scholarly journals Ischemic Tolerance in Pre-Myelinated White Matter: The Role of Astrocyte Glycogen in Brain Pathology

2015 ◽  
Vol 35 (6) ◽  
pp. 951-958 ◽  
Author(s):  
Robert Fern
Keyword(s):  
White Matter ◽  
Neural Development ◽  
Energy Supply ◽  
Necessary Conditions ◽  
Volume Fraction ◽  
Glycogen Metabolism ◽  
Ischemic Tolerance ◽  
Mitochondrial Volume ◽  
Glycogen Particles

In isolated white matter, ischemic tolerance changes dramatically in the period immediately before the onset of myelination. In the absence of an extrinsic energy source, postnatal day 0 to 2 (P0 to P2) white matter axons are here shown to maintain excitability for over twice as long as axons > P2, a differential that was dependent on glycogen metabolism. Prolonged withdrawal of extrinsic energy supply tended to spare axons in zones around astrocytes, which are shown to be the sole repository for glycogen particles in developing white matter. Analysis of mitochondrial volume fraction revealed that neither axons nor astrocytes had a low metabolic rate in neonatal white matter, while oligodendroglia at older ages had an elevated metabolism. The astrocyte population is established early in neural development, and exhibits reduced cell density as maturation progresses and white matter expands. The findings show that this event establishes the necessary conditions for ischemia sensitivity in white matter and indicates that astrocyte proximity may be significant for the survival of neuronal elements in conditions associated with compromised energy supply.

scholarly journals THE ROLE OF NUTRITION IN BRAIN DEVELOPMENT

2016 ◽  
Vol 65 (2) ◽  
pp. 150-154
Author(s):  
Dana-Teodora Anton-Paduraru ◽  
◽  
Ana Simona Drochioi ◽  
Oana Teslariu ◽  
◽  
...  
Keyword(s):  
Energy Supply ◽  
Necessary Conditions ◽  
Biologically Active ◽  
Early Prevention ◽  
Complex Processes ◽  
Natural Birth ◽  
The Impact ◽  
The Brain ◽  
Active Substances

The brain is an organ that functions harmoniously special only through a balanced intake of biologically active substances. The phrase “food for brain” expresses the important role of nutrition in the development and energy supply of the brain. There is a brief presentation of data on the development of the brain, the existence and functionality of the microbiome-gut-brain axis and the impact of the key nutrients in these complex processes. The authors concluded that nutritional assistance to the pregnant woman since the onset of pregnancy, the prophylaxis of prematurity, the early prevention of the gut microbiome of infant through encouragement of natural birth and breast-feeding are necessary conditions for the development of the brain.

scholarly journals ROLE OF THE SARCOPLASMIC RETICULUM IN GLYCOGEN METABOLISM

1972 ◽  
Vol 54 (2) ◽  
pp. 206-224 ◽  
Author(s):  
Jean-Claude Wanson ◽  
Pierre Drochmans
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Binding Sites ◽  
Microsomal Fraction ◽  
Glycogen Metabolism ◽  
Phosphorylase Kinase ◽  
Synthetase Activity ◽  
Polysaccharide Synthesis ◽  
Glycogen Particles ◽  
Differential Precipitation

Sarcoplasmic vesicles and ß-glycogen particles 30–40 mµ in diameter were isolated from perfused rabbit skeletal muscle by the differential precipitation-centrifugation method. This microsomal fraction was subjected to zonal centrifugation on buffered sucrose gradients, in a B XIV Anderson type rotor, for 15 hr at 45,000 rpm in order to separate the two cytoplasmic organelles. Zonal profiles of absorbance at 280 mµ, proteins, glycogen, and enzymatic activities (phosphorylase b kinase, phosphorylase b, and glycogen synthetase) were performed. Whereas the entire synthetase activity was found combined with the glycogen particles, 39% of phosphorylase and 53% of phosphorylase b kinase activities, present in the microsomal fraction, were recovered in the purified vesicular fraction (d = 1.175). This latter fraction consists of vesicles, derived from the sarcoplasmic reticulum, and of small particles 10–20 mµ in diameter attached to the outer surface of the membranes. These particles disappear after α-amylase treatment. Incubation of the sarcovesicular fraction with 14C-labeled glucose-1-phosphate confirms the localization of a polysaccharide synthesis at the level of the membranes. "Flash activation" of phosphorylase b, i.e. Ca "activation" of phosphorylase kinase followed by a conversion of phosphorylase b into a, was demonstrated in the purified sarcovesicular fraction. Moreover, the active enzymatic sites were detected on the membranes by electron microscopy. The presence of binding sites between the membranes of the sarcoplasmic vesicles and a glycogen-enzyme complex suggests that this association plays a role in the glycogenolysis during muscle contraction.

Regulation of Electricity Storage, Intelligent Grids, and Clean Energies in an Open Market in Mexico

2018 ◽  
Author(s):  
José Juan González Márquez ◽  
Margarita González Brambila
Keyword(s):  
Energy Storage ◽  
Energy Supply ◽  
Carbon Dioxide Emission ◽  
Energy Transition ◽  
Legal Framework ◽  
Open Market ◽  
Innovative Strategy ◽  
Electricity Storage ◽  
Storage Technologies

This chapter analyses the role of electricity storage as an innovative strategy to attain the Mexican Government’s goals regarding carbon dioxide emission reduction and energy transition. The survey includes the analysis of the different electricity storage technologies as well as the legal framework governing electricity storage as the fifth link of the energy supply chain from a comparative perspective. The authors discuss whether energy storage is a generation or a distribution/transmission asset. The chapter also analyses Mexico’s experiences in energy storage and briefly describes the way it is regulated in other jurisdictions. Finally, the authors propose the regulation of energy storage as a separate licensed activity.

scholarly journals Implication of Contactins in Demyelinating Pathologies

Life ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 51
Author(s):  
Ilias Kalafatakis ◽  
Maria Savvaki ◽  
Theodora Velona ◽  
Domna Karagogeos
Keyword(s):  
Nervous System ◽  
White Matter ◽  
Cell Adhesion Molecules ◽  
White Matter Lesions ◽  
Myelinated Axon ◽  
Immunoglobulin Superfamily ◽  
Proper Function ◽  
Myelinated Axons ◽  
And Function

Demyelinating pathologies comprise of a variety of conditions where either central or peripheral myelin is attacked, resulting in white matter lesions and neurodegeneration. Myelinated axons are organized into molecularly distinct domains, and this segregation is crucial for their proper function. These defined domains are differentially affected at the different stages of demyelination as well as at the lesion and perilesion sites. Among the main players in myelinated axon organization are proteins of the contactin (CNTN) group of the immunoglobulin superfamily (IgSF) of cell adhesion molecules, namely Contactin-1 and Contactin-2 (CNTN1, CNTN2). The two contactins perform their functions through intermolecular interactions, which are crucial for myelinated axon integrity and functionality. In this review, we focus on the implication of these two molecules as well as their interactors in demyelinating pathologies in humans. At first, we describe the organization and function of myelinated axons in the central (CNS) and the peripheral (PNS) nervous system, further analyzing the role of CNTN1 and CNTN2 as well as their interactors in myelination. In the last section, studies showing the correlation of the two contactins with demyelinating pathologies are reviewed, highlighting the importance of these recognition molecules in shaping the function of the nervous system in multiple ways.

The role of iron homeostasis in adipocyte metabolism

2021 ◽  
Author(s):  
Wan Ma ◽  
Li Jia ◽  
Qingqing Xiong ◽  
Yunfei Feng ◽  
Huahua Du
Keyword(s):  
Adipose Tissue ◽  
Energy Supply ◽  
Iron Homeostasis ◽  
Vital Role ◽  
Physiological Functions ◽  
The One

Iron plays a vital role in the metabolism of adipose tissue. On the one hand, iron is essential for differentiation, endocrine, energy supply and other physiological functions of adipocyte. Iron...

scholarly journals Secondary Forests and Agrarian Transitions: Insights from Nepal and Peru

Human Ecology ◽  
2021 ◽  
Author(s):  
Adam Pain ◽  
Kristina Marquardt ◽  
Dil Khatri
Keyword(s):  
Forest Regeneration ◽  
Agricultural Intensification ◽  
Necessary Conditions ◽  
Secondary Forest ◽  
Social Groups ◽  
Agrarian Change ◽  
Secondary Forests ◽  
Land Access ◽  
San Martín

AbstractWe provide an analytical contrast of the dynamics of secondary forest regeneration in Nepal and Peru framed by a set of common themes: land access, boundaries, territories, and rights, seemingly more secure in Nepal than Peru; processes of agrarian change and their consequences for forest-agriculture interactions and the role of secondary forest in the landscape, more marked in Peru, where San Martín is experiencing apparent agricultural intensification, than in Nepal; and finally processes of social differentiation that have consequences for different social groups, livelihood construction and their engagement with trees, common to both countries. These themes address the broader issue of the necessary conditions for secondary forest regeneration and the extent to which the rights and livelihood benefits of those actively managing it are secured.

scholarly journals The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

2021 ◽  
Vol 11 (5) ◽  
pp. 632
Author(s):  
Valentina Pacella ◽  
Giuseppe Kenneth Ricciardi ◽  
Silvia Bonadiman ◽  
Elisabetta Verzini ◽  
Federica Faraoni ◽  
...  
Keyword(s):  
White Matter ◽  
Single Case ◽  
Brain Lesion ◽  
Structural Connectivity ◽  
Disconnection Syndrome ◽  
Neuroimaging Data ◽  
Neuropsychological Investigation ◽  
Anterior Posterior

The anarchic hand syndrome refers to an inability to control the movements of one’s own hand, which acts as if it has a will of its own. The symptoms may differ depending on whether the brain lesion is anterior, posterior, callosal or subcortical, but the relative classifications are not conclusive. This study investigates the role of white matter disconnections in a patient whose symptoms are inconsistent with the mapping of the lesion site. A repeated neuropsychological investigation was associated with a review of the literature on the topic to identify the frequency of various different symptoms relating to this syndrome. Furthermore, an analysis of the neuroimaging regarding structural connectivity allowed us to investigate the grey matter lesions and white matter disconnections. The results indicated that some of the patient’s symptoms were associated with structures that, although not directly damaged, were dysfunctional due to a disconnection in their networks. This suggests that the anarchic hand may be considered as a disconnection syndrome involving the integration of multiple antero-posterior, insular and interhemispheric networks. In order to comprehend this rare syndrome better, the clinical and neuroimaging data need to be integrated with the clinical reports available in the literature on this topic.

scholarly journals Role of Exclusive Breastfeeding in Conferring Protection in Children At-Risk for Autism Spectrum Disorder: Results from a Sibling Case–control Study

2018 ◽  
Vol 09 (01) ◽  
pp. 132-136 ◽  
Author(s):  
Harshini Manohar ◽  
Madhavapuri Pravallika ◽  
Preeti Kandasamy ◽  
Venkatesh Chandrasekaran ◽  
Ravi Philip Rajkumar
Keyword(s):  
Neural Development ◽  
Exclusive Breastfeeding ◽  
Feeding Practices ◽  
Autism Spectrum ◽  
Gut Microflora ◽  
Typically Developing ◽  
Lower Odds ◽  
Children With Asd ◽  
Typically Developing Siblings

ABSTRACTBackground: Gut microflora influences neural development through complex mechanisms. Feeding practices, especially breastfeeding influence gut microbiome and thereby play a pivotal role in immune and neural development. Current understandings of the role of healthy distal gut microflora in the development of immune and neural systems provide insights into immunological mechanisms as one of the possible etiologies in autism spectrum disorder (ASD). Studies have shown that optimal breastfeeding is associated with lower odds of being at-risk for ASD and children with ASD are suboptimally breastfed. Methods: The feeding practices of children with ASD (n = 30) was compared to their typically developing siblings as matched controls (n = 30). Information regarding feeding practices was collected from mothers through a semi-structured questionnaire. Results: About 43.3% of children with ASD received exclusive breastfeeding, whereas 76.7% of their typically developing siblings were exclusively breastfed. Exclusive breastfeeding was associated with lower odds for ASD (odds ratio [OR] = 0.166; 95% confidence interval [CI] = 0.025–0.65), while early introduction of top feeds was associated with higher odds (OR = 6; 95% CI = 1.33–55.19). Difficulties in breastfeeding were attributed to child-related factors in 13.2% of the children. Conclusion: Children with ASD are suboptimally breastfed compared to their typically developing siblings. Exclusive breastfeeding may confer protection in vulnerable children. Further studies on larger prospective sample are required to establish the association.

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