The role of iron homeostasis in adipocyte metabolism

2021 ◽  
Author(s):  
Wan Ma ◽  
Li Jia ◽  
Qingqing Xiong ◽  
Yunfei Feng ◽  
Huahua Du
Keyword(s):  
Adipose Tissue ◽  
Energy Supply ◽  
Iron Homeostasis ◽  
Vital Role ◽  
Physiological Functions ◽  
The One

Iron plays a vital role in the metabolism of adipose tissue. On the one hand, iron is essential for differentiation, endocrine, energy supply and other physiological functions of adipocyte. Iron...

Identification of critical genes and pathways involved in intervertebral disc degeneration (IDD) An integrated bioinformatics analysis

2020 ◽  
Author(s):  
Jingyang Zhou ◽  
Feng Xin ◽  
Chuyu Xiao ◽  
Wuyuan Zhou
Keyword(s):  
Daily Life ◽  
Vital Role ◽  
Ppi Network ◽  
Hub Genes ◽  
Protein Protein Interaction ◽  
Diagnosis And Prognosis ◽  
Study Results ◽  
Validation Experiment ◽  
The One

Abstract Background: In western countries and China, back and neck pain has become a common problem that bothers daily life and severely influences the quality of our daily life. Among all factors that lead to chronic neck and back pain, IDD is the one that couldn’t be easily neglected. Methods: This study aims to figure out the critical genes and pathways involved in the development of IDD and provide a new aspect of following investigations on the etiology of IDD. We firstly systemically searched the GEO database and identified the differentially expressed genes (DEGs) from the expression profile dataset we selected. We secondly constructed the protein-protein interaction (PPI) network for DEGs, identified the top ten hub genes from the whole PPI network and found two statically and medically significant modules from the network, we then performed the GO and KEGG analysis on the DEGs, top ten hub genes, the PPI network and the two statically and medically modules. In the end, we provided the primers of the mRNAs of all DEGs, which will be useful for the validation experiment of this study. Results: FN1, MMP2, POSTN, COL3A1, TIMP3, FBN1, GJA1, TGFBI, EFEMP1 and ID1 were top ten hub genes identified from this study, and they may play a vital role in the development of IDD. Angiogenesis and integrin binging are crucial biological process and molecular function defined in this study, which are worthy of being intensely investigated.Conclusion: More studies on the top ten hub genes, the role of angiogenesis and integrin binding in IDD are urgently needed, which will benefit the prevention, screening, diagnosis and prognosis of IDD.

scholarly journals The Role of Adipose Tissue in the Pathogenesis and Therapeutic Outcomes of Inflammatory Bowel Disease

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 628 ◽  
Author(s):  
Eder ◽  
Adler ◽  
Dobrowolska ◽  
Kamhieh-Milz ◽  
Witowski
Keyword(s):  
Inflammatory Bowel Disease ◽  
Adipose Tissue ◽  
Bowel Disease ◽  
Future Research ◽  
Therapeutic Outcomes ◽  
Mesenteric Fat ◽  
Energy Store ◽  
Inflammatory Bowel ◽  
The One

Abstract: Though historically regarded as an inert energy store, adipose tissue is a complex endocrine organ, which is increasingly implicated in the pathogenesis of inflammatory bowel disease (IBD). Accumulating evidence points to visceral adipose tissue and specifically to its mesenteric component, or “creeping fat” as impacting on the disease course through its immunomodulatory properties. On the one hand, mesenteric fat acts as a physical barrier to inflammation and is involved in controlling host immune response to translocation of gut bacteria. On the other hand, however, there exists a strong link between visceral fat and complicated course of the disease with unfavorable therapeutic outcomes. Furthermore, “creeping fat” appears to play different roles in different IBD phenotypes, with the greatest pathogenetic contribution probably to an ileal form of Crohn’s disease. In this review, we summarize and discuss the existing literature on the subject and identify high-priority areas for future research. It may be that a better understanding of the role of mesenteric fat in IBD will determine new therapeutic targets and translate into improved clinical outcomes.

scholarly journals The Role of Elected Scholars on Interfaith Harmony in Pakistan - A Research Study

2020 ◽  
Vol 3 (01) ◽  
pp. 1-18
Author(s):  
Dr. Hafiz Ghulam Anwar Azhari ◽  
Zahoor Alam
Keyword(s):  
Research Study ◽  
Vital Role ◽  
The Other ◽  
Internal Conflicts ◽  
Other Hand ◽  
The World ◽  
Welfare Society ◽  
The One ◽  
The Way

Islam is a humanity based religion and unity plays of a vital role in it. It is not possible for a humane person to deny the importance of unity for a better society. It is the one thing that leads the nations of the world in the way of progress and prosperity. On the other hand chaos and anarchy is such a curse that makes a nation fall into the depths of disgrace. No enemy needs to fight such nation to defeat it. Their own internal conflicts and chaos is enough to dismantle them. Unfortunately this egoism and prejudice has reached its climax among the Muslims of Pakistan. We have failed ourselves in building a balanced progressive and welfare society based on two nation theory. Witnessing this situation many scholars from different schools of thoughts have tried their best towards the progress of inter-Muslim harmony and tolerance. In this regard they have highlighted the evil effects of chaos and positivity of unity. They have also brought forward such advises both in speech and written through which damage caused by sectarianism can be handled.

State Protection of Energy Consumers

2020 ◽  
pp. 139-159
Author(s):  
Hanri Mostert ◽  
Tjakie Naude
Keyword(s):  
South African ◽  
Consumer Protection ◽  
Energy Supply ◽  
The State ◽  
The European Union ◽  
Market Models ◽  
Role Of The State ◽  
The One ◽  
State Protection

This chapter scrutinizes the role of the state in ensuring electricity supply and protecting end-consumers along a spectrum of energy market models. On the one end, there are markets dominated by virtual state monopolies, such as the South African example, where supply and consumer protection take on a different shape, compared to those on the other end of the spectrum, where distribution of energy to end-consumers is privatized. The European Union (EU) exemplifies the latter. Analyses of both the Australian and Nigerian models of energy supply and end-consumer protection are included to demonstrate variations within privatized markets, and comment on the role of the state in implementing privatization. Issues of procedural and participatory justice are considered. Social justice issues are raised, furthermore, in that the type of consumer protection in a system is influenced by the degree of affluence of the community and the resilience of the system of governance.

Role of Adipokines in Obesity and Obesity related Metabolic Disorders

2021 ◽  
pp. 4261-4264
Author(s):  
Jayamathi Govindaraj ◽  
Keerthidaa Govindaraj ◽  
S. Raghavendra Jayesh ◽  
Kesavaram Padmavathy ◽  
Mathangi Ramalingam ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Metabolic Disorders ◽  
Vital Role ◽  
Novel Therapies ◽  
Metabolic Homeostasis ◽  
Associated Diseases

Obesity is defined as an excessive growth of adipose tissue. It is associated with over nutrition, which impairs systemic metabolic homeostasis. Adipokines secreted by adipose tissue could play an vital role in the development of obesity and associated metabolic disorders includes insulin resistance, inflammation, hypertension, cardiovascular risk etc. Adipokines will be of importance in the development of novel therapies for obesity-associated diseases. This review emphasises on obesity and the role of some Adipokines in obesity and related metabolic disorders.

scholarly journals The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Hong-Jin Chen ◽  
Ting Meng ◽  
Ping-Jin Gao ◽  
Cheng-Chao Ruan
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cardiovascular Health ◽  
Stromal Vascular Fraction ◽  
Protective Role ◽  
Vital Role ◽  
Brown Adipocytes ◽  
Glucose And Lipid Metabolism ◽  
Brown Adipose

Brown adipose tissue (BAT), consisted of brown adipocytes and stromal vascular fraction, which includes endothelial cells, lymphocytes, fibroblasts and stem cells, plays a vital role in regulating cardiovascular health and diseases. As a thermogenic organ, BAT can influence body through strengthening energy expenditure by promoting glucose and lipid metabolism. In addition, BAT is also an endocrine organ which is able to secret adipokines in an autocrine and/or paracrine fashion. BAT plays a protective role in cardiovascular system through attenuating cardiac remodeling and suppressing inflammatory response. In this review, we summarize the advances from the discovery of BAT to the present and provide an overview on the role of BAT dysfunction in cardiovascular diseases.

scholarly journals Humor as Monotony Breaker in Funny Ads: A Multi-Modal Discourse Analysis of Ads of Pakistani Ufone & Jazz Cellular Companies

2019 ◽  
Vol 10 (1) ◽  
pp. 69
Author(s):  
Fatima Zafar Baig ◽  
Saima Umer ◽  
Muhammad Zammad Aslam ◽  
Muhammad Shehzad Razaq ◽  
Samina Khan ◽  
...  
Keyword(s):  
Discourse Analysis ◽  
3D Model ◽  
Vital Role ◽  
Visual Design ◽  
Discursive Strategies ◽  
The Social ◽  
The One ◽  
And Function ◽  
Analyze Data

The present study explores and analyzes the role of humor in the advertisement as the message in advertisements keeps a pivotal value constructing and promoting the idea of promotional activity by any company. So, the companies and promoters of products utilize and employ various distinctive and discursive strategies to promote their products focusing on the interests of their consumers. The research concludes that Pakistan is the one amongst other countries, in which, advertisers and promotors utilize humor as an important feature in advertainments at a huge level. Along with entertainment, the promoters promote the text and its discourse through humor which influences the decision-buying process of consumers. However, they often try to utilize humor neutralizing the social or personal values. Recent studies prove that intelligent and sensible use of humor by the companies can lead them to success if it is more relevant to the products’ nature and function. A Multi-Modal Approach, employing Fairclough’s (1989) 3D model along with Kress and van Leeuwen’s (1996) grammar of visual design, is employed to analyze data. The findings of the study suggest that the humor if handled properly, can play a vital role in captivating consumers’ interest towards the product as it takes them away from the tensions of life and makes the product more appealing. Moreover, humor as a monotony breaker makes the ad more attractive that ultimately adds to the promotion of the product.

scholarly journals ”och mymlan flög / och mjölken for”

Barnboken ◽  
2021 ◽  
Author(s):  
Johan Alfredsson
Keyword(s):  
Vital Role ◽  
The Other ◽  
Delicate Balance ◽  
The One ◽  
Child Reader ◽  
Child Readers

The Child Readers and Poetry in Tove Jansson’s Picturebook The Book about Moomin, Mymble and Little My Abstract: Tove Jansson’s picturebook Hur gick det sen? Boken om Mymlan, Mumintrollet och lilla My (The Book about Moomin, Mymble and Little My) from 1952 is a book which makes use of its material aspects in many regards, employing the interactivity of the picturebook format to its maximum. Given the fact that it is written in verse, and is considered a classic by all means, it is surprising to find that the function that poetry plays within the book has been scarcely explored in prior research. By examining how the format of this particular picturebook guides the manner in which the child reader experiences it, and by studying the function of poetry within that framework, the article shows that poetry potentially plays a vital role in how child readers make sense of it. In particular, the role of poetry manifests itself as an opportunity for child readers to – at their own pace, and in their own manner – deal with the delicate balance between the attachmentseeking struggles of the anxious character of Moomin, on the one hand, and the exploratory individuation of the adventurous character of Little My, on the other. Through these examinations, the article demonstrates how the use of poetry can facilitate an emancipatory opportunity for child readers within picturebooks – and how this potential is ever-present within the format and the reading situation of picturebooks for children in general. 

scholarly journals A Review of the Role of Micronutrients and Bioactive Compounds on Immune System Supporting to Fight against the COVID-19 Disease

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1088
Author(s):  
Montaña Cámara ◽  
María Cortes Sánchez-Mata ◽  
Virginia Fernández-Ruiz ◽  
Rosa María Cámara ◽  
Elena Cebadera ◽  
...  
Keyword(s):  
Immune System ◽  
Scientific Evidence ◽  
Well Being ◽  
Vital Role ◽  
Health Claims ◽  
Positive Effects ◽  
Improved Outcomes ◽  
The One ◽  
Potential Use

Micronutrients are critical for an adequate function of the immune system and play a vital role in promoting health and nutritional well-being. The present work is aimed at reviewing (1) the role of micronutrients in helping the immune system to fight against the COVID-19 disease through the diet with food or food supplements and (2) the potential use of food health claims regarding immune function according to the European Food Safety Authority (EFSA) requirements. Till date, there are some health claims authorized by the European Commission that refer to the role of certain essential nutrients (vitamins B6, B9, B12, A, D, C, and Cu, Fe, Se) to contribute to the proper functioning of the immune system. Vitamins D, C, Zn, and Se, have been thoroughly studied as a strategy to improve the immune system to fight against COVID-19 disease. From all the micronutrients, Vitamin D is the one with more scientific evidence suggesting positive effects against COVID-19 disease as it is linked to a reduction of infection rates, as well as an improved outcomes in patients. To validate scientific evidence, different clinical trials are ongoing currently, with promising preliminary results although inconclusive yet.

Asiana Airlines Flight 214

2014 ◽  
Vol 4 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Stephanie Chow ◽  
Stephen Yortsos ◽  
Najmedin Meshkati
Keyword(s):  
Human Factors ◽  
Aviation Safety ◽  
Cultural Factors ◽  
Vital Role ◽  
Cultural Issues ◽  
Flight Crew ◽  
Pilot Performance ◽  
Engineering Designs ◽  
Flight Deck

This article focuses on a major human factors–related issue that includes the undeniable role of cultural factors and cockpit automation and their serious impact on flight crew performance, communication, and aviation safety. The report concentrates on the flight crew performance of the Boeing 777–Asiana Airlines Flight 214 accident, by exploring issues concerning mode confusion and autothrottle systems. It also further reviews the vital role of cultural factors in aviation safety and provides a brief overview of past, related accidents. Automation progressions have been created in an attempt to design an error-free flight deck. However, to do that, the pilot must still thoroughly understand every component of the flight deck – most importantly, the automation. Otherwise, if pilots are not completely competent in terms of their automation, the slightest errors can lead to fatal accidents. As seen in the case of Asiana Flight 214, even though engineering designs and pilot training have greatly evolved over the years, there are many cultural, design, and communication factors that affect pilot performance. It is concluded that aviation systems designers, in cooperation with pilots and regulatory bodies, should lead the strategic effort of systematically addressing the serious issues of cockpit automation, human factors, and cultural issues, including their interactions, which will certainly lead to better solutions for safer flights.

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