scholarly journals Evaluation of the relationship between ventricular function and serum growth differentiation factor-15 levels in patients with operated tetralogy of Fallot

2021 ◽  
pp. 1-6
Author(s):  
Damla Önal ◽  
Ayşe G. Eroğlu ◽  
Nazlı G. Akyel ◽  
Esra K. Yüksel ◽  
Hasan Karakaş ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Cardiac Mri ◽  
Pulmonary Regurgitation ◽  
Volume Index ◽  
Healthy Children ◽  
Growth Differentiation Factor 15 ◽  
Systolic Volume ◽  
Differentiation Factor ◽  
Significant Difference ◽  
The Relationship

Abstract Aim: Growth differentiation factor-15 is a novel biomarker of increasing importance in cardiovascular diseases. This study aimed to evaluate the relationship between ventricular measurements assessed by cardiac magnetic resonance imaging (MRI) and serum growth differentiation factor-15 levels in children with surgically corrected tetralogy of Fallot. Materials and method: Serum growth differentiation factor-15 levels were measured in 40 patients (mean age: 15.2 ± 2.9 years; 52.5% male; 87.5% NYHA I). End-diastolic volume index, end-systolic volume index, and ejection fractions of both ventricles and pulmonary regurgitation fraction were measured on cardiac MRI. The correlation between growth differentiation factor-15 levels and cardiac MRI parameters of the patients was investigated. Also, growth differentiation factor-15 levels of the patients were compared with healthy controls since reference values have not been determined in children. Results: The mean growth differentiation factor-15 level was 254.9 ± 6.3 pg/ml in the patient group. There was no correlation between growth differentiation factor-15 levels and cardiac MRI parameters in patients. Also, there was no significant difference in growth differentiation factor-15 levels between the patients and control groups. Conclusion: The serum levels of growth differentiation factor-15 were uncorrelated with ventricular size, function, and pulmonary regurgitation fraction assessed by cardiac MRI in children with operated tetralogy of Fallot. Moreover, growth differentiation factor-15 levels were not different in these patients from healthy children.

scholarly journals Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jin Ook Chung ◽  
Seon-Young Park ◽  
Dong Hyeok Cho ◽  
Dong Jin Chung ◽  
Min Young Chung
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Growth Differentiation Factor 15 ◽  
Type 2 Dm ◽  
Differentiation Factor ◽  
Significant Difference ◽  
The Relationship

AbstractThe purpose of our study was to investigate the relationship between plasma growth differentiation factor-15 (GDF-15) concentrations and diabetic retinopathy in patients with type 2 diabetes mellitus (DM). We evaluated 235 patients with type 2 DM in a cross-sectional study. Significantly increased levels of the plasma GDF-15 were found in individuals with diabetic retinopathy versus those without. According to the degree of diabetic retinopathy, there was a significant difference in the average plasma GDF-15 levels (no diabetic retinopathy, 1114 ng/L; nonproliferative diabetic retinopathy, 1327 ng/L; proliferative diabetic retinopathy, 1445 ng/L; p for trend = 0.035) after adjustments for confounders. Logistic regression analyses indicated that plasma GDF-15 concentrations were significantly associated with diabetic retinopathy (odds ratio per 1 standard deviation increment in the log-transformed value, 1.78; 95% confidence interval, 1.05–3.03, p = 0.032). Our study showed a significant positive relationship between plasma GDF-15 concentrations and diabetic retinopathy in type 2 DM patients.

scholarly journals Arrhythmias in repaired pediatric and adolescent Fallot tetralogy, correlation with cardiac MRI parameters

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Samira Saraya ◽  
Ahmed Ramadan ◽  
Antoine AbdelMassih ◽  
Gehan Hussein ◽  
Fatma Al zahraa Mostafa ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Cardiac Mri ◽  
Surgical Repair ◽  
Pulmonary Regurgitation ◽  
Ventricular Dilatation ◽  
Volume Index ◽  
Cross Sectional ◽  
Transthoracic Doppler Echocardiography ◽  
Significant Difference ◽  
Right Ventricular Dilatation

Abstract Background Tetralogy of Fallot (TOF) is a common congenital cyanotic heart disease in which arrhythmias could develop even after successful operative repair. Pulmonary regurgitation and right ventricular dilatation develop in many cases. The relation between arrhythmias and right ventricular dilatation is not established. Our aim is to assess the relation in between the degree of right ventricular volume affection and the severity of the pulmonary regurgitation, associated arrhythmias and the need for pulmonary valve repair in Egyptian pediatric and adolescent cases after successful TOF repair. Results A cross sectional descriptive study was conducted on 32 cases after successful surgical repair. Transthoracic Doppler echocardiography, 24 h Holter monitoring and cardiac MRI for assessment of pulmonary regurgitation fraction (PRF), ventricular volumes and function were measured. Cases were classified according to right ventricular end diastolic volume index (RVEDVI) into 2 groups with cut off value 150 ml/m2. Mean age of the studied cases was (12.96 ± 3.384) years, mean age at time of surgical repair was (34.23 ± 22.1) months, and mean duration postoperatively was (121.72 ± 41.028) months. Eighteen cases (56%) had RVEDVI ≥ 150 ml/m2, PRF was significantly higher in cases with increased RVEDVI (p value 0.007), with positive significant correlation between RVEDVI and PRF (p value = 0.0001, r = 0.61). Arrhythmias were detected in 18 cases (56%), the most common of which was infrequent supraventricular ectopy. No significant difference in incidence of arrhythmias between the 2 groups (p value = 1) with also no significant correlation between arrhythmias and increased RVEDVI (p value = 0.76, r = 0.05). No difference between cases with and without arrhythmias regarding RVEDVI (p value = 0.56) or PRF (p value = 0.5). Conclusion Holter detected arrhythmias after successful surgical repair of TOF were significantly associated with increased postoperative duration but not with PRF or RVEDVI.

scholarly journals Three Dimensional (3D) Echocardiography as a Tool of Left Ventricular Assessment in Children with Dilated Cardiomyopathy: Comparison to Cardiac MRI

2018 ◽  
Vol 6 (12) ◽  
pp. 2310-2315
Author(s):  
Nevin Mohamed Habeeb ◽  
Omneya Ibrahim Youssef ◽  
Waleed Mohamed Elguindy ◽  
Ahmed samir Ibrahim ◽  
Walaa Hamed Hussein
Keyword(s):  
Cardiac Mri ◽  
Systolic Function ◽  
Three Dimensional ◽  
Lateral Wall ◽  
Left Ventricular ◽  
3D Echocardiography ◽  
Prognostic Indicators ◽  
Systolic Volume ◽  
Significant Difference ◽  
Lv Volumes

BACKGROUND: Left ventricular (LV) volumes and ejection fraction (EF) is Strong prognostic indicators for DCM. Cardiac MRI (CMRI) is a preferred technique for LV volumes and EF assessment due to high spatial resolution and complete volumetric datasets. Three-dimensional echocardiography is a promising new technique under investigations. AIM: Evaluate 3D echocardiography as a tool in LV assessment in DCM children about CMRI. PATIENTS AND METHODS: A group of 20 DCM children (LVdiastolic diameter < 2 Z score, LVEF < 35%) at Children s Hospital, Ain-Shams University (gp1) (mean age 6.6 years) were compared to 20 age and sex-matched children as controls (gp2). Patients were subjected to: clinical examination, conventional echocardiography, automated 3D LV quantification, 3D speckle tracking echocardiography (3D-STE) (VIVID E9 Vingmed, Norway) and CMRI (Philips Achieva Nova, 1.5 Tesla scanner) for LV end systolic volume (LVESV), LVend diastolic volume (LVEDV) that were indexed to body surface area, EF% and wall motion abnormalities assessment. RESUTS: No statistically significant difference was found between automated 3D LV quantification echocardiography, 3D-STE, and CMRI in ESV/BSA and EDV/BSA assessment (p = 1, 0.99 respectively), between automated LV quantification echocardiography and CMRI in EF% assessment (p = 0.99) and between CMRI and 3D-STE in LV Global hypokinesia detection (P = 0.255). As for segmental hypokinesia CMRI was more sensitive [45% of patients vs. 40%, (P = 0,036), basal septal hypokinesia 85% vs. 75%, (p = 0.045), mid septal hypokinesia 80% vs. 65%, (p = 0.012) and lateral wall hypokinesia 75% vs. 65%, (p = 0.028)]. CONCLUSION: Automated 3D LV quantification echocardiography and 3D-STE are reliable tools in LV volumetric and systolic function assessment about CMRIas a standard method. 3D speckle echocardiography is comparable to CMRI in global wall hypokinesia detection but less sensitive in segmental wall hypokinesia which mandates further studies.

scholarly journals Association between Growth Differentiation Factor 15 and Non-Dipping Circadian Pattern in Patients with Newly Diagnosed Essential Hypertension

2019 ◽  
Vol 28 (6) ◽  
pp. 566-572 ◽  
Author(s):  
Erdoğan Sökmen ◽  
Cahit Uçar ◽  
Serkan Sivri ◽  
Mustafa Çelik ◽  
Yalçın Boduroğlu ◽  
...  
Keyword(s):  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Newly Diagnosed ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Linear Correlation Analysis ◽  
Normotensive Subjects ◽  
Relationship Of ◽  
Independent Marker ◽  
The Relationship

Objective: Non-dipper hypertension (HT) confers greater risk compared with dipper HT. Growth differentiation factor 15 (GDF-15) recently emerged as a novel and independent marker of cardiovascular disease, both in diagnostic and prognostic scopes. Our aim was to evaluate the relationship of circadian blood pressure (BP) pattern with serum GDF-15 level in newly diagnosed HT patients without left ventricular hypertrophy. Subjects and Methods: Newly diagnosed non-dipper (n = 66) and dipper (n = 60) HT patients were selected according to 24-h ambulatory BP monitoring (ABPM). The controls comprised healthy normotensive subjects (n = 31). Data was collected through physical examination, laboratory analysis, ABPM, and echocardiography. GDF-15 was measured using ELISA. Results: Greater GDF-15 level was found in the non-dippers compared with the dippers and the controls (557.53 ± 91.7, 513.79 ± 62.86, and 494.44 ± 79.30 ng/L, respectively, p < 0.001). In bivariate linear correlation analysis, GDF-15 correlated positively with glomerular filtration rate (r = 0.180, p =0.030), total cholesterol (r = 0.170, p = 0.038), septal E/E′ ratio (r = 0.344, p = 0.001), lateral E/E′ ratio (r = 0.366, p < 0.001), nighttime systolic BP (r = 0.166, p = 0.046), and nighttime diastolic BP (r = 0.188, p = 0.024); however, it correlated negatively with septal and lateral E′ velocities (r = 0.268, p = 0.005 and r = 0.236, p = 0.013, respectively). Furthermore, GDF-15 level and nighttime diastolic BP remained independently associated with non-dipper HT. In ROC analysis, optimal cutoff value for GDF-15 was 524.6 ng/L with 56.7% sensitivity and 72.4% specificity (AUC: 0.676, 95% CI: 0.580–0.772, p < 0.05). Conclusion: Our results showed GDF-15 upregulation in the non-dipper HT group. GDF-15 and nighttime diastolic BP were independently associated with the non-dipping pattern. This study may suggest possible utilization of GDF-15 in the prediction of non-dipper HT.

P6597Long-term impact of catheter ablation on growth differentiation factor-15 and neutrophil-lymphocyte ratio in paroxysmal atrial fibrillation

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
K Bin Waleed ◽  
Y L Xia ◽  
L J Gao ◽  
Y Xiaomeng ◽  
G Tse ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Sinus Rhythm ◽  
Inflammatory Biomarkers ◽  
Growth Differentiation Factor 15 ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Differentiation Factor ◽  
Significant Difference

Abstract Background There is increasing evidence that inflammatory biomarkers growth differentiation factor 15 (GDF-15) and neutrophil-lymphocyte ratio (NLR) appear to be associated with stroke and adverse cardiovascular events in patients with atrial fibrillation (AF). However, long-term impact of catheter ablation (CA) on GDF-15 and NLR is still unknown. Objective To evaluate the long-term change in GDF-15 and NLR after CA in paroxysmal AF patients. Methods A total of 58 paroxysmal AF patients were consecutively enrolled to perform CA. The inflammatory biomarkers GDF-15 and NLR were measured at baseline and 6-months postablation. Results All patients except one could complete 6-Months follow up. Fifty (87.7%) patients maintained sinus rhythm (SR group) and seven (12.3%) patients sustained AF recurrence (AFR group). No significant difference was noted in clinical and procedural characteristics between two groups (p>0.05), except mean fluoroscopy time (minutes 22±11.7 vs. 13±5.3, p=0.001) significantly longer in AFR than SR group. The GDF-15 (pg/ml 195±57 vs. 216±88, p=0.398), and NLR (% 1.8 (1.3–3) vs. 2.6 (1.4–3.4), p=0.395) were comparable at baseline in both SR and AFR groups respectively. At 6-months postablation, GDF-15 (pg/ml 133±41 vs. 195±57, p<0.001), and NLR (% 1.6 (1.1–2) vs. 1.8 (1.3–3), p=0.004) were significant deceased compared to baseline levels in SR group. However, GDF-15 (pg/ml 139±86 vs. 216±88, p=0.064), and NLR (% 1.6 (1.2–3) vs. 2.6 (1.4–3.4), p=0.398) biomarkers remained comparable to baseline level in AFR group (p>0.05) Conclusion Inflammatory biomarkers; GDF-15 and NLR significantly decreased at long-term on successful maintenance of sinus rhythm by CA in paroxysmal AF patients. Acknowledgement/Funding None

scholarly journals Assessment of flow pattern of right ventricle outflow and pulmonary arteries in surgically corrected tetralogy of Fallot patients by four-dimensional cardiac magnetic resonance flow

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Mahmoud Shaaban ◽  
Mai Salama ◽  
Ayman Alsaied ◽  
Raghda Elsheikh ◽  
Magdy Elmasry
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Right Ventricle ◽  
Tetralogy Of Fallot ◽  
Pulmonary Arteries ◽  
Pulmonary Regurgitation ◽  
Peak Systolic Velocity ◽  
Volume Index ◽  
Flow Measurements ◽  
Good Agreement

Abstract Background The most common post-surgical complication of tetralogy of Fallot (TOF) is pulmonary regurgitation (PR) which can lead to right ventricle (RV) dysfunction/failure. Cardiac magnetic resonance (CMR) is the imaging modality of choice to follow-up a repaired TOF. However, the conventional two-dimensional phase-contrast (2D-PC) flow usually underestimates PR as well as the pulmonary peak systolic velocity (PSV). Recently, four-dimensional (4D) CMR flow is introduced for more accurate quantitative flow assessment. This work aimed to compare between 4D-CMR and 2D-PC flow across the main (MPA), right (RPA), and left (LPA) pulmonary arteries (PAs) in surgically corrected TOF patients. Results This study was conducted on 20 repaired TOF patients (range 3–9 years, 50% males). All patients had CMR exam on 1.5T scanner. 4D-CMR and 2D-PC flows were obtained at the proximal segments of the MPA, RPA, and LPA. The stroke volume index (SVI), regurgitation fraction (RF), and PSV measured by 4D-CMR were compared to 2D-PC flow. The SVI across the PAs was nearly similar between both methods (P = 0.179 for MPA, 0.218 for RPA, and 0.091 for LPA). However, the RF was significantly higher by 4D-CMR in comparison to 2D-PC flow (P = 0.027 for MPA, 0.039 for RPA, and 0.046 for LPA). The PSV as well was significantly higher by 4D-CMR flow (P = 0.003 for MPA, < 0.001 for RPA, and 0.002 for LPA). The Bland-Altman plots showed a good agreement between 4D-CMR and 2D-PC flow for the SVI, RF, and PSV across the pulmonary arteries. Conclusion A good agreement existed between the two studied methods regarding pulmonary flow measurements. Because of its major advantage of performing a comprehensive flow assessment in a shorter time, 4D-CMR flow plays an important role in the assessment of patients with complex CHD especially in the pediatric group.

scholarly journals The Relationship Between Circulating Growth Differentiation Factor 15 Levels and Diabetic Retinopathy in Patients With Type 2 Diabetes

2021 ◽  
Vol 12 ◽  
Author(s):  
Yixin Niu ◽  
Weiwei Zhang ◽  
Jie Shi ◽  
Yueming Liu ◽  
Hongmei Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Imaging System ◽  
Digital Camera ◽  
Albumin Creatinine Ratio ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Increased Risk ◽  
The Relationship

ObjectiveGrowth differentiation factor 15 (GDF-15) is a member of the TGF-β superfamily that has anti-inflammatory properties. The objective of this study was to evaluate the relationship between circulating GDF-15 levels and diabetic retinopathy (DR) in patients with type 2 diabetes.Materials/MethodsA case–control study was performed in which 402 patients with type 2 diabetes were enrolled. Of these, 171 patients had DR and the remaining 231 patients without DR acted as controls. The plasma GDF-15 levels were measured using ELISA, while DR was diagnosed using the canon ophthalmic digital imaging system and the Canon EOS 10D digital camera (Canon, Tokyo, Japan) through a non-pharmacologically dilated pupil.ResultsThe levels of GDF-15 were significantly higher in patients with DR [168.9 (112.9–228.3) pg/ml vs. 127.8 (96.1–202.8) pg/ml, P &lt; 0.001] compared to controls. Results of the Spearman correlation analysis showed that the GDF-15 levels were positively associated with the duration of diabetes morbidity, fasting plasma glucose, systolic blood pressure, albumin/creatinine ratio, creatinine, and liver enzymes, but negatively associated with eGFR (both P &lt; 0.001). The participants in the highest GDF-15 quartile had a significantly increased risk for DR (OR = 2.15, 95% CI 1.53–3.02) after adjusting for potential cofounders.ConclusionsThe circulating GDF-15 levels are positively associated with DR independent of potential cofounders.

scholarly journals Evaluación del Talk Test como método para estimar la intensidad del ejercicio en niños sanos (Evaluation of the Talk Test as a method to estimate exercise intensity in healthy children)

Retos ◽  
2019 ◽  
pp. 303-308
Author(s):  
Danissa Hernández ◽  
Natalia Pacheco ◽  
Issis Poblete ◽  
Héctor Tórres ◽  
Iván Rodríguez-Núnez
Keyword(s):  
Heart Rate ◽  
Exercise Intensity ◽  
Healthy Children ◽  
Exercise Tests ◽  
Indirect Methods ◽  
A Value ◽  
Significant Difference ◽  
Intensity Of Exercise ◽  
Incremental Step ◽  
The Relationship

Introducción: La frecuencia cardíaca (FC) ha sido tradicionalmente utilizada para regular la intensidad del ejercicio, sin embargo, presenta limitaciones para su cuantificación sin un monitor cardiaco. En consecuencia, métodos indirectos, como el Talk Test (TT), han sido validados en adultos, no así en población infantil. El objetivo de este estudio fue determinar la relación entre el TT y los métodos objetivos para cuantificar la intensidad del ejercicio en niños sanos chilenos. Métodos: Se consideró a niños sanos de ambos géneros entre 8 y 12 años. Los sujetos realizaron dos pruebas de ejercicio incremental en escalón separadas por 7 días. El TT se incorporó en una de las dos pruebas aleatoriamente. Se midió la FC, percepción del esfuerzo (PE) y carga de trabajo, cada un minuto durante la prueba. Se comparó la FC, PE y carga de trabajo entre la respuesta positiva (TT+/+), equívoca (TT+/-) y negativa (TT-/-) del TT. Adicionalmente, se determinó la confiabilidad de los parámetros cardiorrespiratorios durante el TT. Un valor de p<.05 se consideró significativo. Resultados: Ingresaron 48 sujetos, edad 9.7±1.1 años. Existió diferencia significativa en los parámetros cardiorrespiratorios entre las respuestas del TT (p<.0001). El % de la FC máxima en TT+/+ fue 72.2 ± 8.2, en TT+/- fue 87.9 ± 8.1 y en TT-/- fue 92.0 ± 7.5%. La confiabilidad de los parámetros cardiorrespiratorios durante el TT fue regular a excelente en ambos géneros. Conclusiones: El TT se relacionó con los parámetros cardiorrespiratorios para regular la intensidad del ejercicio en niños sanos.Abstract. Introduction: Heart rate (HR) has traditionally been used to regulate the intensity of exercise; however, its measurement is limited in the absence of a heart rate device. Consequently, indirect methods, such as the Talk Test (TT), have been validated in adults, yet not in children. The objective of this study was to determine the relationship between TT and objective methods to quantify the intensity of exercise in healthy Chilean children. Methods: Healthy children of both genders aged between 8 and 12 years old were considered for the study. The participants performed two incremental step exercise tests separated by 7 days. The TT was incorporated in one of the two tests randomly. The HR, effort perception (EP) and workload were measured every one minute during the test. HR, EP and workload were compared by positive (TT + / +), equivocal (TT +/-), and negative (TT - / -) response of the TT. Additionally, the reliability of cardiorespiratory parameters during TT was determined. A value of p <0.05 was considered significant. Results: 48 participants aged 9.7 ± 1.1 years old were selected. There was a significant difference in cardiorespiratory parameters between the TT responses (p <.001). The percent of maximum HR in TT + / + was 72.2 ± 8.2%, in TT +/- was 87.9 ± 8.1% and in TT - / - was 92.0 ± 7.5%. The reliability of cardiorespiratory parameters during TT was fair to excellent in both genders. Conclusions: TT was associated to cardiorespiratory parameters to regulate exercise intensity in healthy children.

scholarly journals Plasma Growth Differentiation Factor-15 as a Prognostic Biomarker in Children with Congestive Heart Failure

2020 ◽  
pp. 34-42
Author(s):  
Abrar Mohamed Khayal ◽  
Shimaa Basyoni El- Nemr ◽  
Hesham Ahmed El- Serogy ◽  
Amr Mohamed Zoair
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Plasma Level ◽  
Plasma Levels ◽  
Prognostic Value ◽  
Control Group ◽  
Healthy Children ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Echocardiographic Assessment

Aim and Objectives: This study aimed to evaluate the plasma levels of Growth Differentiation Factor-15 (GDF-15) in children with congestive heart failure, also to evaluate the diagnostic and prognostic value of this novel biomarker in pediatric congestive heart failure, by correlation of its levels with the clinical status and the echocardiographic data of these patients. Subjects and Methods: This study was conducted on Thirty (30) children with congestive heart failure (CHF), Patients were selected from those admitted to Pediatric Cardiology Unit, Pediatric Department, Tanta University Hospital, from (August 2018-April 2020), and thirty (30) healthy children, matched for age and sex, were enrolled as a control group. All children in this study were subjected to Plain X-ray chest and heart: Cardiothoracic ratio (CTR) was measured, and Echocardiographic assessment: Doppler and Two-dimensional, M-mode Echocardiographic evaluation of these parameters and Plasma level of Growth Differentiation Factor-15 (GDF-15) was measured.   Results: the results revealed that The best cutoff point of GDF-15 to differentiate between cases with CHF and control group was >446.5 ng/l with 93.33% sensitivity, 90% specificity, 90.3% PPV, 93.1% NPV and AUC was 0.992. There was significant decrease of EF% and FS% (systolic dysfunction of LV) in patients with CHF as compared to control group. There was statistically significant positive correlation between plasma level of GDF-15 and Ross clinical stage of CHF. There was statistically significant negative correlation between GDF-15 and EF%, FS % by echocardiography. Conclusion: Plasma levels of GDF-15 were elevated in children with CHF, and these levels were correlated to the Ross staging of CHF and echocardiographic assessment of LV function. Plasma levels of GDF-15 were elevated in patients with bad prognosis, denoting its prognostic value as a novel biomarker in pediatric CHF.

Sign in / Sign up

Export Citation Format

Share Document