scholarly journals Habitual physical activity mediates the acute exercise-induced modulation of anxiety-related amygdala functional connectivity

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yu-Chun Chen ◽  
Chenyi Chen ◽  
Róger Marcelo Martínez ◽  
Jennifer L. Etnier ◽  
Yawei Cheng
Keyword(s):  
Physical Activity ◽  
Functional Connectivity ◽  
Acute Exercise ◽  
Neural Mechanism ◽  
Habitual Physical Activity ◽  
Treadmill Running ◽  
Beneficial Effects ◽  
Fmri Study ◽  
Exercise Induced ◽  
Amygdala Reactivity

AbstractAerobic exercise, in relation to physical activity, has been shown to have beneficial effects on anxiety. However, the underlyig neural mechanism remains elusive. Using a within-subject crossover design, this fMRI study examined how exercise (12-min treadmill running versus walking) mediated amygdala reactivity to explicit and implicit (backward masked) perception of emotional faces in young adults (N = 40). Results showed that acute exercise-induced differences of state anxiety (STAI-S) varied as a function of individual’s habitual physical activity (IPAQ). Subjects with high IPAQ levels showed significant STAI-S reduction (P < 0.05). Path analyses indicated that IPAQ explained 14.67% of the variance in acute exercise-induced STAI-S differences. Running elicited stronger amygdala reactivity to implicit happiness than fear, whereas walking did the opposite. The exercise-induced amygdala reactivity to explicit fear was associated with the IPAQ scores and STAI-S differences. Moreover, after running, the amygdala exhibited a positive functional connectivity with the orbitofrontal cortex and insula to implicit happiness, but a negative connectivity with the parahippocampus and subgenual cingulate to implicit fear. The findings suggest that habitual physical activity could mediate acute exercise-induced anxiolytic effects in regards to amygdala reactivity, and help establish exercise training as a form of anxiolytic therapy towards clinical applications.

P.0072 Anxious distress in major depression: an fMRI study of amygdala reactivity and functional connectivity

2021 ◽  
Vol 53 ◽  
pp. S51-S52
Author(s):  
L. Nawijn ◽  
R. Dinga ◽  
M. Aghajani ◽  
N.J.A. Van der Wee ◽  
M.J. Van Tol ◽  
...  
Keyword(s):  
Major Depression ◽  
Functional Connectivity ◽  
Fmri Study ◽  
Amygdala Reactivity

Effects of exercise on endothelium and endothelium/smooth muscle cross talk: role of exercise-induced hemodynamics

2011 ◽  
Vol 111 (1) ◽  
pp. 311-320 ◽  
Author(s):  
S. C. Newcomer ◽  
Dick H. J. Thijssen ◽  
D. J. Green
Keyword(s):  
Physical Activity ◽  
Shear Stress ◽  
Wall Stress ◽  
Beneficial Effects ◽  
Exercise Induced ◽  
Response To Exercise ◽  
And Training

Physical activity, exercise training, and fitness are associated with decreased cardiovascular risk. In the context that a risk factor “gap” exists in the explanation for the beneficial effects of exercise on cardiovascular disease, it has recently been proposed that exercise generates hemodynamic stimuli which exert direct effects on the vasculature that are antiatherogenic. In this review we briefly introduce some of the in vitro and in vivo evidence relating exercise hemodynamic modulation and vascular adaptation. In vitro data clearly demonstrate the importance of shear stress as a potential mechanism underlying vascular adaptations associated with exercise. Supporting this is in vivo human data demonstrating that exercise-mediated shear stress induces localized impacts on arterial function and diameter. Emerging evidence suggests that exercise-related changes in hemodynamic stimuli other than shear stress may also be associated with arterial remodeling. Taken together, in vitro and in vivo data strongly imply that hemodynamic influences combine to orchestrate a response to exercise and training that regulates wall stress and peripheral vascular resistance and contributes to the antiatherogenic impacts of physical activity, fitness, and training.

scholarly journals Exercise Induced Adipokine Changes and the Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Saeid Golbidi ◽  
Ismail Laher
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
The Body ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Before And After ◽  
Inflammatory State ◽  
Exercise Induced

The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of secreting many cytokines that are though to be involved in the pathophysiology of obesity, insulin resistance, and metabolic syndrome. Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. Lifestyle change in terms of increased physical activity and exercise is the best nonpharmacological treatment for obesity since these can reduce insulin resistance, counteract the inflammatory state, and improve the lipid profile. There is growing evidence that exercise exerts its beneficial effects partly through alterations in the adipokine profile; that is, exercise increases secretion of anti-inflammatory adipokines and reduces proinflammatory cytokines. In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.

Muscle microvascular adaptation and angiogenic gene induction in response to exercise training are attenuated in middle-aged rats

2015 ◽  
Vol 11 (1) ◽  
pp. 23-33
Author(s):  
J. Suzuki
Keyword(s):  
Exercise Training ◽  
Acute Exercise ◽  
Young Group ◽  
Treadmill Running ◽  
Mrna Levels ◽  
Aged Rats ◽  
Middle Aged ◽  
Vegf Mrna ◽  
Aged Group ◽  
Exercise Induced

This study was designed to investigate exercise-induced changes in muscle capillarisation, the mRNA expression of angiogenic genes, and microRNA levels in young and middle-aged rats. Rats in the training groups were subjected to treadmill running 5 days a week for 3 weeks. The exercise protocol for the young (12-week old) group was 20-25 m/min, 40-60 min/day with a gradient of 15%, and for the middle-aged (12-month old) group was 18-20 m/min, 40-60 min/day with a gradient of 5%. The enzyme histochemical identification of capillary profiles was performed on cross-sections of gastrocnemius muscle. Total RNA was isolated, reverse transcription was performed, and mRNA and microRNA levels were determined by real-time PCR. The capillary-to-fibre ratio was significantly increased by exercise training in the young group (by 10%), but only slightly in the middle-aged (by 5%) group. Vascular endothecial growth factor (VEGF) mRNA levels were at significantly higher values after acute exercise (1.6-fold) and the 3-week training protocol (1.9-fold) in the young group, but not in the middle-aged group. VEGF protein expression levels were significantly increased after training in the young group only. Endothelial nitric oxide synthase, VEGF-R2 and thrombospondin-1 mRNA levels were significantly lower in the middle-aged group than in the young group. Anti-angiogenic miR-195 levels were significantly enhanced by exercise training in the middle-aged group only. These results indicated that the exercise-induced adaptation of muscle capillarity was attenuated in middle-aged rats, possibly by the lower induction of VEGF and up-regulation of anti-angiogenic miRNA expression.

Acute Exercise Enhances Preschoolers’ Ability to Sustain Attention

2013 ◽  
Vol 35 (4) ◽  
pp. 433-437 ◽  
Author(s):  
Kara K. Palmer ◽  
Matthew W. Miller ◽  
Leah E. Robinson
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Acute Exercise ◽  
School Age Children ◽  
School Age ◽  
Beneficial Effects ◽  
Single Bout ◽  
Growing Body

A growing body of research has illuminated beneficial effects of a single bout of physical activity (i.e., acute exercise) on cognitive function in school-age children. However, the influence of acute exercise on preschoolers’ cognitive function has not been reported. To address this shortcoming, the current study examined the effects of a 30-min bout of exercise on preschoolers’ cognitive function. Preschoolers’ cognitive function was assessed following a single bout of exercise and a single sedentary period. Results revealed that, after engaging in a bout of exercise, preschoolers exhibited markedly better ability to sustain attention, relative to after being sedentary (p = .006, partial eta square = .400). Based on these findings, providing exercise opportunities appears to enhance preschoolers’ cognitive function.

scholarly journals Unmasking Anxiety in Autism: Explicit and Implicit Threat Dissociate Amygdala-centered Functional Connectivity

2020 ◽  
Author(s):  
Yu-Chun Chen ◽  
Chenyi Chen ◽  
Chia-Chien Liu ◽  
Róger Marcelo Martínez ◽  
Yang-Tang Fan ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Relevant Information ◽  
Autism Spectrum ◽  
Autism Spectrum Quotient ◽  
Neural Pathways ◽  
Backward Masking ◽  
Threat Processing ◽  
Fmri Study ◽  
Socially Relevant ◽  
Amygdala Reactivity

Abstract Background Anxiety is the most prevalent comorbidity in individuals diagnosed with autism spectrum disorder (ASD). Amygdala reactivity to explicit and implicit threat processing offers a platform to assess anxiety. The neural mechanisms underlying the link between anxiety and ASD remains elusive.Methods In this fMRI study, we recruited young adults with ASD (N = 31) and matched them with controls, then proceeded to assess their autistic and anxiety traits by the use of the Autism-Spectrum Quotient (AQ) and the State-Trait Anxiety Inventory (STAI-S), respectively; and scanned their amygdala reactivity in response to explicit and implicit (backward masking) perception of threatening faces.Results As compared to controls, the amygdala reactivity in ASD subjects was significantly reduced to explicit threat, but comparable to implicit threat. The correlations of the amygdala reactivity with the AQ and STAI-S were dissociated depending on threat processing (explicit or implicit). Furthermore, the amygdala in ASD relative to controls had a more negative functional connectivity with the superior parietal cortex, fusiform gyrus, and hippocampus for explicit threat, whereas a more positive connectivity with the medial prefrontal cortex, temporal pole, and hippocampus for implicit threat.Conclusion In ASD, the transmission of socially relevant information along dorsal and ventral neural pathways centered on the amygdala is dissociated depending on explicit and implicit threat processing. This dissociation, ascribed to their failure to compromise pre-existing hyperarousal, might contribute to anxiety in ASD.

scholarly journals Effects of chronic nitric oxide synthase inhibition on responses to acute exercise in swine

2008 ◽  
Vol 104 (1) ◽  
pp. 186-197 ◽  
Author(s):  
Richard M. McAllister ◽  
Sean C. Newcomer ◽  
Eric R. Pope ◽  
James R. Turk ◽  
M. Harold Laughlin
Keyword(s):  
Nitric Oxide ◽  
Acute Exercise ◽  
Maximal Exercise ◽  
Tap Water ◽  
Treadmill Running ◽  
Blood Flows ◽  
No Formation ◽  
Exercise Induced ◽  
Oxide Synthase

Nitric oxide (NO) is potentially involved in several responses to acute exercise. We tested the hypotheses that inhibition of NO formation reduces maximal O2 delivery to muscle, but does not affect O2 utilization by muscle, therefore lowering maximal O2 consumption. To test these hypotheses, swine (∼30 kg) drank either tap water (Con, n = 25) or water with NG-nitro-l-arginine methyl ester (8.0 ± 0.4 mg·kg−1·day−1 for ≥4 wk; LN, n = 24). Treatment efficacy was reflected by higher mean arterial pressure and lower plasma NO metabolite concentration in LN than Con (both P < 0.05). Swine completed two graded treadmill running tests to maximum. In the first test, O2 consumption was determined at rest through maximal exercise intensity. O2 consumption did not differ between groups at rest or at most exercise intensities, including maximum (Con, 40.8 ± 1.8 ml·min−1·kg−1; LN, 40.4 ± 2.9; not significant). In the second test, tissue-specific blood flows were determined using the radiolabeled-microsphere technique. At rest, blood flows were lower ( P < 0.05) in LN compared with Con for a number of tissues, including kidney, adrenal, lung, and several skeletal muscles. During both submaximal and maximal exercise, however, blood flows were similar between Con and LN for all 16 muscles examined; only blood flows to kidney (Con, 99 ± 16 ml·min−1·100 g; LN, 55 ± 15; P < 0.05) and pancreas (Con, 25 ± 7; LN, 6 ± 2; P < 0.05) were lower in LN at maximum. Endothelium-dependent, but not -independent, relaxation of renal arterial segments was reduced ( P < 0.05) in vitro. These data indicate that exercise-induced increases in muscle blood flows are maintained with chronic inhibition of NO formation and that maximal O2 consumption is therefore preserved. Redundant vasodilatory pathways and/or upregulation of these pathways may underlie these findings.

Comparison and Relationship of VO2peak and Physical Activity Patterns in Elementary and High School Females

1998 ◽  
Vol 10 (2) ◽  
pp. 153-163 ◽  
Author(s):  
Mark Loftin ◽  
Patricia Strikmiller ◽  
Barbara Warren ◽  
Leann Myers ◽  
Leslie Schroth ◽  
...  
Keyword(s):  
Physical Activity ◽  
High School ◽  
Vigorous Physical Activity ◽  
Activity Patterns ◽  
Habitual Physical Activity ◽  
Treadmill Running ◽  
Physical Activity Patterns ◽  
Median Correlation ◽  
Low Levels ◽  
Relationship Of

Peak cardiorespiratory responses, physical activity patterns, and the association of VO2peak and physical activity were examined in 16 elementary (ES) and 16 high school (HS) females. Peak responses were assessed during treadmill running, and physical activity patterns were examined over two 12-hour weekdays. Results indicated similar relative VO2peak responses between groups (ES: M = 46.8 ml · kg−1 · min−1;HS:M = 46.6 ml · kg−1 · min−1). No statistical differences (p ≤ .05) were noted when moderate to vigorous physical activity (MVPA) and vigorous physical activity (VPA) were compared. Also, a three-way (Group × HR level × Sustained minutes) ANOVA revealed no statistical differences. A median correlation (r = .27) was found from 8 independent correlations of habitual physical activity and VO2peak. ES and HS appeared similar in regard to VO2peak, accumulative and sustained MVPA and VPA. Low levels of sustained MVPA and VPA (≥ 10 min) were evident in both groups.

Self-Efficacy Influences Feeling States Associated with Acute Exercise

1994 ◽  
Vol 16 (3) ◽  
pp. 326-333 ◽  
Author(s):  
Shannon Bezoian ◽  
W. Jack Rejeski ◽  
Edward McAuley
Keyword(s):  
Physical Activity ◽  
Construct Validity ◽  
Social Cognitive ◽  
Acute Exercise ◽  
Exercise Bout ◽  
Psychological Responses ◽  
Acute Bout ◽  
Feeling States ◽  
Exercise Induced ◽  
Positive Engagement

The present study examined the role that preexisting efficacy cognitions played in the generation of exercise-induced feeling states during and following an acute bout of exercise. In so doing, the construct validity of a newly developed measure of psychological responses to exercise, the Exercise-Induced Feeling Inventory (EFI; Gauvin & Rejeski, 1993), was investigated. Female undergraduates, classified as having either high or low physical efficacy, engaged in an acute exercise bout and feeling states were recorded prior to, during, and following the activity. More efficacious females maintained a sense of energy during exercise and felt more revitalized and experienced increased positive engagement postexercise than did their less efficacious counterparts. Such findings provide further support for a social-cognitive interpretation of how psychological responses to physical activity might be generated. Results are further discussed in terms of the measurement of exercise-induced feeling states and future applications of the EFI.

scholarly journals Impact of Different Physical Exercises on the Expression of Autophagy Markers in Mice

2021 ◽  
Vol 22 (5) ◽  
pp. 2635
Author(s):  
Ana P. Pinto ◽  
Alisson L. da Rocha ◽  
Bruno B. Marafon ◽  
Rafael L. Rovina ◽  
Vitor R. Muñoz ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Gastrocnemius Muscle ◽  
Acute Exercise ◽  
Colchicine Treatment ◽  
Heart Tissue ◽  
Beclin 1 ◽  
Liver Protein ◽  
Beneficial Effects ◽  
Protein Levels ◽  
Exercise Induced

Although physical exercise-induced autophagy activation has been considered a therapeutic target to enhance tissue health and extend lifespan, the effects of different exercise models on autophagy in specific metabolic tissues are not completely understood. This descriptive investigation compared the acute effects of endurance (END), exhaustive (ET), strength (ST), and concurrent (CC) physical exercise protocols on markers of autophagy, genes, and proteins in the gastrocnemius muscle, heart, and liver of mice. The animals were euthanized immediately (0 h) and six hours (6 h) after the acute exercise for the measurement of glycogen levels, mRNA expression of Prkaa1, Ppargc1a, Mtor, Ulk1, Becn1, Atg5, Map1lc3b, Sqstm1, and protein levels of Beclin 1 and ATG5. The markers of autophagy were measured by quantifying the protein levels of LC3II and Sqstm1/p62 in response to three consecutive days of intraperitoneal injections of colchicine. In summary, for gastrocnemius muscle samples, the main alterations in mRNA expressions were observed after 6 h and for the ST group, and the markers of autophagy for the CC group were increased (i.e., LC3II and Sqstm1/p62). In the heart, the Beclin 1 and ATG5 levels were downregulated for the ET group. Regarding the markers of autophagy, the Sqstm1/p62 in the heart tissue was upregulated for the END and ST groups, highlighting the beneficial effects of these exercise models. The liver protein levels of ATG5 were downregulated for the ET group. After the colchicine treatment, the liver protein levels of Sqstm1/p62 were decreased for the END and ET groups compared to the CT, ST, and CC groups. These results could be related to diabetes and obesity development or liver dysfunction improvement, demanding further investigations.

Sign in / Sign up

Export Citation Format

Share Document