scholarly journals No effect of moderate alcohol intake on the detection of concealed identity information in the laboratory

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kristina Suchotzki ◽  
Heidi May ◽  
Matthias Gamer
Keyword(s):  
Field Study ◽  
Personal Information ◽  
Alcohol Intoxication ◽  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Control Group ◽  
Concealed Information Test ◽  
Group Assignment ◽  
Study Results ◽  
Moderate Alcohol Intake

AbstractThe Concealed Information Test (CIT) enables the detection of certain (e.g., crime-relevant or personal) information, even if participants aim to conceal their knowledge. The current preregistered study investigated whether previously observed impairing effects of alcohol intoxication on participants’ performance in a reaction time CIT (RT CIT) field study also translate to a laboratory environment. In contrast to the previous study of Suchotzki and Gamer (Sci Rep 8:7825, 2018) in which alcohol consumption was voluntary and self-administered, the current study used a randomized assignment of participants to either an alcohol group (n = 88; receiving a drink with 3 cl alcohol) or a sober control group (n = 89; receiving a drink with just some alcohol drops to hide group assignment). After drink administration, participants completed an RT CIT, in which they were instructed to hide knowledge of their own identity. Blood alcohol concentration (BAC) was estimated via breath alcohol ratio. In contrast to the previous field study, results revealed no differences in CIT-performance between intoxicated and sober participants. Aside from questioning the robustness of the result of the previous field study, our results also point to a number of interesting theoretical explanations for the discrepancy between both results, which are elaborated in the discussion.

Auto-brewery syndrome: Ethanol pseudo-toxicity in diabetic and hepatic patients

2016 ◽  
Vol 36 (5) ◽  
pp. 445-450 ◽  
Author(s):  
EM Hafez ◽  
MA Hamad ◽  
M Fouad ◽  
A Abdel-Lateff
Keyword(s):  
Ethanol Production ◽  
Metabolic Pathways ◽  
Alcohol Intoxication ◽  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Gas Chromatography Mass Spectrometry ◽  
Control Group ◽  
Blood Alcohol ◽  
Carbohydrate Ingestion ◽  
Headspace Gas

Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (DM), liver cirrhosis (LC) and presence of both (DM and LC) on blood alcohol concentration (BAC) especially after carbohydrate ingestion. BAC has been measured by headspace gas chromatography-mass spectrometry in three groups of humans namely control, DM, LC and both (DM and LC) groups. The results showed that BAC in control group was 0.01–.3 mg/dL with mean 0.3 ± 0.41 mg/dL. In patients with DM, BAC is significantly higher than that of control group 4.85 ± 3.96 mg/dL. In patients with LC, BAC was 3.45 ± 2.65 mg/dL. In patients with both DM and LC, BAC increases to reach 10.88 ± 5.36 mg/dL. Endogenous ethanol production appears to increase in DM and LC. Also, it increased much more in patients with both diseases, but it did not reach toxic levels. On comparing BAC and blood glucose level in each group, all groups show insignificant correlations ( p > 0.05).

scholarly journals Impact of legislation to reduce the drink-drive limit on road traffic accidents and alcohol consumption in Scotland: a natural experiment study

2019 ◽  
Vol 7 (12) ◽  
pp. 1-46 ◽  
Author(s):  
Jim Lewsey ◽  
Houra Haghpanahan ◽  
Daniel Mackay ◽  
Emma McIntosh ◽  
Jill Pell ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Health Research ◽  
Traffic Accidents ◽  
Road Traffic ◽  
Blood Alcohol Concentration ◽  
Public Health Research ◽  
Alcohol Concentration ◽  
Control Group ◽  
England And Wales ◽  
Per Capita

Background It is widely recognised that drink driving is a leading cause of road traffic accidents (RTAs). There is evidence that changing the drink-drive limit from a blood alcohol concentration of 0.08 to 0.05 g/dl is effective in reducing RTAs. Scotland changed the blood alcohol concentration limit to 0.05 g/dl on 5 December 2014. Aims To assess whether or not the numbers and rates of RTAs and per capita alcohol consumption in Scotland were reduced because of the 2014 drink-drive legislation. To assess whether or not the 2014 change in legislation provided good value for money. Design A natural experimental, quantitative study. The control group was England and Wales, that is, the other countries in Great Britain, where the drink-drive legislation remained unchanged. Setting Great Britain. Participants The entire population of Scotland, England and Wales for the period of January 2013–December 2016. Intervention The change to drink-drive legislation in Scotland. Outcome measures The counts and rates of RTAs; and per capita alcohol consumption. Methods For the numbers and rates of RTAs (both traffic flow and population denominators were used), and separately for the intervention and control trial groups, negative binomial regression models were fitted to panel data sets to test for a change in outcome level after the new 2014 legislation was in place. To obtain a ‘difference-in-differences’ (DiD)-type measure of effect, an interaction term between the intervention group indicator and the binary covariate for indicating pre and post change in legislation (‘pseudo’-change for the control group) was assessed. For off- and on-trade per capita alcohol sales, and separately for the intervention and control trial group, seasonal autoregressive integrated moving average error models were fitted to the relevant time series. Results The change to drink-drive legislation was associated with a 2% relative decrease in RTAs in Scotland [relative risk (RR) 0.98, 95% CI 0.91 to 1.04; p = 0.53]. However, the pseudo-change in legislation was associated with a 5% decrease in RTAs in England and Wales (RR 0.95, 95% CI 0.90 to 1.00; p = 0.05). For RTA rates, with traffic flow as the denominator, the DiD-type estimate indicated a 7% increase in rates for Scotland relative to England and Wales (unadjusted RR 1.07, 95% CI 0.98 to 1.17; p = 0.1). The change to drink-drive legislation was associated with a 0.3% relative decrease in per capita off-trade sales (–0.3%, 95% CI –1.7% to 1.1%; p = 0.71) and a 0.7% decrease in per capita on-trade sales (–0.7%, 95% CI –0.8% to –0.5%; p < 0.001). Conclusion The change to drink-drive legislation in Scotland in December 2014 did not have the expected effect of reducing RTAs in the country, and nor did it change alcohol drinking levels in Scotland. This main finding for RTAs was unexpected and the research has shown that a lack of enforcement is the most likely reason for legislation failure. Future work Investigations into how the public interpret and act on changes in drink-drive legislation would be welcome, as would research into whether or not previous change in drink-drive legislation effects on RTAs in other jurisdictions are associated with the level of enforcement that took place. Trial registration Current Controlled Trials ISRCTN38602189. Funding This project was funded by the National Institute for Health Research (NIHR) Public Health Research programme and will be published in full in Public Health Research; Vol. 7, No. 12. See the NIHR Journals Library website for further project information.

scholarly journals The co-occurrence of mental disorders among Dutch adolescents admitted for acute alcohol intoxication

2020 ◽  
Author(s):  
Loes de Veld ◽  
Joris J. van Hoof ◽  
Inge M. Wolberink ◽  
Nicolaas van der Lely
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Mental Disorders ◽  
Attention Deficit ◽  
Alcohol Intoxication ◽  
Blood Alcohol Concentration ◽  
Autism Spectrum ◽  
Alcohol Concentration ◽  
Acute Alcohol Intoxication ◽  
Cross Sectional ◽  
Hyperactivity Disorder

Abstract Adolescents with substance use disorders are often diagnosed with co-occurring mental disorders. However, it is unknown if adolescent hospital admission for acute alcohol intoxication is also associated with co-occurring mental disorders. Therefore, the primary aim of this study is to estimate the prevalence of co-occurring mental disorders among Dutch adolescents admitted for acute alcohol intoxication. Secondly, this study aims to explore the cross-sectional relationship between the co-occurrence of mental disorders and patient characteristics, such as sex, age and blood alcohol concentration at admittance. Data were retrospectively collected from 726 adolescents admitted for acute alcohol intoxication. Overall, 245 (34%) of the 726 adolescents treated for acute alcohol intoxication were diagnosed with a co-occurring mental health disorder, such as attention-deficit hyperactivity disorder (13%) or autism spectrum disorder (2.1%). Attention-deficit hyperactivity disorder in particular seems to be more prevalent in the study population than in the general Dutch adolescent population. Conclusion: This study demonstrates that among adolescents admitted for acute alcohol intoxication, the prevalence of co-occurring mental disorders is a common and a relevant issue for treatment and prevention strategies. What is Known:• Alcohol consumption among adolescents has been associated with negative psychosocial effect.• Among adolescents admitted for acute alcohol intoxication, risk factors for psychological dysfunction appear to be inadequately assessed, documented and followed up. What is New:• The current study reports on the prevalence of co-occurring mental disorders among a substantial sample of adolescents admitted for acute alcohol intoxication.• Understanding the prevalence of co-occurring mental disorders is clinically relevant for the outpatient follow-up of adolescents admitted for acute alcohol intoxication.

scholarly journals Sex Differences in the Presence and Severity of Alcohol Hangover Symptoms

2019 ◽  
Vol 8 (6) ◽  
pp. 867 ◽  
Author(s):  
van Lawick van Pabst ◽  
Devenney ◽  
Verster
Keyword(s):  
Sex Differences ◽  
Alcohol Intoxication ◽  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Blood Alcohol ◽  
Small Magnitude ◽  
Severity Scores ◽  
Alcohol Hangover ◽  
Peak Blood ◽  
Drinking Occasion

Studies have demonstrated significant sex differences in alcohol intoxication effects. In contrast, the majority of studies on the alcohol hangover phase did not investigate sex differences. Therefore, the current study examined possible sex differences in the presence and severity of alcohol hangover symptoms. Data from n = 2446 Dutch students (male = 50.7%, female = 49.3%) were analyzed. They reported the presence and severity of 22 hangover symptoms experienced after their past month heaviest drinking occasion. Subjects were categorized according to their estimated peak blood alcohol concentration (eBAC) and presence and severity of the hangover symptoms were compared between men and women. In the lowest eBAC group (0% ≤ eBAC < 0.08%), no significant sex differences were found. In the subsequent eBAC group (0.08% ≤ eBAC < 0.11%), severity of nausea was significantly higher in women than in men. In the third eBAC group (0.11% ≤ eBAC < 0.2%), women reported higher severity scores on nausea, tiredness, weakness, and dizziness than men. Men reported the presence of confusion significantly more often than women, and women reported the presence of shivering significantly more often than men. In the fourth eBAC group (0.2% ≤ eBAC < 0.3%), women reported higher severity scores on nausea and tiredness than men. In the highest eBAC group (0.3% ≤ eBAC < 0.4%), no significant sex differences were found. In conclusion, across the eBAC groups, severity scores of nausea and tiredness were higher in women than in men. However, albeit statistically significant, the observed sex differences in presence and severity of hangover symptoms were of small magnitude, and therefore, have little clinical relevance.

scholarly journals The Effect of Alcohol Intoxication on Mortality of Blunt Head Injury

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Hsing-Lin Lin ◽  
Tsung-Ying Lin ◽  
Kwan-Ming Soo ◽  
Chao-Wen Chen ◽  
Liang-Chi Kuo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Logistic Regression ◽  
Head Injury ◽  
Traffic Accident ◽  
Alcohol Intoxication ◽  
Head Injuries ◽  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Brain Computed Tomography ◽  
Adjusted Logistic Regression

Alcohol is found to have neuroprotection in recent studies in head injuries. We investigated the association of blood alcohol concentration (BAC) with mortality of patients with blunt head injury after traffic accident. All patients sustaining blunt head injury caused by traffic accident brought to our emergency department who had obtained a brain computed tomography scans and BAC were analyzed. Patients with unknown mechanisms, transfers from outside hospitals, and incomplete data were excluded. Logistic regression was used to identify independent predictors of mortality. During the study period, 3,628 patients with brain computed tomography (CT) were included. Of these, BAC was measured in 556 patients. Patients with the lowest BAC (less than 8 mg/dl) had lower mortality; intoxicated patients with BAC between 8 and less than 100 mg/dl were associated with significantly higher mortality than those patients in other intoxicated groups. Adjusted logistic regression demonstrated higher BAC group and Glasgow coma scale (GCS) scores, and lower ISS and age were identified as independent predictors of reduced mortality. In our study, we found that patients who had moderate alcohol intoxication had higher risk of mortality. However, higher GCS scores, lower ISS, and younger age were identified as independent predictors of reduced mortality in the study patients.

Paclitaxel Formulation as a Cause of Ethanol Intoxication

1997 ◽  
Vol 31 (7-8) ◽  
pp. 873-875 ◽  
Author(s):  
David B. Wilson ◽  
Thomas M. Beck ◽  
Catherine A. Gundlach
Keyword(s):  
Alcohol Intoxication ◽  
Blood Alcohol Concentration ◽  
Metastatic Breast ◽  
Alcohol Concentration ◽  
Ethanol Intoxication ◽  
Metastatic Breast Carcinoma ◽  
Case Summary ◽  
Short Period ◽  
Patient Series ◽  
Higher Doses

OBJECTIVE: To report a case of ethyl alcohol intoxication associated with paclitaxel administration. CASE SUMMARY: A patient who received a 3-hour paclitaxel infusion for metastatic breast carcinoma and developed symptoms of acute alcohol intoxication. A blood ethanol concentration drawn at the end of the paclitaxel infusion was 97.8 mg/dL (0.098%). DISCUSSION: The amount of alcohol contained in paclitaxel is discussed. A review of the literature revealed one patient series where the highest blood alcohol concentration was one-third that seen in our patient. CONCLUSIONS: Clinicians should recognize the potential for alcohol intoxication with paclitaxel administration. This is especially pertinent when higher doses are given over a short period of time.

The Tracometer as an Intoxication Warning Device

1987 ◽  
Vol 31 (7) ◽  
pp. 751-755 ◽  
Author(s):  
Y. Ian Noy
Keyword(s):  
Alcohol Intoxication ◽  
Blood Alcohol Concentration ◽  
Drunk Driving ◽  
Alcohol Concentration ◽  
Tracking Task ◽  
Alcoholic Beverages ◽  
Subsequent Test ◽  
Pursuit Tracking ◽  
Wide Range ◽  
Male Subjects

An experiment was conducted to investigate the feasibility of developing an in-vehicle skill-based drunk driver detection and deterrence system. The experiment compared two well-developed psychomotor test devices, the Tracometer and the Critical Tracking Task (CTT), for their ability to detect alcohol intoxication. The Tracometer employed a pursuit tracking task whereas the CTT employed a compensatory tracking task. Twenty male subjects, aged 19 − 30 were trained on the Tracometer and the CTT over a three day period. On two subsequent test days, they were treated with either placebo or alcoholic beverages designed to bring their peak Blood Alcohol Concentration (BAC) to 1.2% (1200 mg/L). On each day, the subjects were tested once before treatment and six times after treatment at hourly intervals as their BAC levels declined. The results indicate that the Tracometer was more sensitive than the CTT to the the effects of alcohol over a wide range of BAC levels. At a BAC level of .08%, performance on the Tracometer deteriorated by 16% whereas performance on the CTT deteriorated by only 7%. Using optimized pass/fail protocols, the Tracometer failed 60% of subjects with BAC in the range .08–1.0%, whereas the CTT failed 34%. At BAC levels above 1.0%, the Tracometer failed about 85% whereas the CTT failed 40%. These results clearly illustrate the potential of the Tracometer as a test of alcohol intoxication. Although the impetus behind the study was the development of drunk-driving countermeasures, the technology can be easily extended to include other applications.

Ethanol-induced symptoms in patients receiving gemcitabine diluted from a concentrate for solution for infusion containing ethanol

2017 ◽  
Vol 24 (7) ◽  
pp. 511-516
Author(s):  
Raúl Diez-Fernández ◽  
Rocío Vázquez-Sánchez ◽  
Laura López-Esteban ◽  
Santos Enrech-Frances ◽  
Ana María Sánchez-Peña ◽  
...  
Keyword(s):  
Ethanol Concentration ◽  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Control Group ◽  
Study Group ◽  
Blood Alcohol ◽  
Double Blind ◽  
Impaired Balance ◽  
The Difference ◽  
Symptoms And Signs

Purpose Ethanol as an excipient is used to enhance the solubility of gemcitabine, but, sometimes, the dose of ethanol a patient may be given is much higher than the dose considered to be toxic. We aimed to assess ethanol-related symptoms and signs in patients receiving two formulations of gemcitabine, with and without ethanol. Methods A randomized double blind cross-over study was conducted. All patients being treated with gemcitabine received two consecutive doses of the drug, one diluted from a concentrate for solution for infusion (CSI) containing ethanol and the other from a lyophilized powder, without ethanol, which was used as control group. After each administration, patients were surveyed in order to assess the appearance of any alcohol consumption symptoms (dizziness, difficulty speaking, unsteady walking, impaired balance, mood swings and slower reactions). Widmark formula and the amount of alcohol measured on the breath (breathalyzer) were used to estimate blood alcohol concentration. Results Twenty-four patients received both formulations and were included in the analysis. Mean administered ethanol dose when prepared from CSI was 15.81 ± 2.25 g (mean ± SD). When using CSI gemcitabine, estimated blood ethanol concentration was 0.033 g/dl according to Widmark formula and 0.02 g/dl according to breathalyzer results. Although overall incidence of symptoms was higher in the study group, the difference was not statistically significant (33% vs. 25%; p = 0.53). Conclusions These findings prove there is no difference in the onset of ethanol related symptoms when using CSI instead of lyophilized powder on the reconstitution of gemcitabine.

scholarly journals Co-use of medication and alcohol: The influence on subjective effects of intoxication and affect

2020 ◽  
Author(s):  
Ashley C. Helle ◽  
Andrea M Wycoff ◽  
Sarah A Griffin ◽  
Megan Fleming ◽  
Lindsey K Freeman ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Positive Affect ◽  
Subjective Experience ◽  
Alcohol Intoxication ◽  
Subjective Effects ◽  
Blood Alcohol Concentration ◽  
Medication Use ◽  
Prescription Medication ◽  
Alcohol Concentration ◽  
Specific Medication

Co-use of alcohol and medication can have serious negative health effects (e.g., overdose risk, liver damage). Research has primarily focused on older adults or the pharmacokinetics of specific medication-alcohol combinations. Little work has been done on the subjective experience of persons who take alcohol-interactive (AI) medications and also drink alcohol, particularly in psychiatric samples at high risk for problematic alcohol use and high rates of prescription medication use, such as individuals with borderline personality disorder (BPD). Data from a larger ecological momentary assessment (EMA) study of alcohol use in 52 persons diagnosed with BPD (83% women; Mage=26 years) were used to examine the influence of alcohol intoxication (i.e., estimated blood alcohol concentration; eBAC) and medication co-use on momentary subjective experience while drinking. Participants reported AI medication use at baseline and completed multiple EMA reports per day over 21 days, which included reports of alcohol use, subjective effects of alcohol (e.g., pleasure, feeling worse), and negative and positive affect. AI medications significantly moderated the association between eBAC and pleasurable effects of alcohol, such that at higher levels of eBAC, those taking AI medications experienced blunted subjective pleasure compared to those not taking AI medications. AI medications did not moderate the associations between eBAC and subjective relief, feeling worse, positive affect, or negative affect. Attenuated pleasure during drinking could lead to increased drinking in an attempt to achieve a desirable state among individuals who co-use psychiatric medications and alcohol, and therefore may represent a useful target for prevention and intervention.

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