scholarly journals Associations between maternal dietary patterns and infant birth weight, small and large for gestational age in the Norwegian Mother and Child Cohort Study

2018 ◽  
Vol 73 (9) ◽  
pp. 1270-1282 ◽  
Author(s):  
Linda Englund-Ögge ◽  
Anne Lise Brantsæter ◽  
Julius Juodakis ◽  
Margareta Haugen ◽  
Helle Margrete Meltzer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Gestational Age ◽  
Dietary Patterns ◽  
Large For Gestational Age ◽  
Mother And Child ◽  
Infant Birth

scholarly journals Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

2013 ◽  
Vol 17 (9) ◽  
pp. 2071-2080 ◽  
Author(s):  
Kristine Vejrup ◽  
Anne Lise Brantsæter ◽  
Helle K Knutsen ◽  
Per Magnus ◽  
Jan Alexander ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Dietary Exposure ◽  
Increased Risk ◽  
Mother And Child ◽  
Multivariable Regression Models ◽  
Infant Birth ◽  
In Pregnancy

AbstractObjectiveTo examine the association between calculated maternal dietary exposure to Hg in pregnancy and infant birth weight in the Norwegian Mother and Child Cohort Study (MoBa).DesignExposure was calculated with use of a constructed database of Hg in food items and reported dietary intake during pregnancy. Multivariable regression models were used to explore the association between maternal Hg exposure and infant birth weight, and to model associations with small-for-gestational-age offspring.SettingThe study is based on data from MoBa.SubjectsThe study sample consisted of 62 941 women who answered a validated FFQ which covered the habitual diet during the first five months of pregnancy.ResultsMedian exposure to Hg was 0·15 μg/kg body weight per week and the contribution from seafood intake was 88 % of total Hg exposure. Women in the highest quintile compared with the lowest quintile of Hg exposure delivered offspring with 34 g lower birth weight (95 % CI −46 g, −22 g) and had an increased risk of giving birth to small-for-gestational-age offspring, adjusted OR = 1·19 (95 % CI 1·08, 1·30). Although seafood intake was positively associated with increased birth weight, stratified analyses showed negative associations between Hg exposure and birth weight within strata of seafood intake.ConclusionsAlthough seafood intake in pregnancy is positively associated with birth weight, Hg exposure is negatively associated with birth weight. Seafood consumption during pregnancy should not be avoided, but clarification is needed to identify at what level of Hg exposure this risk might exceed the benefits of seafood.

Paternal height has an impact on birth weight of their offspring in a Japanese population: the Japan Environment and Children’s Study

2019 ◽  
Vol 10 (5) ◽  
pp. 542-554 ◽  
Author(s):  
K. Takagi ◽  
N. Iwama ◽  
H. Metoki ◽  
Y. Uchikura ◽  
Y. Matsubara ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Gestational Age ◽  
Multinomial Logistic Regression ◽  
Large For Gestational Age ◽  
Birth Cohort Study ◽  
Male And Female ◽  
Japanese General Population ◽  
Infant Birth ◽  
The Impact

AbstractThis study examines the relationship between paternal height or body mass index (BMI) and birth weight of their offspring in a Japanese general population. The sample included 33,448 pregnant Japanese women and used fixed data, including maternal, paternal and infant characteristics, from the Japan Environment and Children’s Study (JECS), an ongoing nationwide birth cohort study. Relationships between paternal height or BMI and infant birth weight [i.e., small for gestational age (SGA) and large for gestational age (LGA)] were examined using a multinomial logistic regression model. Since fetal programming may be a sex-specific process, male and female infants were analyzed separately. Multivariate analysis showed that the higher the paternal height, the higher the odds of LGA and the lower the odds of SGA in both male and female infants. The effects of paternal BMI on the odds of both SGA and LGA in male infants were similar to those of paternal height; however, paternal height had a stronger impact than BMI on the odds of male LGA. In addition, paternal BMI showed no association with the odds of SGA and only a weak association with the odds of LGA in female infants. This cohort study showed that paternal height was associated with birth weight of their offspring and had stronger effects than paternal BMI, suggesting that the impact of paternal height on infant birth weight could be explained by genetic factors. The sex-dependent effect of paternal BMI on infant birth weight may be due to epigenetic effects.

scholarly journals Maternal seafood consumption and infant birth weight, length and head circumference in the Norwegian Mother and Child Cohort Study

2011 ◽  
Vol 107 (3) ◽  
pp. 436-444 ◽  
Author(s):  
Anne Lise Brantsæter ◽  
Bryndis Eva Birgisdottir ◽  
Helle Margrete Meltzer ◽  
Helen Engelstad Kvalem ◽  
Jan Alexander ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Head Circumference ◽  
Birth Size ◽  
Seafood Consumption ◽  
Birth Registry ◽  
Negatively Associated ◽  
Lean Fish ◽  
Mother And Child ◽  
Infant Birth

Results from previous studies on associations between maternal fish and seafood intakes and fetal growth are inconclusive. The aim of the present study was to investigate how maternal intakes of seafood, subtypes of seafood and supplementary n-3 fatty acids were associated with infant birth weight, length and head circumference in a prospective study in Norway. The study population included 62 099 participants in the Norwegian Mother and Child Cohort Study. The mothers answered an FFQ in mid pregnancy. The FFQ comprised detailed questions about intake of various seafood items and n-3 supplements. Data on infant birth weight, length and head circumference were obtained from the Medical Birth Registry. We used multivariable regression to examine how total seafood, various seafood subtypes and supplementary n-3 intakes were associated with birth size measures. Total seafood intake was positively associated with birth weight and head circumference. Lean fish was positively associated with all birth size measures; shellfish was positively associated with birth weight, while fatty fish was not associated with any birth size measures. Intake of supplementary n-3 was negatively associated with head circumference. The relative risk of giving birth to a small baby ( < 2500 g) in full-term pregnancies was significantly lower in women who consumed >60 g/d of seafood than in women who consumed ≤ 5 g/d (OR = 0·56 (95 % CI 0·35, 0·88). In conclusion, maternal seafood consumption was positively associated with birth size, driven by lean fish intake, while supplementary n-3 intake was negatively associated with infant head circumference.

scholarly journals Placental lncRNA expression associated with placental cadmium concentrations and birth weight

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Michael R Hussey ◽  
Amber Burt ◽  
Maya A Deyssenroth ◽  
Brian P Jackson ◽  
Ke Hao ◽  
...  
Keyword(s):  
Birth Weight ◽  
Rhode Island ◽  
Gestational Age ◽  
Maternal Education ◽  
Health Study ◽  
Large For Gestational Age ◽  
Illumina Hiseq ◽  
Smoking During Pregnancy ◽  
Lncrna Expression ◽  
Infant Birth

Abstract Heavy metal exposures, such as cadmium, can have negative effects on infant birth weight (BW)—among other developmental outcomes—with placental dysfunction potentially playing a role in these effects. In this study, we examined how differential placental expression of long non-coding RNAs (lncRNAs) may be associated with cadmium levels in placenta and whether differences in the expression of those lncRNAs were associated with fetal growth. In the Rhode Island Child Health Study, we used data from Illumina HiSeq whole transcriptome RNA sequencing (n = 199) to examine association between lncRNA expression and measures of infant BW as well as placental cadmium concentrations controlled for appropriate covariates. Of the 1191 lncRNAs sequenced, 46 demonstrated associations (q &lt; 0.05) with BW in models controlling for infant sex, maternal age, BMI, maternal education, and smoking during pregnancy. Furthermore, four of these transcripts were associated with placental cadmium concentrations, with MIR22HG and ERVH48-1 demonstrating increases in expression associated with increasing cadmium exposure and elevated odds of small for gestational age birth, while AC114763.2 and LINC02595 demonstrated reduced expression associated with cadmium, but elevated odds of large for gestational age birth with increasing expression. We identified relationships between lncRNA expression with both placental cadmium concentrations and BW. This study provides evidence that disrupted placental expression of lncRNAs may be a part of cadmium’s mechanisms of reproductive toxicity.

scholarly journals Birth weight of infants after maternal exposure to typical and atypical antipsychotics: Prospective comparison study

2008 ◽  
Vol 192 (5) ◽  
pp. 333-337 ◽  
Author(s):  
James J. Newham ◽  
Simon H. Thomas ◽  
Karine MacRitchie ◽  
Patricia R. McElhatton ◽  
R. Hamish McAllister-Williams
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Atypical Antipsychotics ◽  
Reference Group ◽  
In Utero ◽  
Maternal Exposure ◽  
Large For Gestational Age ◽  
Prospective Comparison ◽  
Infant Birth ◽  
Typical Antipsychotics

BackgroundThe effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown.AimsTo determine whether atypical and typical antipsychotics differ in their effects on birth weight after maternal exposure during pregnancy.MethodProspective data on gestational age and birth weight collected by the National Teratology Information Service for infants exposed to typical (n=45) and atypical (n=25) antipsychotics was compared with data for a reference group of infants (n=38).ResultsInfants exposed to atypical antipsychotics had a significantly higher incidence of large for gestational age (LGA) than both comparison groups and a mean birth weight significantly heavier than those exposed to typical antipsychotics. In contrast those exposed to typical antipsychotics had a significantly lower mean birth weight and a higher incidence of small for gestational age infants than the reference group.ConclusionsIn utero exposure to atypical antipsychotic drugs may increase infant birth weight and risk of LGA.

scholarly journals Maternal Dietary Patterns and Birth Outcomes: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 10 (4) ◽  
pp. 685-695 ◽  
Author(s):  
Ai-Ru Chia ◽  
Ling-Wei Chen ◽  
Jun Shi Lai ◽  
Chun Hong Wong ◽  
Nithya Neelakantan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Gestational Age ◽  
Dietary Patterns ◽  
Lower Risk ◽  
Observational Studies ◽  
Meta Analysis ◽  
Mean Difference ◽  
Large For Gestational Age ◽  
Processed Meat

ABSTRACT Findings on the relations of maternal dietary patterns during pregnancy and risk of preterm birth and offspring birth size remain inconclusive. We aimed to systematically review and quantify these associations. We searched MEDLINE, Embase, CENTRAL, and CINAHL up to December 2017. Three authors independently conducted a literature search, study selection, data extraction, and quality assessment. Summary effect sizes were calculated with random effects models and studies were summarized narratively if results could not be pooled. We included 36 studies and pooled results from 25 observational studies (167,507 participants). Two common dietary patterns—“healthy” and “unhealthy”—were identified. Healthy dietary patterns—characterized by high intakes of vegetables, fruits, wholegrains, low-fat dairy, and lean protein foods—were associated with lower risk of preterm birth (OR for top compared with bottom tertile: 0.79; 95% CI: 0.68, 0.91; I2 = 32%) and a weak trend towards a lower risk of small-for-gestational-age (OR: 0.86; 95% CI: 0.73, 1.01; I2 = 34%). Only statistically data-driven healthy dietary patterns, and not dietary index-based patterns, were associated with higher birth weight (mean difference: 67 g; 95% CI: 37, 96 g; I2 = 75%). Unhealthy dietary patterns—characterized by high intakes of refined grains, processed meat, and foods high in saturated fat or sugar—were associated with lower birth weight (mean difference: −40 g; 95% CI: −61, −20 g; I2 = 0%) and a trend towards a higher risk of preterm birth (OR: 1.17; 95% CI: 0.99, 1.39; I2 = 76%). Data from observational studies indicate that greater adherence to healthy dietary patterns during pregnancy is significantly related to lower risk of preterm birth. No consistent associations with birth weight and small- or large-for-gestational-age were observed.

scholarly journals Maternal betaine status, but not that of choline or methionine, is inversely associated with infant birth weight

2019 ◽  
Vol 121 (11) ◽  
pp. 1279-1286 ◽  
Author(s):  
Yu-Feng Du ◽  
Yuan Wei ◽  
Jing Yang ◽  
Zi-Yi Cheng ◽  
Xi-Fang Zuo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Regression Models ◽  
Maternal Plasma ◽  
Large For Gestational Age ◽  
Methyl Donors ◽  
Logistic Regression Models ◽  
Methionine Concentration ◽  
One Carbon Metabolism ◽  
Infant Birth

AbstractMaternal one-carbon metabolism during pregnancy is crucial for fetal development and programming by DNA methylation. However, evidence on one-carbon biomarkers other than folate is lacking. We, therefore, investigated whether maternal plasma methyl donors, that is, choline, betaine and methionine, are associated with birth outcomes. Blood samples were obtained from 115 women during gestation (median 26·3 weeks, 90 % range 22·7–33·0 weeks). Plasma choline, betaine, methionine and dimethylglycine were measured using HPLC-tandem MS. Multivariate linear and logistic regression models were used to estimate the association between plasma biomarkers and birth weight, birth length, the risk of small-for-gestational-age and large-for-gestational-age (LGA). Higher level of maternal betaine was associated with lower birth weight (–130·3 (95 % CI –244·8, –15·9) per 1 sd increment for log-transformed betaine). Higher maternal methionine was associated with lower risk of LGA, and adjusted OR, with 95 % CI for 1 sd increase in methionine concentration was 0·44 (95 % CI 0·21, 0·89). Stratified analyses according to infant sex or maternal plasma homocysteine status showed that reduction in birth weight in relation to maternal betaine was only limited to male infants or to who had higher maternal homocysteine status (≥5·1 µmol/l). Higher maternal betaine status was associated with reduced birth weight. Maternal methionine was inversely associated with LGA risk. These findings are needed to be replicated in future larger studies.

scholarly journals Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yiting Mao ◽  
Chen Zhang ◽  
Yinyu Wang ◽  
Yicong Meng ◽  
Lei Chen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Birth Weight ◽  
Preterm Infants ◽  
Gestational Age ◽  
Paternal Age ◽  
Large For Gestational Age ◽  
Term Infants ◽  
Advanced Paternal Age ◽  
Increased Risk ◽  
Infant Birth

PurposeWhile it is well documented that maternal adverse exposures contribute to a series defects on offspring health according to the Developmental Origins of Health and Disease (DOHaD) theory, paternal evidence is still insufficient. Advanced paternal age is associated with multiple metabolism and psychiatric disorders. Birth weight is the most direct marker to evaluate fetal growth. Therefore, we designed this study to explore the association between paternal age and birth weight among infants born at term and preterm (&lt;37 weeks gestation).MethodsA large retrospective study was conducted using population-based hospital data from January 2015 to December 2019 that included 69,964 cases of singleton infant births with complete paternal age data. The primary outcome was infant birth weight stratified by sex and gestational age including small for gestational age (SGA, 10th percentile) and large for gestational age (LGA, 90th percentile). Birth weight percentiles by gestational age were based on those published in the INTERGROWTH-21st neonatal weight-for gestational-age standard. Logistic regression analysis and linear regression model were used to estimate the association between paternal age and infant birth weight.ResultsAdvanced paternal age was associated with a higher risk for a preterm birth [35–44 years: adjusted odds ratio (OR) = 1.13, 95%CI (1.03 to 1.24); &gt;44 years: OR = 1.36, 95%CI (1.09 to 1.70)]. Paternal age exerted an opposite effect on birth weight with an increased risk of SGA among preterm infants (35–44years: OR = 1.85, 95%CI (1.18 to 2.89) and a decreased risk among term infant (35–44years: OR = 0.81, 95%CI (0.68 to 0.98); &gt;44 years: OR = 0.50, 95%CI (0.26 to 0.94). U-shaped associations were found in that LGA risk among term infants was higher in both younger (&lt;25 years) (OR = 1.32; 95%CI, 1.07 to 1.62) and older (35–44 years) (OR = 1.07; 95% CI, 1.01 to 1.14) fathers in comparison to those who were 25 to 34 years old at the time of delivery.ConclusionsOur study found advanced paternal age increased the risk of SGA among preterm infants and for LGA among term infants. These findings likely reflect a pathophysiology etiology and have important preconception care implications and suggest the need for antenatal monitoring.

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