Association between betel-nut chewing and chronic kidney disease in men

AbstractBackgroundBetel-nut use is associated with metabolic syndrome and obesity. However, the association between betel-nut chewing and risk for chronic kidney disease (CKD) is unknown. The present study was conducted to determine the association between betel-nut chewing and CKD in men.MethodsWe retrospectively reviewed health-check records of 3264 men in a hospital-based cross-sectional screening programme from 2003 to 2006. CKD was defined as estimated glomerular filtration rate less than 60 ml/min/1·73 m2 calculated by the Modification of Diet in Renal Disease formula. Risk factors for CKD including diabetes, hypertension, BMI, smoking, alcohol consumption and age were also considered.ResultsA total of 677 (20·7 %) men were found to have CKD and 427 (13·1 %) participants reported a history of betel-nut use. The prevalence (24·8 %) of CKD in betel-nut users was significantly higher than that (11·3 %) of participants without betel-nut use (P = 0·026). In multivariate logistic regression analysis with adjustments for age, hypertension, diabetes and hyperlipidaemia, betel-nut use was independently associated with CKD (P < 0·001). The adjusted odds ratio for betel-nut use was 2·572 (95 % CI 1·917, 3·451).ConclusionsBetel-nut use is associated with CKD in men. The association between betel-nut use and CKD is independent of age, BMI, smoking, alcohol consumption, hypertension, diabetes and hyperlipidaemia.

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P0825ASSOCIATION OF BODY MASS INDEX CHANGES WITH CHRONIC KIDNEY DISEASE IN A JAPANESE GENERAL POPULATION

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0825 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Akiko Toda ◽

Shigeko Hara ◽

Hiroshi Tsuji ◽

Yasuji Arase

Keyword(s):

Body Mass Index ◽

Chronic Kidney Disease ◽

Risk Factor ◽

Kidney Disease ◽

Body Mass ◽

Estimated Glomerular Filtration Rate ◽

Multivariate Logistic Regression Analysis ◽

Health Check ◽

Japanese General Population ◽

Index Changes

Abstract Background and Aims Obesity is a risk factor for chronic kidney disease (CKD), but the effect of reducing body mass index (BMI) on the prevention of CKD is controversial. One of reasons for this disagreement is that part of patients with a BMI decrease may have an unfavourable health status. In such cases, the BMI decrease could be a risk factor for the development of CKD. Therefore, by analysing the data of annual health check-ups, we examined an association between BMI change and CKD development to determine whether BMI reduction helps prevent CKD development. Method We analysed the data of 6,959 subjects who underwent annual health check-ups in both 2013 and 2018. By a multivariate logistic regression analysis, we investigated a relationship between BMI change and CKD development within the 5 years between 2013 and 2018. The percent change in the BMI (ΔBMI) was calculated using the following equation: {(BMI in 2018 − BMI in 2013)/BMI in 2013} ×100. For analyses, we classified the subjects into five groups based on their ΔBMI value: (i) severe BMI decrease (ΔBMI <−2.5%); (ii) moderate BMI decrease (ΔBMI ≥−2.5% but <0%); (iii) maintained BMI (ΔBMI ≥0% but <2.5%); (iv) moderate BMI increase (ΔBMI ≥2.5% but <5%); (v) severe BMI increase (ΔBMI ≥5%). For further analysis, we divided the subjects into non-obesity category (basal BMI <25 Kg/m2) and obesity category (basal BMI ≥25 Kg/m2). Subjects with an estimated glomerular filtration rate <60 mL/min./1.73 m2 were defined as having a CKD. Results After adjusting several covariates, compared with the maintained BMI group, the severe BMI decrease group showed a significantly low risk of CKD development (odds ratio (OR) 0.70, 95% confidence intervals (CI) 0.54-0.91, p <0.01) and the severe BMI increase group had a significantly high risk (OR 1.40, CI 1.08-1.81, p = 0.01). A farther analysis revealed that the OR of CKD development for the severe BMI increase group in the obesity category was higher than that in the non-obesity category (OR 1.75 vs. 1.29). Conclusion In subjects who underwent annual health check-ups, BMI reduction had a significant effect on the prevention of CKD development, whereas an increase in the BMI was a risk factor for CKD development. Moreover, by severe increase in the BMI, obesity subjects showed higher risk of CKD development than non-obesity subjects.

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Factors Associated With Chronic Kidney Disease in Patients With Type 2 Diabetes in Bangladesh

10.20944/preprints202111.0342.v1 ◽

2021 ◽

Author(s):

Sheikh Mohammed Shariful Islam ◽

Masudus Salehin ◽

Sojib Bin Zaman ◽

Tania Tansi ◽

Rajat Das Gupta ◽

...

Keyword(s):

Type 2 Diabetes ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Household Income ◽

Multivariate Logistic Regression Analysis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Public Health Burden ◽

Factors Associated

Diabetes and chronic kidney disease (CKD) are a major public health burden in low-and-middle-income countries. This study aimed to explore factors associated with CKD in patients with type 2 diabetes (T2D) in Bangladesh. A cross-sectional study was conducted among 315 adults with T2D presenting at the outpatient department of Bangladesh Institute of Health Sciences (BIHS) hospital between July 2013 to December 2013. CKD was diagnosed based on estimated Glomerular Filtration Rate using the ‘Modification of Diet in Renal Disease’ equations and presence of albuminuria estimated by the albumin-to-creatinine ratio. Multivariate logistic regression analysis was used to determine the factors associated with CKD. The overall prevalence of CKD among patients with T2D was 21.3%. In the unadjusted model Factors associated with CKD were: aged 40-49 years (OR: 5.7, 95% CI: 1.3-25.4), age 50-59 years (7.0, 1.6-39), age ≥60 years (7.6, 1.7-34); being female (2.2, 1.2-3.8), hypertensive (1.9, 1.1-3.5) and household income between 128.2-256.4 US$ (2.9, 1.0-8.2) compared with income ≤128.2$. However, after adjustment of other covariates, only duration of hypertension and household income (128.2-256.4 US$) remained statistically significant. There is a need to implement policies and programs for early detection and management of hypertension and CKD in T2D patients in Bangladesh.

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Increased Interleukin-6 as Inﬂ ammatory Response and Magnesium Deﬁ ciency in Pre-dialysis Chronic Kidney Disease of Indonesian Children

Indonesian Journal of Tropical and Infectious Disease ◽

10.20473/ijtid.v9i2.21479 ◽

2021 ◽

Vol 9 (2) ◽

pp. 93

Author(s):

Astrid Kristina Kardani ◽

Ninik Asmaningsih Soemyarso ◽

Jusli Aras Aras ◽

Risky Vitria Prasetyo ◽

Mohammad Sjaifullah Noer

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Interleukin 6 ◽

Inverse Correlation ◽

Cross Sectional Study ◽

The Body ◽

Cross Sectional ◽

Duration Of Illness ◽

History Of ◽

Spearman’S Correlation

Chronic kidney disease (CKD) is a serious health problem in children, with increasing morbidity and mortality rates throughout the world. Children with CKD tend to experience magnesium (Mg) deﬁ ciency that can stimulate an inﬂ ammatory response in the body. One of the inﬂ ammatory responses is an increase of Interleukin-6 (IL-6). Study to analyze the correlation between Mg and IL-6 in pre-dialysis CKD children. The methods a cross sectional study was conducted in Dr Soetomo General Academic Hospital from November 2018 to April 2019. Children with pre-dialyis CKD were included in this study. Variables of serum Mg level (mg/dL) and inﬂ ammatory marker (IL-6) were measured from the blood and analyzed by ELISA method. The correlation between Mg and IL-6 was analyzed with Spearman’s correlation test with p <0.05. Result a total of 47 children (27 boys vs 20 girls) between 3 months to 18 years old, with pre-dialysis CKD and no history of magnesium supplementation were included. The primary disease that causes of CKD were lupus nephritis (38.3%), nephrotic syndrome (23.4%), urologic disorder (23.4%), tubulopathy (10.6%) and others (4.3%). The average IL-6 level was 55.42±43.04 pg/dL and Mg level was 2.06±1.54 mg/dL. There were no signiﬁ cant correlation between IL-6 level and Mg level with staging of CKD and duration of illness (p>0.05), but there was a signiﬁ cant correlation between serum Mg level and IL-6 level (r=-0.748; p<0.001). Magnesium levels have a signiﬁ cant inverse correlation with IL-6 levels in pre-dialysis CKD children. The lower the Mg levels in the blood, the higher IL-6 levels and vice versa.

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Abstract TP138: Chronic Kidney Disease in Heart Failure Patients is Associated with Increased Prevalence of Atrial Fibrillation or Atrial Flutter as well as CVA/TIA

Stroke ◽

10.1161/str.51.suppl_1.tp138 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Christopher Lu ◽

Jack Chan ◽

Zejia Yu ◽

Paula Anzenberg ◽

Mikhail Torosoff

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Risk Assessment ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Atrial Flutter ◽

Stroke Risk ◽

Multivariate Logistic Regression Analysis ◽

History Of ◽

Get With The Guidelines

Background: The CHADS-VASC score does not incorporate renal dysfunction in stroke risk assessment in patients with atrial fibrillation and the prevalence of atrial fibrillation, atrial flutter, and cerebrovascular accidents (CVA) in patients with concurrent CHF and CKD is not well investigated. Objective: Evaluate the prevalence of history of stroke, atrial fibrillation, atrial flutter in patients with CHF and CKD. Methods: Data from the single institution Get With The Guidelines- Heart Failure (GWG-HF) cohort of 2938 consecutive inpatients with known GFR was utilized. CHADS-VASC score was calculated from the GWG-HF variables. Chronic kidney disease (CKD) was defined as GFR <60 ml/min. Results: An overwhelming majority (95%) of GWG-HF patients had elevated >1 CHADS-VASC score, which was also significantly more common in patients with CKD (97.6% vs. 91.7% in patients without CKD, p<0.0001). Average CHADS-VASC score was also significantly increased in patients with CKD (4+/-1.3 vs. 3.3+/-1.4, p<0.0001). Furthermore, CKD was associated with increased prevalence of atrial fibrillation and/or flutter (45.6% vs. 35.3%, p<0.0001) and stroke history (17.5% vs. 12.3%, p=0.002). When stroke and TIA histories were removed from the CHADS-VASC score ("CHAD-VASC score"), the remaining variables were strongly predictive of stroke or TIA (14.2% vs. 3.8%, p<0.0001). In multivariate logistic regression analysis, both CHAD-VASC score (OR 2.6, 95%CI 1.3-5.4, p=0.009) and CKD (OR 1.5, 95%CI 1.2-1.8, p=0.001) were associated significantly increased odds of prior stroke or TIA. Conclusions: In patients admitted with heart failure, CKD is associated with increased prevalence of atrial fibrillation or atrial flutter as well as increased prevalence of CVA/TIA. Further prospective studies are warranted to examine whether CKD history should be included in stroke risk assessment in patients with atrial fibrillation or atrial flutter, in conjunction with existing risk assessment frameworks.

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Relationships of Fat and Muscle Mass with Chronic Kidney Disease in Older Adults: A Cross-Sectional Pilot Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17239124 ◽

2020 ◽

Vol 17 (23) ◽

pp. 9124

Author(s):

Bokun Kim ◽

Hyuntae Park ◽

Gwonmin Kim ◽

Tomonori Isobe ◽

Takeji Sakae ◽

...

Keyword(s):

Older Adults ◽

Chronic Kidney Disease ◽

Pilot Study ◽

Kidney Disease ◽

Muscle Mass ◽

Estimated Glomerular Filtration Rate ◽

Fat Free Mass ◽

Creatinine Concentration ◽

Cross Sectional ◽

Assess Body Composition

This cross-sectional pilot study aimed to assess the relationships of fat and muscle mass with chronic kidney disease (CKD) in older adults. Serum creatinine concentration was used to measure estimated glomerular filtration rate (mL/min/1.73 m2) in the 236 subjects, who were allocated to three groups: a normal (≥60.0), a mild CKD (45.0–59.9), and a moderate to severe CKD (<45.0) group. The Jonckheere-Terpstra test and multivariate logistic regression were employed to assess body composition trends and the relationships of % fat mass (FM) or % muscle mass index (MMI) with moderate-to-severe CKD. Body weight, fat-free mass, MMI, and %MMI tended to decrease with an increase in the severity of CKD, but the opposite trend was identified for %FM. No relationship with BMI was identified. The participants in the middle-high and highest quartile for %FM were 6.55 and 14.31 times more likely to have moderate to severe CKD. Conversely, the participants in the highest quartile for %MMI were 0.07 times less likely to have moderate to severe CKD. Thus, high fat and low muscle mass may be more strongly associated with CKD than obesity per se.

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Cognitive Impairment in Advanced Chronic Kidney Disease: The Canadian Frailty Observation and Interventions Trial

American Journal of Nephrology ◽

10.1159/000450837 ◽

2016 ◽

Vol 44 (6) ◽

pp. 473-480 ◽

Cited By ~ 22

Author(s):

Rukhsana Foster ◽

Simon Walker ◽

Ranveer Brar ◽

Brett Hiebert ◽

Paul Komenda ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Cognitive Impairment ◽

Cognitive Function ◽

Kidney Disease ◽

High Rate ◽

Control Group ◽

Cross Sectional ◽

History Of ◽

Poor Nutrition

Background: Chronic kidney disease (CKD) affects more than one third of older adults, and is a strong risk factor for vascular disease and cognitive impairment. Cognitive impairment can have detrimental effects on the quality of life through decreased treatment adherence and poor nutrition and results in increased costs of care and early mortality. Though widely studied in hemodialysis populations, little is known about cognitive impairment in patients with pre-dialysis CKD. Methods: Multicenter, cross-sectional, prospective cohort study including 385 patients with CKD stages G4-G5. Cognitive function was measured with a validated tool called the Montreal Cognitive Assessment (MoCA) as part of a comprehensive frailty assessment in the Canadian Frailty Observation and Interventions Trial. Cognitive impairment was defined as a MoCA score of ≤24. We determined the prevalence and risk factors for cognitive impairment in patients with CKD stages G4-G5, not on dialysis. Results: Two hundred and thirty seven participants (61%) with CKD stages G4-G5 had cognitive impairment at baseline assessment. When compared to a control group, this population scored lower in all domains of cognition, with the most pronounced deficits observed in recall, attention, and visual/executive function (p < 0.01 for all comparisons). Older age, recent history of falls and history of stroke were independently associated with cognitive impairment. Conclusions: Our study uncovered a high rate of unrecognized cognitive impairment in an advanced CKD population. This impairment is global, affecting all aspects of cognition and is likely vascular in nature. The longitudinal trajectory of cognitive function and its effect on dialysis decision-making and outcomes deserves further study.

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Epidemiology of chronic kidney disease of undetermined aetiology in Taiwanese farmers: a cross-sectional study from Changhua Community-based Integrated Screening programme

Occupational and Environmental Medicine ◽

10.1136/oemed-2021-107369 ◽

2021 ◽

pp. oemed-2021-107369

Author(s):

Jerry Che-Jui Chang ◽

Hsiao-Yu Yang

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Sex Education ◽

Screening Programme ◽

Asian Countries ◽

Community Based ◽

Cross Sectional ◽

Thermal Hazards ◽

Increased Risk ◽

Integrated Screening

ObjectivesChronic kidney disease of undetermined or non-traditional aetiology (CKDu or CKDnT) has been reported in Mesoamerica among farmers under heat stress. Epidemiological evidence was lacking in Asian countries with similar climatic conditions. The objective of this study was to investigate the prevalence of CKDu and possible risk factors.MethodsWe used the data from the Changhua Community-based Integrated Screening programme from 2005 to 2014, which is the annual screening for chronic diseases in Taiwan’s largest rice-farming county since 2005. Our study population included farmers and non-farmers aged 15–60 years. CKDu was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 at age under 60 years without hypertension, diabetes, proteinuria, haematuria or using Chinese herbal medicine. We estimated the adjusted prevalence OR (POR) of CKDu by farmers, age, sex, education, urbanisation, smoking, body mass index, hyperuricaemia, hyperlipidaemia, heart disease and chronic liver disease.Results5555 farmers and 35 761 non-farmers were included in this study. CKDu accounted for 48.9% of all CKD cases. The prevalence of CKDu was 2.3% in the farmers and 0.9% in the non-farmers. The crude POR of CKDu in farmers compared with non-farmers was 2.73 (2.13–3.50), and the adjusted POR was 1.45 (1.10–1.90). Dehydration (blood urea nitrogen-to-creatinine ratio >20) was found in 22% of the farmers and 14% of the non-farmers.ConclusionsFarmers in subtropical Asian countries are at increased risk of CKDu. Governments should take the CKDu epidemics seriously and provide farmers with occupational health education programmes on thermal hazards.

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Factors Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes in Bangladesh

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182312277 ◽

2021 ◽

Vol 18 (23) ◽

pp. 12277

Author(s):

Sheikh Mohammed Shariful Islam ◽

Masudus Salehin ◽

Sojib Bin Zaman ◽

Tania Tansi ◽

Rajat Das Gupta ◽

...

Keyword(s):

Type 2 Diabetes ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Household Income ◽

Multivariate Logistic Regression Analysis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Public Health Burden ◽

Factors Associated

Diabetes and chronic kidney disease (CKD) are a major public health burden in low- and middle-income countries. This study aimed to explore factors associated with CKD in patients with type 2 diabetes (T2D) in Bangladesh. A cross-sectional study was conducted among 315 adults with T2D presenting at the outpatient department of Bangladesh Institute of Health Sciences (BIHS) hospital between July 2013 to December 2013. CKD was diagnosed based on the estimated glomerular filtration rate using the ‘Modification of Diet in Renal Disease’ equations and the presence of albuminuria estimated by the albumin-to-creatinine ratio. Multivariate logistic regression analysis was used to determine the factors associated with CKD. The overall prevalence of CKD among patients with T2D was 21.3%. In the unadjusted model, factors associated with CKD included age 40–49 years (OR: 5.7, 95% CI: 1.3–25.4), age 50–59 years (7.0, 1.6–39), age ≥60 years (7.6, 1.7–34), being female (2.2, 1.2–3.8), being hypertensive (1.9, 1.1–3.5), and household income between 10,001 and 20,000 Bangladeshi taka, BDT (2.9, 1.0–8.2) compared with income ≤10,000 BDT. However, after adjustment of other covariates, only the duration of hypertension and household income (10,001–20,000 BDT) remained statistically significant. There is a need to implement policies and programs for early detection and management of hypertension and CKD in T2D patients in Bangladesh.

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A cross-sectional study on socio-demographic profile and associated risk factors of chronic kidney disease patients in a tertiary care hospital of Andhra Pradesh

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20204753 ◽

2020 ◽

Vol 7 (11) ◽

pp. 4512

Author(s):

S. Suneeti Kanyari ◽

Sangram Panda ◽

Peethala Shruthi

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Andhra Pradesh ◽

Cross Sectional Study ◽

Demographic Characteristics ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Associated Risk Factors

Background: Chronic kidney disease (CKD) is a global problem, and its prevalence is increasing dramatically. In chronic kidney disease (CKD) there is progressive loss in kidney function over a period of time. The objectives of this study were to study the socio-demographic characteristics and associated risk factors in CKD patients so as to suggest preventive measures for CKD and its long term health consequences.Methods: A cross-sectional study was conducted at MIMS Medical College, Vizianagaram, Andhra Pradesh among 194 confirmed CKD patients. A pre-tested, pre-designed questionnaire was used for collecting data on socio-demographic characteristics like age, education, occupation, residence, income etc. After completion of the questionnaire, the patients were subjected to anthropometric measurements, abdominal ultrasonography and their laboratory reports were assessed.Results: Out of 194 CKD patients, 148 were males and 46 were females. Hypertension and diabetes were present in 74.2% and 41.2% cases respectively and both of these risk factors were found to be significantly associated with CKD. Family history of diabetes/hypertension/CKD were present in 40.2% of cases and the association was found to be significant.Conclusions: Early screening and intervention is necessary for prevention of risk factors of CKD. All patients with hypertension, diabetes, family history of CKD/hypertension/diabetes, history of chronic NSAID use should be periodically screened for CKD for its early detection and effective management.

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Role of Hepcidin in Pediatric Chronic Kidney Disease with Anemia

Green Medical Journal ◽

10.33096/gmj.v3i3.87 ◽

2021 ◽

Vol 3 (3) ◽

pp. 100-107

Author(s):

Jusli Aras ◽

Astrid Kristina Kardani ◽

Ninik Asmaningsih Soemaryo ◽

Risky Vitria Prasetyo ◽

Mohammad Sjaifullah Noer ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Complete Blood Count ◽

Ferritin Level ◽

Transferrin Saturation ◽

Cross Sectional Study ◽

Spearman Correlation ◽

Cross Sectional ◽

History Of

Introduction: Anemia is a frequent complication of chronic kidney disease (CKD) in children and it causes an increase in morbidity, mortality and accelerates the rate of progression of CKD. Inflammation and impaired kidney clearance increase plasma hepcidin, inhibiting duodenal iron absorption and sequestering iron in macrophages. However, the role of hepcidin in increasing the risk of anemia in children with CKD is still uncertain. This study aimed to investigate the association between hepcidin levels and anemia in children with pre-dialysis CKD. Methods: A cross-sectional study was conducted at Dr. Soetomo Academic Hospital from December 2018 to February 2019. Children with pre-dialysis CKD were enrolled in this study. The subject had no history of erythropoietin administration and blood transfusion 3 months before the blood sample were withdrawn. A complete blood count, ferritin serum, transferrin saturation (TSAT) and hepcidin serum were performed. The correlations between Hepcidin and ferritin level, between ferritin level and anemia, and between TSAT and anemia were analyzed using Spearman correlation and the Mann-Whitney test. Results: A total of 47 children, 27 boys and 20 girls, ranged in age from 3 months to 18 years old. There was a significant correlation between hepcidin and ferritin levels (p=0.006) and the value of the Spearman correlation was r=0.392. While the correlation between ferritin level and anemia showed a significant result, p=0.001. However, TSAT did not show any significant correlation with anemia (p=0.230). Conclusion: There was an indirect association between hepcidin level and anemia by increasing ferritin level that induces anemia in pre-dialysis CKD children.

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