychotic symptoms was concentrated among participants who had used at least weekly at any point (adjusted OR 2.85, 95% CI 1.21–6.69). Use of methamphetamine less than weekly was not associated with increased psychosis risk. We found no evidence for a persistent vulnerability to psychosis in the absence of continuing methamphetamine use. Conclusion Methamphetamine use is associated with increased risk of psychotic symptoms in the general population. Increased risk is chiefly confined to people who ever used regularly (at least weekly), and recently.

scholarly journals Relationship between workers’ return to work, job retention and income in industrial accidents in Korea: a longitudinal study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e039948
Author(s):  
Suk Won Bae ◽  
Inchul Jeong ◽  
Jin-Ha Yoon ◽  
Seung Wook Lee ◽  
Tae Hyun Kim ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Return To Work ◽  
Original Work ◽  
Occupational Injury ◽  
Economic Status ◽  
Panel Study ◽  
Estimating Equation ◽  
Job Retention ◽  
Industrial Accidents ◽  
Priority Assignment

ObjectiveThis study aims to compare workers’ income before and after an occupational injury, with regard to return to work and job retention, over a period of 5 years.DesignThis study was designed as a longitudinal study.SettingThe Panel Study of Workers’ Compensation Insurance (PSWCI) survey targeted workers involved in industrial accidents for which medical care was terminated in the year 2012.ParticipantsThe panel study was conducted on a final sample of 2000 workers who were selected proportionally by region (nine regions) after priority assignment by disability rating (six levels). A total of 1458 workers were finally included in this study.MethodsThis study used data from the first to fifth PSWCI. To identify the effect on income after occupational injury considering return to work and job retention, we used the generalised estimating equation.ResultsIn regard to workers’ return to work, the OR that income after an occupational injury would be higher than that before an occupational injury was 3.17 (2.41–4.17) for those who returned to original work and 2.32 (1.81–2.97) for those re-employed as compared with who did not return to work and 1.27 (1.07–1.15) for those who retained their job as compared with those who did not. The ORs were 2.91 (2.26–3.75) for those who were re-employed and retained jobs and 2.96 (2.15–4.08) for those who returned to original work and did not retain jobs as compared with those who did not return to work and did not retain jobs.ConclusionsIt is important for accident victims to retain their jobs to maintain their economic status.

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